SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q073_LEIMA

TriTrypDb:

LmjF.36.6820 , LMJLV39_360083400 , LMJSD75_360083200

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q073

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q073

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.438
CLV_NRD_NRD_1	128	130	PF00675	0.449
CLV_NRD_NRD_1	261	263	PF00675	0.424
CLV_PCSK_KEX2_1	128	130	PF00082	0.449
CLV_PCSK_KEX2_1	261	263	PF00082	0.391
CLV_PCSK_SKI1_1	142	146	PF00082	0.447
CLV_PCSK_SKI1_1	35	39	PF00082	0.279
DEG_APCC_DBOX_1	34	42	PF00400	0.276
DEG_Nend_Nbox_1	1	3	PF02207	0.394
DEG_SPOP_SBC_1	282	286	PF00917	0.448
DOC_CYCLIN_RxL_1	267	277	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	240	243	PF00134	0.506
DOC_MAPK_gen_1	63	73	PF00069	0.494
DOC_MAPK_MEF2A_6	66	75	PF00069	0.485
DOC_MAPK_MEF2A_6	8	17	PF00069	0.466
DOC_PP2B_LxvP_1	17	20	PF13499	0.477
DOC_PP2B_LxvP_1	240	243	PF13499	0.550
DOC_USP7_MATH_1	147	151	PF00917	0.579
DOC_USP7_MATH_1	282	286	PF00917	0.491
LIG_14-3-3_CanoR_1	140	145	PF00244	0.502
LIG_14-3-3_CanoR_1	159	167	PF00244	0.475
LIG_14-3-3_CanoR_1	24	29	PF00244	0.443
LIG_14-3-3_CanoR_1	273	282	PF00244	0.566
LIG_14-3-3_CanoR_1	81	87	PF00244	0.551
LIG_APCC_ABBA_1	272	277	PF00400	0.535
LIG_BIR_III_4	350	354	PF00653	0.533
LIG_BRCT_BRCA1_1	162	166	PF00533	0.503
LIG_Clathr_ClatBox_1	288	292	PF01394	0.500
LIG_Clathr_ClatBox_1	52	56	PF01394	0.433
LIG_FHA_1	249	255	PF00498	0.696
LIG_FHA_1	282	288	PF00498	0.544
LIG_FHA_1	319	325	PF00498	0.595
LIG_FHA_2	163	169	PF00498	0.351
LIG_FHA_2	31	37	PF00498	0.313
LIG_FHA_2	333	339	PF00498	0.670
LIG_IRF3_LxIS_1	71	76	PF10401	0.414
LIG_LIR_Gen_1	231	241	PF02991	0.444
LIG_LIR_Gen_1	297	305	PF02991	0.522
LIG_LIR_Gen_1	335	343	PF02991	0.634
LIG_LIR_Gen_1	76	87	PF02991	0.350
LIG_LIR_Nem_3	103	109	PF02991	0.388
LIG_LIR_Nem_3	217	223	PF02991	0.335
LIG_LIR_Nem_3	226	230	PF02991	0.399
LIG_LIR_Nem_3	231	236	PF02991	0.413
LIG_LIR_Nem_3	297	302	PF02991	0.533
LIG_LIR_Nem_3	335	339	PF02991	0.645
LIG_LIR_Nem_3	76	82	PF02991	0.362
LIG_LRP6_Inhibitor_1	29	35	PF00058	0.286
LIG_PTAP_UEV_1	242	247	PF05743	0.453
LIG_REV1ctd_RIR_1	104	110	PF16727	0.336
LIG_SH2_CRK	299	303	PF00017	0.536
LIG_SH2_CRK	79	83	PF00017	0.390
LIG_SH2_SRC	97	100	PF00017	0.495
LIG_SH2_STAT5	156	159	PF00017	0.359
LIG_SH2_STAT5	299	302	PF00017	0.560
LIG_SH2_STAT5	60	63	PF00017	0.447
LIG_SH2_STAT5	97	100	PF00017	0.339
LIG_SH3_3	240	246	PF00018	0.556
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.352
