NUC153 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0A5_LEIMA

TriTrypDb:

LmjF.36.6520 , LMJLV39_360079600 , LMJSD75_360079400

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0A5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.441
CLV_C14_Caspase3-7	303	307	PF00656	0.647
CLV_NRD_NRD_1	182	184	PF00675	0.357
CLV_NRD_NRD_1	324	326	PF00675	0.472
CLV_NRD_NRD_1	451	453	PF00675	0.455
CLV_NRD_NRD_1	503	505	PF00675	0.494
CLV_NRD_NRD_1	54	56	PF00675	0.384
CLV_NRD_NRD_1	541	543	PF00675	0.561
CLV_PCSK_FUR_1	317	321	PF00082	0.607
CLV_PCSK_KEX2_1	182	184	PF00082	0.433
CLV_PCSK_KEX2_1	319	321	PF00082	0.519
CLV_PCSK_KEX2_1	323	325	PF00082	0.520
CLV_PCSK_KEX2_1	451	453	PF00082	0.455
CLV_PCSK_KEX2_1	503	505	PF00082	0.494
CLV_PCSK_KEX2_1	53	55	PF00082	0.395
CLV_PCSK_KEX2_1	541	543	PF00082	0.557
CLV_PCSK_KEX2_1	576	578	PF00082	0.544
CLV_PCSK_KEX2_1	596	598	PF00082	0.603
CLV_PCSK_KEX2_1	97	99	PF00082	0.467
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.558
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.568
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.657
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.467
CLV_PCSK_PC7_1	320	326	PF00082	0.587
CLV_PCSK_SKI1_1	164	168	PF00082	0.528
CLV_PCSK_SKI1_1	433	437	PF00082	0.575
CLV_PCSK_SKI1_1	453	457	PF00082	0.478
CLV_PCSK_SKI1_1	460	464	PF00082	0.464
CLV_PCSK_SKI1_1	509	513	PF00082	0.480
CLV_PCSK_SKI1_1	519	523	PF00082	0.479
CLV_PCSK_SKI1_1	625	629	PF00082	0.517
CLV_PCSK_SKI1_1	97	101	PF00082	0.402
DEG_APCC_DBOX_1	481	489	PF00400	0.615
DEG_APCC_DBOX_1	52	60	PF00400	0.280
DOC_ANK_TNKS_1	596	603	PF00023	0.624
DOC_MAPK_gen_1	522	533	PF00069	0.474
DOC_MAPK_MEF2A_6	104	112	PF00069	0.437
DOC_PP1_RVXF_1	263	269	PF00149	0.423
DOC_PP4_FxxP_1	234	237	PF00568	0.434
DOC_PP4_MxPP_1	25	28	PF00568	0.508
DOC_USP7_MATH_1	250	254	PF00917	0.426
DOC_USP7_MATH_1	298	302	PF00917	0.556
DOC_USP7_MATH_1	609	613	PF00917	0.648
DOC_USP7_MATH_1	8	12	PF00917	0.595
DOC_USP7_UBL2_3	315	319	PF12436	0.605
DOC_USP7_UBL2_3	449	453	PF12436	0.480
DOC_USP7_UBL2_3	456	460	PF12436	0.466
DOC_USP7_UBL2_3	501	505	PF12436	0.509
DOC_USP7_UBL2_3	625	629	PF12436	0.529
DOC_WW_Pin1_4	23	28	PF00397	0.751
DOC_WW_Pin1_4	233	238	PF00397	0.512
LIG_14-3-3_CanoR_1	265	269	PF00244	0.508
LIG_14-3-3_CanoR_1	275	280	PF00244	0.493
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_CaM_IQ_9	423	438	PF13499	0.636
LIG_CaM_IQ_9	534	550	PF13499	0.610
LIG_CSL_BTD_1	41	44	PF09270	0.608
LIG_FHA_1	532	538	PF00498	0.699
LIG_FHA_2	14	20	PF00498	0.630
LIG_FHA_2	284	290	PF00498	0.488
LIG_FHA_2	538	544	PF00498	0.571
LIG_LIR_Apic_2	231	237	PF02991	0.441
LIG_LIR_Gen_1	62	71	PF02991	0.347
LIG_LIR_Nem_3	178	184	PF02991	0.476
LIG_LIR_Nem_3	62	66	PF02991	0.356
LIG_LIR_Nem_3	70	75	PF02991	0.320
LIG_Pex14_2	264	268	PF04695	0.410
LIG_REV1ctd_RIR_1	617	628	PF16727	0.619
LIG_SH2_CRK	326	330	PF00017	0.491
LIG_SH2_CRK	72	76	PF00017	0.355
LIG_SH2_NCK_1	193	197	PF00017	0.323
LIG_SH2_STAP1	326	330	PF00017	0.448
LIG_SH2_STAP1	72	76	PF00017	0.356
LIG_SH2_STAT5	227	230	PF00017	0.378
LIG_SH2_STAT5	295	298	PF00017	0.557
LIG_SH3_3	136	142	PF00018	0.664
LIG_SH3_3	147	153	PF00018	0.744
LIG_SUMO_SIM_par_1	84	89	PF11976	0.540
LIG_TRAF2_1	28	31	PF00917	0.718
LIG_TRAF2_1	286	289	PF00917	0.671
LIG_WRC_WIRS_1	195	200	PF05994	0.329
LIG_WRC_WIRS_1	251	256	PF05994	0.411
MOD_CDK_SPxxK_3	233	240	PF00069	0.507
MOD_CK1_1	2	8	PF00069	0.694
