Putative ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ATPase

Gene product:

ATPase, putative

Species:

Leishmania major

UniProt:

Q4Q076_LEIMA

TriTrypDb:

LmjF.36.6790 , LMJLV39_360083100 , LMJSD75_360082900

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q076

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q076

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.681
CLV_NRD_NRD_1	158	160	PF00675	0.306
CLV_NRD_NRD_1	184	186	PF00675	0.394
CLV_NRD_NRD_1	3	5	PF00675	0.642
CLV_NRD_NRD_1	30	32	PF00675	0.504
CLV_NRD_NRD_1	314	316	PF00675	0.361
CLV_NRD_NRD_1	526	528	PF00675	0.616
CLV_NRD_NRD_1	8	10	PF00675	0.533
CLV_NRD_NRD_1	92	94	PF00675	0.588
CLV_PCSK_KEX2_1	128	130	PF00082	0.394
CLV_PCSK_KEX2_1	157	159	PF00082	0.304
CLV_PCSK_KEX2_1	183	185	PF00082	0.379
CLV_PCSK_KEX2_1	19	21	PF00082	0.455
CLV_PCSK_KEX2_1	193	195	PF00082	0.325
CLV_PCSK_KEX2_1	3	5	PF00082	0.639
CLV_PCSK_KEX2_1	314	316	PF00082	0.367
CLV_PCSK_KEX2_1	526	528	PF00082	0.421
CLV_PCSK_KEX2_1	8	10	PF00082	0.536
CLV_PCSK_KEX2_1	92	94	PF00082	0.642
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.394
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.304
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.583
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.374
CLV_PCSK_PC7_1	4	10	PF00082	0.623
CLV_PCSK_SKI1_1	104	108	PF00082	0.591
CLV_PCSK_SKI1_1	193	197	PF00082	0.406
CLV_PCSK_SKI1_1	413	417	PF00082	0.304
CLV_Separin_Metazoa	208	212	PF03568	0.218
DEG_APCC_DBOX_1	240	248	PF00400	0.425
DEG_APCC_DBOX_1	490	498	PF00400	0.495
DEG_Nend_Nbox_1	1	3	PF02207	0.656
DOC_ANK_TNKS_1	435	442	PF00023	0.464
DOC_MAPK_DCC_7	194	204	PF00069	0.413
DOC_MAPK_gen_1	172	180	PF00069	0.425
DOC_MAPK_MEF2A_6	211	218	PF00069	0.296
DOC_PP1_RVXF_1	411	417	PF00149	0.304
DOC_PP2B_PxIxI_1	430	436	PF00149	0.410
DOC_PP4_FxxP_1	300	303	PF00568	0.304
DOC_USP7_MATH_1	449	453	PF00917	0.708
DOC_USP7_MATH_1	73	77	PF00917	0.663
DOC_USP7_MATH_1	87	91	PF00917	0.555
DOC_WW_Pin1_4	150	155	PF00397	0.320
DOC_WW_Pin1_4	186	191	PF00397	0.442
DOC_WW_Pin1_4	210	215	PF00397	0.338
DOC_WW_Pin1_4	46	51	PF00397	0.340
DOC_WW_Pin1_4	519	524	PF00397	0.364
DOC_WW_Pin1_4	65	70	PF00397	0.567
LIG_14-3-3_CanoR_1	158	166	PF00244	0.393
LIG_14-3-3_CanoR_1	183	190	PF00244	0.424
LIG_14-3-3_CanoR_1	259	265	PF00244	0.427
LIG_14-3-3_CanoR_1	42	51	PF00244	0.440
LIG_Actin_WH2_2	198	213	PF00022	0.293
LIG_BRCT_BRCA1_1	236	240	PF00533	0.391
LIG_BRCT_BRCA1_1	260	264	PF00533	0.306
LIG_BRCT_BRCA1_1	474	478	PF00533	0.579
LIG_deltaCOP1_diTrp_1	326	336	PF00928	0.393
LIG_FHA_1	110	116	PF00498	0.518
LIG_FHA_1	140	146	PF00498	0.339
LIG_FHA_1	211	217	PF00498	0.339
LIG_FHA_1	221	227	PF00498	0.260
LIG_FHA_1	378	384	PF00498	0.320
LIG_FHA_1	415	421	PF00498	0.304
LIG_FHA_1	430	436	PF00498	0.496
LIG_FHA_1	47	53	PF00498	0.377
LIG_FHA_2	19	25	PF00498	0.432
LIG_FHA_2	305	311	PF00498	0.218