LIG_SUMO_SIM_par_1	19	25	PF11976	0.489
LIG_SUMO_SIM_par_1	206	212	PF11976	0.471
LIG_SUMO_SIM_par_1	321	328	PF11976	0.666
LIG_SUMO_SIM_par_1	36	42	PF11976	0.319
LIG_TRAF2_1	215	218	PF00917	0.315
LIG_TRAF2_1	232	235	PF00917	0.401
LIG_Vh1_VBS_1	19	37	PF01044	0.269
LIG_WRC_WIRS_1	179	184	PF05994	0.340
MOD_CK1_1	146	152	PF00069	0.594
MOD_CK1_1	162	168	PF00069	0.412
MOD_CK1_1	178	184	PF00069	0.301
MOD_CK1_1	248	254	PF00069	0.523
MOD_CK1_1	255	261	PF00069	0.435
MOD_CK1_1	297	303	PF00069	0.627
MOD_CK1_1	322	328	PF00069	0.596
MOD_CK1_1	59	65	PF00069	0.468
MOD_CK2_1	228	234	PF00069	0.411
MOD_CK2_1	30	36	PF00069	0.307
MOD_GlcNHglycan	145	148	PF01048	0.523
MOD_GlcNHglycan	149	152	PF01048	0.539
MOD_GlcNHglycan	162	165	PF01048	0.467
MOD_GlcNHglycan	201	204	PF01048	0.434
MOD_GlcNHglycan	243	246	PF01048	0.587
MOD_GSK3_1	142	149	PF00069	0.564
MOD_GSK3_1	241	248	PF00069	0.644
MOD_GSK3_1	252	259	PF00069	0.460
MOD_GSK3_1	297	304	PF00069	0.627
MOD_GSK3_1	318	325	PF00069	0.590
MOD_GSK3_1	328	335	PF00069	0.449
MOD_GSK3_1	82	89	PF00069	0.473
MOD_NEK2_1	123	128	PF00069	0.392
MOD_NEK2_1	283	288	PF00069	0.598
MOD_NEK2_1	30	35	PF00069	0.543
MOD_NEK2_1	39	44	PF00069	0.377
MOD_NEK2_1	82	87	PF00069	0.373
MOD_PIKK_1	252	258	PF00454	0.584
MOD_PK_1	110	116	PF00069	0.439
MOD_PKA_2	109	115	PF00069	0.324
MOD_PKA_2	124	130	PF00069	0.408
MOD_PKA_2	160	166	PF00069	0.523
MOD_PKB_1	140	148	PF00069	0.447
MOD_Plk_1	297	303	PF00069	0.470
MOD_Plk_1	30	36	PF00069	0.390
MOD_Plk_4	162	168	PF00069	0.388
MOD_Plk_4	178	184	PF00069	0.299
MOD_Plk_4	223	229	PF00069	0.499
MOD_Plk_4	283	289	PF00069	0.503
MOD_Plk_4	319	325	PF00069	0.686
MOD_Plk_4	82	88	PF00069	0.342
MOD_SUMO_rev_2	349	356	PF00179	0.533
MOD_SUMO_rev_2	48	53	PF00179	0.487
TRG_DiLeu_BaEn_1	48	53	PF01217	0.487
TRG_ENDOCYTIC_2	227	230	PF00928	0.427
TRG_ENDOCYTIC_2	233	236	PF00928	0.376
TRG_ENDOCYTIC_2	299	302	PF00928	0.560
TRG_ENDOCYTIC_2	3	6	PF00928	0.455
TRG_ENDOCYTIC_2	79	82	PF00928	0.348
TRG_ER_diArg_1	128	130	PF00400	0.464
TRG_ER_diArg_1	139	142	PF00400	0.407
TRG_ER_diArg_1	158	161	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB0	Leptomonas seymouri	71%	98%
A0A1X0NLD0	Trypanosomatidae	44%	99%
A0A3R7NY74	Trypanosoma rangeli	42%	99%
A0A3S7XCE5	Leishmania donovani	97%	100%
A4ICC2	Leishmania infantum	97%	100%
D0A3Q5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AIY5	Leishmania braziliensis	89%	100%
E9AUB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DDV5	Trypanosoma cruzi	44%	99%