UFL1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

UFL1

Gene product:

CG1104 protein-like protein

Species:

Leishmania major

UniProt:

Q4Q075_LEIMA

TriTrypDb:

LmjF.36.6800 , LMJLV39_360083200 , LMJSD75_360083000

Length:

737

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q075

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q075

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	2
GO:0008152	metabolic process	1	12
GO:0009894	regulation of catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	12
GO:0030162	regulation of proteolysis	6	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	7	2
GO:0032446	protein modification by small protein conjugation	6	12
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0036211	protein modification process	4	12
GO:0042176	regulation of protein catabolic process	5	2
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0050896	response to stimulus	1	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061136	regulation of proteasomal protein catabolic process	6	2
GO:0065007	biological regulation	1	2
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071569	protein ufmylation	7	12
GO:0071704	organic substance metabolic process	2	12
GO:0080090	regulation of primary metabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	2
GO:1990564	protein polyufmylation	8	2
GO:1990592	protein K69-linked ufmylation	9	2
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0061666	UFM1 ligase activity	5	12
GO:0071568	UFM1 transferase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.501
CLV_NRD_NRD_1	204	206	PF00675	0.370
CLV_NRD_NRD_1	304	306	PF00675	0.662
CLV_NRD_NRD_1	307	309	PF00675	0.648
CLV_NRD_NRD_1	585	587	PF00675	0.481
CLV_PCSK_KEX2_1	11	13	PF00082	0.449
CLV_PCSK_KEX2_1	204	206	PF00082	0.415
CLV_PCSK_KEX2_1	242	244	PF00082	0.415
CLV_PCSK_KEX2_1	585	587	PF00082	0.482
CLV_PCSK_KEX2_1	61	63	PF00082	0.328
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.449
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.475
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.449
CLV_PCSK_SKI1_1	152	156	PF00082	0.435
CLV_PCSK_SKI1_1	420	424	PF00082	0.546
CLV_PCSK_SKI1_1	494	498	PF00082	0.595
CLV_PCSK_SKI1_1	576	580	PF00082	0.492
CLV_PCSK_SKI1_1	730	734	PF00082	0.461
CLV_Separin_Metazoa	195	199	PF03568	0.475
CLV_Separin_Metazoa	458	462	PF03568	0.546
DEG_APCC_DBOX_1	585	593	PF00400	0.430
DEG_Nend_UBRbox_2	1	3	PF02207	0.628
DEG_SCF_FBW7_1	552	558	PF00400	0.373