LIG_FHA_2	435	441	PF00498	0.632
LIG_FHA_2	511	517	PF00498	0.539
LIG_LIR_Apic_2	68	73	PF02991	0.609
LIG_LIR_Gen_1	219	229	PF02991	0.301
LIG_LIR_Gen_1	24	34	PF02991	0.442
LIG_LIR_Gen_1	261	271	PF02991	0.361
LIG_LIR_Gen_1	355	362	PF02991	0.316
LIG_LIR_Gen_1	419	430	PF02991	0.316
LIG_LIR_Gen_1	486	494	PF02991	0.415
LIG_LIR_Gen_1	514	525	PF02991	0.483
LIG_LIR_Gen_1	94	103	PF02991	0.656
LIG_LIR_Nem_3	219	224	PF02991	0.301
LIG_LIR_Nem_3	24	29	PF02991	0.418
LIG_LIR_Nem_3	261	267	PF02991	0.324
LIG_LIR_Nem_3	355	359	PF02991	0.304
LIG_LIR_Nem_3	419	425	PF02991	0.300
LIG_LIR_Nem_3	427	433	PF02991	0.449
LIG_LIR_Nem_3	486	490	PF02991	0.448
LIG_LIR_Nem_3	514	520	PF02991	0.447
LIG_LIR_Nem_3	94	99	PF02991	0.654
LIG_LYPXL_yS_3	430	433	PF13949	0.384
LIG_PCNA_yPIPBox_3	200	210	PF02747	0.395
LIG_Pex14_2	236	240	PF04695	0.359
LIG_Rb_pABgroove_1	142	150	PF01858	0.404
LIG_SH2_CRK	70	74	PF00017	0.632
LIG_SH2_GRB2like	408	411	PF00017	0.413
LIG_SH2_STAP1	26	30	PF00017	0.414
LIG_SH2_STAP1	472	476	PF00017	0.523
LIG_SH2_STAP1	59	63	PF00017	0.554
LIG_SH2_STAT3	54	57	PF00017	0.406
LIG_SH2_STAT5	132	135	PF00017	0.361
LIG_SH2_STAT5	502	505	PF00017	0.388
LIG_SH2_STAT5	54	57	PF00017	0.438
LIG_SH2_STAT5	70	73	PF00017	0.683
LIG_SH3_3	339	345	PF00018	0.425
LIG_SH3_3	425	431	PF00018	0.343
LIG_SUMO_SIM_par_1	142	149	PF11976	0.341
LIG_SUMO_SIM_par_1	379	384	PF11976	0.339
LIG_SUMO_SIM_par_1	400	406	PF11976	0.304
LIG_SUMO_SIM_par_1	431	437	PF11976	0.578
LIG_UBA3_1	298	306	PF00899	0.374
LIG_ULM_U2AF65_1	101	106	PF00076	0.446
LIG_WRC_WIRS_1	162	167	PF05994	0.320
LIG_WRC_WIRS_1	221	226	PF05994	0.320
LIG_WRC_WIRS_1	484	489	PF05994	0.445
MOD_CDK_SPK_2	186	191	PF00069	0.451
MOD_CDK_SPxxK_3	150	157	PF00069	0.389
MOD_CDK_SPxxK_3	186	193	PF00069	0.451
MOD_CDK_SPxxK_3	519	526	PF00069	0.336
MOD_CDK_SPxxK_3	65	72	PF00069	0.660
MOD_CK1_1	14	20	PF00069	0.518
MOD_CK1_1	164	170	PF00069	0.339
MOD_CK1_1	186	192	PF00069	0.446
MOD_CK1_1	443	449	PF00069	0.645
MOD_CK1_1	456	462	PF00069	0.628
MOD_CK1_1	68	74	PF00069	0.669
MOD_CK2_1	164	170	PF00069	0.425
MOD_CK2_1	18	24	PF00069	0.451
MOD_CK2_1	186	192	PF00069	0.451
MOD_CK2_1	304	310	PF00069	0.218
MOD_CK2_1	460	466	PF00069	0.607
MOD_CK2_1	525	531	PF00069	0.610
MOD_GlcNHglycan	109	112	PF01048	0.504
MOD_GlcNHglycan	185	188	PF01048	0.387
MOD_GlcNHglycan	260	263	PF01048	0.425
MOD_GlcNHglycan	367	370	PF01048	0.439
MOD_GlcNHglycan	442	445	PF01048	0.676
MOD_GlcNHglycan	451	454	PF01048	0.632
MOD_GlcNHglycan	466	472	PF01048	0.503
MOD_GlcNHglycan	498	501	PF01048	0.491
MOD_GlcNHglycan	516	520	PF01048	0.512
MOD_GlcNHglycan	75	78	PF01048	0.637
MOD_GSK3_1	10	17	PF00069	0.475
MOD_GSK3_1	105	112	PF00069	0.617
MOD_GSK3_1	157	164	PF00069	0.367
MOD_GSK3_1	377	384	PF00069	0.367
MOD_GSK3_1	416	423	PF00069	0.429
MOD_GSK3_1	42	49	PF00069	0.504
MOD_GSK3_1	443	450	PF00069	0.626
MOD_GSK3_1	456	463	PF00069	0.727
