LeishMANIAdb
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EF-hand domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
Protein of unknown function (DUF2453), putative
Species:
Leishmania major
UniProt:
Q4Q071_LEIMA
TriTrypDb:
LmjF.36.6840 * , LMJLV39_360083600 * , LMJSD75_360083400 *
Length:
350

Annotations

LeishMANIAdb annotations

These Kinetoplastid proteins share considerable homology with the animal TMEM65 proteins at their membrane domains, with a unique EF-hand at the N-terminus.. While the animal orthologs have a mitochondrial transit signal, it seems to be absent from the Kinetoplastid proteins. The latter have an alanine-rich segment of unclear function.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005739 mitochondrion 5 2
GO:0016020 membrane 2 12
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 12
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Expansion

Sequence features

Q4Q071
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q071

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0005488 binding 1 11
GO:0005509 calcium ion binding 5 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 186 190 PF00656 0.244
CLV_C14_Caspase3-7 341 345 PF00656 0.371
CLV_NRD_NRD_1 115 117 PF00675 0.360
CLV_NRD_NRD_1 244 246 PF00675 0.258
CLV_NRD_NRD_1 68 70 PF00675 0.329
CLV_PCSK_KEX2_1 114 116 PF00082 0.355
CLV_PCSK_KEX2_1 122 124 PF00082 0.412
CLV_PCSK_KEX2_1 244 246 PF00082 0.256
CLV_PCSK_KEX2_1 67 69 PF00082 0.329
CLV_PCSK_PC1ET2_1 114 116 PF00082 0.406
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P806 Leptomonas seymouri 80% 99%
A0A0S4J8V3 Bodo saltans 34% 100%
A0A0S4JY67 Bodo saltans 56% 100%
A0A1X0NL71 Trypanosomatidae 55% 100%
A0A3S7XCB7 Leishmania donovani 95% 100%
A4HQK4 Leishmania braziliensis 85% 100%
A4ICC4 Leishmania infantum 96% 100%
E9AUB9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5BGX0 Trypanosoma cruzi 35% 84%
V5BHN9 Trypanosoma cruzi 54% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS