Putative nuclear lim interactor-interacting factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear lim interactor-interacting factor, putative

Species:

Leishmania major

UniProt:

Q4Q077_LEIMA

TriTrypDb:

LmjF.36.6780 , LMJLV39_360082900 , LMJSD75_360082700

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q077

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q077

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004721	phosphoprotein phosphatase activity	3	4
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.349
CLV_NRD_NRD_1	281	283	PF00675	0.661
CLV_NRD_NRD_1	36	38	PF00675	0.564
CLV_NRD_NRD_1	6	8	PF00675	0.584
CLV_PCSK_FUR_1	127	131	PF00082	0.404
CLV_PCSK_FUR_1	3	7	PF00082	0.703
CLV_PCSK_KEX2_1	129	131	PF00082	0.404
CLV_PCSK_KEX2_1	281	283	PF00082	0.634
CLV_PCSK_KEX2_1	36	38	PF00082	0.559
CLV_PCSK_KEX2_1	5	7	PF00082	0.593
DEG_COP1_1	199	208	PF00400	0.357
DEG_SPOP_SBC_1	99	103	PF00917	0.404
DOC_CYCLIN_RxL_1	136	147	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	48	51	PF00134	0.449
DOC_MAPK_gen_1	197	205	PF00069	0.388
DOC_MAPK_gen_1	271	280	PF00069	0.703
DOC_MAPK_gen_1	36	43	PF00069	0.517
DOC_MAPK_gen_1	57	66	PF00069	0.259
DOC_MAPK_MEF2A_6	36	43	PF00069	0.593
DOC_MAPK_MEF2A_6	57	66	PF00069	0.233
DOC_PP2B_LxvP_1	48	51	PF13499	0.372
DOC_PP2B_PxIxI_1	38	44	PF00149	0.515
DOC_PP4_FxxP_1	262	265	PF00568	0.491
DOC_USP7_MATH_1	274	278	PF00917	0.729
DOC_WW_Pin1_4	154	159	PF00397	0.268
DOC_WW_Pin1_4	209	214	PF00397	0.500
DOC_WW_Pin1_4	35	40	PF00397	0.584
LIG_14-3-3_CanoR_1	59	63	PF00244	0.242
LIG_14-3-3_CanoR_1	6	12	PF00244	0.465
LIG_BIR_III_2	18	22	PF00653	0.394
LIG_FHA_1	136	142	PF00498	0.322
LIG_FHA_1	148	154	PF00498	0.291
LIG_FHA_1	210	216	PF00498	0.482
LIG_FHA_1	59	65	PF00498	0.289
LIG_FHA_2	202	208	PF00498	0.372
LIG_GBD_Chelix_1	62	70	PF00786	0.263
LIG_LIR_Apic_2	260	265	PF02991	0.483
LIG_LIR_Apic_2	44	50	PF02991	0.379
LIG_LIR_Nem_3	10	14	PF02991	0.539
LIG_LIR_Nem_3	248	253	PF02991	0.460
LIG_LYPXL_yS_3	250	253	PF13949	0.447
LIG_NRBOX	183	189	PF00104	0.374
LIG_SH2_CRK	231	235	PF00017	0.455
LIG_SH2_CRK	244	248	PF00017	0.604
LIG_SH2_NCK_1	244	248	PF00017	0.430
LIG_SH2_PTP2	79	82	PF00017	0.289
LIG_SH2_SRC	107	110	PF00017	0.289
LIG_SH2_STAP1	107	111	PF00017	0.243
LIG_SH2_STAP1	164	168	PF00017	0.398
LIG_SH2_STAT3	72	75	PF00017	0.404
LIG_SH2_STAT5	15	18	PF00017	0.548
LIG_SH2_STAT5	208	211	PF00017	0.372
LIG_SH2_STAT5	231	234	PF00017	0.343
LIG_SH2_STAT5	47	50	PF00017	0.470
LIG_SH2_STAT5	79	82	PF00017	0.290
LIG_SH3_1	47	53	PF00018	0.498
LIG_SH3_3	11	17	PF00018	0.582
LIG_SH3_3	47	53	PF00018	0.482
LIG_SUMO_SIM_anti_2	186	193	PF11976	0.315
LIG_SUMO_SIM_par_1	149	155	PF11976	0.306
LIG_SUMO_SIM_par_1	20	27	PF11976	0.420
LIG_SUMO_SIM_par_1	60	65	PF11976	0.263
LIG_TRAF2_1	23	26	PF00917	0.419
MOD_CDK_SPK_2	209	214	PF00069	0.493
MOD_CK1_1	245	251	PF00069	0.641
