Prolyl endopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prolyl endopeptidase

Species:

Leishmania major

UniProt:

Q4Q080_LEIMA

TriTrypDb:

LmjF.36.6750 , LMJLV39_360082600 , LMJSD75_360082400

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q080

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q080

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004252	serine-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008236	serine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0017171	serine hydrolase activity	3	11
GO:0070012	oligopeptidase activity	5	2
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.478
CLV_C14_Caspase3-7	420	424	PF00656	0.405
CLV_NRD_NRD_1	309	311	PF00675	0.262
CLV_NRD_NRD_1	358	360	PF00675	0.344
CLV_NRD_NRD_1	9	11	PF00675	0.261
CLV_PCSK_KEX2_1	9	11	PF00082	0.261
CLV_PCSK_SKI1_1	10	14	PF00082	0.304
CLV_PCSK_SKI1_1	336	340	PF00082	0.329
CLV_PCSK_SKI1_1	482	486	PF00082	0.263
CLV_PCSK_SKI1_1	675	679	PF00082	0.217
DEG_Kelch_Keap1_1	157	162	PF01344	0.464
DEG_Nend_UBRbox_1	1	4	PF02207	0.442
DEG_SCF_FBW7_1	472	479	PF00400	0.303
DOC_CDC14_PxL_1	186	194	PF14671	0.479
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	653	659	PF00134	0.416
DOC_MAPK_gen_1	310	318	PF00069	0.449
DOC_MAPK_gen_1	368	374	PF00069	0.488
DOC_MAPK_gen_1	385	391	PF00069	0.421
DOC_MAPK_MEF2A_6	106	114	PF00069	0.495
DOC_MAPK_MEF2A_6	310	318	PF00069	0.505
DOC_MAPK_MEF2A_6	341	349	PF00069	0.479
DOC_PP1_RVXF_1	165	171	PF00149	0.505
DOC_PP1_RVXF_1	273	280	PF00149	0.603
DOC_PP1_RVXF_1	480	486	PF00149	0.280
DOC_PP2B_LxvP_1	226	229	PF13499	0.462
DOC_PP2B_LxvP_1	370	373	PF13499	0.481
DOC_PP2B_LxvP_1	493	496	PF13499	0.302
DOC_PP2B_PxIxI_1	620	626	PF00149	0.302
DOC_PP4_FxxP_1	113	116	PF00568	0.449
DOC_PP4_FxxP_1	396	399	PF00568	0.449
DOC_PP4_FxxP_1	669	672	PF00568	0.416
DOC_USP7_MATH_1	399	403	PF00917	0.472
DOC_USP7_MATH_1	410	414	PF00917	0.462
DOC_USP7_MATH_1	636	640	PF00917	0.283
DOC_USP7_MATH_1	73	77	PF00917	0.462
DOC_USP7_UBL2_3	671	675	PF12436	0.283
DOC_WW_Pin1_4	457	462	PF00397	0.338
DOC_WW_Pin1_4	472	477	PF00397	0.312
DOC_WW_Pin1_4	535	540	PF00397	0.302
DOC_WW_Pin1_4	606	611	PF00397	0.283
LIG_14-3-3_CanoR_1	65	72	PF00244	0.526
LIG_14-3-3_CanoR_1	9	17	PF00244	0.468
LIG_APCC_ABBA_1	345	350	PF00400	0.479
LIG_APCC_ABBA_1	414	419	PF00400	0.370
LIG_FHA_1	109	115	PF00498	0.479
LIG_FHA_1	12	18	PF00498	0.544
LIG_FHA_1	122	128	PF00498	0.421
LIG_FHA_1	520	526	PF00498	0.269
LIG_FHA_1	539	545	PF00498	0.406
LIG_FHA_1	65	71	PF00498	0.506
LIG_FHA_1	671	677	PF00498	0.280
LIG_FHA_2	19	25	PF00498	0.479
LIG_FHA_2	266	272	PF00498	0.527
LIG_FHA_2	318	324	PF00498	0.518
LIG_HCF-1_HBM_1	243	246	PF13415	0.530
LIG_LIR_Apic_2	111	116	PF02991	0.462
LIG_LIR_Apic_2	394	399	PF02991	0.449
LIG_LIR_Apic_2	591	596	PF02991	0.283
LIG_LIR_Gen_1	148	158	PF02991	0.462
LIG_LIR_Gen_1	24	32	PF02991	0.463
LIG_LIR_Gen_1	243	252	PF02991	0.466
LIG_LIR_Gen_1	268	277	PF02991	0.559
LIG_LIR_Gen_1	387	396	PF02991	0.544
LIG_LIR_Gen_1	428	437	PF02991	0.367
LIG_LIR_Gen_1	563	572	PF02991	0.416
LIG_LIR_Gen_1	681	691	PF02991	0.287
LIG_LIR_Nem_3	136	141	PF02991	0.508
LIG_LIR_Nem_3	148	153	PF02991	0.439
