Similarity to endo-1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

putative dienelactone hydrolase

Species:

Leishmania major

UniProt:

Q4Q0A1_LEIMA

TriTrypDb:

LmjF.36.6540 , LMJLV39_360080000 , LMJSD75_360079800

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0A1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	197	199	PF00082	0.330
CLV_PCSK_KEX2_1	54	56	PF00082	0.365
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.352
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.417
CLV_PCSK_SKI1_1	162	166	PF00082	0.365
DOC_CYCLIN_RxL_1	222	233	PF00134	0.617
DOC_MAPK_gen_1	162	171	PF00069	0.565
DOC_MAPK_MEF2A_6	162	171	PF00069	0.554
DOC_PP2B_LxvP_1	169	172	PF13499	0.565
DOC_PP4_FxxP_1	72	75	PF00568	0.533
DOC_USP7_MATH_1	151	155	PF00917	0.515
DOC_USP7_MATH_1	185	189	PF00917	0.561
DOC_USP7_MATH_1	33	37	PF00917	0.561
DOC_WW_Pin1_4	163	168	PF00397	0.527
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_BRCT_BRCA1_1	52	56	PF00533	0.589
LIG_deltaCOP1_diTrp_1	80	87	PF00928	0.545
LIG_FHA_1	164	170	PF00498	0.542
LIG_FHA_2	215	221	PF00498	0.565
LIG_FHA_2	98	104	PF00498	0.605
LIG_GBD_Chelix_1	42	50	PF00786	0.365
LIG_LIR_Apic_2	71	75	PF02991	0.533
LIG_LIR_Gen_1	100	109	PF02991	0.568
LIG_LIR_Gen_1	53	61	PF02991	0.592
LIG_LIR_Gen_1	86	95	PF02991	0.500
LIG_LIR_Nem_3	100	105	PF02991	0.542
LIG_LIR_Nem_3	45	50	PF02991	0.564
LIG_LIR_Nem_3	53	59	PF02991	0.569
LIG_LIR_Nem_3	71	76	PF02991	0.584
LIG_LIR_Nem_3	89	95	PF02991	0.423
LIG_OCRL_FandH_1	198	210	PF00620	0.533
LIG_Pex14_1	83	87	PF04695	0.527
LIG_REV1ctd_RIR_1	204	212	PF16727	0.565
LIG_REV1ctd_RIR_1	232	240	PF16727	0.565
LIG_SH2_NCK_1	21	25	PF00017	0.727
LIG_SH2_STAT5	216	219	PF00017	0.565
LIG_SH2_STAT5	95	98	PF00017	0.478
LIG_SH3_3	187	193	PF00018	0.552
LIG_SH3_3	64	70	PF00018	0.565
LIG_Sin3_3	112	119	PF02671	0.589
LIG_SUMO_SIM_anti_2	166	173	PF11976	0.542
LIG_SUMO_SIM_par_1	166	173	PF11976	0.560
LIG_SUMO_SIM_par_1	39	45	PF11976	0.523
LIG_TRAF2_1	217	220	PF00917	0.559
LIG_TRFH_1	47	51	PF08558	0.561
LIG_UBA3_1	46	54	PF00899	0.617
MOD_CK1_1	154	160	PF00069	0.546
MOD_CK2_1	170	176	PF00069	0.527
MOD_CK2_1	214	220	PF00069	0.565
MOD_GlcNHglycan	1	4	PF01048	0.685
MOD_N-GLC_2	7	9	PF02516	0.720
MOD_NEK2_1	235	240	PF00069	0.601
MOD_PIKK_1	97	103	PF00454	0.551
MOD_Plk_4	151	157	PF00069	0.552
MOD_ProDKin_1	163	169	PF00069	0.527
MOD_SUMO_rev_2	214	224	PF00179	0.565
TRG_DiLeu_BaEn_1	62	67	PF01217	0.561
TRG_ER_diLys_1	236	240	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	228	233	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P241	Leptomonas seymouri	61%	99%
A0A0S4KTD2	Bodo saltans	36%	100%
A0A2V5GSC6	Aspergillus violaceofuscus (strain CBS 115571)	30%	98%
A0A3S7XCB3	Leishmania donovani	93%	100%
A4HQH7	Leishmania braziliensis	72%	100%
A4ICB3	Leishmania infantum	93%	100%
B8M9K0	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	27%	94%
E9AU90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O14359	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	96%
Q5RBU3	Pongo abelii	24%	98%
Q5XH09	Xenopus laevis	26%	98%
Q6P7K0	Xenopus tropicalis	27%	98%
Q7TP52	Rattus norvegicus	25%	98%
Q8R1G2	Mus musculus	26%	98%
Q96DG6	Homo sapiens	24%	98%
Q9P7U1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	97%
W7MAD3	Gibberella moniliformis (strain M3125 / FGSC 7600)	28%	92%