Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q064_LEIMA

TriTrypDb:

LmjF.36.6900 , LMJLV39_360084400 , LMJSD75_360084200

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000164	protein phosphatase type 1 complex	5	2
GO:0005929	cilium	4	7
GO:0008287	protein serine/threonine phosphatase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:1902494	catalytic complex	2	2
GO:1903293	phosphatase complex	3	2

Expansion

Sequence features

Q4Q064

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q064

Function

Biological processes
Term	Name	Level	Count
GO:0009893	positive regulation of metabolic process	4	2
GO:0010562	positive regulation of phosphorus metabolic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031399	regulation of protein modification process	6	2
GO:0031401	positive regulation of protein modification process	7	2
GO:0035303	regulation of dephosphorylation	7	2
GO:0035304	regulation of protein dephosphorylation	7	2
GO:0035306	positive regulation of dephosphorylation	8	2
GO:0035307	positive regulation of protein dephosphorylation	8	2
GO:0045937	positive regulation of phosphate metabolic process	7	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051174	regulation of phosphorus metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051247	positive regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	2
GO:0004864	protein phosphatase inhibitor activity	5	2
GO:0004865	protein serine/threonine phosphatase inhibitor activity	6	2
GO:0019208	phosphatase regulator activity	3	2
GO:0019212	phosphatase inhibitor activity	4	2
GO:0019888	protein phosphatase regulator activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2
GO:0140678	molecular function inhibitor activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.410
CLV_C14_Caspase3-7	241	245	PF00656	0.478
CLV_C14_Caspase3-7	435	439	PF00656	0.606
CLV_C14_Caspase3-7	681	685	PF00656	0.633
CLV_C14_Caspase3-7	701	705	PF00656	0.515
CLV_NRD_NRD_1	150	152	PF00675	0.509
CLV_NRD_NRD_1	153	155	PF00675	0.565
CLV_NRD_NRD_1	204	206	PF00675	0.419
CLV_NRD_NRD_1	21	23	PF00675	0.482
CLV_NRD_NRD_1	372	374	PF00675	0.599
CLV_NRD_NRD_1	468	470	PF00675	0.631
CLV_NRD_NRD_1	595	597	PF00675	0.662
CLV_NRD_NRD_1	652	654	PF00675	0.600
CLV_PCSK_FUR_1	151	155	PF00082	0.432
CLV_PCSK_KEX2_1	120	122	PF00082	0.385
CLV_PCSK_KEX2_1	150	152	PF00082	0.519
CLV_PCSK_KEX2_1	153	155	PF00082	0.579
CLV_PCSK_KEX2_1	158	160	PF00082	0.413