MOD_CK2_1	20	26	PF00069	0.591
MOD_CK2_1	201	207	PF00069	0.365
MOD_GlcNHglycan	135	138	PF01048	0.309
MOD_GlcNHglycan	259	262	PF01048	0.653
MOD_GlcNHglycan	43	46	PF01048	0.562
MOD_GSK3_1	20	27	PF00069	0.560
MOD_GSK3_1	219	226	PF00069	0.508
MOD_GSK3_1	35	42	PF00069	0.561
MOD_GSK3_1	94	101	PF00069	0.275
MOD_N-GLC_1	132	137	PF02516	0.363
MOD_NEK2_1	132	137	PF00069	0.363
MOD_NEK2_1	148	153	PF00069	0.273
MOD_NEK2_1	24	29	PF00069	0.572
MOD_NEK2_1	66	71	PF00069	0.259
MOD_NEK2_2	180	185	PF00069	0.332
MOD_PK_1	37	43	PF00069	0.595
MOD_PKA_2	58	64	PF00069	0.259
MOD_PKB_1	5	13	PF00069	0.477
MOD_Plk_1	148	154	PF00069	0.308
MOD_Plk_1	180	186	PF00069	0.243
MOD_Plk_1	24	30	PF00069	0.613
MOD_Plk_1	66	72	PF00069	0.267
MOD_Plk_2-3	201	207	PF00069	0.397
MOD_Plk_4	121	127	PF00069	0.307
MOD_Plk_4	148	154	PF00069	0.307
MOD_Plk_4	183	189	PF00069	0.306
MOD_Plk_4	58	64	PF00069	0.284
MOD_Plk_4	66	72	PF00069	0.250
MOD_Plk_4	83	89	PF00069	0.289
MOD_Plk_4	94	100	PF00069	0.193
MOD_ProDKin_1	154	160	PF00069	0.268
MOD_ProDKin_1	209	215	PF00069	0.495
MOD_ProDKin_1	35	41	PF00069	0.578
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.414
TRG_ENDOCYTIC_2	231	234	PF00928	0.362
TRG_ENDOCYTIC_2	244	247	PF00928	0.516
TRG_ENDOCYTIC_2	250	253	PF00928	0.685
TRG_ER_diArg_1	126	129	PF00400	0.355
TRG_ER_diArg_1	2	5	PF00400	0.535
TRG_ER_diArg_1	271	274	PF00400	0.696
TRG_ER_diArg_1	280	282	PF00400	0.641
TRG_ER_diArg_1	35	37	PF00400	0.543
TRG_NES_CRM1_1	55	68	PF08389	0.404
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z9	Leptomonas seymouri	76%	100%
A0A0N1IKD3	Leptomonas seymouri	41%	100%
A0A0S4IUQ9	Bodo saltans	35%	81%
A0A0S4JU61	Bodo saltans	49%	100%
A0A0S4JWE2	Bodo saltans	39%	100%
A0A1X0NJT2	Trypanosomatidae	42%	100%
A0A1X0NLU1	Trypanosomatidae	53%	100%
A0A1X0P5T3	Trypanosomatidae	35%	92%
A0A1X0PA23	Trypanosomatidae	34%	83%
A0A3R7LAC9	Trypanosoma rangeli	34%	81%
A0A3R7NSE5	Trypanosoma rangeli	40%	100%
A0A3S7X8P8	Leishmania donovani	42%	100%
A0A3S7XCG7	Leishmania donovani	98%	100%
A0A422NVW2	Trypanosoma rangeli	53%	100%
A4HEM1	Leishmania braziliensis	27%	100%
A4HM58	Leishmania braziliensis	42%	100%
A4HQK0	Leishmania braziliensis	88%	100%
A4IAS0	Leishmania infantum	42%	100%
A4ICB8	Leishmania infantum	99%	100%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	69%
C9ZL07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	80%
C9ZZ90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A2E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A3Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AEA2	Leishmania major	42%	100%
E9AEJ6	Leishmania major	41%	93%
E9AUB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B5Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
Q9PTJ6	Gallus gallus	26%	100%
V5BHN4	Trypanosoma cruzi	55%	100%
V5BSW0	Trypanosoma cruzi	39%	100%
V5BX67	Trypanosoma cruzi	36%	79%