RNA_lig_T4_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA ligase/AAA domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q069_LEIMA

TriTrypDb:

LmjF.36.6850 , LMJLV39_360083800 , LMJSD75_360083600

Length:

906

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q069

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q069

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016874	ligase activity	2	10
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.464
CLV_C14_Caspase3-7	522	526	PF00656	0.399
CLV_C14_Caspase3-7	75	79	PF00656	0.494
CLV_C14_Caspase3-7	868	872	PF00656	0.417
CLV_NRD_NRD_1	115	117	PF00675	0.288
CLV_NRD_NRD_1	181	183	PF00675	0.414
CLV_NRD_NRD_1	207	209	PF00675	0.378
CLV_NRD_NRD_1	340	342	PF00675	0.522
CLV_NRD_NRD_1	460	462	PF00675	0.290
CLV_NRD_NRD_1	535	537	PF00675	0.322
CLV_NRD_NRD_1	555	557	PF00675	0.287
CLV_NRD_NRD_1	614	616	PF00675	0.543
CLV_NRD_NRD_1	703	705	PF00675	0.597
CLV_NRD_NRD_1	869	871	PF00675	0.663
CLV_NRD_NRD_1	880	882	PF00675	0.480
CLV_PCSK_KEX2_1	181	183	PF00082	0.417
CLV_PCSK_KEX2_1	207	209	PF00082	0.288
CLV_PCSK_KEX2_1	339	341	PF00082	0.528
CLV_PCSK_KEX2_1	460	462	PF00082	0.336
CLV_PCSK_KEX2_1	5	7	PF00082	0.528
CLV_PCSK_KEX2_1	535	537	PF00082	0.322
CLV_PCSK_KEX2_1	614	616	PF00082	0.475
CLV_PCSK_KEX2_1	869	871	PF00082	0.570
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.574
CLV_PCSK_SKI1_1	138	142	PF00082	0.375
CLV_PCSK_SKI1_1	150	154	PF00082	0.268
CLV_PCSK_SKI1_1	245	249	PF00082	0.324
CLV_PCSK_SKI1_1	297	301	PF00082	0.294
CLV_PCSK_SKI1_1	603	607	PF00082	0.445
CLV_PCSK_SKI1_1	693	697	PF00082	0.514
CLV_PCSK_SKI1_1	70	74	PF00082	0.288
CLV_PCSK_SKI1_1	803	807	PF00082	0.452
DEG_APCC_DBOX_1	149	157	PF00400	0.344
DEG_APCC_DBOX_1	34	42	PF00400	0.503
DEG_APCC_DBOX_1	392	400	PF00400	0.383
DEG_APCC_DBOX_1	719	727	PF00400	0.503
DEG_Nend_UBRbox_2	1	3	PF02207	0.427
DOC_CKS1_1	14	19	PF01111	0.559
DOC_CYCLIN_RxL_1	145	157	PF00134	0.468
DOC_CYCLIN_RxL_1	690	700	PF00134	0.558
DOC_MAPK_gen_1	295	304	PF00069	0.382
DOC_MAPK_gen_1	339	347	PF00069	0.425
DOC_MAPK_gen_1	44	54	PF00069	0.323
DOC_MAPK_gen_1	535	543	PF00069	0.378
DOC_MAPK_gen_1	648	657	PF00069	0.418
DOC_MAPK_MEF2A_6	287	296	PF00069	0.457
DOC_MAPK_MEF2A_6	393	400	PF00069	0.343
DOC_MAPK_MEF2A_6	409	416	PF00069	0.319
DOC_MAPK_MEF2A_6	651	659	PF00069	0.378
DOC_MAPK_NFAT4_5	287	295	PF00069	0.324
DOC_PP1_RVXF_1	691	697	PF00149	0.573
DOC_PP1_RVXF_1	702	709	PF00149	0.595
DOC_PP4_FxxP_1	559	562	PF00568	0.393
DOC_SPAK_OSR1_1	749	753	PF12202	0.424
DOC_USP7_MATH_1	250	254	PF00917	0.422
DOC_USP7_MATH_1	306	310	PF00917	0.461
DOC_USP7_MATH_1	407	411	PF00917	0.417
DOC_USP7_MATH_1	581	585	PF00917	0.508
DOC_USP7_MATH_1	635	639	PF00917	0.445
DOC_USP7_MATH_1	684	688	PF00917	0.598
DOC_USP7_MATH_1	77	81	PF00917	0.326
