Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q085_LEIMA

TriTrypDb:

LmjF.36.6700 , LMJLV39_360081800 , LMJSD75_360081700

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q085

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q085

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.602
CLV_C14_Caspase3-7	282	286	PF00656	0.719
CLV_C14_Caspase3-7	6	10	PF00656	0.551
CLV_NRD_NRD_1	188	190	PF00675	0.457
CLV_NRD_NRD_1	395	397	PF00675	0.611
CLV_NRD_NRD_1	84	86	PF00675	0.428
CLV_PCSK_FUR_1	82	86	PF00082	0.457
CLV_PCSK_KEX2_1	188	190	PF00082	0.457
CLV_PCSK_KEX2_1	332	334	PF00082	0.287
CLV_PCSK_KEX2_1	353	355	PF00082	0.623
CLV_PCSK_KEX2_1	395	397	PF00082	0.608
CLV_PCSK_KEX2_1	82	84	PF00082	0.434
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.317
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.653
CLV_PCSK_SKI1_1	188	192	PF00082	0.434
CLV_PCSK_SKI1_1	220	224	PF00082	0.383
CLV_PCSK_SKI1_1	71	75	PF00082	0.420
CLV_Separin_Metazoa	68	72	PF03568	0.559
DEG_APCC_DBOX_1	187	195	PF00400	0.671
DEG_SCF_FBW7_1	435	441	PF00400	0.449
DEG_SPOP_SBC_1	263	267	PF00917	0.543
DOC_CDC14_PxL_1	252	260	PF14671	0.589
DOC_CKS1_1	407	412	PF01111	0.448
DOC_CKS1_1	435	440	PF01111	0.449
DOC_CYCLIN_RxL_1	390	402	PF00134	0.422
DOC_CYCLIN_RxL_1	458	469	PF00134	0.589
DOC_MAPK_DCC_7	250	260	PF00069	0.565
DOC_MAPK_MEF2A_6	144	151	PF00069	0.529
DOC_PP1_RVXF_1	393	400	PF00149	0.421
DOC_PP2B_LxvP_1	137	140	PF13499	0.576
DOC_USP7_MATH_1	107	111	PF00917	0.585
DOC_USP7_MATH_1	234	238	PF00917	0.638
DOC_USP7_MATH_1	264	268	PF00917	0.698
DOC_USP7_MATH_1	270	274	PF00917	0.749
DOC_USP7_MATH_1	276	280	PF00917	0.754
DOC_USP7_MATH_1	319	323	PF00917	0.754
DOC_USP7_MATH_1	438	442	PF00917	0.441
DOC_USP7_MATH_1	44	48	PF00917	0.640
DOC_WW_Pin1_4	406	411	PF00397	0.452
DOC_WW_Pin1_4	434	439	PF00397	0.449
DOC_WW_Pin1_4	88	93	PF00397	0.641
LIG_14-3-3_CanoR_1	144	148	PF00244	0.578
LIG_14-3-3_CanoR_1	333	343	PF00244	0.344
LIG_14-3-3_CanoR_1	443	448	PF00244	0.637
LIG_14-3-3_CanoR_1	71	76	PF00244	0.567
LIG_14-3-3_CanoR_1	83	89	PF00244	0.621
LIG_Actin_WH2_2	145	160	PF00022	0.553
LIG_BIR_II_1	1	5	PF00653	0.705
LIG_BRCT_BRCA1_1	159	163	PF00533	0.550
LIG_FHA_1	144	150	PF00498	0.546
LIG_FHA_1	264	270	PF00498	0.569
LIG_FHA_1	28	34	PF00498	0.538
LIG_FHA_1	407	413	PF00498	0.455
LIG_FHA_1	417	423	PF00498	0.365
LIG_FHA_1	435	441	PF00498	0.288
LIG_FHA_1	72	78	PF00498	0.568
LIG_FHA_2	280	286	PF00498	0.722
LIG_FHA_2	416	422	PF00498	0.417
LIG_FHA_2	89	95	PF00498	0.608
LIG_GBD_Chelix_1	459	467	PF00786	0.387
LIG_GLEBS_BUB3_1	123	131	PF00400	0.586
LIG_LIR_Gen_1	16	25	PF02991	0.517
LIG_LIR_Gen_1	466	473	PF02991	0.646
LIG_LIR_LC3C_4	111	116	PF02991	0.617
LIG_LIR_Nem_3	16	21	PF02991	0.507
LIG_LIR_Nem_3	224	229	PF02991	0.588
LIG_LIR_Nem_3	466	471	PF02991	0.636
LIG_LIR_Nem_3	74	78	PF02991	0.467
LIG_PDZ_Class_2	468	473	PF00595	0.554
LIG_Pex14_1	132	136	PF04695	0.626
LIG_Pex14_2	163	167	PF04695	0.537
LIG_Pex14_2	295	299	PF04695	0.626
LIG_Rb_pABgroove_1	395	403	PF01858	0.398
LIG_SH2_CRK	165	169	PF00017	0.633
LIG_SH2_CRK	252	256	PF00017	0.574
LIG_SH2_CRK	336	340	PF00017	0.413
LIG_SH2_CRK	75	79	PF00017	0.611
LIG_SH2_PTP2	18	21	PF00017	0.509
LIG_SH2_STAP1	336	340	PF00017	0.363
LIG_SH2_STAP1	401	405	PF00017	0.391
LIG_SH2_STAT5	136	139	PF00017	0.645
LIG_SH2_STAT5	18	21	PF00017	0.508
LIG_SH2_STAT5	36	39	PF00017	0.463
LIG_SH2_STAT5	426	429	PF00017	0.413
LIG_SH2_STAT5	59	62	PF00017	0.522
LIG_SH3_3	19	25	PF00018	0.571
