LeishMANIAdb
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Organic solute transporter Ostalpha-domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Organic solute transporter Ostalpha-domain-containing protein
Gene product:
f2o10.10 protein-like protein
Species:
Leishmania major
UniProt:
Q4Q086_LEIMA
TriTrypDb:
LmjF.36.6690 , LMJLV39_360081700 * , LMJSD75_360081600
Length:
372

Annotations

LeishMANIAdb annotations

Member of the poorly studied TMEM184 family ubiquitious in Eukaryota.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

Q4Q086
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q086

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 14 16 PF00675 0.359
CLV_PCSK_KEX2_1 14 16 PF00082 0.358
CLV_PCSK_SKI1_1 153 157 PF00082 0.329
CLV_PCSK_SKI1_1 244 248 PF00082 0.295
CLV_PCSK_SKI1_1 86 90 PF00082 0.301
DEG_MDM2_SWIB_1 258 266 PF02201 0.301
DEG_SCF_FBW7_2 327 334 PF00400 0.593
DOC_MAPK_gen_1 83 93 PF00069 0.448
DOC_MAPK_MEF2A_6 185 194 PF00069 0.317
DOC_MAPK_MEF2A_6 254 261 PF00069 0.460
DOC_MAPK_NFAT4_5 254 262 PF00069 0.452
DOC_PP1_RVXF_1 252 259 PF00149 0.448
DOC_PP1_RVXF_1 84 90 PF00149 0.448
DOC_PP2B_LxvP_1 102 105 PF13499 0.386
DOC_PP4_FxxP_1 75 78 PF00568 0.448
DOC_PP4_FxxP_1 89 92 PF00568 0.301
DOC_USP7_MATH_1 200 204 PF00917 0.364
DOC_WW_Pin1_4 164 169 PF00397 0.448
DOC_WW_Pin1_4 284 289 PF00397 0.353
DOC_WW_Pin1_4 327 332 PF00397 0.590
LIG_14-3-3_CanoR_1 212 217 PF00244 0.353
LIG_14-3-3_CanoR_1 345 354 PF00244 0.543
LIG_14-3-3_CanoR_1 9 18 PF00244 0.664
LIG_BIR_II_1 1 5 PF00653 0.624
LIG_BRCT_BRCA1_1 202 206 PF00533 0.353
LIG_Clathr_ClatBox_1 295 299 PF01394 0.301
LIG_CORNRBOX 187 195 PF00104 0.421
LIG_eIF4E_1 124 130 PF01652 0.301
LIG_FHA_1 141 147 PF00498 0.516
LIG_FHA_1 187 193 PF00498 0.358
LIG_FHA_1 213 219 PF00498 0.249
LIG_FHA_1 226 232 PF00498 0.255
LIG_FHA_1 336 342 PF00498 0.708
LIG_FHA_1 347 353 PF00498 0.610
LIG_FHA_1 80 86 PF00498 0.448
LIG_GBD_Chelix_1 187 195 PF00786 0.421
LIG_LIR_Apic_2 73 78 PF02991 0.448
LIG_LIR_Gen_1 109 118 PF02991 0.287
LIG_LIR_Gen_1 224 235 PF02991 0.310
LIG_LIR_Gen_1 23 32 PF02991 0.317
LIG_LIR_Gen_1 299 309 PF02991 0.301
LIG_LIR_Gen_1 64 72 PF02991 0.301
LIG_LIR_Nem_3 109 113 PF02991 0.287
LIG_LIR_Nem_3 116 121 PF02991 0.248
LIG_LIR_Nem_3 138 144 PF02991 0.301
LIG_LIR_Nem_3 215 219 PF02991 0.344
LIG_LIR_Nem_3 224 230 PF02991 0.258
LIG_LIR_Nem_3 23 27 PF02991 0.317
LIG_LIR_Nem_3 260 265 PF02991 0.327
LIG_LIR_Nem_3 299 305 PF02991 0.301
LIG_LIR_Nem_3 64 69 PF02991 0.301
LIG_NRBOX 290 296 PF00104 0.248
LIG_Pex14_1 20 24 PF04695 0.317
LIG_Pex14_2 258 262 PF04695 0.301
LIG_Rb_LxCxE_1 293 313 PF01857 0.301
LIG_SH2_CRK 141 145 PF00017 0.448
LIG_SH2_CRK 234 238 PF00017 0.489
LIG_SH2_CRK 55 59 PF00017 0.301
LIG_SH2_GRB2like 110 113 PF00017 0.248
LIG_SH2_PTP2 35 38 PF00017 0.421
LIG_SH2_SRC 160 163 PF00017 0.553
LIG_SH2_STAP1 118 122 PF00017 0.248
LIG_SH2_STAT3 354 357 PF00017 0.458
LIG_SH2_STAT5 110 113 PF00017 0.244
LIG_SH2_STAT5 121 124 PF00017 0.421
LIG_SH2_STAT5 160 163 PF00017 0.553
LIG_SH2_STAT5 216 219 PF00017 0.327
LIG_SH2_STAT5 232 235 PF00017 0.301
LIG_SH2_STAT5 309 312 PF00017 0.295
LIG_SH2_STAT5 316 319 PF00017 0.546
LIG_SH2_STAT5 35 38 PF00017 0.421
LIG_SH2_STAT5 354 357 PF00017 0.531
LIG_SH2_STAT5 55 58 PF00017 0.117
LIG_SUMO_SIM_anti_2 189 196 PF11976 0.317
LIG_SUMO_SIM_anti_2 2 8 PF11976 0.613
LIG_SUMO_SIM_anti_2 98 104 PF11976 0.386
LIG_SUMO_SIM_par_1 142 148 PF11976 0.534
LIG_SUMO_SIM_par_1 189 196 PF11976 0.315
LIG_TRAF2_1 331 334 PF00917 0.680
LIG_UBA3_1 178 185 PF00899 0.301
LIG_UBA3_1 190 198 PF00899 0.301
LIG_UBA3_1 205 210 PF00899 0.202
LIG_UBA3_1 3 11 PF00899 0.562
LIG_UBA3_1 36 43 PF00899 0.437
LIG_WRC_WIRS_1 21 26 PF05994 0.293
LIG_WRC_WIRS_1 258 263 PF05994 0.317
LIG_WRC_WIRS_1 276 281 PF05994 0.260
LIG_WRC_WIRS_1 48 53 PF05994 0.184
MOD_CK1_1 2 8 PF00069 0.641
MOD_CK1_1 98 104 PF00069 0.371
MOD_CK2_1 344 350 PF00069 0.552
MOD_CK2_1 73 79 PF00069 0.448
MOD_GlcNHglycan 270 273 PF01048 0.307
MOD_GSK3_1 136 143 PF00069 0.383
MOD_GSK3_1 221 228 PF00069 0.297
MOD_GSK3_1 43 50 PF00069 0.361
MOD_N-GLC_1 219 224 PF02516 0.301
MOD_N-GLC_1 43 48 PF02516 0.643
MOD_NEK2_1 193 198 PF00069 0.383
MOD_NEK2_1 201 206 PF00069 0.241
MOD_NEK2_1 352 357 PF00069 0.526
MOD_NEK2_1 61 66 PF00069 0.331
MOD_NEK2_1 96 101 PF00069 0.331
MOD_NEK2_2 136 141 PF00069 0.301
MOD_PK_1 43 49 PF00069 0.416
MOD_PKA_2 114 120 PF00069 0.326
MOD_PKA_2 344 350 PF00069 0.562
MOD_Plk_1 219 225 PF00069 0.301
MOD_Plk_1 43 49 PF00069 0.435
MOD_Plk_4 117 123 PF00069 0.327
MOD_Plk_4 136 142 PF00069 0.139
MOD_Plk_4 166 172 PF00069 0.460
MOD_Plk_4 186 192 PF00069 0.117
MOD_Plk_4 2 8 PF00069 0.668
MOD_Plk_4 201 207 PF00069 0.148
MOD_Plk_4 257 263 PF00069 0.301
MOD_Plk_4 43 49 PF00069 0.352
MOD_Plk_4 61 67 PF00069 0.179
MOD_ProDKin_1 164 170 PF00069 0.448
MOD_ProDKin_1 284 290 PF00069 0.353
MOD_ProDKin_1 327 333 PF00069 0.592
TRG_DiLeu_BaEn_1 109 114 PF01217 0.260
TRG_ENDOCYTIC_2 110 113 PF00928 0.300
TRG_ENDOCYTIC_2 124 127 PF00928 0.301
TRG_ENDOCYTIC_2 141 144 PF00928 0.448
TRG_ENDOCYTIC_2 18 21 PF00928 0.297
TRG_ENDOCYTIC_2 232 235 PF00928 0.322
TRG_ENDOCYTIC_2 35 38 PF00928 0.382
TRG_ENDOCYTIC_2 55 58 PF00928 0.117
TRG_Pf-PMV_PEXEL_1 142 147 PF00026 0.248
TRG_Pf-PMV_PEXEL_1 238 242 PF00026 0.322