LIG_LIR_Nem_3	24	29	PF02991	0.480
LIG_LIR_Nem_3	243	249	PF02991	0.466
LIG_LIR_Nem_3	268	273	PF02991	0.545
LIG_LIR_Nem_3	278	282	PF02991	0.440
LIG_LIR_Nem_3	3	8	PF02991	0.441
LIG_LIR_Nem_3	378	384	PF02991	0.522
LIG_LIR_Nem_3	387	391	PF02991	0.481
LIG_LIR_Nem_3	428	433	PF02991	0.371
LIG_LIR_Nem_3	46	51	PF02991	0.496
LIG_LIR_Nem_3	563	568	PF02991	0.302
LIG_LIR_Nem_3	599	605	PF02991	0.283
LIG_LIR_Nem_3	606	611	PF02991	0.284
LIG_LYPXL_S_1	4	8	PF13949	0.304
LIG_LYPXL_yS_3	189	192	PF13949	0.479
LIG_LYPXL_yS_3	5	8	PF13949	0.338
LIG_LYPXL_yS_3	620	623	PF13949	0.283
LIG_PAM2_1	76	88	PF00658	0.544
LIG_PCNA_yPIPBox_3	571	582	PF02747	0.297
LIG_Pex14_1	589	593	PF04695	0.283
LIG_REV1ctd_RIR_1	182	189	PF16727	0.449
LIG_SH2_CRK	290	294	PF00017	0.455
LIG_SH2_CRK	358	362	PF00017	0.495
LIG_SH2_CRK	608	612	PF00017	0.263
LIG_SH2_PTP2	152	155	PF00017	0.544
LIG_SH2_PTP2	430	433	PF00017	0.361
LIG_SH2_SRC	530	533	PF00017	0.397
LIG_SH2_STAP1	684	688	PF00017	0.302
LIG_SH2_STAT3	85	88	PF00017	0.464
LIG_SH2_STAT5	152	155	PF00017	0.508
LIG_SH2_STAT5	209	212	PF00017	0.563
LIG_SH2_STAT5	246	249	PF00017	0.496
LIG_SH2_STAT5	28	31	PF00017	0.503
LIG_SH2_STAT5	292	295	PF00017	0.468
LIG_SH2_STAT5	348	351	PF00017	0.454
LIG_SH2_STAT5	403	406	PF00017	0.505
LIG_SH2_STAT5	430	433	PF00017	0.431
LIG_SH2_STAT5	530	533	PF00017	0.338
LIG_SH2_STAT5	642	645	PF00017	0.283
LIG_SH3_3	226	232	PF00018	0.457
LIG_SH3_3	615	621	PF00018	0.362
LIG_SH3_4	671	678	PF00018	0.283
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.479
LIG_SUMO_SIM_par_1	622	627	PF11976	0.283
LIG_TRAF2_1	269	272	PF00917	0.464
LIG_TRAF2_1	320	323	PF00917	0.505
LIG_TRAF2_1	596	599	PF00917	0.304
LIG_TYR_ITIM	618	623	PF00017	0.302
LIG_UBA3_1	260	265	PF00899	0.505
LIG_UBA3_1	299	306	PF00899	0.453
LIG_UBA3_1	345	353	PF00899	0.437
LIG_WRC_WIRS_1	283	288	PF05994	0.554
LIG_WRC_WIRS_1	388	393	PF05994	0.467
MOD_CDC14_SPxK_1	479	482	PF00782	0.338
MOD_CDK_SPxK_1	476	482	PF00069	0.338
MOD_CK1_1	174	180	PF00069	0.559
MOD_CK1_1	455	461	PF00069	0.485
MOD_CK1_1	538	544	PF00069	0.302
MOD_CK1_1	76	82	PF00069	0.505
MOD_CK2_1	130	136	PF00069	0.461
MOD_CK2_1	18	24	PF00069	0.479
MOD_CK2_1	265	271	PF00069	0.532
MOD_CK2_1	317	323	PF00069	0.450
MOD_CK2_1	51	57	PF00069	0.495
MOD_GlcNHglycan	119	122	PF01048	0.330
MOD_GlcNHglycan	173	176	PF01048	0.322
MOD_GlcNHglycan	203	206	PF01048	0.330
MOD_GlcNHglycan	438	441	PF01048	0.433
MOD_GlcNHglycan	525	528	PF01048	0.407
MOD_GSK3_1	117	124	PF00069	0.544
MOD_GSK3_1	141	148	PF00069	0.471
MOD_GSK3_1	302	309	PF00069	0.510
MOD_GSK3_1	387	394	PF00069	0.434
MOD_GSK3_1	436	443	PF00069	0.366
MOD_GSK3_1	470	477	PF00069	0.322
MOD_GSK3_1	519	526	PF00069	0.372
MOD_GSK3_1	535	542	PF00069	0.231
MOD_GSK3_1	671	678	PF00069	0.269
MOD_GSK3_1	72	79	PF00069	0.505
MOD_N-GLC_1	94	99	PF02516	0.273
MOD_N-GLC_2	253	255	PF02516	0.248
MOD_NEK2_1	100	105	PF00069	0.483
MOD_NEK2_1	139	144	PF00069	0.479
MOD_NEK2_1	300	305	PF00069	0.537
MOD_NEK2_1	391	396	PF00069	0.462
MOD_NEK2_1	470	475	PF00069	0.324
MOD_NEK2_1	545	550	PF00069	0.283
MOD_NEK2_2	412	417	PF00069	0.558
MOD_NEK2_2	636	641	PF00069	0.302
MOD_PK_1	312	318	PF00069	0.478
MOD_PKA_1	452	458	PF00069	0.457