DOC_CDC14_PxL_1	352	360	PF14671	0.586
DOC_CKS1_1	552	557	PF01111	0.571
DOC_CYCLIN_RxL_1	573	583	PF00134	0.507
DOC_CYCLIN_yClb5_NLxxxL_5	37	46	PF00134	0.398
DOC_MAPK_gen_1	39	47	PF00069	0.348
DOC_MAPK_gen_1	431	437	PF00069	0.666
DOC_MAPK_gen_1	585	592	PF00069	0.541
DOC_MAPK_gen_1	627	637	PF00069	0.515
DOC_MAPK_gen_1	691	698	PF00069	0.614
DOC_MAPK_MEF2A_6	321	329	PF00069	0.677
DOC_MAPK_MEF2A_6	39	47	PF00069	0.414
DOC_MAPK_MEF2A_6	628	637	PF00069	0.512
DOC_MIT_MIM_1	8	16	PF04212	0.449
DOC_PP1_RVXF_1	511	518	PF00149	0.399
DOC_PP2B_LxvP_1	208	211	PF13499	0.342
DOC_PP2B_LxvP_1	449	452	PF13499	0.549
DOC_PP4_FxxP_1	622	625	PF00568	0.475
DOC_USP7_MATH_1	211	215	PF00917	0.442
DOC_USP7_MATH_1	292	296	PF00917	0.703
DOC_USP7_MATH_1	357	361	PF00917	0.515
DOC_USP7_MATH_1	426	430	PF00917	0.535
DOC_USP7_MATH_1	618	622	PF00917	0.479
DOC_USP7_MATH_1	648	652	PF00917	0.619
DOC_USP7_MATH_1	94	98	PF00917	0.359
DOC_USP7_UBL2_3	306	310	PF12436	0.793
DOC_WW_Pin1_4	551	556	PF00397	0.476
LIG_14-3-3_CanoR_1	12	17	PF00244	0.423
LIG_14-3-3_CanoR_1	326	330	PF00244	0.638
LIG_14-3-3_CanoR_1	532	542	PF00244	0.435
LIG_14-3-3_CanoR_1	585	590	PF00244	0.503
LIG_14-3-3_CanoR_1	691	699	PF00244	0.607
LIG_14-3-3_CanoR_1	730	735	PF00244	0.468
LIG_Actin_WH2_2	142	158	PF00022	0.283
LIG_APCC_ABBA_1	375	380	PF00400	0.547
LIG_APCC_ABBA_1	578	583	PF00400	0.458
LIG_BRCT_BRCA1_1	146	150	PF00533	0.413
LIG_BRCT_BRCA1_2	146	152	PF00533	0.475
LIG_CaM_IQ_9	10	26	PF13499	0.383
LIG_deltaCOP1_diTrp_1	382	387	PF00928	0.371
LIG_eIF4E_1	203	209	PF01652	0.449
LIG_FHA_1	102	108	PF00498	0.358
LIG_FHA_1	406	412	PF00498	0.525
LIG_FHA_1	440	446	PF00498	0.336
LIG_FHA_1	501	507	PF00498	0.538
LIG_FHA_1	612	618	PF00498	0.418
LIG_FHA_1	665	671	PF00498	0.475
LIG_FHA_1	729	735	PF00498	0.570
LIG_FHA_1	86	92	PF00498	0.437
LIG_FHA_2	518	524	PF00498	0.491
LIG_FHA_2	54	60	PF00498	0.449
LIG_FHA_2	605	611	PF00498	0.535
LIG_FHA_2	723	729	PF00498	0.557
LIG_GBD_Chelix_1	470	478	PF00786	0.530
LIG_LIR_Apic_2	276	281	PF02991	0.629
LIG_LIR_Apic_2	621	625	PF02991	0.470
LIG_LIR_Gen_1	138	146	PF02991	0.371
LIG_LIR_Gen_1	175	186	PF02991	0.437
LIG_LIR_Gen_1	503	512	PF02991	0.464
LIG_LIR_Gen_1	56	65	PF02991	0.328
LIG_LIR_Gen_1	632	642	PF02991	0.517
LIG_LIR_Nem_3	175	181	PF02991	0.403
LIG_LIR_Nem_3	207	212	PF02991	0.455
LIG_LIR_Nem_3	231	237	PF02991	0.460
LIG_LIR_Nem_3	258	262	PF02991	0.345
LIG_LIR_Nem_3	382	388	PF02991	0.513
LIG_LIR_Nem_3	394	399	PF02991	0.475
LIG_LIR_Nem_3	454	459	PF02991	0.482