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7Z6 Leptomonas seymouri 85% 100%
A0A0S4IIT6 Bodo saltans 59% 97%
A0A0S4JJ01 Bodo saltans 32% 81%
A0A0S4JTI7 Bodo saltans 29% 94%
A0A0S4KNU2 Bodo saltans 28% 69%
A0A1X0NLV0 Trypanosomatidae 66% 100%
A0A1X0NUV4 Trypanosomatidae 34% 70%
A0A3R7KK37 Trypanosoma rangeli 33% 70%
A0A3S7XCD1 Leishmania donovani 98% 100%
A0A422NVU2 Trypanosoma rangeli 66% 99%
A2VDL9 Bos taurus 35% 91%
A4HQJ2 Leishmania braziliensis 89% 100%
D0A3P0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9AI01 Leishmania infantum 98% 100%
E9AUA5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
F4JTN2 Arabidopsis thaliana 28% 77%
P36142 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 89%
Q09906 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 87%
Q17QL9 Bos taurus 34% 85%
Q1RMW2 Bos taurus 32% 90%
Q28CV2 Xenopus tropicalis 33% 84%
Q3TPR7 Mus musculus 33% 71%
Q3UFJ6 Mus musculus 33% 88%
Q4QQS1 Rattus norvegicus 32% 88%
Q54PI4 Dictyostelium discoideum 32% 75%
Q54WM0 Dictyostelium discoideum 35% 100%
Q5BPZ5 Arabidopsis thaliana 27% 92%
Q5RET6 Pongo abelii 34% 85%
Q5ZMP3 Gallus gallus 32% 84%
Q6GQE1 Xenopus laevis 31% 84%
Q6ZMB5 Homo sapiens 32% 90%
Q75JN3 Dictyostelium discoideum 28% 73%
Q810F5 Rattus norvegicus 33% 74%
Q8BG09 Mus musculus 35% 91%
Q94CA0 Arabidopsis thaliana 30% 77%
Q9NVA4 Homo sapiens 34% 85%
Q9Y519 Homo sapiens 35% 91%
V5BRV8 Trypanosoma cruzi 34% 70%
V5DDU5 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS