LeishMANIAdb
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Protein disulfide-isomerase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein disulfide-isomerase
Gene product:
protein disulfide isomerase 2
Species:
Leishmania major
UniProt:
Q4Q059_LEIMA
TriTrypDb:
LmjF.36.6940 , LMJLV39_360084900 * , LMJSD75_360084700
Length:
477

Annotations

LeishMANIAdb annotations

Appears to be a family of secreted proteins, probably ER-localized, like its homologs in other Eukaryotes.. Seems to carry a putative KDEL-like signal on its C-terminus.. Localization: Secreted (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 10, no: 1
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 2
GO:0005788 endoplasmic reticulum lumen 5 10
GO:0031974 membrane-enclosed lumen 2 10
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043233 organelle lumen 3 10
GO:0070013 intracellular organelle lumen 4 10
GO:0110165 cellular anatomical entity 1 11
GO:0016020 membrane 2 1

Expansion

Sequence features

Q4Q059
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q059

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 2
GO:0006950 response to stress 2 2
GO:0009987 cellular process 1 2
GO:0033554 cellular response to stress 3 2
GO:0034976 response to endoplasmic reticulum stress 4 2
GO:0050896 response to stimulus 1 2
GO:0051716 cellular response to stimulus 2 2
Molecular functions
Term Name Level Count
GO:0003756 protein disulfide isomerase activity 3 12
GO:0003824 catalytic activity 1 12
GO:0016853 isomerase activity 2 12
GO:0016860 intramolecular oxidoreductase activity 3 12
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 278 282 PF00656 0.420
CLV_NRD_NRD_1 195 197 PF00675 0.304
CLV_NRD_NRD_1 309 311 PF00675 0.426
CLV_PCSK_KEX2_1 309 311 PF00082 0.426
CLV_PCSK_SKI1_1 216 220 PF00082 0.334
CLV_PCSK_SKI1_1 3 7 PF00082 0.526
CLV_PCSK_SKI1_1 331 335 PF00082 0.478
CLV_PCSK_SKI1_1 394 398 PF00082 0.262
DEG_APCC_DBOX_1 2 10 PF00400 0.516
DEG_Nend_UBRbox_3 1 3 PF02207 0.586
DOC_MAPK_gen_1 140 148 PF00069 0.450
DOC_MAPK_gen_1 243 252 PF00069 0.492
DOC_MAPK_gen_1 270 277 PF00069 0.310
DOC_MAPK_MEF2A_6 445 454 PF00069 0.257
DOC_MAPK_MEF2A_6 89 96 PF00069 0.315
DOC_PP1_RVXF_1 243 250 PF00149 0.363
DOC_PP2B_LxvP_1 292 295 PF13499 0.375
DOC_PP4_FxxP_1 377 380 PF00568 0.281
DOC_PP4_FxxP_1 43 46 PF00568 0.315
DOC_USP7_MATH_1 188 192 PF00917 0.515
DOC_USP7_MATH_1 319 323 PF00917 0.236
DOC_USP7_MATH_1 462 466 PF00917 0.571
DOC_USP7_UBL2_3 334 338 PF12436 0.435
DOC_USP7_UBL2_3 85 89 PF12436 0.326
DOC_WW_Pin1_4 181 186 PF00397 0.443
DOC_WW_Pin1_4 205 210 PF00397 0.281
DOC_WW_Pin1_4 315 320 PF00397 0.304
LIG_BIR_III_2 344 348 PF00653 0.446
LIG_eIF4E_1 271 277 PF01652 0.426
LIG_FHA_1 141 147 PF00498 0.599
LIG_FHA_1 218 224 PF00498 0.393
LIG_FHA_1 354 360 PF00498 0.328
LIG_FHA_1 368 374 PF00498 0.281
LIG_FHA_1 91 97 PF00498 0.281
LIG_FHA_2 130 136 PF00498 0.438
LIG_FHA_2 152 158 PF00498 0.487
LIG_FHA_2 276 282 PF00498 0.349
LIG_FHA_2 410 416 PF00498 0.375