CLV_PCSK_KEX2_1	204	206	PF00082	0.419
CLV_PCSK_KEX2_1	371	373	PF00082	0.601
CLV_PCSK_KEX2_1	652	654	PF00082	0.600
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.385
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.468
CLV_PCSK_PC7_1	154	160	PF00082	0.417
CLV_PCSK_SKI1_1	121	125	PF00082	0.344
CLV_PCSK_SKI1_1	169	173	PF00082	0.538
CLV_PCSK_SKI1_1	197	201	PF00082	0.413
CLV_PCSK_SKI1_1	314	318	PF00082	0.488
CLV_PCSK_SKI1_1	343	347	PF00082	0.385
CLV_PCSK_SKI1_1	376	380	PF00082	0.565
CLV_PCSK_SKI1_1	63	67	PF00082	0.360
CLV_PCSK_SKI1_1	695	699	PF00082	0.576
DEG_APCC_DBOX_1	296	304	PF00400	0.388
DEG_Nend_UBRbox_2	1	3	PF02207	0.422
DEG_SCF_FBW7_1	378	383	PF00400	0.520
DEG_SCF_FBW7_1	415	422	PF00400	0.603
DEG_SPOP_SBC_1	214	218	PF00917	0.436
DEG_SPOP_SBC_1	414	418	PF00917	0.644
DOC_CDC14_PxL_1	332	340	PF14671	0.363
DOC_CDC14_PxL_1	567	575	PF14671	0.595
DOC_CKS1_1	635	640	PF01111	0.542
DOC_CYCLIN_RxL_1	309	322	PF00134	0.392
DOC_CYCLIN_RxL_1	340	349	PF00134	0.328
DOC_CYCLIN_RxL_1	692	702	PF00134	0.615
DOC_CYCLIN_yCln2_LP_2	224	227	PF00134	0.632
DOC_MAPK_DCC_7	309	318	PF00069	0.382
DOC_MAPK_DCC_7	584	593	PF00069	0.557
DOC_MAPK_gen_1	120	126	PF00069	0.352
DOC_MAPK_gen_1	201	209	PF00069	0.355
DOC_MAPK_gen_1	22	30	PF00069	0.445
DOC_MAPK_gen_1	297	305	PF00069	0.550
DOC_MAPK_gen_1	309	318	PF00069	0.351
DOC_MAPK_gen_1	584	593	PF00069	0.574
DOC_MAPK_gen_1	652	663	PF00069	0.607
DOC_MAPK_MEF2A_6	23	32	PF00069	0.434
DOC_MAPK_MEF2A_6	297	305	PF00069	0.580
DOC_MAPK_MEF2A_6	351	358	PF00069	0.480
DOC_MAPK_MEF2A_6	88	97	PF00069	0.327
DOC_PP2B_LxvP_1	224	227	PF13499	0.632
DOC_PP2B_LxvP_1	591	594	PF13499	0.639
DOC_USP7_MATH_1	106	110	PF00917	0.373
DOC_USP7_MATH_1	136	140	PF00917	0.433
DOC_USP7_MATH_1	214	218	PF00917	0.499
DOC_USP7_MATH_1	384	388	PF00917	0.689
DOC_USP7_MATH_1	395	399	PF00917	0.538
DOC_USP7_MATH_1	414	418	PF00917	0.736
DOC_USP7_MATH_1	419	423	PF00917	0.584
DOC_USP7_MATH_1	456	460	PF00917	0.581
DOC_USP7_MATH_1	519	523	PF00917	0.653
DOC_USP7_MATH_1	529	533	PF00917	0.679
DOC_USP7_MATH_1	582	586	PF00917	0.620
DOC_USP7_MATH_1	605	609	PF00917	0.633
DOC_USP7_MATH_1	678	682	PF00917	0.707
DOC_USP7_MATH_1	688	692	PF00917	0.587
DOC_USP7_UBL2_3	116	120	PF12436	0.429
DOC_USP7_UBL2_3	466	470	PF12436	0.611
DOC_WW_Pin1_4	371	376	PF00397	0.656
DOC_WW_Pin1_4	380	385	PF00397	0.568
DOC_WW_Pin1_4	406	411	PF00397	0.685
DOC_WW_Pin1_4	415	420	PF00397	0.613
DOC_WW_Pin1_4	634	639	PF00397	0.615