LIG_LIR_Nem_3	465	470	PF02991	0.391
LIG_LIR_Nem_3	503	508	PF02991	0.458
LIG_LIR_Nem_3	56	60	PF02991	0.328
LIG_LIR_Nem_3	632	637	PF02991	0.563
LIG_LYPXL_S_1	395	399	PF13949	0.572
LIG_LYPXL_yS_3	396	399	PF13949	0.573
LIG_NRBOX	664	670	PF00104	0.447
LIG_PCNA_PIPBox_1	143	152	PF02747	0.398
LIG_SH2_CRK	259	263	PF00017	0.328
LIG_SH2_NCK_1	278	282	PF00017	0.616
LIG_SH2_PTP2	234	237	PF00017	0.475
LIG_SH2_PTP2	634	637	PF00017	0.502
LIG_SH2_SRC	117	120	PF00017	0.328
LIG_SH2_STAP1	174	178	PF00017	0.385
LIG_SH2_STAT3	174	177	PF00017	0.385
LIG_SH2_STAT5	117	120	PF00017	0.328
LIG_SH2_STAT5	174	177	PF00017	0.344
LIG_SH2_STAT5	234	237	PF00017	0.328
LIG_SH2_STAT5	273	276	PF00017	0.561
LIG_SH2_STAT5	351	354	PF00017	0.514
LIG_SH2_STAT5	54	57	PF00017	0.351
LIG_SH2_STAT5	634	637	PF00017	0.542
LIG_SH3_3	565	571	PF00018	0.553
LIG_SH3_3	675	681	PF00018	0.405
LIG_SH3_3	693	699	PF00018	0.490
LIG_SH3_3	75	81	PF00018	0.344
LIG_SUMO_SIM_par_1	103	108	PF11976	0.437
LIG_SUMO_SIM_par_1	407	412	PF11976	0.560
LIG_SUMO_SIM_par_1	614	621	PF11976	0.578
LIG_SUMO_SIM_par_1	82	88	PF11976	0.395
LIG_TRAF2_1	192	195	PF00917	0.475
LIG_TRAF2_1	414	417	PF00917	0.592
LIG_TRAF2_1	496	499	PF00917	0.505
LIG_TRAF2_1	725	728	PF00917	0.586
LIG_TYR_ITIM	257	262	PF00017	0.328
LIG_UBA3_1	377	383	PF00899	0.588
LIG_UBA3_1	589	597	PF00899	0.573
LIG_WRC_WIRS_1	619	624	PF05994	0.480
LIG_WRC_WIRS_1	86	91	PF05994	0.444
MOD_CK1_1	172	178	PF00069	0.404
MOD_CK1_1	296	302	PF00069	0.757
MOD_CK1_1	551	557	PF00069	0.544
MOD_CK1_1	664	670	PF00069	0.434
MOD_CK1_1	85	91	PF00069	0.428
MOD_CK2_1	53	59	PF00069	0.449
MOD_CK2_1	604	610	PF00069	0.509
MOD_CK2_1	697	703	PF00069	0.552
MOD_CK2_1	714	720	PF00069	0.550
MOD_CK2_1	722	728	PF00069	0.482
MOD_CK2_1	94	100	PF00069	0.361
MOD_Cter_Amidation	306	309	PF01082	0.666
MOD_GlcNHglycan	298	301	PF01048	0.764
MOD_GlcNHglycan	331	334	PF01048	0.573
MOD_GlcNHglycan	400	403	PF01048	0.613
MOD_GlcNHglycan	411	414	PF01048	0.518
MOD_GlcNHglycan	480	483	PF01048	0.599
MOD_GlcNHglycan	526	529	PF01048	0.528
MOD_GlcNHglycan	610	614	PF01048	0.490
MOD_GSK3_1	131	138	PF00069	0.354
MOD_GSK3_1	19	26	PF00069	0.428
MOD_GSK3_1	290	297	PF00069	0.652
MOD_GSK3_1	325	332	PF00069	0.585
MOD_GSK3_1	405	412	PF00069	0.463
MOD_GSK3_1	426	433	PF00069	0.532
MOD_GSK3_1	435	442	PF00069	0.598
MOD_GSK3_1	551	558	PF00069	0.565
MOD_GSK3_1	581	588	PF00069	0.517
MOD_GSK3_1	660	667	PF00069	0.494
MOD_GSK3_1	730	737	PF00069	0.545
MOD_N-GLC_1	548	553	PF02516	0.455
