Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q093_LEIMA

TriTrypDb:

LmjF.36.6620 , LMJLV39_360080800 , LMJSD75_360080700

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q093

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q093

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	327	329	PF00675	0.477
CLV_NRD_NRD_1	388	390	PF00675	0.502
CLV_NRD_NRD_1	74	76	PF00675	0.475
CLV_PCSK_KEX2_1	327	329	PF00082	0.477
CLV_PCSK_KEX2_1	388	390	PF00082	0.502
CLV_PCSK_KEX2_1	74	76	PF00082	0.475
DOC_CDC14_PxL_1	359	367	PF14671	0.624
DOC_CKS1_1	185	190	PF01111	0.609
DOC_CYCLIN_yCln2_LP_2	148	154	PF00134	0.424
DOC_MAPK_gen_1	191	198	PF00069	0.712
DOC_MAPK_gen_1	74	82	PF00069	0.714
DOC_MAPK_MEF2A_6	74	82	PF00069	0.755
DOC_MAPK_RevD_3	374	389	PF00069	0.501
DOC_PP4_FxxP_1	142	145	PF00568	0.477
DOC_USP7_MATH_1	15	19	PF00917	0.602
DOC_WW_Pin1_4	184	189	PF00397	0.609
DOC_WW_Pin1_4	228	233	PF00397	0.525
LIG_14-3-3_CanoR_1	191	196	PF00244	0.713
LIG_14-3-3_CanoR_1	197	202	PF00244	0.387
LIG_14-3-3_CanoR_1	23	29	PF00244	0.705
LIG_14-3-3_CanoR_1	327	336	PF00244	0.745
LIG_14-3-3_CanoR_1	54	64	PF00244	0.351
LIG_14-3-3_CanoR_1	91	97	PF00244	0.673
LIG_Actin_WH2_2	283	298	PF00022	0.556
LIG_Actin_WH2_2	58	76	PF00022	0.440
LIG_BRCT_BRCA1_1	198	202	PF00533	0.501
LIG_BRCT_BRCA1_1	306	310	PF00533	0.340
LIG_EH_1	180	184	PF12763	0.716
LIG_EH1_1	211	219	PF00400	0.622
LIG_FHA_1	110	116	PF00498	0.325
LIG_FHA_1	203	209	PF00498	0.355
LIG_FHA_1	300	306	PF00498	0.459
LIG_FHA_1	312	318	PF00498	0.301
LIG_FHA_1	400	406	PF00498	0.719
LIG_FHA_1	57	63	PF00498	0.445
LIG_FHA_1	9	15	PF00498	0.769
LIG_FHA_1	95	101	PF00498	0.705
LIG_FHA_2	185	191	PF00498	0.608
LIG_GBD_Chelix_1	365	373	PF00786	0.542
LIG_LIR_Gen_1	106	115	PF02991	0.499
LIG_LIR_Gen_1	194	203	PF02991	0.524
LIG_LIR_Gen_1	255	263	PF02991	0.447
LIG_LIR_Gen_1	284	295	PF02991	0.556
LIG_LIR_Gen_1	3	12	PF02991	0.709
LIG_LIR_Gen_1	354	364	PF02991	0.458
LIG_LIR_LC3C_4	112	115	PF02991	0.397
LIG_LIR_Nem_3	106	110	PF02991	0.505
LIG_LIR_Nem_3	194	198	PF02991	0.550
LIG_LIR_Nem_3	199	204	PF02991	0.414
LIG_LIR_Nem_3	20	25	PF02991	0.588
LIG_LIR_Nem_3	255	259	PF02991	0.462
LIG_LIR_Nem_3	273	279	PF02991	0.593
LIG_LIR_Nem_3	284	290	PF02991	0.531
LIG_LIR_Nem_3	3	7	PF02991	0.707
LIG_LIR_Nem_3	307	313	PF02991	0.307
LIG_LIR_Nem_3	354	359	PF02991	0.458
LIG_NRBOX	368	374	PF00104	0.490
LIG_PDZ_Class_2	403	408	PF00595	0.692
LIG_Pex14_2	318	322	PF04695	0.397
LIG_SH2_NCK_1	89	93	PF00017	0.700
LIG_SH2_PTP2	41	44	PF00017	0.501
LIG_SH2_SRC	41	44	PF00017	0.445
LIG_SH2_STAP1	137	141	PF00017	0.494
LIG_SH2_STAT5	125	128	PF00017	0.428
LIG_SH2_STAT5	130	133	PF00017	0.495