LIG_14-3-3_CanoR_1	137	145	PF00244	0.366
LIG_14-3-3_CanoR_1	164	169	PF00244	0.439
LIG_14-3-3_CanoR_1	182	192	PF00244	0.448
LIG_14-3-3_CanoR_1	314	319	PF00244	0.394
LIG_14-3-3_CanoR_1	426	434	PF00244	0.548
LIG_14-3-3_CanoR_1	458	465	PF00244	0.606
LIG_14-3-3_CanoR_1	549	557	PF00244	0.629
LIG_14-3-3_CanoR_1	602	612	PF00244	0.620
LIG_14-3-3_CanoR_1	658	664	PF00244	0.551
LIG_14-3-3_CanoR_1	67	72	PF00244	0.414
LIG_14-3-3_CanoR_1	693	698	PF00244	0.630
LIG_BIR_III_4	322	326	PF00653	0.437
LIG_BRCT_BRCA1_1	386	390	PF00533	0.577
LIG_BRCT_BRCA1_1	490	494	PF00533	0.610
LIG_BRCT_BRCA1_1	645	649	PF00533	0.650
LIG_BRCT_BRCA1_1	659	663	PF00533	0.581
LIG_BRCT_BRCA1_1	690	694	PF00533	0.639
LIG_BRCT_BRCA1_2	386	392	PF00533	0.512
LIG_CaM_IQ_9	187	203	PF13499	0.527
LIG_Clathr_ClatBox_1	252	256	PF01394	0.345
LIG_deltaCOP1_diTrp_1	536	540	PF00928	0.536
LIG_DLG_GKlike_1	58	65	PF00625	0.410
LIG_DLG_GKlike_1	67	74	PF00625	0.320
LIG_eIF4E_1	3	9	PF01652	0.359
LIG_eIF4E_1	342	348	PF01652	0.368
LIG_eIF4E_1	87	93	PF01652	0.322
LIG_FHA_1	201	207	PF00498	0.475
LIG_FHA_1	325	331	PF00498	0.412
LIG_FHA_1	604	610	PF00498	0.677
LIG_FHA_2	106	112	PF00498	0.396
LIG_FHA_2	136	142	PF00498	0.383
LIG_FHA_2	184	190	PF00498	0.542
LIG_FHA_2	191	197	PF00498	0.433
LIG_FHA_2	36	42	PF00498	0.414
LIG_FHA_2	399	405	PF00498	0.668
LIG_FHA_2	531	537	PF00498	0.547
LIG_FHA_2	628	634	PF00498	0.580
LIG_LIR_Gen_1	139	149	PF02991	0.406
LIG_LIR_Gen_1	2	9	PF02991	0.366
LIG_LIR_Gen_1	25	32	PF02991	0.449
LIG_LIR_Gen_1	276	284	PF02991	0.449
LIG_LIR_Gen_1	329	340	PF02991	0.365
LIG_LIR_Gen_1	38	48	PF02991	0.276
LIG_LIR_Gen_1	534	543	PF02991	0.543
LIG_LIR_Nem_3	127	131	PF02991	0.396
LIG_LIR_Nem_3	139	145	PF02991	0.427
LIG_LIR_Nem_3	147	152	PF02991	0.276
LIG_LIR_Nem_3	2	6	PF02991	0.379
LIG_LIR_Nem_3	25	30	PF02991	0.396
LIG_LIR_Nem_3	276	280	PF02991	0.476
LIG_LIR_Nem_3	329	335	PF02991	0.375
LIG_LIR_Nem_3	38	43	PF02991	0.267
LIG_LIR_Nem_3	534	540	PF02991	0.540
LIG_LIR_Nem_3	60	65	PF02991	0.411
LIG_LIR_Nem_3	691	697	PF02991	0.663
LIG_MYND_1	223	227	PF01753	0.567
LIG_MYND_1	571	575	PF01753	0.613
LIG_NRBOX	88	94	PF00104	0.320
LIG_PTB_Apo_2	36	43	PF02174	0.279
LIG_SH2_CRK	142	146	PF00017	0.366
LIG_SH2_CRK	342	346	PF00017	0.340
LIG_SH2_STAP1	142	146	PF00017	0.383
LIG_SH2_STAT5	463	466	PF00017	0.531
LIG_SH2_STAT5	48	51	PF00017	0.357
LIG_SH3_1	569	575	PF00018	0.618
LIG_SH3_3	220	226	PF00018	0.554
LIG_SH3_3	349	355	PF00018	0.409
