ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calphotin-like protein

Species:

Leishmania major

UniProt:

Q4Q068_LEIMA

TriTrypDb:

LmjF.36.6860 , LMJLV39_360083900 , LMJSD75_360083700

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q068

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q068

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.573
CLV_NRD_NRD_1	221	223	PF00675	0.560
CLV_NRD_NRD_1	250	252	PF00675	0.522
CLV_NRD_NRD_1	282	284	PF00675	0.548
CLV_NRD_NRD_1	299	301	PF00675	0.469
CLV_PCSK_KEX2_1	188	190	PF00082	0.647
CLV_PCSK_KEX2_1	221	223	PF00082	0.560
CLV_PCSK_KEX2_1	282	284	PF00082	0.550
CLV_PCSK_KEX2_1	299	301	PF00082	0.467
CLV_PCSK_KEX2_1	305	307	PF00082	0.465
CLV_PCSK_KEX2_1	99	101	PF00082	0.594
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.647
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.541
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.501
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.594
CLV_PCSK_SKI1_1	17	21	PF00082	0.660
CLV_PCSK_SKI1_1	185	189	PF00082	0.585
CLV_PCSK_SKI1_1	221	225	PF00082	0.656
CLV_PCSK_SKI1_1	351	355	PF00082	0.581
DEG_APCC_DBOX_1	410	418	PF00400	0.621
DEG_SCF_SKP2-CKS1_1	86	93	PF00560	0.534
DOC_CKS1_1	135	140	PF01111	0.496
DOC_MAPK_MEF2A_6	330	338	PF00069	0.427
DOC_PP1_RVXF_1	15	22	PF00149	0.660
DOC_PP1_RVXF_1	158	165	PF00149	0.497
DOC_PP1_RVXF_1	199	205	PF00149	0.492
DOC_PP2B_LxvP_1	56	59	PF13499	0.679
DOC_PP4_FxxP_1	270	273	PF00568	0.505
DOC_PP4_MxPP_1	48	51	PF00568	0.490
DOC_USP7_MATH_1	229	233	PF00917	0.556
DOC_USP7_MATH_1	57	61	PF00917	0.553
DOC_WW_Pin1_4	117	122	PF00397	0.664
DOC_WW_Pin1_4	134	139	PF00397	0.548
DOC_WW_Pin1_4	2	7	PF00397	0.656
DOC_WW_Pin1_4	269	274	PF00397	0.509
DOC_WW_Pin1_4	317	322	PF00397	0.459
DOC_WW_Pin1_4	409	414	PF00397	0.594
DOC_WW_Pin1_4	63	68	PF00397	0.639
DOC_WW_Pin1_4	87	92	PF00397	0.594
DOC_WW_Pin1_4	9	14	PF00397	0.613
LIG_14-3-3_CanoR_1	143	150	PF00244	0.616
LIG_14-3-3_CanoR_1	17	22	PF00244	0.570
LIG_14-3-3_CanoR_1	178	184	PF00244	0.587
LIG_14-3-3_CanoR_1	189	197	PF00244	0.459
LIG_14-3-3_CanoR_1	228	234	PF00244	0.693
LIG_14-3-3_CanoR_1	73	80	PF00244	0.651
LIG_Actin_WH2_2	57	75	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_EVH1_2	121	125	PF00568	0.660
LIG_FHA_1	18	24	PF00498	0.635
LIG_FHA_1	188	194	PF00498	0.583
LIG_FHA_1	241	247	PF00498	0.629
LIG_FHA_1	3	9	PF00498	0.548
LIG_FHA_1	308	314	PF00498	0.485
LIG_FHA_1	392	398	PF00498	0.539
LIG_FHA_1	419	425	PF00498	0.492
LIG_FHA_1	79	85	PF00498	0.534
LIG_FHA_2	73	79	PF00498	0.696
LIG_LIR_Nem_3	291	297	PF02991	0.583
LIG_LIR_Nem_3	344	350	PF02991	0.486
LIG_LYPXL_S_1	108	112	PF13949	0.627
LIG_LYPXL_yS_3	109	112	PF13949	0.631
LIG_NRBOX	333	339	PF00104	0.307
LIG_PCNA_PIPBox_1	208	217	PF02747	0.526
LIG_Pex14_1	265	269	PF04695	0.487
