ZZ-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q095_LEIMA

TriTrypDb:

LmjF.36.6600 , LMJLV39_360080600 , LMJSD75_360080500

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q095

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q095

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.436
CLV_C14_Caspase3-7	238	242	PF00656	0.305
CLV_C14_Caspase3-7	506	510	PF00656	0.643
CLV_NRD_NRD_1	155	157	PF00675	0.542
CLV_NRD_NRD_1	598	600	PF00675	0.463
CLV_PCSK_SKI1_1	336	340	PF00082	0.476
CLV_PCSK_SKI1_1	451	455	PF00082	0.446
CLV_PCSK_SKI1_1	599	603	PF00082	0.422
CLV_PCSK_SKI1_1	619	623	PF00082	0.361
CLV_Separin_Metazoa	637	641	PF03568	0.508
DEG_APCC_DBOX_1	330	338	PF00400	0.480
DEG_APCC_DBOX_1	356	364	PF00400	0.491
DEG_SCF_FBW7_1	693	700	PF00400	0.717
DEG_SCF_SKP2-CKS1_1	692	699	PF00560	0.636
DOC_CDC14_PxL_1	196	204	PF14671	0.452
DOC_CDC14_PxL_1	638	646	PF14671	0.501
DOC_CKS1_1	685	690	PF01111	0.623
DOC_CYCLIN_RxL_1	596	606	PF00134	0.425
DOC_MAPK_DCC_7	213	221	PF00069	0.511
DOC_MAPK_DCC_7	573	583	PF00069	0.607
DOC_MAPK_gen_1	331	339	PF00069	0.492
DOC_MAPK_gen_1	354	362	PF00069	0.450
DOC_MAPK_gen_1	396	404	PF00069	0.387
DOC_MAPK_MEF2A_6	333	341	PF00069	0.487
DOC_MAPK_MEF2A_6	354	362	PF00069	0.467
DOC_PP1_RVXF_1	524	530	PF00149	0.320
DOC_PP2B_LxvP_1	315	318	PF13499	0.435
DOC_PP2B_LxvP_1	608	611	PF13499	0.515
DOC_PP2B_LxvP_1	622	625	PF13499	0.331
DOC_PP4_FxxP_1	477	480	PF00568	0.523
DOC_USP7_MATH_1	141	145	PF00917	0.526
DOC_USP7_MATH_1	487	491	PF00917	0.739
DOC_USP7_MATH_1	535	539	PF00917	0.515
DOC_USP7_MATH_1	571	575	PF00917	0.620
DOC_USP7_MATH_1	697	701	PF00917	0.712
DOC_USP7_MATH_1	745	749	PF00917	0.696
DOC_WW_Pin1_4	139	144	PF00397	0.542
DOC_WW_Pin1_4	42	47	PF00397	0.517
DOC_WW_Pin1_4	458	463	PF00397	0.482
DOC_WW_Pin1_4	489	494	PF00397	0.704
DOC_WW_Pin1_4	514	519	PF00397	0.574
DOC_WW_Pin1_4	684	689	PF00397	0.517
DOC_WW_Pin1_4	693	698	PF00397	0.552
DOC_WW_Pin1_4	708	713	PF00397	0.589
DOC_WW_Pin1_4	93	98	PF00397	0.533
LIG_14-3-3_CanoR_1	23	28	PF00244	0.507
LIG_14-3-3_CanoR_1	281	287	PF00244	0.470
LIG_14-3-3_CanoR_1	336	342	PF00244	0.447
LIG_14-3-3_CanoR_1	396	402	PF00244	0.481
LIG_14-3-3_CanoR_1	526	530	PF00244	0.504
LIG_14-3-3_CanoR_1	669	679	PF00244	0.525
LIG_APCC_ABBAyCdc20_2	399	405	PF00400	0.497
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BRCT_BRCA1_1	378	382	PF00533	0.459
LIG_FAT_LD_1	449	457	PF03623	0.473
LIG_FHA_1	202	208	PF00498	0.474
LIG_FHA_1	232	238	PF00498	0.479
LIG_FHA_1	275	281	PF00498	0.519
LIG_FHA_1	585	591	PF00498	0.409
LIG_FHA_2	107	113	PF00498	0.492
LIG_FHA_2	180	186	PF00498	0.495
LIG_FHA_2	212	218	PF00498	0.521
LIG_FHA_2	338	344	PF00498	0.539
LIG_FHA_2	354	360	PF00498	0.376
LIG_FHA_2	386	392	PF00498	0.461
LIG_FHA_2	504	510	PF00498	0.636
LIG_LIR_Apic_2	474	480	PF02991	0.387
LIG_LIR_Gen_1	223	232	PF02991	0.457
LIG_LIR_Gen_1	284	294	PF02991	0.461
LIG_LIR_Gen_1	400	409	PF02991	0.483
LIG_LIR_Gen_1	516	527	PF02991	0.418
LIG_LIR_Gen_1	605	614	PF02991	0.479
