Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q081_LEIMA

TriTrypDb:

LmjF.36.6740 , LMJLV39_360082400 , LMJSD75_360082300

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q081

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q081

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	254	256	PF00675	0.486
CLV_NRD_NRD_1	26	28	PF00675	0.740
CLV_PCSK_FUR_1	131	135	PF00082	0.429
CLV_PCSK_KEX2_1	111	113	PF00082	0.442
CLV_PCSK_KEX2_1	125	127	PF00082	0.272
CLV_PCSK_KEX2_1	133	135	PF00082	0.374
CLV_PCSK_KEX2_1	216	218	PF00082	0.378
CLV_PCSK_KEX2_1	254	256	PF00082	0.469
CLV_PCSK_KEX2_1	26	28	PF00082	0.662
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.487
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.265
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.388
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.455
CLV_PCSK_SKI1_1	133	137	PF00082	0.425
CLV_PCSK_SKI1_1	177	181	PF00082	0.422
CLV_PCSK_SKI1_1	200	204	PF00082	0.369
CLV_PCSK_SKI1_1	216	220	PF00082	0.335
CLV_PCSK_SKI1_1	74	78	PF00082	0.530
DEG_APCC_DBOX_1	57	65	PF00400	0.452
DEG_APCC_DBOX_1	73	81	PF00400	0.381
DEG_SPOP_SBC_1	5	9	PF00917	0.516
DOC_CKS1_1	201	206	PF01111	0.580
DOC_CKS1_1	28	33	PF01111	0.412
DOC_MAPK_gen_1	216	222	PF00069	0.561
DOC_MAPK_gen_1	233	242	PF00069	0.608
DOC_MAPK_gen_1	58	66	PF00069	0.448
DOC_MAPK_HePTP_8	230	242	PF00069	0.615
DOC_MAPK_MEF2A_6	233	242	PF00069	0.672
DOC_PP1_RVXF_1	227	233	PF00149	0.608
DOC_USP7_MATH_1	5	9	PF00917	0.549
DOC_USP7_UBL2_3	260	264	PF12436	0.650
DOC_WW_Pin1_4	200	205	PF00397	0.561
DOC_WW_Pin1_4	27	32	PF00397	0.348
DOC_WW_Pin1_4	7	12	PF00397	0.577
LIG_14-3-3_CanoR_1	112	121	PF00244	0.600
LIG_14-3-3_CanoR_1	217	221	PF00244	0.606
LIG_14-3-3_CanoR_1	99	105	PF00244	0.606
LIG_Actin_RPEL_3	51	70	PF02755	0.465
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_deltaCOP1_diTrp_1	188	194	PF00928	0.585
LIG_eIF4E_1	201	207	PF01652	0.629
LIG_FHA_1	201	207	PF00498	0.579
LIG_FHA_1	33	39	PF00498	0.526
LIG_FHA_2	243	249	PF00498	0.688
LIG_FHA_2	28	34	PF00498	0.520
LIG_LIR_Apic_2	198	204	PF02991	0.560
LIG_LIR_Apic_2	44	50	PF02991	0.428
LIG_LIR_Nem_3	103	109	PF02991	0.663
LIG_LIR_Nem_3	169	174	PF02991	0.603
LIG_LIR_Nem_3	245	249	PF02991	0.607
LIG_LIR_Nem_3	65	69	PF02991	0.380
LIG_NRBOX	37	43	PF00104	0.488
LIG_Pex14_1	190	194	PF04695	0.580
LIG_Pex14_2	207	211	PF04695	0.637
LIG_REV1ctd_RIR_1	240	248	PF16727	0.622
LIG_SH2_CRK	78	82	PF00017	0.388
LIG_SH2_PTP2	201	204	PF00017	0.618
LIG_SH2_STAP1	115	119	PF00017	0.585
LIG_SH2_STAP1	78	82	PF00017	0.480
LIG_SH2_STAT3	121	124	PF00017	0.515
LIG_SH2_STAT5	171	174	PF00017	0.526
LIG_SH2_STAT5	201	204	PF00017	0.567
LIG_SH2_STAT5	209	212	PF00017	0.554
LIG_SH2_STAT5	63	66	PF00017	0.510
LIG_SH3_3	158	164	PF00018	0.559
LIG_SH3_3	25	31	PF00018	0.425
LIG_SH3_3	66	72	PF00018	0.383
LIG_SH3_4	260	267	PF00018	0.659
LIG_TYR_ITSM	167	174	PF00017	0.523
MOD_CK1_1	9	15	PF00069	0.667
MOD_CK2_1	242	248	PF00069	0.589
MOD_DYRK1A_RPxSP_1	27	31	PF00069	0.530
MOD_GSK3_1	5	12	PF00069	0.711
MOD_GSK3_1	50	57	PF00069	0.653
MOD_N-GLC_1	256	261	PF02516	0.617
MOD_NEK2_1	242	247	PF00069	0.520
MOD_NEK2_1	76	81	PF00069	0.456
MOD_NEK2_2	34	39	PF00069	0.459
MOD_PIKK_1	135	141	PF00454	0.560
MOD_PKA_1	216	222	PF00069	0.537
MOD_PKA_2	113	119	PF00069	0.552
MOD_PKA_2	216	222	PF00069	0.514
MOD_PKA_2	98	104	PF00069	0.606
MOD_Plk_1	32	38	PF00069	0.671
MOD_Plk_4	76	82	PF00069	0.417
MOD_ProDKin_1	200	206	PF00069	0.450
MOD_ProDKin_1	27	33	PF00069	0.424
MOD_ProDKin_1	7	13	PF00069	0.750
MOD_SUMO_for_1	179	182	PF00179	0.540
TRG_ENDOCYTIC_2	171	174	PF00928	0.396
TRG_ENDOCYTIC_2	63	66	PF00928	0.654
TRG_ENDOCYTIC_2	78	81	PF00928	0.335
TRG_ER_diArg_1	112	115	PF00400	0.559
TRG_ER_diArg_1	253	255	PF00400	0.602
TRG_ER_diArg_1	26	28	PF00400	0.587
TRG_NLS_MonoExtN_4	108	115	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFV7	Leptomonas seymouri	78%	100%
A0A0S4JY76	Bodo saltans	50%	100%
A0A1X0NLD5	Trypanosomatidae	69%	100%
A0A3Q8II78	Leishmania donovani	95%	100%
A4HQJ6	Leishmania braziliensis	88%	100%
D0A3P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AI06	Leishmania infantum	95%	100%
E9AUA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BHN0	Trypanosoma cruzi	66%	100%