ACB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q099_LEIMA

TriTrypDb:

LmjF.36.6560 , LMJLV39_360080200 , LMJSD75_360080100

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q099

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q099

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	11
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0033218	amide binding	2	11
GO:0036094	small molecule binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0120227	acyl-CoA binding	3	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:1901567	fatty acid derivative binding	3	11
GO:1901681	sulfur compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.537
CLV_PCSK_KEX2_1	156	158	PF00082	0.537
CLV_PCSK_SKI1_1	121	125	PF00082	0.623
CLV_PCSK_SKI1_1	211	215	PF00082	0.581
CLV_PCSK_SKI1_1	286	290	PF00082	0.743
CLV_PCSK_SKI1_1	34	38	PF00082	0.335
CLV_Separin_Metazoa	206	210	PF03568	0.522
DEG_Nend_UBRbox_2	1	3	PF02207	0.542
DEG_SPOP_SBC_1	101	105	PF00917	0.523
DOC_CYCLIN_RxL_1	209	221	PF00134	0.554
DOC_PP1_RVXF_1	32	38	PF00149	0.355
DOC_USP7_MATH_1	102	106	PF00917	0.689
DOC_USP7_MATH_1	135	139	PF00917	0.726
DOC_USP7_MATH_1	140	144	PF00917	0.738
DOC_USP7_MATH_1	52	56	PF00917	0.378
DOC_WW_Pin1_4	127	132	PF00397	0.613
DOC_WW_Pin1_4	157	162	PF00397	0.722
DOC_WW_Pin1_4	23	28	PF00397	0.539
DOC_WW_Pin1_4	245	250	PF00397	0.632
DOC_WW_Pin1_4	311	316	PF00397	0.636
LIG_14-3-3_CanoR_1	286	293	PF00244	0.727
LIG_14-3-3_CanoR_1	73	78	PF00244	0.381
LIG_BRCT_BRCA1_1	318	322	PF00533	0.587
LIG_eIF4E_1	202	208	PF01652	0.564
LIG_FHA_1	147	153	PF00498	0.527
LIG_FHA_2	161	167	PF00498	0.657
LIG_FHA_2	90	96	PF00498	0.480
LIG_LIR_Apic_2	233	239	PF02991	0.523
LIG_LIR_Gen_1	75	84	PF02991	0.343
LIG_LIR_Nem_3	7	12	PF02991	0.341
LIG_MYND_1	259	263	PF01753	0.674
LIG_Pex14_2	83	87	PF04695	0.447
LIG_PTB_Apo_2	196	203	PF02174	0.535
LIG_PTB_Phospho_1	196	202	PF10480	0.535
LIG_SH2_CRK	236	240	PF00017	0.519
LIG_SH2_STAT5	15	18	PF00017	0.407
LIG_SH2_STAT5	19	22	PF00017	0.438
LIG_SH2_STAT5	202	205	PF00017	0.459
LIG_SH3_3	111	117	PF00018	0.643
LIG_SH3_3	257	263	PF00018	0.592
LIG_SH3_3	272	278	PF00018	0.652
LIG_SH3_3	309	315	PF00018	0.671
LIG_Vh1_VBS_1	189	207	PF01044	0.543
LIG_WRC_WIRS_1	74	79	PF05994	0.285
MOD_CDK_SPxxK_3	127	134	PF00069	0.502
MOD_CK1_1	105	111	PF00069	0.619
MOD_CK1_1	160	166	PF00069	0.668
MOD_CK1_1	172	178	PF00069	0.547
MOD_CK1_1	193	199	PF00069	0.580
MOD_CK1_1	221	227	PF00069	0.660
MOD_CK1_1	267	273	PF00069	0.654
MOD_CK1_1	284	290	PF00069	0.617
MOD_CK1_1	316	322	PF00069	0.650
MOD_CK2_1	160	166	PF00069	0.758
MOD_CK2_1	175	181	PF00069	0.591
MOD_CK2_1	188	194	PF00069	0.621
MOD_CK2_1	221	227	PF00069	0.594
MOD_CK2_1	284	290	PF00069	0.739
MOD_CK2_1	72	78	PF00069	0.325
MOD_CK2_1	89	95	PF00069	0.439
MOD_CMANNOS	321	324	PF00535	0.532
MOD_DYRK1A_RPxSP_1	311	315	PF00069	0.648
MOD_GlcNHglycan	104	107	PF01048	0.672
MOD_GlcNHglycan	177	180	PF01048	0.629
MOD_GlcNHglycan	219	223	PF01048	0.708
MOD_GlcNHglycan	249	252	PF01048	0.773
MOD_GlcNHglycan	269	272	PF01048	0.595
MOD_GlcNHglycan	283	286	PF01048	0.600
MOD_GlcNHglycan	315	318	PF01048	0.678
MOD_GSK3_1	101	108	PF00069	0.599
MOD_GSK3_1	171	178	PF00069	0.601
MOD_GSK3_1	228	235	PF00069	0.672
MOD_GSK3_1	23	30	PF00069	0.533
MOD_GSK3_1	313	320	PF00069	0.650
MOD_GSK3_1	48	55	PF00069	0.368
MOD_N-GLC_1	228	233	PF02516	0.728
MOD_N-GLC_1	267	272	PF02516	0.601
MOD_N-GLC_1	95	100	PF02516	0.613
MOD_NEK2_1	1	6	PF00069	0.518
MOD_NEK2_1	170	175	PF00069	0.738
MOD_NEK2_1	218	223	PF00069	0.560
MOD_NEK2_1	94	99	PF00069	0.626
MOD_PIKK_1	89	95	PF00454	0.529
MOD_PKA_2	281	287	PF00069	0.689
MOD_PKA_2	293	299	PF00069	0.444
MOD_PKA_2	72	78	PF00069	0.434
MOD_Plk_1	1	7	PF00069	0.514
MOD_Plk_1	193	199	PF00069	0.452
MOD_Plk_1	232	238	PF00069	0.658
MOD_Plk_4	317	323	PF00069	0.613
MOD_Plk_4	52	58	PF00069	0.329
MOD_ProDKin_1	127	133	PF00069	0.620
MOD_ProDKin_1	157	163	PF00069	0.724
MOD_ProDKin_1	23	29	PF00069	0.532
MOD_ProDKin_1	245	251	PF00069	0.633
MOD_ProDKin_1	311	317	PF00069	0.629
MOD_SUMO_rev_2	118	125	PF00179	0.578
TRG_DiLeu_BaEn_4	24	30	PF01217	0.480
TRG_DiLeu_LyEn_5	24	29	PF01217	0.538
TRG_ENDOCYTIC_2	9	12	PF00928	0.368
TRG_ER_diArg_1	155	157	PF00400	0.541
TRG_ER_diArg_1	208	211	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA6	Leptomonas seymouri	44%	100%
A0A1X0NL99	Trypanosomatidae	35%	100%
A0A3S7XC89	Leishmania donovani	90%	100%
A0A422P468	Trypanosoma rangeli	29%	100%
A4HQH9	Leishmania braziliensis	65%	98%
E9AHY9	Leishmania infantum	91%	100%
E9AU92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5A2D1	Trypanosoma cruzi	36%	100%
V5B4W0	Trypanosoma cruzi	36%	100%