LIG_FHA_2 444 450 PF00498 0.352
LIG_FHA_2 68 74 PF00498 0.349
LIG_FHA_2 75 81 PF00498 0.282
LIG_GBD_Chelix_1 165 173 PF00786 0.446
LIG_GBD_Chelix_1 6 14 PF00786 0.574
LIG_LIR_Apic_2 428 433 PF02991 0.281
LIG_LIR_Gen_1 28 38 PF02991 0.343
LIG_LIR_Gen_1 4 13 PF02991 0.513
LIG_LIR_Nem_3 225 230 PF02991 0.384
LIG_LIR_Nem_3 233 238 PF02991 0.383
LIG_LIR_Nem_3 28 33 PF02991 0.343
LIG_LIR_Nem_3 283 288 PF02991 0.437
LIG_LIR_Nem_3 297 303 PF02991 0.194
LIG_LIR_Nem_3 362 366 PF02991 0.445
LIG_LIR_Nem_3 4 8 PF02991 0.514
LIG_LIR_Nem_3 424 429 PF02991 0.337
LIG_NRBOX 9 15 PF00104 0.519
LIG_OCRL_FandH_1 306 318 PF00620 0.281
LIG_PDZ_Class_3 472 477 PF00595 0.624
LIG_Pex14_2 303 307 PF04695 0.281
LIG_Pex14_2 377 381 PF04695 0.281
LIG_Pex14_2 43 47 PF04695 0.346
LIG_SH2_CRK 106 110 PF00017 0.426
LIG_SH2_CRK 285 289 PF00017 0.370
LIG_SH2_CRK 392 396 PF00017 0.254
LIG_SH2_NCK_1 392 396 PF00017 0.352
LIG_SH2_SRC 279 282 PF00017 0.281
LIG_SH2_STAP1 392 396 PF00017 0.341
LIG_SH2_STAT3 271 274 PF00017 0.426
LIG_SH2_STAT5 204 207 PF00017 0.424
LIG_SH2_STAT5 226 229 PF00017 0.420
LIG_SH2_STAT5 279 282 PF00017 0.281
LIG_SH2_STAT5 332 335 PF00017 0.518
LIG_SH2_STAT5 366 369 PF00017 0.341
LIG_SH2_STAT5 430 433 PF00017 0.313
LIG_SH2_STAT5 95 98 PF00017 0.380
LIG_SUMO_SIM_anti_2 37 42 PF11976 0.342
LIG_SUMO_SIM_par_1 263 269 PF11976 0.304
LIG_TRAF2_1 132 135 PF00917 0.344
LIG_TRAF2_1 472 475 PF00917 0.685
LIG_TRAF2_1 77 80 PF00917 0.304
LIG_WRC_WIRS_1 215 220 PF05994 0.282
MOD_CK1_1 153 159 PF00069 0.414
MOD_CK1_1 160 166 PF00069 0.385
MOD_CK1_1 168 174 PF00069 0.386
MOD_CK1_1 214 220 PF00069 0.414
MOD_CK1_1 398 404 PF00069 0.419
MOD_CK1_1 456 462 PF00069 0.557
MOD_CK1_1 469 475 PF00069 0.712
MOD_CK2_1 128 134 PF00069 0.420
MOD_CK2_1 151 157 PF00069 0.385
MOD_CK2_1 443 449 PF00069 0.401
MOD_CK2_1 469 475 PF00069 0.755
MOD_CK2_1 67 73 PF00069 0.466
MOD_CK2_1 74 80 PF00069 0.442
MOD_GlcNHglycan 18 21 PF01048 0.583
MOD_GlcNHglycan 220 223 PF01048 0.456
MOD_GlcNHglycan 257 260 PF01048 0.289
MOD_GlcNHglycan 34 37 PF01048 0.426
MOD_GlcNHglycan 422 426 PF01048 0.349
MOD_GlcNHglycan 460 463 PF01048 0.583
MOD_GlcNHglycan 464 467 PF01048 0.642
MOD_GlcNHglycan 468 471 PF01048 0.669
MOD_GSK3_1 153 160 PF00069 0.466
MOD_GSK3_1 214 221 PF00069 0.473
MOD_GSK3_1 315 322 PF00069 0.367
MOD_GSK3_1 32 39 PF00069 0.413
MOD_GSK3_1 421 428 PF00069 0.346
MOD_GSK3_1 458 465 PF00069 0.656
MOD_GSK3_1 74 81 PF00069 0.418
MOD_NEK2_1 1 6 PF00069 0.616
MOD_NEK2_1 218 223 PF00069 0.302
MOD_NEK2_1 260 265 PF00069 0.356
MOD_NEK2_1 409 414 PF00069 0.335
MOD_NEK2_1 421 426 PF00069 0.259
MOD_NEK2_1 453 458 PF00069 0.547
MOD_PIKK_1 168 174 PF00454 0.483
MOD_PIKK_1 270 276 PF00454 0.391
MOD_PIKK_1 367 373 PF00454 0.304
MOD_PKA_1 140 146 PF00069 0.394
MOD_Plk_1 36 42 PF00069 0.409
MOD_Plk_1 78 84 PF00069 0.492
MOD_Plk_4 114 120 PF00069 0.426
MOD_Plk_4 157 163 PF00069 0.448
MOD_Plk_4 190 196 PF00069 0.288
MOD_Plk_4 214 220 PF00069 0.382
MOD_Plk_4 260 266 PF00069 0.444
MOD_Plk_4 275 281 PF00069 0.348
MOD_Plk_4 337 343 PF00069 0.541
