Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0A3_LEIMA

TriTrypDb:

LmjF.36.6525 , LMJLV39_360079800 , LMJSD75_360079600

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0A3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.698
CLV_C14_Caspase3-7	411	415	PF00656	0.578
CLV_NRD_NRD_1	428	430	PF00675	0.612
CLV_NRD_NRD_1	476	478	PF00675	0.552
CLV_NRD_NRD_1	583	585	PF00675	0.553
CLV_PCSK_KEX2_1	174	176	PF00082	0.519
CLV_PCSK_KEX2_1	428	430	PF00082	0.580
CLV_PCSK_KEX2_1	476	478	PF00082	0.552
CLV_PCSK_KEX2_1	524	526	PF00082	0.645
CLV_PCSK_KEX2_1	583	585	PF00082	0.525
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.572
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.645
CLV_PCSK_SKI1_1	161	165	PF00082	0.617
CLV_PCSK_SKI1_1	175	179	PF00082	0.367
CLV_PCSK_SKI1_1	416	420	PF00082	0.644
CLV_PCSK_SKI1_1	440	444	PF00082	0.542
DEG_APCC_DBOX_1	415	423	PF00400	0.637
DEG_SPOP_SBC_1	145	149	PF00917	0.654
DEG_SPOP_SBC_1	338	342	PF00917	0.423
DOC_CDC14_PxL_1	391	399	PF14671	0.543
DOC_CKS1_1	536	541	PF01111	0.625
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.432
DOC_CYCLIN_yCln2_LP_2	537	543	PF00134	0.631
DOC_MAPK_DCC_7	507	517	PF00069	0.641
DOC_MAPK_gen_1	524	530	PF00069	0.586
DOC_MAPK_gen_1	583	590	PF00069	0.530
DOC_PP1_RVXF_1	159	165	PF00149	0.616
DOC_PP2B_LxvP_1	218	221	PF13499	0.445
DOC_PP2B_LxvP_1	288	291	PF13499	0.393
DOC_PP2B_LxvP_1	537	540	PF13499	0.626
DOC_PP4_FxxP_1	242	245	PF00568	0.567
DOC_PP4_FxxP_1	363	366	PF00568	0.622
DOC_SPAK_OSR1_1	362	366	PF12202	0.560
DOC_USP7_MATH_1	118	122	PF00917	0.638
DOC_USP7_MATH_1	267	271	PF00917	0.698
DOC_USP7_MATH_1	303	307	PF00917	0.643
DOC_USP7_MATH_1	338	342	PF00917	0.459
DOC_USP7_MATH_1	542	546	PF00917	0.638
DOC_USP7_MATH_1	554	558	PF00917	0.618
DOC_WW_Pin1_4	124	129	PF00397	0.748
DOC_WW_Pin1_4	156	161	PF00397	0.619
DOC_WW_Pin1_4	319	324	PF00397	0.471
DOC_WW_Pin1_4	535	540	PF00397	0.642
LIG_14-3-3_CanoR_1	175	183	PF00244	0.490
LIG_14-3-3_CanoR_1	210	219	PF00244	0.554
LIG_14-3-3_CanoR_1	304	309	PF00244	0.671
LIG_14-3-3_CanoR_1	33	38	PF00244	0.586
LIG_14-3-3_CanoR_1	400	404	PF00244	0.628
LIG_14-3-3_CanoR_1	428	432	PF00244	0.676
LIG_14-3-3_CanoR_1	434	440	PF00244	0.637
LIG_14-3-3_CanoR_1	51	59	PF00244	0.426
LIG_14-3-3_CanoR_1	525	529	PF00244	0.742
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_BRCT_BRCA1_1	113	117	PF00533	0.518
LIG_BRCT_BRCA1_1	148	152	PF00533	0.628
LIG_BRCT_BRCA1_1	359	363	PF00533	0.509
LIG_deltaCOP1_diTrp_1	358	363	PF00928	0.563
LIG_DLG_GKlike_1	33	41	PF00625	0.473
LIG_FHA_1	137	143	PF00498	0.703
LIG_FHA_1	33	39	PF00498	0.561
LIG_FHA_1	338	344	PF00498	0.415
LIG_FHA_1	391	397	PF00498	0.626
