PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cop9 signalosome complex subunit, putative

Species:

Leishmania major

UniProt:

Q4Q0A6_LEIMA

TriTrypDb:

LmjF.36.6510 , LMJLV39_360079500 , LMJSD75_360079300

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0A6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.530
CLV_NRD_NRD_1	205	207	PF00675	0.440
CLV_PCSK_KEX2_1	205	207	PF00082	0.440
CLV_PCSK_KEX2_1	380	382	PF00082	0.465
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.465
CLV_PCSK_SKI1_1	230	234	PF00082	0.340
CLV_PCSK_SKI1_1	300	304	PF00082	0.360
CLV_PCSK_SKI1_1	330	334	PF00082	0.450
CLV_PCSK_SKI1_1	34	38	PF00082	0.448
DEG_APCC_DBOX_1	229	237	PF00400	0.341
DOC_CYCLIN_RxL_1	318	329	PF00134	0.421
DOC_MAPK_gen_1	391	399	PF00069	0.551
DOC_MAPK_JIP1_4	393	399	PF00069	0.524
DOC_MAPK_MEF2A_6	391	398	PF00069	0.533
DOC_PP1_RVXF_1	109	116	PF00149	0.375
DOC_PP2B_LxvP_1	261	264	PF13499	0.404
DOC_USP7_MATH_1	211	215	PF00917	0.346
DOC_USP7_MATH_1	289	293	PF00917	0.412
DOC_WW_Pin1_4	129	134	PF00397	0.443
DOC_WW_Pin1_4	3	8	PF00397	0.440
LIG_14-3-3_CanoR_1	111	116	PF00244	0.324
LIG_14-3-3_CanoR_1	210	216	PF00244	0.354
LIG_14-3-3_CanoR_1	34	39	PF00244	0.439
LIG_14-3-3_CanoR_1	79	88	PF00244	0.529
LIG_APCC_ABBA_1	323	328	PF00400	0.393
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_BRCT_BRCA1_1	121	125	PF00533	0.382
LIG_BRCT_BRCA1_1	4	8	PF00533	0.579
LIG_deltaCOP1_diTrp_1	70	78	PF00928	0.404
LIG_FHA_1	260	266	PF00498	0.385
LIG_FHA_1	356	362	PF00498	0.388
LIG_FHA_2	102	108	PF00498	0.449
LIG_FHA_2	130	136	PF00498	0.365
LIG_FHA_2	26	32	PF00498	0.359
LIG_FHA_2	331	337	PF00498	0.439
LIG_FHA_2	372	378	PF00498	0.535
LIG_LIR_Apic_2	70	76	PF02991	0.402
LIG_LIR_Gen_1	101	109	PF02991	0.398
LIG_LIR_Gen_1	132	141	PF02991	0.382
LIG_LIR_Gen_1	314	323	PF02991	0.391
LIG_LIR_Gen_1	336	345	PF02991	0.369
LIG_LIR_Gen_1	357	367	PF02991	0.415
LIG_LIR_Gen_1	42	53	PF02991	0.387
LIG_LIR_Nem_3	101	106	PF02991	0.538
LIG_LIR_Nem_3	122	128	PF02991	0.385
LIG_LIR_Nem_3	132	137	PF02991	0.360
LIG_LIR_Nem_3	165	170	PF02991	0.406
LIG_LIR_Nem_3	214	218	PF02991	0.438
LIG_LIR_Nem_3	314	318	PF02991	0.391
LIG_LIR_Nem_3	336	341	PF02991	0.378
LIG_LIR_Nem_3	357	363	PF02991	0.376
LIG_LIR_Nem_3	376	382	PF02991	0.429
LIG_LIR_Nem_3	42	48	PF02991	0.392
LIG_MLH1_MIPbox_1	122	126	PF16413	0.461
LIG_NRBOX	336	342	PF00104	0.381
LIG_PCNA_yPIPBox_3	239	253	PF02747	0.313
LIG_PDZ_Class_2	394	399	PF00595	0.554
LIG_Pex14_2	212	216	PF04695	0.406
LIG_SH2_CRK	128	132	PF00017	0.364
