ATP synthase subunit delta, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase delta (OSCP) subunit, putative

Species:

Leishmania major

UniProt:

Q4Q079_LEIMA

TriTrypDb:

LmjF.36.6760 , LMJLV39_360082700 , LMJSD75_360082500

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000274	mitochondrial proton-transporting ATP synthase, stator stalk	4	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	9
GO:0032991	protein-containing complex	1	2
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	2
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	2
GO:0045265	proton-transporting ATP synthase, stator stalk	3	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2

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Expansion

Sequence features

Q4Q079

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q079

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006164	purine nucleotide biosynthetic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006754	ATP biosynthetic process	8	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005261	monoatomic cation channel activity	5	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015078	proton transmembrane transporter activity	5	12
GO:0015252	proton channel activity	6	12
GO:0015267	channel activity	4	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.460
CLV_NRD_NRD_1	239	241	PF00675	0.494
CLV_NRD_NRD_1	3	5	PF00675	0.551
CLV_PCSK_KEX2_1	135	137	PF00082	0.385
CLV_PCSK_KEX2_1	3	5	PF00082	0.551
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.385
CLV_PCSK_SKI1_1	135	139	PF00082	0.455
CLV_Separin_Metazoa	237	241	PF03568	0.498
DEG_APCC_DBOX_1	239	247	PF00400	0.495
DEG_Nend_Nbox_1	1	3	PF02207	0.589

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D0	Leptomonas seymouri	84%	100%
A0A0S4JTF5	Bodo saltans	59%	100%
A0A1X0NM19	Trypanosomatidae	65%	100%
A0A3Q8IS23	Leishmania donovani	96%	100%
A0A3S5IS13	Trypanosoma rangeli	65%	100%
A4HQJ8	Leishmania braziliensis	87%	100%
A4ICB6	Leishmania infantum	96%	100%
D0A3P7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AUB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5AXN2	Trypanosoma cruzi	65%	91%

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