LIG_FHA_1	536	542	PF00498	0.693
LIG_FHA_1	564	570	PF00498	0.684
LIG_FHA_2	176	182	PF00498	0.503
LIG_FHA_2	43	49	PF00498	0.502
LIG_FHA_2	436	442	PF00498	0.609
LIG_FHA_2	445	451	PF00498	0.409
LIG_FHA_2	459	465	PF00498	0.409
LIG_LIR_Apic_2	239	245	PF02991	0.634
LIG_LIR_Apic_2	360	366	PF02991	0.544
LIG_LIR_Gen_1	178	188	PF02991	0.437
LIG_LIR_Gen_1	234	245	PF02991	0.503
LIG_LIR_Gen_1	349	357	PF02991	0.408
LIG_LIR_Nem_3	178	183	PF02991	0.474
LIG_LIR_Nem_3	186	191	PF02991	0.399
LIG_LIR_Nem_3	234	240	PF02991	0.540
LIG_NRBOX	54	60	PF00104	0.562
LIG_PCNA_PIPBox_1	436	445	PF02747	0.558
LIG_Pex14_1	359	363	PF04695	0.564
LIG_SH2_STAP1	352	356	PF00017	0.514
LIG_SH2_STAT5	144	147	PF00017	0.571
LIG_SH2_STAT5	237	240	PF00017	0.487
LIG_SH2_STAT5	30	33	PF00017	0.578
LIG_SH2_STAT5	364	367	PF00017	0.712
LIG_SH3_1	258	264	PF00018	0.468
LIG_SH3_1	429	435	PF00018	0.571
LIG_SH3_3	154	160	PF00018	0.624
LIG_SH3_3	258	264	PF00018	0.570
LIG_SH3_3	320	326	PF00018	0.463
LIG_SH3_3	429	435	PF00018	0.571
LIG_SH3_3	507	513	PF00018	0.697
LIG_SH3_3	514	520	PF00018	0.698
LIG_SH3_3	533	539	PF00018	0.510
LIG_SH3_3	558	564	PF00018	0.642
LIG_SUMO_SIM_anti_2	311	318	PF11976	0.399
LIG_SUMO_SIM_anti_2	572	578	PF11976	0.530
LIG_SUMO_SIM_par_1	395	402	PF11976	0.555
LIG_TRAF2_1	65	68	PF00917	0.478
LIG_WRC_WIRS_1	343	348	PF05994	0.432
LIG_WRC_WIRS_1	82	87	PF05994	0.607
MOD_CDK_SPK_2	156	161	PF00069	0.559
MOD_CK1_1	116	122	PF00069	0.724
MOD_CK1_1	148	154	PF00069	0.619
MOD_CK1_1	167	173	PF00069	0.580
MOD_CK1_1	22	28	PF00069	0.631
MOD_CK1_1	265	271	PF00069	0.679
MOD_CK1_1	274	280	PF00069	0.602
MOD_CK1_1	32	38	PF00069	0.573
MOD_CK1_1	404	410	PF00069	0.707
MOD_CK1_1	495	501	PF00069	0.652
MOD_CK1_1	526	532	PF00069	0.644
MOD_CK1_1	86	92	PF00069	0.654
MOD_CK2_1	211	217	PF00069	0.546
MOD_CK2_1	347	353	PF00069	0.387
MOD_CK2_1	444	450	PF00069	0.483
MOD_CK2_1	452	458	PF00069	0.460
MOD_CK2_1	554	560	PF00069	0.771
MOD_CK2_1	590	596	PF00069	0.571
MOD_CK2_1	9	15	PF00069	0.560
MOD_GlcNHglycan	128	131	PF01048	0.634
MOD_GlcNHglycan	183	186	PF01048	0.412
MOD_GlcNHglycan	233	236	PF01048	0.503
MOD_GlcNHglycan	269	272	PF01048	0.605
MOD_GlcNHglycan	311	314	PF01048	0.432
MOD_GlcNHglycan	406	409	PF01048	0.689
MOD_GlcNHglycan	410	413	PF01048	0.608
MOD_GlcNHglycan	429	432	PF01048	0.679
MOD_GlcNHglycan	454	457	PF01048	0.582
MOD_GlcNHglycan	494	497	PF01048	0.696
MOD_GlcNHglycan	556	559	PF01048	0.651
MOD_GlcNHglycan	88	91	PF01048	0.799
MOD_GSK3_1	132	139	PF00069	0.579
MOD_GSK3_1	144	151	PF00069	0.538
MOD_GSK3_1	227	234	PF00069	0.671
MOD_GSK3_1	236	243	PF00069	0.338
MOD_GSK3_1	262	269	PF00069	0.719
MOD_GSK3_1	29	36	PF00069	0.498
MOD_GSK3_1	304	311	PF00069	0.642