LIG_SH2_STAT5	234	237	PF00017	0.543
LIG_SH2_STAT5	24	27	PF00017	0.701
LIG_SH2_STAT5	311	314	PF00017	0.482
LIG_SH2_STAT5	41	44	PF00017	0.504
LIG_SH3_3	115	121	PF00018	0.430
LIG_SH3_3	170	176	PF00018	0.384
LIG_SH3_3	182	188	PF00018	0.641
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.399
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.353
LIG_SUMO_SIM_anti_2	58	64	PF11976	0.307
LIG_SUMO_SIM_par_1	250	255	PF11976	0.385
LIG_SUMO_SIM_par_1	301	307	PF11976	0.414
LIG_TRAF2_1	335	338	PF00917	0.601
LIG_TRFH_1	277	281	PF08558	0.691
LIG_TYR_ITIM	274	279	PF00017	0.696
LIG_TYR_ITIM	39	44	PF00017	0.482
LIG_WRC_WIRS_1	1	6	PF05994	0.717
MOD_CDK_SPxxK_3	184	191	PF00069	0.608
MOD_CK1_1	255	261	PF00069	0.424
MOD_CK1_1	3	9	PF00069	0.700
MOD_CK1_1	358	364	PF00069	0.594
MOD_CK1_1	399	405	PF00069	0.711
MOD_GlcNHglycan	17	20	PF01048	0.447
MOD_GlcNHglycan	237	240	PF01048	0.750
MOD_GlcNHglycan	30	33	PF01048	0.392
MOD_GlcNHglycan	396	399	PF01048	0.550
MOD_GlcNHglycan	70	73	PF01048	0.407
MOD_GSK3_1	228	235	PF00069	0.487
MOD_GSK3_1	24	31	PF00069	0.589
MOD_GSK3_1	295	302	PF00069	0.430
MOD_GSK3_1	347	354	PF00069	0.380
MOD_GSK3_1	90	97	PF00069	0.680
MOD_N-GLC_1	56	61	PF02516	0.424
MOD_NEK2_1	212	217	PF00069	0.525
MOD_NEK2_1	295	300	PF00069	0.397
MOD_NEK2_1	304	309	PF00069	0.372
MOD_NEK2_1	394	399	PF00069	0.692
MOD_NEK2_1	68	73	PF00069	0.387
MOD_NEK2_2	351	356	PF00069	0.419
MOD_PKA_1	327	333	PF00069	0.675
MOD_PKA_2	196	202	PF00069	0.307
MOD_PKA_2	327	333	PF00069	0.738
MOD_PKA_2	90	96	PF00069	0.692
MOD_Plk_1	56	62	PF00069	0.424
MOD_Plk_4	103	109	PF00069	0.590
MOD_Plk_4	144	150	PF00069	0.360
MOD_Plk_4	17	23	PF00069	0.697
MOD_Plk_4	197	203	PF00069	0.378
MOD_Plk_4	252	258	PF00069	0.397
MOD_Plk_4	299	305	PF00069	0.400
MOD_ProDKin_1	184	190	PF00069	0.609
MOD_ProDKin_1	228	234	PF00069	0.524
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.307
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.581
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.683
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.754
TRG_ENDOCYTIC_2	180	183	PF00928	0.684
TRG_ENDOCYTIC_2	276	279	PF00928	0.738
TRG_ENDOCYTIC_2	41	44	PF00928	0.482
TRG_ENDOCYTIC_2	89	92	PF00928	0.696
TRG_ER_diArg_1	326	328	PF00400	0.674
TRG_ER_diArg_1	388	390	PF00400	0.704
TRG_ER_diArg_1	73	75	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I240	Leptomonas seymouri	51%	100%
A0A1X0NN35	Trypanosomatidae	22%	100%
A0A3S7XCE6	Leishmania donovani	91%	100%
A4HQI5	Leishmania braziliensis	73%	100%
E9AHZ4	Leishmania infantum	91%	100%
E9AU98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%