DOC_USP7_UBL2_3	511	515	PF12436	0.335
DOC_WW_Pin1_4	13	18	PF00397	0.553
DOC_WW_Pin1_4	424	429	PF00397	0.365
LIG_14-3-3_CanoR_1	305	311	PF00244	0.349
LIG_14-3-3_CanoR_1	316	321	PF00244	0.393
LIG_14-3-3_CanoR_1	33	39	PF00244	0.527
LIG_14-3-3_CanoR_1	379	387	PF00244	0.495
LIG_14-3-3_CanoR_1	393	399	PF00244	0.314
LIG_14-3-3_CanoR_1	418	428	PF00244	0.423
LIG_14-3-3_CanoR_1	586	595	PF00244	0.367
LIG_14-3-3_CanoR_1	603	610	PF00244	0.385
LIG_14-3-3_CanoR_1	651	656	PF00244	0.442
LIG_14-3-3_CanoR_1	704	709	PF00244	0.630
LIG_14-3-3_CanoR_1	756	762	PF00244	0.493
LIG_14-3-3_CanoR_1	803	809	PF00244	0.421
LIG_14-3-3_CanoR_1	832	838	PF00244	0.529
LIG_Actin_WH2_2	652	669	PF00022	0.443
LIG_Actin_WH2_2	688	706	PF00022	0.406
LIG_BRCT_BRCA1_1	214	218	PF00533	0.417
LIG_Clathr_ClatBox_1	125	129	PF01394	0.290
LIG_Clathr_ClatBox_1	489	493	PF01394	0.288
LIG_deltaCOP1_diTrp_1	97	106	PF00928	0.334
LIG_FHA_1	22	28	PF00498	0.610
LIG_FHA_1	255	261	PF00498	0.439
LIG_FHA_1	381	387	PF00498	0.529
LIG_FHA_1	395	401	PF00498	0.288
LIG_FHA_1	409	415	PF00498	0.257
LIG_FHA_1	525	531	PF00498	0.217
LIG_FHA_1	605	611	PF00498	0.514
LIG_FHA_1	631	637	PF00498	0.469
LIG_FHA_1	661	667	PF00498	0.442
LIG_FHA_1	713	719	PF00498	0.418
LIG_FHA_1	791	797	PF00498	0.446
LIG_FHA_2	18	24	PF00498	0.565
LIG_FHA_2	221	227	PF00498	0.417
LIG_FHA_2	257	263	PF00498	0.324
LIG_FHA_2	370	376	PF00498	0.482
LIG_GBD_Chelix_1	412	420	PF00786	0.324
LIG_LIR_Apic_2	185	189	PF02991	0.322
LIG_LIR_Gen_1	215	225	PF02991	0.417
LIG_LIR_Gen_1	257	265	PF02991	0.305
LIG_LIR_Gen_1	269	278	PF02991	0.287
LIG_LIR_Gen_1	298	307	PF02991	0.413
LIG_LIR_Gen_1	427	435	PF02991	0.367
LIG_LIR_Gen_1	687	696	PF02991	0.579
LIG_LIR_Gen_1	748	757	PF02991	0.396
LIG_LIR_Nem_3	215	221	PF02991	0.461
LIG_LIR_Nem_3	257	261	PF02991	0.340
LIG_LIR_Nem_3	269	274	PF02991	0.254
LIG_LIR_Nem_3	298	304	PF02991	0.341
LIG_LIR_Nem_3	427	432	PF02991	0.288
LIG_LIR_Nem_3	687	691	PF02991	0.589
LIG_LIR_Nem_3	748	753	PF02991	0.398
LIG_LIR_Nem_3	871	876	PF02991	0.671
LIG_NRBOX	415	421	PF00104	0.324
LIG_NRBOX	621	627	PF00104	0.496
LIG_PCNA_yPIPBox_3	456	466	PF02747	0.326
LIG_Pex14_1	106	110	PF04695	0.378
LIG_Pex14_1	254	258	PF04695	0.417
LIG_Pex14_1	505	509	PF04695	0.417
LIG_Pex14_1	708	712	PF04695	0.510
LIG_SH2_GRB2like	763	766	PF00017	0.476
LIG_SH2_GRB2like	883	886	PF00017	0.505
LIG_SH2_NCK_1	516	520	PF00017	0.378
LIG_SH2_PTP2	301	304	PF00017	0.445
LIG_SH2_SRC	320	323	PF00017	0.444
LIG_SH2_SRC	763	766	PF00017	0.566
LIG_SH2_STAP1	516	520	PF00017	0.378
LIG_SH2_STAT3	780	783	PF00017	0.504
LIG_SH2_STAT5	258	261	PF00017	0.394
LIG_SH2_STAT5	30	33	PF00017	0.533
LIG_SH2_STAT5	301	304	PF00017	0.445
LIG_SH2_STAT5	320	323	PF00017	0.315
LIG_SH2_STAT5	520	523	PF00017	0.294
LIG_SH2_STAT5	763	766	PF00017	0.566