LIG_SH3_3	552	558	PF00018	0.571
LIG_SH3_3	565	571	PF00018	0.605
LIG_SH3_3	621	627	PF00018	0.602
LIG_SUMO_SIM_anti_2	251	256	PF11976	0.409
LIG_TRAF2_1	108	111	PF00917	0.387
LIG_TRAF2_1	550	553	PF00917	0.612
LIG_TYR_ITIM	126	131	PF00017	0.343
LIG_WRC_WIRS_1	385	390	PF05994	0.601
LIG_WRC_WIRS_1	59	64	PF05994	0.356
LIG_WW_3	593	597	PF00397	0.610
MOD_CDK_SPK_2	371	376	PF00069	0.612
MOD_CDK_SPK_2	406	411	PF00069	0.523
MOD_CK1_1	163	169	PF00069	0.350
MOD_CK1_1	293	299	PF00069	0.470
MOD_CK1_1	383	389	PF00069	0.633
MOD_CK1_1	398	404	PF00069	0.545
MOD_CK1_1	417	423	PF00069	0.570
MOD_CK1_1	451	457	PF00069	0.565
MOD_CK1_1	506	512	PF00069	0.618
MOD_CK1_1	532	538	PF00069	0.576
MOD_CK1_1	548	554	PF00069	0.656
MOD_CK1_1	604	610	PF00069	0.621
MOD_CK1_1	631	637	PF00069	0.646
MOD_CK1_1	642	648	PF00069	0.585
MOD_CK1_1	659	665	PF00069	0.523
MOD_CK1_1	70	76	PF00069	0.406
MOD_CK2_1	105	111	PF00069	0.400
MOD_CK2_1	135	141	PF00069	0.391
MOD_CK2_1	183	189	PF00069	0.544
MOD_CK2_1	190	196	PF00069	0.441
MOD_CK2_1	245	251	PF00069	0.445
MOD_CK2_1	35	41	PF00069	0.405
MOD_CK2_1	388	394	PF00069	0.593
MOD_CK2_1	398	404	PF00069	0.581
MOD_CK2_1	530	536	PF00069	0.588
MOD_CK2_1	539	545	PF00069	0.550
MOD_CK2_1	627	633	PF00069	0.547
MOD_Cter_Amidation	118	121	PF01082	0.389
MOD_Cter_Amidation	650	653	PF01082	0.611
MOD_GlcNHglycan	138	141	PF01048	0.410
MOD_GlcNHglycan	217	220	PF01048	0.546
MOD_GlcNHglycan	247	250	PF01048	0.459
MOD_GlcNHglycan	348	351	PF01048	0.418
MOD_GlcNHglycan	368	371	PF01048	0.467
MOD_GlcNHglycan	380	383	PF01048	0.595
MOD_GlcNHglycan	419	422	PF01048	0.605
MOD_GlcNHglycan	428	431	PF01048	0.535
MOD_GlcNHglycan	446	449	PF01048	0.673
MOD_GlcNHglycan	450	453	PF01048	0.603
MOD_GlcNHglycan	495	499	PF01048	0.596
MOD_GlcNHglycan	603	606	PF01048	0.635
MOD_GlcNHglycan	609	612	PF01048	0.594
MOD_GlcNHglycan	615	618	PF01048	0.544
MOD_GlcNHglycan	669	672	PF01048	0.762
MOD_GlcNHglycan	680	683	PF01048	0.616
MOD_GlcNHglycan	684	687	PF01048	0.573
MOD_GSK3_1	160	167	PF00069	0.454
MOD_GSK3_1	376	383	PF00069	0.785
MOD_GSK3_1	384	391	PF00069	0.581
MOD_GSK3_1	395	402	PF00069	0.509
MOD_GSK3_1	413	420	PF00069	0.515
MOD_GSK3_1	444	451	PF00069	0.703
MOD_GSK3_1	541	548	PF00069	0.671
MOD_GSK3_1	600	607	PF00069	0.632
MOD_GSK3_1	627	634	PF00069	0.659
MOD_GSK3_1	63	70	PF00069	0.377
MOD_GSK3_1	639	646	PF00069	0.545
MOD_GSK3_1	659	666	PF00069	0.531
MOD_GSK3_1	667	674	PF00069	0.554
MOD_GSK3_1	678	685	PF00069	0.621
MOD_GSK3_1	689	696	PF00069	0.583