MOD_CK1_1	200	206	PF00069	0.361
MOD_CK1_1	236	242	PF00069	0.617
MOD_CK1_1	257	263	PF00069	0.483
MOD_CK1_1	26	32	PF00069	0.453
MOD_CK1_1	9	15	PF00069	0.660
MOD_CK2_1	13	19	PF00069	0.588
MOD_CK2_1	26	32	PF00069	0.491
MOD_CK2_1	283	289	PF00069	0.626
MOD_CK2_1	298	304	PF00069	0.496
MOD_CK2_1	381	387	PF00069	0.631
MOD_CK2_1	496	502	PF00069	0.520
MOD_CK2_1	537	543	PF00069	0.572
MOD_Cter_Amidation	594	597	PF01082	0.645
MOD_Cter_Amidation	95	98	PF01082	0.371
MOD_GlcNHglycan	128	133	PF01048	0.743
MOD_GlcNHglycan	199	202	PF01048	0.369
MOD_GlcNHglycan	217	221	PF01048	0.371
MOD_GlcNHglycan	256	259	PF01048	0.446
MOD_GlcNHglycan	436	439	PF01048	0.473
MOD_GlcNHglycan	498	501	PF01048	0.520
MOD_GlcNHglycan	6	9	PF01048	0.766
MOD_GSK3_1	148	155	PF00069	0.699
MOD_GSK3_1	2	9	PF00069	0.656
MOD_GSK3_1	250	257	PF00069	0.448
MOD_GSK3_1	275	282	PF00069	0.448
MOD_GSK3_1	372	379	PF00069	0.520
MOD_GSK3_1	418	425	PF00069	0.721
MOD_GSK3_1	556	563	PF00069	0.551
MOD_GSK3_1	580	587	PF00069	0.653
MOD_GSK3_1	605	612	PF00069	0.664
MOD_GSK3_1	86	93	PF00069	0.467
MOD_N-GLC_1	361	366	PF02516	0.514
MOD_NEK2_1	254	259	PF00069	0.388
MOD_NEK2_1	279	284	PF00069	0.530
MOD_NEK2_1	455	460	PF00069	0.585
MOD_NEK2_1	531	536	PF00069	0.567
MOD_NEK2_1	569	574	PF00069	0.653
MOD_NEK2_1	585	590	PF00069	0.397
MOD_NEK2_1	86	91	PF00069	0.522
MOD_NEK2_2	250	255	PF00069	0.425
MOD_PIKK_1	257	263	PF00454	0.400
MOD_PIKK_1	531	537	PF00454	0.685
MOD_PIKK_1	569	575	PF00454	0.610
MOD_PIKK_1	580	586	PF00454	0.678
MOD_PKA_2	264	270	PF00069	0.421
MOD_PKA_2	496	502	PF00069	0.665
MOD_Plk_1	376	382	PF00069	0.607
MOD_Plk_1	411	417	PF00069	0.581
MOD_Plk_1	580	586	PF00069	0.431
MOD_Plk_1	613	619	PF00069	0.598
MOD_Plk_1	86	92	PF00069	0.417
MOD_Plk_2-3	143	149	PF00069	0.665
MOD_Plk_2-3	372	378	PF00069	0.542
MOD_Plk_4	403	409	PF00069	0.674
MOD_Plk_4	86	92	PF00069	0.551
MOD_ProDKin_1	23	29	PF00069	0.740
MOD_ProDKin_1	233	239	PF00069	0.508
MOD_SUMO_rev_2	307	316	PF00179	0.628
MOD_SUMO_rev_2	416	424	PF00179	0.561
MOD_SUMO_rev_2	601	607	PF00179	0.689
TRG_DiLeu_BaEn_4	30	36	PF01217	0.626
TRG_ENDOCYTIC_2	192	195	PF00928	0.342
TRG_ENDOCYTIC_2	208	211	PF00928	0.349
TRG_ENDOCYTIC_2	326	329	PF00928	0.444
TRG_ENDOCYTIC_2	72	75	PF00928	0.369
TRG_ER_diArg_1	181	183	PF00400	0.437
TRG_ER_diArg_1	322	325	PF00400	0.484
TRG_ER_diArg_1	450	452	PF00400	0.476
TRG_ER_diArg_1	53	55	PF00400	0.402
TRG_ER_diArg_1	597	600	PF00400	0.521
TRG_ER_diLys_1	624	629	PF00400	0.534
TRG_NES_CRM1_1	378	392	PF08389	0.672
TRG_NES_CRM1_1	70	84	PF08389	0.351
TRG_NLS_Bipartite_1	504	526	PF00514	0.494
TRG_NLS_MonoCore_2	622	627	PF00514	0.479
TRG_NLS_MonoExtC_3	455	460	PF00514	0.472
TRG_NLS_MonoExtC_3	521	526	PF00514	0.518
TRG_NLS_MonoExtC_3	595	600	PF00514	0.652
TRG_NLS_MonoExtN_4	453	460	PF00514	0.495
TRG_NLS_MonoExtN_4	519	526	PF00514	0.475
TRG_NLS_MonoExtN_4	593	600	PF00514	0.644
TRG_NLS_MonoExtN_4	623	628	PF00514	0.487
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	98	103	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z4	Leptomonas seymouri	71%	86%
A0A0S4IQI8	Bodo saltans	49%	85%
A0A3S5IRC1	Trypanosoma rangeli	54%	92%
A0A3S7XCB2	Leishmania donovani	91%	100%
A4HQH3	Leishmania braziliensis	80%	90%
A4ICA9	Leishmania infantum	92%	100%
D0A3M2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	88%
E9AU86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5AXL9	Trypanosoma cruzi	52%	92%