LIG_LIR_Gen_1	646	656	PF02991	0.514
LIG_LIR_Nem_3	117	123	PF02991	0.373
LIG_LIR_Nem_3	187	192	PF02991	0.345
LIG_LIR_Nem_3	223	227	PF02991	0.364
LIG_LIR_Nem_3	284	289	PF02991	0.474
LIG_LIR_Nem_3	400	404	PF02991	0.488
LIG_LIR_Nem_3	516	522	PF02991	0.513
LIG_LIR_Nem_3	528	532	PF02991	0.547
LIG_LIR_Nem_3	605	610	PF02991	0.487
LIG_LIR_Nem_3	646	652	PF02991	0.493
LIG_LYPXL_S_1	198	202	PF13949	0.450
LIG_LYPXL_SIV_4	188	196	PF13949	0.351
LIG_LYPXL_yS_3	199	202	PF13949	0.404
LIG_LYPXL_yS_3	641	644	PF13949	0.499
LIG_NRBOX	171	177	PF00104	0.437
LIG_NRBOX	448	454	PF00104	0.493
LIG_NRBOX	616	622	PF00104	0.464
LIG_PCNA_yPIPBox_3	423	435	PF02747	0.304
LIG_PCNA_yPIPBox_3	669	679	PF02747	0.507
LIG_Pex14_2	227	231	PF04695	0.457
LIG_Rb_pABgroove_1	167	175	PF01858	0.490
LIG_SH2_CRK	173	177	PF00017	0.480
LIG_SH2_CRK	189	193	PF00017	0.228
LIG_SH2_CRK	519	523	PF00017	0.483
LIG_SH2_CRK	649	653	PF00017	0.453
LIG_SH2_GRB2like	713	716	PF00017	0.702
LIG_SH2_NCK_1	473	477	PF00017	0.459
LIG_SH2_SRC	465	468	PF00017	0.444
LIG_SH2_SRC	678	681	PF00017	0.573
LIG_SH2_SRC	77	80	PF00017	0.560
LIG_SH2_STAP1	473	477	PF00017	0.459
LIG_SH2_STAP1	649	653	PF00017	0.367
LIG_SH2_STAT5	224	227	PF00017	0.339
LIG_SH2_STAT5	288	291	PF00017	0.521
LIG_SH2_STAT5	401	404	PF00017	0.519
LIG_SH2_STAT5	432	435	PF00017	0.456
LIG_SH2_STAT5	465	468	PF00017	0.452
LIG_SH2_STAT5	539	542	PF00017	0.467
LIG_SH2_STAT5	559	562	PF00017	0.208
LIG_SH2_STAT5	607	610	PF00017	0.479
LIG_SH2_STAT5	678	681	PF00017	0.398
LIG_SH2_STAT5	692	695	PF00017	0.591
LIG_SH2_STAT5	713	716	PF00017	0.702
LIG_SH3_3	194	200	PF00018	0.419
LIG_SH3_3	277	283	PF00018	0.489
LIG_SH3_3	359	365	PF00018	0.485
LIG_SH3_3	40	46	PF00018	0.506
LIG_SH3_3	529	535	PF00018	0.511
LIG_SH3_3	549	555	PF00018	0.278
LIG_SH3_3	576	582	PF00018	0.564
LIG_SH3_3	636	642	PF00018	0.533
LIG_SH3_3	682	688	PF00018	0.574
LIG_SH3_5	73	77	PF00018	0.534
LIG_SUMO_SIM_anti_2	359	364	PF11976	0.480
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.466
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.197
LIG_SUMO_SIM_anti_2	587	595	PF11976	0.522
LIG_SUMO_SIM_par_1	600	606	PF11976	0.485
LIG_TRAF2_1	57	60	PF00917	0.494
LIG_TRAF2_1	748	751	PF00917	0.702
LIG_TRFH_1	93	97	PF08558	0.535
LIG_TYR_ITIM	171	176	PF00017	0.465
LIG_TYR_ITIM	197	202	PF00017	0.419
LIG_TYR_ITIM	639	644	PF00017	0.493
LIG_TYR_ITIM	647	652	PF00017	0.357
LIG_UBA3_1	448	454	PF00899	0.416
LIG_WW_2	579	582	PF00397	0.558
MOD_CDK_SPxK_1	684	690	PF00069	0.547
MOD_CDK_SPxK_1	693	699	PF00069	0.571
MOD_CK1_1	114	120	PF00069	0.552
MOD_CK1_1	32	38	PF00069	0.552
MOD_CK1_1	538	544	PF00069	0.543
MOD_CK1_1	643	649	PF00069	0.489
MOD_CK1_1	711	717	PF00069	0.749
MOD_CK2_1	179	185	PF00069	0.480
MOD_CK2_1	200	206	PF00069	0.423
MOD_CK2_1	385	391	PF00069	0.404
MOD_CK2_1	42	48	PF00069	0.439
MOD_CK2_1	54	60	PF00069	0.405
MOD_CK2_1	745	751	PF00069	0.704
MOD_GlcNHglycan	124	127	PF01048	0.438
MOD_GlcNHglycan	163	166	PF01048	0.605
MOD_GlcNHglycan	193	196	PF01048	0.446