LIG_SH2_STAT5	780	783	PF00017	0.563
LIG_SH3_3	233	239	PF00018	0.308
LIG_SH3_3	678	684	PF00018	0.602
LIG_SH3_3	733	739	PF00018	0.488
LIG_SH3_3	751	757	PF00018	0.524
LIG_Sin3_3	271	278	PF02671	0.417
LIG_SUMO_SIM_anti_2	397	402	PF11976	0.405
LIG_SUMO_SIM_anti_2	487	493	PF11976	0.439
LIG_SUMO_SIM_par_1	121	127	PF11976	0.301
LIG_SUMO_SIM_par_1	271	276	PF11976	0.300
LIG_SUMO_SIM_par_1	487	493	PF11976	0.413
LIG_SUMO_SIM_par_1	638	645	PF11976	0.570
LIG_SUMO_SIM_par_1	737	743	PF11976	0.345
LIG_SUMO_SIM_par_1	899	906	PF11976	0.484
LIG_TRAF2_1	563	566	PF00917	0.563
LIG_TRAF2_1	745	748	PF00917	0.421
LIG_WRC_WIRS_1	688	693	PF05994	0.413
MOD_CDK_SPK_2	13	18	PF00069	0.392
MOD_CK1_1	101	107	PF00069	0.442
MOD_CK1_1	356	362	PF00069	0.483
MOD_CK1_1	369	375	PF00069	0.367
MOD_CK1_1	427	433	PF00069	0.480
MOD_CK1_1	481	487	PF00069	0.378
MOD_CK1_1	524	530	PF00069	0.378
MOD_CK1_1	584	590	PF00069	0.517
MOD_CK1_1	617	623	PF00069	0.513
MOD_CK1_1	642	648	PF00069	0.470
MOD_CK1_1	687	693	PF00069	0.614
MOD_CK1_1	864	870	PF00069	0.487
MOD_CK2_1	220	226	PF00069	0.417
MOD_CK2_1	331	337	PF00069	0.535
MOD_CK2_1	419	425	PF00069	0.416
MOD_CK2_1	541	547	PF00069	0.494
MOD_CK2_1	560	566	PF00069	0.313
MOD_CK2_1	674	680	PF00069	0.468
MOD_GlcNHglycan	240	243	PF01048	0.398
MOD_GlcNHglycan	283	286	PF01048	0.246
MOD_GlcNHglycan	333	336	PF01048	0.525
MOD_GlcNHglycan	355	358	PF01048	0.402
MOD_GlcNHglycan	480	483	PF01048	0.362
MOD_GlcNHglycan	485	489	PF01048	0.332
MOD_GlcNHglycan	543	546	PF01048	0.252
MOD_GlcNHglycan	607	610	PF01048	0.403
MOD_GlcNHglycan	644	647	PF01048	0.677
MOD_GlcNHglycan	699	702	PF01048	0.501
MOD_GlcNHglycan	735	739	PF01048	0.554
MOD_GlcNHglycan	771	774	PF01048	0.573
MOD_GSK3_1	100	107	PF00069	0.438
MOD_GSK3_1	13	20	PF00069	0.607
MOD_GSK3_1	212	219	PF00069	0.384
MOD_GSK3_1	250	257	PF00069	0.478
MOD_GSK3_1	277	284	PF00069	0.241
MOD_GSK3_1	312	319	PF00069	0.468
MOD_GSK3_1	448	455	PF00069	0.378
MOD_GSK3_1	626	633	PF00069	0.477
MOD_GSK3_1	635	642	PF00069	0.574
MOD_GSK3_1	704	711	PF00069	0.603
MOD_GSK3_1	712	719	PF00069	0.572
MOD_GSK3_1	775	782	PF00069	0.490
MOD_GSK3_1	790	797	PF00069	0.421
MOD_GSK3_1	804	811	PF00069	0.493
MOD_GSK3_1	819	826	PF00069	0.592
MOD_N-GLC_1	254	259	PF02516	0.324
MOD_N-GLC_1	495	500	PF02516	0.417
MOD_N-GLC_1	861	866	PF02516	0.500
MOD_N-GLC_1	876	881	PF02516	0.401
MOD_NEK2_1	100	105	PF00069	0.378
MOD_NEK2_1	121	126	PF00069	0.288
MOD_NEK2_1	159	164	PF00069	0.358
MOD_NEK2_1	248	253	PF00069	0.441
MOD_NEK2_1	277	282	PF00069	0.388
MOD_NEK2_1	380	385	PF00069	0.520
MOD_NEK2_1	419	424	PF00069	0.417
MOD_NEK2_1	605	610	PF00069	0.447
MOD_NEK2_1	639	644	PF00069	0.555
MOD_NEK2_1	673	678	PF00069	0.492
MOD_NEK2_1	712	717	PF00069	0.340
MOD_NEK2_1	781	786	PF00069	0.480
MOD_NEK2_1	808	813	PF00069	0.484