LIG_SUMO_SIM_par_1	256	261	PF11976	0.624
LIG_SUMO_SIM_par_1	30	35	PF11976	0.639
LIG_TRAF2_1	125	128	PF00917	0.651
LIG_TRFH_1	468	472	PF08558	0.546
LIG_TRFH_1	75	79	PF08558	0.481
LIG_TYR_ITIM	334	339	PF00017	0.413
LIG_TYR_ITIM	73	78	PF00017	0.463
MOD_CK1_1	201	207	PF00069	0.731
MOD_CK1_1	238	244	PF00069	0.578
MOD_CK1_1	27	33	PF00069	0.529
MOD_CK1_1	279	285	PF00069	0.781
MOD_CK1_1	61	67	PF00069	0.655
MOD_CK2_1	122	128	PF00069	0.646
MOD_CK2_1	211	217	PF00069	0.660
MOD_CK2_1	88	94	PF00069	0.630
MOD_CK2_1	95	101	PF00069	0.582
MOD_GlcNHglycan	123	127	PF01048	0.414
MOD_GlcNHglycan	15	18	PF01048	0.304
MOD_GlcNHglycan	213	216	PF01048	0.477
MOD_GlcNHglycan	26	29	PF01048	0.300
MOD_GlcNHglycan	266	269	PF01048	0.510
MOD_GlcNHglycan	272	275	PF01048	0.538
MOD_GlcNHglycan	278	281	PF01048	0.515
MOD_GlcNHglycan	311	314	PF01048	0.519
MOD_GlcNHglycan	316	319	PF01048	0.501
MOD_GlcNHglycan	321	324	PF01048	0.344
MOD_GlcNHglycan	336	339	PF01048	0.280
MOD_GlcNHglycan	364	367	PF01048	0.739
MOD_GlcNHglycan	387	390	PF01048	0.619
MOD_GlcNHglycan	46	49	PF01048	0.279
MOD_GlcNHglycan	60	63	PF01048	0.343
MOD_GlcNHglycan	94	98	PF01048	0.372
MOD_GSK3_1	224	231	PF00069	0.540
MOD_GSK3_1	23	30	PF00069	0.532
MOD_GSK3_1	234	241	PF00069	0.601
MOD_GSK3_1	276	283	PF00069	0.729
MOD_GSK3_1	297	304	PF00069	0.616
MOD_GSK3_1	319	326	PF00069	0.667
MOD_GSK3_1	434	441	PF00069	0.351
MOD_GSK3_1	84	91	PF00069	0.653
MOD_NEK2_1	131	136	PF00069	0.611
MOD_NEK2_1	157	162	PF00069	0.556
MOD_NEK2_1	235	240	PF00069	0.561
MOD_NEK2_1	314	319	PF00069	0.771
MOD_NEK2_1	334	339	PF00069	0.388
MOD_NEK2_1	385	390	PF00069	0.387
MOD_NEK2_1	415	420	PF00069	0.440
MOD_NEK2_1	463	468	PF00069	0.623
MOD_NEK2_1	8	13	PF00069	0.589
MOD_NEK2_1	93	98	PF00069	0.595
MOD_PIKK_1	297	303	PF00454	0.593
MOD_PIKK_1	438	444	PF00454	0.554
MOD_PKA_1	84	90	PF00069	0.608
MOD_PKA_2	143	149	PF00069	0.613
MOD_PKA_2	157	163	PF00069	0.546
MOD_PKA_2	84	90	PF00069	0.608
MOD_PKB_1	82	90	PF00069	0.685
MOD_Plk_1	201	207	PF00069	0.785
MOD_Plk_1	461	467	PF00069	0.615
MOD_Plk_1	8	14	PF00069	0.558
MOD_Plk_4	143	149	PF00069	0.531
MOD_Plk_4	172	178	PF00069	0.569
MOD_Plk_4	235	241	PF00069	0.545
MOD_Plk_4	28	34	PF00069	0.530
MOD_Plk_4	323	329	PF00069	0.663
MOD_Plk_4	463	469	PF00069	0.639
MOD_Plk_4	95	101	PF00069	0.590
MOD_ProDKin_1	406	412	PF00069	0.449
MOD_ProDKin_1	434	440	PF00069	0.449
MOD_ProDKin_1	88	94	PF00069	0.639
TRG_DiLeu_BaEn_1	186	191	PF01217	0.611
TRG_DiLeu_BaEn_4	186	192	PF01217	0.515
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.569
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.492
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.611
TRG_DiLeu_LyEn_5	186	191	PF01217	0.594
TRG_ENDOCYTIC_2	165	168	PF00928	0.626
TRG_ENDOCYTIC_2	18	21	PF00928	0.508
TRG_ENDOCYTIC_2	252	255	PF00928	0.569
TRG_ENDOCYTIC_2	336	339	PF00928	0.363
TRG_ENDOCYTIC_2	401	404	PF00928	0.304
TRG_ENDOCYTIC_2	75	78	PF00928	0.602
TRG_ER_diArg_1	188	190	PF00400	0.656
TRG_ER_diArg_1	394	396	PF00400	0.417
TRG_ER_diArg_1	82	85	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR4	Leptomonas seymouri	66%	98%
A0A0S4ISX7	Bodo saltans	27%	98%
A0A1X0NN06	Trypanosomatidae	43%	100%
A0A3Q8IM62	Leishmania donovani	93%	100%
A0A3R7MQC3	Trypanosoma rangeli	43%	100%
A4HQJ3	Leishmania braziliensis	80%	98%
D0A3P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AI02	Leishmania infantum	93%	100%
E9AUA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BHM6	Trypanosoma cruzi	42%	100%