EVE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EVE domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q067_LEIMA

TriTrypDb:

LmjF.36.6870 , LMJLV39_360084000 , LMJSD75_360083800

Length:

164

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q067

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q067

PDB structure(s): 2ar1_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.443
CLV_NRD_NRD_1	162	164	PF00675	0.469
CLV_NRD_NRD_1	2	4	PF00675	0.580
CLV_PCSK_KEX2_1	127	129	PF00082	0.440
CLV_PCSK_KEX2_1	4	6	PF00082	0.525
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.525
CLV_PCSK_SKI1_1	132	136	PF00082	0.442
CLV_PCSK_SKI1_1	56	60	PF00082	0.295
CLV_Separin_Metazoa	74	78	PF03568	0.443
DEG_APCC_DBOX_1	126	134	PF00400	0.443
DEG_MDM2_SWIB_1	111	119	PF02201	0.417
DOC_MAPK_gen_1	125	135	PF00069	0.326
DOC_PP1_RVXF_1	54	60	PF00149	0.288
DOC_USP7_UBL2_3	101	105	PF12436	0.393
DOC_WW_Pin1_4	31	36	PF00397	0.288
LIG_14-3-3_CanoR_1	140	144	PF00244	0.299
LIG_14-3-3_CanoR_1	49	54	PF00244	0.210
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BRCT_BRCA1_1	89	93	PF00533	0.443
LIG_FHA_2	118	124	PF00498	0.405
LIG_FHA_2	82	88	PF00498	0.296
LIG_LIR_Apic_2	89	95	PF02991	0.417
LIG_LIR_Gen_1	149	157	PF02991	0.331
LIG_LIR_Gen_1	81	87	PF02991	0.417
LIG_LIR_Nem_3	10	16	PF02991	0.443
LIG_LIR_Nem_3	149	154	PF02991	0.331
LIG_LIR_Nem_3	33	39	PF02991	0.298
LIG_LIR_Nem_3	81	86	PF02991	0.417
LIG_MLH1_MIPbox_1	89	93	PF16413	0.443
LIG_Pex14_2	111	115	PF04695	0.296
LIG_SH2_CRK	151	155	PF00017	0.443
LIG_SH2_SRC	151	154	PF00017	0.353
LIG_SH2_STAP1	151	155	PF00017	0.331
LIG_SH2_STAT5	153	156	PF00017	0.443
LIG_SH2_STAT5	92	95	PF00017	0.436
LIG_SUMO_SIM_par_1	116	123	PF11976	0.275
LIG_TYR_ITIM	11	16	PF00017	0.443
MOD_CK1_1	139	145	PF00069	0.381
MOD_CK2_1	117	123	PF00069	0.377
MOD_CK2_1	144	150	PF00069	0.332
MOD_GlcNHglycan	146	149	PF01048	0.440
MOD_NEK2_1	136	141	PF00069	0.333
MOD_NEK2_1	59	64	PF00069	0.291
MOD_PIKK_1	134	140	PF00454	0.381
MOD_PK_1	49	55	PF00069	0.285
MOD_PKA_2	139	145	PF00069	0.296
MOD_Plk_1	81	87	PF00069	0.331
MOD_Plk_4	114	120	PF00069	0.363
MOD_ProDKin_1	31	37	PF00069	0.288
MOD_SUMO_for_1	16	19	PF00179	0.296
MOD_SUMO_rev_2	90	98	PF00179	0.305
TRG_ENDOCYTIC_2	13	16	PF00928	0.331
TRG_ENDOCYTIC_2	151	154	PF00928	0.331
TRG_ENDOCYTIC_2	80	83	PF00928	0.423
TRG_ER_diArg_1	3	6	PF00400	0.565
TRG_NLS_MonoExtC_3	2	7	PF00514	0.566
TRG_NLS_MonoExtN_4	3	8	PF00514	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I255	Leptomonas seymouri	79%	94%
A0A0S4JQP8	Bodo saltans	59%	93%
A0A0S4KI49	Bodo saltans	59%	93%
A0A1X0NLS9	Trypanosomatidae	63%	100%
A0A3R7KTV7	Trypanosoma rangeli	65%	99%
A0A3S7XCF0	Leishmania donovani	98%	80%
A4HQK8	Leishmania braziliensis	89%	100%
A4ICC8	Leishmania infantum	98%	80%
D0A3R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AUC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O94645	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	69%
Q6P3E0	Rattus norvegicus	45%	73%
Q6PFL8	Danio rerio	45%	71%
Q90679	Gallus gallus	42%	68%
Q91YJ3	Mus musculus	45%	73%
Q9P016	Homo sapiens	46%	73%