MOD_GlcNHglycan	444	447	PF01048	0.553
MOD_GlcNHglycan	529	532	PF01048	0.600
MOD_GlcNHglycan	540	543	PF01048	0.508
MOD_GlcNHglycan	546	549	PF01048	0.468
MOD_GlcNHglycan	573	576	PF01048	0.716
MOD_GlcNHglycan	708	711	PF01048	0.718
MOD_GlcNHglycan	719	722	PF01048	0.657
MOD_GSK3_1	161	168	PF00069	0.536
MOD_GSK3_1	454	461	PF00069	0.430
MOD_GSK3_1	584	591	PF00069	0.507
MOD_GSK3_1	693	700	PF00069	0.706
MOD_GSK3_1	713	720	PF00069	0.617
MOD_GSK3_1	89	96	PF00069	0.482
MOD_N-GLC_1	129	134	PF02516	0.485
MOD_N-GLC_1	714	719	PF02516	0.700
MOD_N-GLC_2	416	418	PF02516	0.513
MOD_NEK2_1	231	236	PF00069	0.443
MOD_NEK2_1	274	279	PF00069	0.407
MOD_NEK2_1	337	342	PF00069	0.449
MOD_NEK2_1	419	424	PF00069	0.486
MOD_NEK2_1	456	461	PF00069	0.466
MOD_NEK2_1	527	532	PF00069	0.474
MOD_NEK2_1	602	607	PF00069	0.537
MOD_NEK2_1	706	711	PF00069	0.706
MOD_PIKK_1	419	425	PF00454	0.348
MOD_PIKK_1	456	462	PF00454	0.456
MOD_PK_1	23	29	PF00069	0.511
MOD_PK_1	54	60	PF00069	0.425
MOD_PKA_1	513	519	PF00069	0.520
MOD_PKA_2	353	359	PF00069	0.491
MOD_PKA_2	525	531	PF00069	0.495
MOD_PKB_1	87	95	PF00069	0.472
MOD_Plk_1	129	135	PF00069	0.487
MOD_Plk_1	673	679	PF00069	0.507
MOD_Plk_1	714	720	PF00069	0.715
MOD_Plk_1	89	95	PF00069	0.547
MOD_Plk_4	318	324	PF00069	0.514
MOD_Plk_4	588	594	PF00069	0.536
MOD_Plk_4	603	609	PF00069	0.406
MOD_Plk_4	719	725	PF00069	0.665
MOD_ProDKin_1	139	145	PF00069	0.536
MOD_ProDKin_1	42	48	PF00069	0.520
MOD_ProDKin_1	458	464	PF00069	0.473
MOD_ProDKin_1	489	495	PF00069	0.699
MOD_ProDKin_1	514	520	PF00069	0.563
MOD_ProDKin_1	684	690	PF00069	0.531
MOD_ProDKin_1	693	699	PF00069	0.551
MOD_ProDKin_1	708	714	PF00069	0.589
MOD_ProDKin_1	93	99	PF00069	0.529
TRG_DiLeu_BaEn_2	222	228	PF01217	0.456
TRG_DiLeu_BaEn_2	242	248	PF01217	0.254
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.323
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.455
TRG_DiLeu_BaLyEn_6	616	621	PF01217	0.463
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.474
TRG_ENDOCYTIC_2	120	123	PF00928	0.356
TRG_ENDOCYTIC_2	173	176	PF00928	0.472
TRG_ENDOCYTIC_2	189	192	PF00928	0.254
TRG_ENDOCYTIC_2	199	202	PF00928	0.358
TRG_ENDOCYTIC_2	224	227	PF00928	0.462
TRG_ENDOCYTIC_2	401	404	PF00928	0.477
TRG_ENDOCYTIC_2	519	522	PF00928	0.382
TRG_ENDOCYTIC_2	557	560	PF00928	0.466
TRG_ENDOCYTIC_2	607	610	PF00928	0.479
TRG_ENDOCYTIC_2	641	644	PF00928	0.405
TRG_ENDOCYTIC_2	649	652	PF00928	0.383
TRG_ER_diArg_1	331	334	PF00400	0.491
TRG_ER_diArg_1	480	483	PF00400	0.635
TRG_NES_CRM1_1	384	398	PF08389	0.469
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	633	637	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z3	Leptomonas seymouri	68%	100%
A0A1X0NLV7	Trypanosomatidae	30%	100%
A0A3Q8IJH5	Leishmania donovani	96%	100%
A0A422NKF8	Trypanosoma rangeli	29%	100%
A4HQI3	Leishmania braziliensis	90%	100%
D0A3N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AHZ2	Leishmania infantum	97%	100%
E9AU96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5AXM1	Trypanosoma cruzi	31%	100%