MOD_NEK2_1	823	828	PF00069	0.521
MOD_NEK2_1	833	838	PF00069	0.317
MOD_NEK2_2	256	261	PF00069	0.356
MOD_NEK2_2	581	586	PF00069	0.418
MOD_PIKK_1	206	212	PF00454	0.417
MOD_PIKK_1	366	372	PF00454	0.585
MOD_PIKK_1	419	425	PF00454	0.436
MOD_PIKK_1	495	501	PF00454	0.417
MOD_PIKK_1	55	61	PF00454	0.587
MOD_PIKK_1	779	785	PF00454	0.454
MOD_PIKK_1	876	882	PF00454	0.658
MOD_PKA_1	614	620	PF00069	0.383
MOD_PKA_1	704	710	PF00069	0.661
MOD_PKA_1	869	875	PF00069	0.551
MOD_PKA_2	17	23	PF00069	0.393
MOD_PKA_2	206	212	PF00069	0.378
MOD_PKA_2	34	40	PF00069	0.368
MOD_PKA_2	366	372	PF00069	0.447
MOD_PKA_2	381	387	PF00069	0.467
MOD_PKA_2	478	484	PF00069	0.340
MOD_PKA_2	614	620	PF00069	0.472
MOD_PKA_2	650	656	PF00069	0.532
MOD_PKA_2	712	718	PF00069	0.440
MOD_PKA_2	869	875	PF00069	0.696
MOD_PKB_1	732	740	PF00069	0.457
MOD_Plk_1	101	107	PF00069	0.378
MOD_Plk_1	212	218	PF00069	0.367
MOD_Plk_1	254	260	PF00069	0.324
MOD_Plk_1	47	53	PF00069	0.502
MOD_Plk_1	524	530	PF00069	0.397
MOD_Plk_1	790	796	PF00069	0.365
MOD_Plk_1	819	825	PF00069	0.472
MOD_Plk_1	861	867	PF00069	0.506
MOD_Plk_2-3	220	226	PF00069	0.324
MOD_Plk_2-3	861	867	PF00069	0.506
MOD_Plk_4	101	107	PF00069	0.440
MOD_Plk_4	121	127	PF00069	0.279
MOD_Plk_4	256	262	PF00069	0.356
MOD_Plk_4	316	322	PF00069	0.487
MOD_Plk_4	394	400	PF00069	0.435
MOD_Plk_4	617	623	PF00069	0.449
MOD_Plk_4	635	641	PF00069	0.366
MOD_Plk_4	757	763	PF00069	0.375
MOD_Plk_4	77	83	PF00069	0.378
MOD_Plk_4	795	801	PF00069	0.355
MOD_ProDKin_1	13	19	PF00069	0.551
MOD_ProDKin_1	424	430	PF00069	0.365
MOD_SUMO_for_1	4	7	PF00179	0.530
MOD_SUMO_rev_2	56	65	PF00179	0.433
MOD_SUMO_rev_2	566	575	PF00179	0.472
TRG_DiLeu_BaEn_1	269	274	PF01217	0.367
TRG_DiLeu_BaEn_1	485	490	PF01217	0.344
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.414
TRG_DiLeu_BaLyEn_6	690	695	PF01217	0.616
TRG_ENDOCYTIC_2	258	261	PF00928	0.351
TRG_ENDOCYTIC_2	301	304	PF00928	0.315
TRG_ENDOCYTIC_2	883	886	PF00928	0.505
TRG_ER_diArg_1	161	164	PF00400	0.390
TRG_ER_diArg_1	180	182	PF00400	0.181
TRG_ER_diArg_1	33	36	PF00400	0.491
TRG_ER_diArg_1	338	341	PF00400	0.517
TRG_ER_diArg_1	364	367	PF00400	0.444
TRG_ER_diArg_1	460	462	PF00400	0.367
TRG_ER_diArg_1	731	734	PF00400	0.634
TRG_NES_CRM1_1	262	276	PF08389	0.298
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	418	423	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	744	748	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8U3	Leptomonas seymouri	53%	95%
A0A1X0NM11	Trypanosomatidae	35%	100%
A0A3Q8IWN9	Leishmania donovani	92%	100%
A0A422NVW3	Trypanosoma rangeli	34%	100%
A4HQK6	Leishmania braziliensis	79%	100%
A4ICC6	Leishmania infantum	92%	100%
D0A3Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AUC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BM71	Trypanosoma cruzi	34%	100%