Putative DNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bromodomain factor 1

Species:

Leishmania major

UniProt:

Q4Q066_LEIMA

TriTrypDb:

LmjF.36.6880 , LMJLV39_360084100 , LMJSD75_360083900

Length:

283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	2
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q066

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q066

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	2
GO:0006338	chromatin remodeling	5	2
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0016043	cellular component organization	3	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2
GO:0070577	lysine-acetylated histone binding	4	2
GO:0097159	organic cyclic compound binding	2	10
GO:0140030	modification-dependent protein binding	3	2
GO:0140033	acetylation-dependent protein binding	4	2
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.563
CLV_C14_Caspase3-7	43	47	PF00656	0.320
CLV_NRD_NRD_1	186	188	PF00675	0.387
CLV_NRD_NRD_1	19	21	PF00675	0.500
CLV_NRD_NRD_1	206	208	PF00675	0.306
CLV_NRD_NRD_1	218	220	PF00675	0.595
CLV_NRD_NRD_1	36	38	PF00675	0.441
CLV_NRD_NRD_1	75	77	PF00675	0.366
CLV_PCSK_FUR_1	15	19	PF00082	0.434
CLV_PCSK_KEX2_1	17	19	PF00082	0.452
CLV_PCSK_KEX2_1	186	188	PF00082	0.386
CLV_PCSK_KEX2_1	206	208	PF00082	0.306
CLV_PCSK_KEX2_1	217	219	PF00082	0.591
CLV_PCSK_KEX2_1	36	38	PF00082	0.461
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.462
CLV_PCSK_PC7_1	13	19	PF00082	0.464
CLV_PCSK_PC7_1	213	219	PF00082	0.610
CLV_PCSK_SKI1_1	124	128	PF00082	0.483
CLV_PCSK_SKI1_1	152	156	PF00082	0.527
CLV_PCSK_SKI1_1	178	182	PF00082	0.547
CLV_PCSK_SKI1_1	186	190	PF00082	0.420
CLV_PCSK_SKI1_1	201	205	PF00082	0.565
CLV_PCSK_SKI1_1	207	211	PF00082	0.590
CLV_Separin_Metazoa	153	157	PF03568	0.514
DOC_MAPK_MEF2A_6	112	121	PF00069	0.469
DOC_USP7_MATH_1	192	196	PF00917	0.514
DOC_USP7_MATH_1	209	213	PF00917	0.418
DOC_WW_Pin1_4	261	266	PF00397	0.605
LIG_14-3-3_CanoR_1	124	133	PF00244	0.551
LIG_14-3-3_CanoR_1	53	59	PF00244	0.470
LIG_Actin_WH2_2	114	132	PF00022	0.512
LIG_Actin_WH2_2	162	180	PF00022	0.568
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BRCT_BRCA1_1	3	7	PF00533	0.402
LIG_deltaCOP1_diTrp_1	269	280	PF00928	0.721
LIG_GBD_Chelix_1	113	121	PF00786	0.362
LIG_GBD_Chelix_1	8	16	PF00786	0.572
LIG_PTB_Apo_2	95	102	PF02174	0.445
LIG_PTB_Phospho_1	95	101	PF10480	0.445
LIG_SH2_CRK	103	107	PF00017	0.449
LIG_SH2_SRC	26	29	PF00017	0.528
LIG_SH2_STAP1	61	65	PF00017	0.385
LIG_SH2_STAP1	81	85	PF00017	0.434
LIG_SH2_STAT5	101	104	PF00017	0.375
LIG_SH2_STAT5	26	29	PF00017	0.528
LIG_SH3_1	130	136	PF00018	0.555
LIG_SH3_3	130	136	PF00018	0.456
LIG_SH3_3	62	68	PF00018	0.365
MOD_CDC14_SPxK_1	264	267	PF00782	0.701
MOD_CDK_SPxK_1	261	267	PF00069	0.706
MOD_CK1_1	148	154	PF00069	0.559
MOD_CK1_1	212	218	PF00069	0.631
MOD_CK2_1	191	197	PF00069	0.550
MOD_CK2_1	255	261	PF00069	0.677
MOD_GlcNHglycan	147	150	PF01048	0.573
MOD_GlcNHglycan	194	197	PF01048	0.506
MOD_GSK3_1	141	148	PF00069	0.574
MOD_GSK3_1	40	47	PF00069	0.426
MOD_N-GLC_2	98	100	PF02516	0.449
MOD_PKA_2	192	198	PF00069	0.560
MOD_PKA_2	212	218	PF00069	0.301
MOD_Plk_2-3	40	46	PF00069	0.475
MOD_ProDKin_1	261	267	PF00069	0.608
MOD_SUMO_rev_2	194	203	PF00179	0.585
TRG_ENDOCYTIC_2	103	106	PF00928	0.449
TRG_ENDOCYTIC_2	161	164	PF00928	0.524
TRG_ENDOCYTIC_2	70	73	PF00928	0.449
TRG_ER_diArg_1	12	15	PF00400	0.470
TRG_ER_diArg_1	18	20	PF00400	0.463
TRG_ER_diArg_1	185	187	PF00400	0.379
TRG_ER_diArg_1	205	207	PF00400	0.309
TRG_ER_diArg_1	217	219	PF00400	0.591
TRG_ER_diArg_1	36	38	PF00400	0.439
TRG_NLS_MonoCore_2	16	21	PF00514	0.570
TRG_NLS_MonoExtC_3	16	22	PF00514	0.568
TRG_NLS_MonoExtN_4	15	21	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD97	Leptomonas seymouri	74%	99%
A0A0S4KI88	Bodo saltans	26%	100%
A0A1X0NN00	Trypanosomatidae	37%	95%
A0A3Q8IM77	Leishmania donovani	94%	99%
A0A422NVW8	Trypanosoma rangeli	36%	96%
A4HQK9	Leishmania braziliensis	87%	99%
A4ICC9	Leishmania infantum	94%	99%
D0A3R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	94%
E9AUC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	99%
V5DDW0	Trypanosoma cruzi	33%	96%