MOD_GSK3_1	338	345	PF00069	0.393
MOD_GSK3_1	347	354	PF00069	0.550
MOD_GSK3_1	365	372	PF00069	0.495
MOD_GSK3_1	38	45	PF00069	0.496
MOD_GSK3_1	404	411	PF00069	0.606
MOD_GSK3_1	444	451	PF00069	0.540
MOD_GSK3_1	487	494	PF00069	0.570
MOD_GSK3_1	5	12	PF00069	0.580
MOD_GSK3_1	542	549	PF00069	0.744
MOD_GSK3_1	81	88	PF00069	0.757
MOD_N-GLC_1	211	216	PF02516	0.605
MOD_N-GLC_1	308	313	PF02516	0.382
MOD_N-GLC_1	404	409	PF02516	0.681
MOD_NEK2_1	136	141	PF00069	0.709
MOD_NEK2_1	150	155	PF00069	0.495
MOD_NEK2_1	164	169	PF00069	0.489
MOD_NEK2_1	190	195	PF00069	0.393
MOD_NEK2_1	231	236	PF00069	0.477
MOD_NEK2_1	280	285	PF00069	0.440
MOD_NEK2_1	31	36	PF00069	0.546
MOD_NEK2_1	346	351	PF00069	0.439
MOD_NEK2_1	369	374	PF00069	0.508
MOD_NEK2_1	38	43	PF00069	0.540
MOD_NEK2_1	398	403	PF00069	0.713
MOD_NEK2_1	463	468	PF00069	0.561
MOD_NEK2_1	5	10	PF00069	0.524
MOD_NEK2_1	85	90	PF00069	0.747
MOD_NEK2_2	435	440	PF00069	0.580
MOD_PIKK_1	420	426	PF00454	0.537
MOD_PIKK_1	50	56	PF00454	0.517
MOD_PK_1	297	303	PF00069	0.432
MOD_PKA_1	524	530	PF00069	0.631
MOD_PKA_2	303	309	PF00069	0.676
MOD_PKA_2	32	38	PF00069	0.594
MOD_PKA_2	399	405	PF00069	0.721
MOD_PKA_2	427	433	PF00069	0.632
MOD_PKA_2	491	497	PF00069	0.709
MOD_PKA_2	50	56	PF00069	0.460
MOD_PKA_2	500	506	PF00069	0.697
MOD_PKA_2	524	530	PF00069	0.741
MOD_Plk_1	226	232	PF00069	0.595
MOD_Plk_1	240	246	PF00069	0.528
MOD_Plk_1	297	303	PF00069	0.432
MOD_Plk_1	463	469	PF00069	0.516
MOD_Plk_1	590	596	PF00069	0.636
MOD_Plk_4	183	189	PF00069	0.384
MOD_Plk_4	271	277	PF00069	0.551
MOD_Plk_4	33	39	PF00069	0.522
MOD_Plk_4	339	345	PF00069	0.386
MOD_Plk_4	347	353	PF00069	0.556
MOD_ProDKin_1	124	130	PF00069	0.746
MOD_ProDKin_1	156	162	PF00069	0.621
MOD_ProDKin_1	319	325	PF00069	0.480
MOD_ProDKin_1	535	541	PF00069	0.642
MOD_SUMO_rev_2	380	388	PF00179	0.615
MOD_SUMO_rev_2	500	509	PF00179	0.645
TRG_DiLeu_BaEn_1	68	73	PF01217	0.500
TRG_DiLeu_BaEn_4	68	74	PF01217	0.608
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.645
TRG_ENDOCYTIC_2	188	191	PF00928	0.376
TRG_ENDOCYTIC_2	237	240	PF00928	0.535
TRG_ENDOCYTIC_2	352	355	PF00928	0.414
TRG_ER_diArg_1	105	108	PF00400	0.538
TRG_ER_diArg_1	207	210	PF00400	0.454
TRG_ER_diArg_1	475	477	PF00400	0.553
TRG_ER_diArg_1	582	584	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K6	Leptomonas seymouri	53%	98%
A0A1X0NLK5	Trypanosomatidae	35%	100%
A0A3R7NFJ5	Trypanosoma rangeli	34%	100%
A0A3S7XCD6	Leishmania donovani	93%	100%
A4HQH5	Leishmania braziliensis	76%	100%
A4ICB1	Leishmania infantum	93%	88%
D0A3M4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AU88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DDT5	Trypanosoma cruzi	33%	100%