MOD_GSK3_1	515	522	PF00069	0.319
MOD_GSK3_1	87	94	PF00069	0.613
MOD_N-GLC_1	390	395	PF02516	0.433
MOD_NEK2_1	107	112	PF00069	0.604
MOD_NEK2_1	178	183	PF00069	0.451
MOD_NEK2_1	245	250	PF00069	0.321
MOD_NEK2_1	414	419	PF00069	0.384
MOD_NEK2_1	515	520	PF00069	0.460
MOD_NEK2_1	91	96	PF00069	0.628
MOD_NEK2_2	87	92	PF00069	0.594
MOD_PIKK_1	178	184	PF00454	0.335
MOD_PKA_1	157	163	PF00069	0.389
MOD_PKA_1	183	189	PF00069	0.425
MOD_PKA_2	157	163	PF00069	0.367
MOD_PKA_2	183	189	PF00069	0.369
MOD_PKA_2	258	264	PF00069	0.451
MOD_PKA_2	525	531	PF00069	0.434
MOD_PKA_2	91	97	PF00069	0.605
MOD_PKB_1	40	48	PF00069	0.448
MOD_Plk_1	331	337	PF00069	0.386
MOD_Plk_1	515	521	PF00069	0.415
MOD_Plk_2-3	220	226	PF00069	0.304
MOD_Plk_2-3	434	440	PF00069	0.599
MOD_Plk_2-3	460	466	PF00069	0.691
MOD_Plk_4	139	145	PF00069	0.281
MOD_Plk_4	161	167	PF00069	0.320
MOD_Plk_4	331	337	PF00069	0.342
MOD_Plk_4	377	383	PF00069	0.320
MOD_Plk_4	498	504	PF00069	0.541
MOD_ProDKin_1	150	156	PF00069	0.320
MOD_ProDKin_1	186	192	PF00069	0.442
MOD_ProDKin_1	210	216	PF00069	0.338
MOD_ProDKin_1	46	52	PF00069	0.337
MOD_ProDKin_1	519	525	PF00069	0.369
MOD_ProDKin_1	65	71	PF00069	0.575
TRG_DiLeu_BaEn_2	241	247	PF01217	0.218
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.359
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.355
TRG_ENDOCYTIC_2	26	29	PF00928	0.390
TRG_ENDOCYTIC_2	430	433	PF00928	0.384
TRG_ER_diArg_1	183	185	PF00400	0.392
TRG_ER_diArg_1	2	4	PF00400	0.675
TRG_ER_diArg_1	313	315	PF00400	0.361
TRG_ER_diArg_1	40	43	PF00400	0.446
TRG_ER_diArg_1	490	493	PF00400	0.490
TRG_ER_diArg_1	525	527	PF00400	0.397
TRG_ER_diArg_1	91	93	PF00400	0.615
TRG_NLS_MonoExtN_4	154	161	PF00514	0.363
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P494	Leptomonas seymouri	28%	100%
A0A0N1I0J7	Leptomonas seymouri	65%	100%
A0A0S4J9H9	Bodo saltans	27%	100%
A0A0S4JPV5	Bodo saltans	45%	100%
A0A1X0NK74	Trypanosomatidae	28%	100%
A0A1X0NN10	Trypanosomatidae	47%	100%
A0A3R7K771	Trypanosoma rangeli	28%	100%
A0A3R7L848	Trypanosoma rangeli	48%	100%
A0A3S5H5L6	Leishmania donovani	29%	100%
A0A3S7XCB8	Leishmania donovani	92%	100%
A4H4F1	Leishmania braziliensis	29%	100%
A4HSM8	Leishmania infantum	29%	100%
A4ICB9	Leishmania infantum	92%	100%
C9ZU69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A3Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AIY4	Leishmania braziliensis	80%	100%
E9AKL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AUB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
O42895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P32317	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P46441	Haematobia irritans	27%	100%
Q32PX9	Rattus norvegicus	30%	100%
Q3V384	Mus musculus	29%	100%
Q4QJ96	Leishmania major	29%	100%
Q5TYS0	Danio rerio	28%	100%
Q8WV93	Homo sapiens	28%	100%
V5BD25	Trypanosoma cruzi	48%	100%
V5D7E6	Trypanosoma cruzi	30%	100%