NYD-SP28_assoc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sperm tail/Sperm tail C-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q096_LEIMA

TriTrypDb:

LmjF.36.6590 , LMJLV39_360080500 , LMJSD75_360080400

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	12
GO:0005875	microtubule associated complex	2	12
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	12

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Expansion

Sequence features

Q4Q096

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q096

Function

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Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	2
GO:0003352	regulation of cilium movement	6	2
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0032886	regulation of microtubule-based process	4	2
GO:0043933	protein-containing complex organization	4	12
GO:0048870	cell motility	2	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.555
CLV_NRD_NRD_1	132	134	PF00675	0.355
CLV_NRD_NRD_1	205	207	PF00675	0.458
CLV_NRD_NRD_1	223	225	PF00675	0.326
CLV_NRD_NRD_1	230	232	PF00675	0.469
CLV_NRD_NRD_1	557	559	PF00675	0.518
CLV_NRD_NRD_1	596	598	PF00675	0.262
CLV_NRD_NRD_1	82	84	PF00675	0.269
CLV_PCSK_KEX2_1	205	207	PF00082	0.509
CLV_PCSK_KEX2_1	223	225	PF00082	0.381

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAH6	Leptomonas seymouri	70%	100%
A0A0S4J8E8	Bodo saltans	40%	100%
A0A1X0NL92	Trypanosomatidae	48%	100%
A0A3R7KG47	Trypanosoma rangeli	45%	99%
A0A3S7XCE4	Leishmania donovani	95%	100%
A4HQI2	Leishmania braziliensis	81%	100%
D0A3N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AHZ1	Leishmania infantum	95%	100%
E9AU95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F1QRC1	Danio rerio	25%	97%

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