LIG_SH2_CRK	167	171	PF00017	0.489
LIG_SH2_CRK	266	270	PF00017	0.369
LIG_SH2_CRK	338	342	PF00017	0.368
LIG_SH2_NCK_1	103	107	PF00017	0.451
LIG_SH2_PTP2	268	271	PF00017	0.387
LIG_SH2_STAP1	338	342	PF00017	0.368
LIG_SH2_STAT3	273	276	PF00017	0.415
LIG_SH2_STAT3	293	296	PF00017	0.270
LIG_SH2_STAT5	103	106	PF00017	0.439
LIG_SH2_STAT5	194	197	PF00017	0.339
LIG_SH2_STAT5	208	211	PF00017	0.353
LIG_SH2_STAT5	268	271	PF00017	0.390
LIG_TYR_ITSM	99	106	PF00017	0.427
LIG_UBA3_1	308	313	PF00899	0.350
LIG_WRC_WIRS_1	212	217	PF05994	0.530
MOD_CDK_SPxxK_3	129	136	PF00069	0.455
MOD_CK1_1	147	153	PF00069	0.415
MOD_CK1_1	2	8	PF00069	0.597
MOD_CK1_1	46	52	PF00069	0.385
MOD_CK1_1	80	86	PF00069	0.591
MOD_CK2_1	175	181	PF00069	0.445
MOD_CK2_1	25	31	PF00069	0.439
MOD_CK2_1	330	336	PF00069	0.463
MOD_CK2_1	36	42	PF00069	0.317
MOD_GlcNHglycan	122	125	PF01048	0.429
MOD_GlcNHglycan	157	160	PF01048	0.475
MOD_GlcNHglycan	177	180	PF01048	0.591
MOD_GlcNHglycan	22	25	PF01048	0.386
MOD_GlcNHglycan	256	259	PF01048	0.472
MOD_GlcNHglycan	278	281	PF01048	0.430
MOD_GlcNHglycan	364	367	PF01048	0.470
MOD_GlcNHglycan	38	41	PF01048	0.410
MOD_GlcNHglycan	83	86	PF01048	0.593
MOD_GSK3_1	120	127	PF00069	0.471
MOD_GSK3_1	340	347	PF00069	0.422
MOD_GSK3_1	43	50	PF00069	0.383
MOD_GSK3_1	77	84	PF00069	0.543
MOD_GSK3_1	98	105	PF00069	0.360
MOD_N-GLC_1	20	25	PF02516	0.302
MOD_N-GLC_1	330	335	PF02516	0.349
MOD_N-GLC_1	80	85	PF02516	0.651
MOD_NEK2_1	120	125	PF00069	0.459
MOD_NEK2_1	144	149	PF00069	0.373
MOD_NEK2_1	340	345	PF00069	0.480
MOD_NEK2_2	211	216	PF00069	0.402
MOD_PIKK_1	180	186	PF00454	0.478
MOD_PIKK_1	43	49	PF00454	0.388
MOD_PKA_2	144	150	PF00069	0.383
MOD_PKA_2	254	260	PF00069	0.545
MOD_PKB_1	173	181	PF00069	0.589
MOD_Plk_4	162	168	PF00069	0.471
MOD_Plk_4	211	217	PF00069	0.351
MOD_Plk_4	340	346	PF00069	0.468
MOD_Plk_4	47	53	PF00069	0.318
MOD_ProDKin_1	129	135	PF00069	0.439
MOD_ProDKin_1	3	9	PF00069	0.429
MOD_SUMO_rev_2	322	332	PF00179	0.431
TRG_DiLeu_BaEn_1	336	341	PF01217	0.384
TRG_ENDOCYTIC_2	103	106	PF00928	0.380
TRG_ENDOCYTIC_2	128	131	PF00928	0.384
TRG_ENDOCYTIC_2	167	170	PF00928	0.405
TRG_ENDOCYTIC_2	250	253	PF00928	0.444
TRG_ENDOCYTIC_2	266	269	PF00928	0.344
TRG_ENDOCYTIC_2	338	341	PF00928	0.373
TRG_NES_CRM1_1	207	220	PF08389	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K5	Leptomonas seymouri	55%	100%
A0A3S7XCD5	Leishmania donovani	91%	100%
A4HQH2	Leishmania braziliensis	79%	100%
A4ICA8	Leishmania infantum	91%	100%
E9AU85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%