MOD_GSK3_1	698	705	PF00069	0.517
MOD_LATS_1	312	318	PF00433	0.377
MOD_LATS_1	56	62	PF00433	0.340
MOD_N-GLC_1	175	180	PF02516	0.414
MOD_N-GLC_1	183	188	PF02516	0.479
MOD_N-GLC_1	438	443	PF02516	0.594
MOD_N-GLC_1	576	581	PF02516	0.549
MOD_N-GLC_1	627	632	PF02516	0.754
MOD_N-GLC_1	671	676	PF02516	0.548
MOD_NEK2_1	124	129	PF00069	0.337
MOD_NEK2_1	175	180	PF00069	0.521
MOD_NEK2_1	213	218	PF00069	0.562
MOD_NEK2_1	346	351	PF00069	0.417
MOD_NEK2_1	388	393	PF00069	0.560
MOD_NEK2_1	42	47	PF00069	0.424
MOD_NEK2_1	494	499	PF00069	0.612
MOD_NEK2_1	530	535	PF00069	0.564
MOD_NEK2_1	663	668	PF00069	0.691
MOD_PIKK_1	106	112	PF00454	0.338
MOD_PIKK_1	157	163	PF00454	0.521
MOD_PIKK_1	175	181	PF00454	0.359
MOD_PIKK_1	595	601	PF00454	0.608
MOD_PIKK_1	639	645	PF00454	0.626
MOD_PK_1	164	170	PF00069	0.389
MOD_PKA_2	136	142	PF00069	0.367
MOD_PKA_2	163	169	PF00069	0.378
MOD_PKA_2	200	206	PF00069	0.447
MOD_PKA_2	35	41	PF00069	0.383
MOD_PKA_2	468	474	PF00069	0.726
MOD_PKA_2	548	554	PF00069	0.626
MOD_PKA_2	595	601	PF00069	0.600
MOD_PKA_2	657	663	PF00069	0.583
MOD_PKA_2	678	684	PF00069	0.624
MOD_Plk_1	195	201	PF00069	0.486
MOD_Plk_1	627	633	PF00069	0.758
MOD_Plk_4	256	262	PF00069	0.480
MOD_Plk_4	290	296	PF00069	0.418
MOD_Plk_4	354	360	PF00069	0.607
MOD_Plk_4	643	649	PF00069	0.637
MOD_Plk_4	663	669	PF00069	0.497
MOD_ProDKin_1	371	377	PF00069	0.657
MOD_ProDKin_1	380	386	PF00069	0.569
MOD_ProDKin_1	406	412	PF00069	0.692
MOD_ProDKin_1	415	421	PF00069	0.611
MOD_ProDKin_1	634	640	PF00069	0.614
MOD_SUMO_rev_2	155	160	PF00179	0.455
TRG_DiLeu_BaEn_4	523	529	PF01217	0.522
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.601
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.437
TRG_ENDOCYTIC_2	128	131	PF00928	0.396
TRG_ENDOCYTIC_2	142	145	PF00928	0.419
TRG_ENDOCYTIC_2	3	6	PF00928	0.370
TRG_ENDOCYTIC_2	342	345	PF00928	0.339
TRG_ENDOCYTIC_2	86	89	PF00928	0.385
TRG_ER_diArg_1	149	151	PF00400	0.508
TRG_ER_diArg_1	152	154	PF00400	0.575
TRG_ER_diArg_1	204	206	PF00400	0.419
TRG_ER_diArg_1	297	300	PF00400	0.499
TRG_ER_diArg_1	308	311	PF00400	0.347
TRG_ER_diArg_1	34	37	PF00400	0.394
TRG_ER_diArg_1	371	373	PF00400	0.596
TRG_NLS_MonoExtN_4	466	473	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K7	Leptomonas seymouri	50%	100%
A0A3S7XCG9	Leishmania donovani	87%	100%
A4HQL1	Leishmania braziliensis	59%	97%
A4ICD1	Leishmania infantum	87%	100%
E9AUC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%