MOD_N-GLC_2	254	256	PF02516	0.359
MOD_NEK2_1	135	140	PF00069	0.415
MOD_NEK2_1	150	155	PF00069	0.303
MOD_NEK2_1	212	217	PF00069	0.396
MOD_NEK2_1	228	233	PF00069	0.346
MOD_NEK2_1	250	255	PF00069	0.384
MOD_NEK2_1	427	432	PF00069	0.499
MOD_NEK2_1	478	483	PF00069	0.587
MOD_NEK2_1	490	495	PF00069	0.415
MOD_NEK2_1	581	586	PF00069	0.549
MOD_NEK2_1	604	609	PF00069	0.444
MOD_NEK2_1	611	616	PF00069	0.415
MOD_NEK2_1	661	666	PF00069	0.406
MOD_NEK2_2	618	623	PF00069	0.481
MOD_NEK2_2	82	87	PF00069	0.396
MOD_PIKK_1	135	141	PF00454	0.411
MOD_PIKK_1	517	523	PF00454	0.417
MOD_PIKK_1	563	569	PF00454	0.574
MOD_PK_1	597	603	PF00069	0.584
MOD_PK_1	646	652	PF00069	0.554
MOD_PKA_1	585	591	PF00069	0.508
MOD_PKA_2	325	331	PF00069	0.653
MOD_PKA_2	585	591	PF00069	0.509
MOD_Plk_1	169	175	PF00069	0.411
MOD_Plk_1	548	554	PF00069	0.459
MOD_Plk_1	597	603	PF00069	0.553
MOD_Plk_2-3	53	59	PF00069	0.328
MOD_Plk_4	145	151	PF00069	0.324
MOD_Plk_4	169	175	PF00069	0.449
MOD_Plk_4	212	218	PF00069	0.378
MOD_Plk_4	33	39	PF00069	0.376
MOD_Plk_4	357	363	PF00069	0.504
MOD_Plk_4	400	406	PF00069	0.503
MOD_Plk_4	444	450	PF00069	0.516
MOD_Plk_4	585	591	PF00069	0.567
MOD_Plk_4	664	670	PF00069	0.385
MOD_Plk_4	94	100	PF00069	0.427
MOD_ProDKin_1	551	557	PF00069	0.475
MOD_SUMO_for_1	60	63	PF00179	0.449
MOD_SUMO_for_1	692	695	PF00179	0.599
MOD_SUMO_rev_2	412	422	PF00179	0.516
MOD_SUMO_rev_2	639	648	PF00179	0.552
TRG_DiLeu_BaEn_1	108	113	PF01217	0.344
TRG_DiLeu_BaEn_1	400	405	PF01217	0.567
TRG_DiLeu_BaEn_1	5	10	PF01217	0.333
TRG_DiLeu_BaEn_4	100	106	PF01217	0.398
TRG_DiLeu_BaEn_4	194	200	PF01217	0.475
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.537
TRG_ENDOCYTIC_2	234	237	PF00928	0.457
TRG_ENDOCYTIC_2	259	262	PF00928	0.328
TRG_ENDOCYTIC_2	396	399	PF00928	0.557
TRG_ENDOCYTIC_2	456	459	PF00928	0.506
TRG_ENDOCYTIC_2	634	637	PF00928	0.553
TRG_ER_diArg_1	161	164	PF00400	0.475
TRG_ER_diArg_1	203	205	PF00400	0.417
TRG_NES_CRM1_1	365	380	PF08389	0.512
TRG_NLS_MonoExtC_3	304	309	PF00514	0.675
TRG_NLS_MonoExtN_4	305	312	PF00514	0.648
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM39	Leptomonas seymouri	67%	100%
A0A0S4JTJ6	Bodo saltans	36%	95%
A0A1X0NLV8	Trypanosomatidae	41%	98%
A0A3S7XCH5	Leishmania donovani	91%	100%
A0A422NVV8	Trypanosoma rangeli	42%	99%
A4HQK2	Leishmania braziliensis	82%	100%
A4ICC0	Leishmania infantum	91%	100%
D0A3Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AUB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5AXN4	Trypanosoma cruzi	40%	99%