MOD_PKA_2	512	518	PF00069	0.416
MOD_PKA_2	64	70	PF00069	0.532
MOD_PKA_2	73	79	PF00069	0.462
MOD_Plk_1	563	569	PF00069	0.383
MOD_Plk_1	94	100	PF00069	0.473
MOD_Plk_4	108	114	PF00069	0.416
MOD_Plk_4	282	288	PF00069	0.515
MOD_Plk_4	329	335	PF00069	0.461
MOD_Plk_4	340	346	PF00069	0.445
MOD_Plk_4	376	382	PF00069	0.474
MOD_Plk_4	392	398	PF00069	0.407
MOD_Plk_4	412	418	PF00069	0.423
MOD_Plk_4	94	100	PF00069	0.468
MOD_ProDKin_1	457	463	PF00069	0.332
MOD_ProDKin_1	472	478	PF00069	0.311
MOD_ProDKin_1	535	541	PF00069	0.302
MOD_ProDKin_1	606	612	PF00069	0.283
MOD_SUMO_rev_2	272	282	PF00179	0.604
MOD_SUMO_rev_2	291	300	PF00179	0.371
MOD_SUMO_rev_2	30	40	PF00179	0.479
MOD_SUMO_rev_2	319	326	PF00179	0.538
MOD_SUMO_rev_2	350	355	PF00179	0.449
MOD_SUMO_rev_2	364	370	PF00179	0.449
TRG_DiLeu_BaEn_1	256	261	PF01217	0.417
TRG_DiLeu_BaEn_2	35	41	PF01217	0.479
TRG_ENDOCYTIC_2	152	155	PF00928	0.544
TRG_ENDOCYTIC_2	189	192	PF00928	0.452
TRG_ENDOCYTIC_2	209	212	PF00928	0.362
TRG_ENDOCYTIC_2	246	249	PF00928	0.496
TRG_ENDOCYTIC_2	26	29	PF00928	0.462
TRG_ENDOCYTIC_2	270	273	PF00928	0.572
TRG_ENDOCYTIC_2	290	293	PF00928	0.473
TRG_ENDOCYTIC_2	358	361	PF00928	0.479
TRG_ENDOCYTIC_2	430	433	PF00928	0.389
TRG_ENDOCYTIC_2	467	470	PF00928	0.310
TRG_ENDOCYTIC_2	5	8	PF00928	0.338
TRG_ENDOCYTIC_2	608	611	PF00928	0.272
TRG_ENDOCYTIC_2	620	623	PF00928	0.308
TRG_ENDOCYTIC_2	684	687	PF00928	0.283
TRG_ER_diArg_1	8	10	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	359	364	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P803	Leptomonas seymouri	78%	100%
A0A0N1PDP3	Leptomonas seymouri	20%	80%
A0A0S4IIS9	Bodo saltans	59%	100%
A0A1X0NKN5	Trypanosomatidae	22%	76%
A0A1X0NLB6	Trypanosomatidae	63%	100%
A0A3Q8IJI4	Leishmania donovani	96%	100%
A0A3S5H5P5	Leishmania donovani	21%	77%
A4H4J9	Leishmania braziliensis	20%	77%
A4H5Q8	Leishmania braziliensis	24%	95%
A4HQJ7	Leishmania braziliensis	83%	100%
A4HSS5	Leishmania infantum	21%	77%
A4ICB5	Leishmania infantum	96%	100%
C9ZTC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	77%
D0A3P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
D0A9G2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
E2JFG1	Amanita bisporigera	38%	92%
E2JFG2	Amanita bisporigera	36%	95%
E9AKR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	77%
E9AUB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
H2E7Q7	Galerina marginata (strain CBS 339.88)	37%	94%
H2E7Q8	Galerina marginata (strain CBS 339.88)	36%	95%
O07834	Pseudoxanthomonas mexicana	27%	96%
O70196	Rattus norvegicus	43%	98%
P23687	Sus scrofa	44%	98%
P24555	Escherichia coli (strain K12)	25%	100%
P27028	Elizabethkingia meningoseptica	37%	99%
P27195	Elizabethkingia miricola	36%	99%
P48147	Homo sapiens	44%	98%
P55627	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	21%	92%
P55656	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	21%	99%
Q06903	Aeromonas hydrophila	38%	100%
Q4QJ45	Leishmania major	21%	77%
Q59536	Moraxella lacunata	25%	100%
Q86AS5	Dictyostelium discoideum	35%	92%
Q9QUR6	Mus musculus	44%	98%
Q9XTA2	Bos taurus	43%	98%
V5B5S3	Trypanosoma cruzi	21%	81%
V5BM62	Trypanosoma cruzi	66%	100%