LIG_SH2_CRK	98	102	PF00017	0.559
LIG_SH2_STAT5	161	164	PF00017	0.565
LIG_SH2_STAT5	215	218	PF00017	0.570
LIG_SH2_STAT5	269	272	PF00017	0.636
LIG_SH2_STAT5	294	297	PF00017	0.576
LIG_SH3_3	1	7	PF00018	0.676
LIG_SH3_3	132	138	PF00018	0.501
LIG_SH3_3	27	33	PF00018	0.600
LIG_SH3_3	390	396	PF00018	0.566
LIG_SH3_3	40	46	PF00018	0.560
LIG_SH3_3	410	416	PF00018	0.470
LIG_SH3_3	64	70	PF00018	0.592
LIG_SUMO_SIM_anti_2	332	340	PF11976	0.481
LIG_SUMO_SIM_par_1	179	184	PF11976	0.664
LIG_SUMO_SIM_par_1	332	340	PF11976	0.573
LIG_TRAF2_1	74	77	PF00917	0.701
LIG_Vh1_VBS_1	324	342	PF01044	0.435
LIG_WW_1	158	161	PF00397	0.586
MOD_CDK_SPxK_1	87	93	PF00069	0.562
MOD_CK1_1	117	123	PF00069	0.649
MOD_CK1_1	170	176	PF00069	0.615
MOD_CK1_1	2	8	PF00069	0.649
MOD_CK1_1	232	238	PF00069	0.675
MOD_CK1_1	317	323	PF00069	0.453
MOD_CK1_1	355	361	PF00069	0.513
MOD_CK2_1	142	148	PF00069	0.605
MOD_CK2_1	72	78	PF00069	0.704
MOD_Cter_Amidation	297	300	PF01082	0.450
MOD_GlcNHglycan	116	119	PF01048	0.642
MOD_GlcNHglycan	169	172	PF01048	0.531
MOD_GlcNHglycan	23	26	PF01048	0.606
MOD_GlcNHglycan	246	249	PF01048	0.526
MOD_GlcNHglycan	290	293	PF01048	0.545
MOD_GlcNHglycan	339	342	PF01048	0.506
MOD_GlcNHglycan	354	357	PF01048	0.366
MOD_GlcNHglycan	363	366	PF01048	0.462
MOD_GlcNHglycan	61	64	PF01048	0.535
MOD_GSK3_1	113	120	PF00069	0.640
MOD_GSK3_1	17	24	PF00069	0.641
MOD_GSK3_1	228	235	PF00069	0.687
MOD_GSK3_1	240	247	PF00069	0.536
MOD_GSK3_1	59	66	PF00069	0.532
MOD_NEK2_1	113	118	PF00069	0.636
MOD_NEK2_1	181	186	PF00069	0.642
MOD_NEK2_1	21	26	PF00069	0.608
MOD_NEK2_1	288	293	PF00069	0.445
MOD_NEK2_1	337	342	PF00069	0.448
MOD_PKA_1	17	23	PF00069	0.660
MOD_PKA_1	188	194	PF00069	0.553
MOD_PKA_1	221	227	PF00069	0.571
MOD_PKA_2	142	148	PF00069	0.605
MOD_PKA_2	167	173	PF00069	0.539
MOD_PKA_2	188	194	PF00069	0.553
MOD_PKA_2	221	227	PF00069	0.635
MOD_PKA_2	342	348	PF00069	0.521
MOD_PKA_2	72	78	PF00069	0.658
MOD_Plk_4	330	336	PF00069	0.536
MOD_ProDKin_1	117	123	PF00069	0.667
MOD_ProDKin_1	134	140	PF00069	0.540
MOD_ProDKin_1	2	8	PF00069	0.656
MOD_ProDKin_1	269	275	PF00069	0.507
MOD_ProDKin_1	317	323	PF00069	0.453
MOD_ProDKin_1	409	415	PF00069	0.593
MOD_ProDKin_1	63	69	PF00069	0.642
MOD_ProDKin_1	87	93	PF00069	0.592
MOD_ProDKin_1	9	15	PF00069	0.612
MOD_SUMO_for_1	216	219	PF00179	0.555
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.647
TRG_ENDOCYTIC_2	109	112	PF00928	0.680
TRG_ENDOCYTIC_2	161	164	PF00928	0.565
TRG_ENDOCYTIC_2	215	218	PF00928	0.631
TRG_ENDOCYTIC_2	98	101	PF00928	0.686
TRG_ER_diArg_1	221	223	PF00400	0.560
TRG_ER_diArg_1	348	351	PF00400	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGY1	Leishmania donovani	87%	100%
A4HQK7	Leishmania braziliensis	68%	100%
A4ICC7	Leishmania infantum	86%	100%
E9AUC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%