MOD_Plk_4 354 360 PF00069 0.366
MOD_Plk_4 36 42 PF00069 0.359
MOD_Plk_4 425 431 PF00069 0.281
MOD_Plk_4 90 96 PF00069 0.296
MOD_ProDKin_1 181 187 PF00069 0.437
MOD_ProDKin_1 205 211 PF00069 0.281
MOD_ProDKin_1 315 321 PF00069 0.304
MOD_SUMO_for_1 139 142 PF00179 0.415
MOD_SUMO_for_1 333 336 PF00179 0.531
MOD_SUMO_rev_2 296 301 PF00179 0.311
MOD_SUMO_rev_2 330 340 PF00179 0.443
MOD_SUMO_rev_2 81 91 PF00179 0.280
TRG_DiLeu_BaEn_2 448 454 PF01217 0.380
TRG_DiLeu_BaEn_4 134 140 PF01217 0.401
TRG_ENDOCYTIC_2 285 288 PF00928 0.432
TRG_ENDOCYTIC_2 392 395 PF00928 0.345
TRG_NES_CRM1_1 167 180 PF08389 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P805 Leptomonas seymouri 64% 100%
A0A0S4KL52 Bodo saltans 40% 100%
A0A1X0NMX9 Trypanosomatidae 46% 99%
A0A3Q8IS34 Leishmania donovani 94% 100%
A0A3R7L858 Trypanosoma rangeli 45% 99%
A3KPF5 Arabidopsis thaliana 26% 89%
A4HQL6 Leishmania braziliensis 77% 100%
A4ICD5 Leishmania infantum 94% 100%
D0A3S0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 96%
D3Z6P0 Mus musculus 30% 91%
D4B2L8 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) 35% 91%
E9AUD1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
P04785 Rattus norvegicus 30% 94%
P05307 Bos taurus 30% 94%
P07237 Homo sapiens 29% 94%
P08003 Mus musculus 32% 75%
P09102 Gallus gallus 30% 93%
P09103 Mus musculus 29% 94%
P11598 Rattus norvegicus 32% 94%
P12865 Trypanosoma brucei brucei 37% 96%
P13667 Homo sapiens 34% 74%
P17967 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 91%
P21195 Oryctolagus cuniculus 28% 94%
P27773 Mus musculus 32% 94%
P29828 Medicago sativa 33% 93%
P30101 Homo sapiens 32% 94%
P32474 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 92%
P34329 Caenorhabditis elegans 31% 77%
P38657 Bos taurus 33% 94%
P38658 Schistosoma mansoni 31% 99%
P38659 Rattus norvegicus 32% 74%
P52588 Zea mays 32% 93%
P52589 Triticum aestivum 33% 93%
P54399 Drosophila melanogaster 32% 96%
P55059 Humicola insolens 34% 94%
P80284 Hordeum vulgare 33% 93%
Q00002 Alternaria alternata 27% 100%
Q00248 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 34% 93%
Q0JD42 Oryza sativa subsp. japonica 24% 100%
Q10057 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 97%
Q12730 Aspergillus niger 32% 93%
Q13087 Homo sapiens 32% 91%
Q17770 Caenorhabditis elegans 32% 97%
Q17967 Caenorhabditis elegans 32% 98%
Q29RV1 Bos taurus 33% 74%
Q2HWU2 Macaca fuscata fuscata 29% 94%
Q43116 Ricinus communis 31% 96%
Q4VIT4 Chlorocebus aethiops 32% 94%
Q53LQ0 Oryza sativa subsp. japonica 34% 93%
Q54EN4 Dictyostelium discoideum 31% 93%
Q5R5B6 Pongo abelii 29% 94%
Q5RCH2 Pongo abelii 32% 91%
Q5RDG4 Pongo abelii 32% 94%
Q5WA72 Oryza sativa subsp. japonica 24% 89%
Q5XI02 Rattus norvegicus 21% 81%
Q66GQ3 Arabidopsis thaliana 27% 89%
Q67IX6 Oryza sativa subsp. japonica 30% 85%
Q69ST6 Oryza sativa subsp. japonica 29% 88%
Q7XRB5 Oryza sativa subsp. japonica 30% 92%
Q8JG64 Gallus gallus 32% 94%
Q8N807 Homo sapiens 21% 82%
Q8R4U2 Cricetulus griseus 29% 94%
Q8VX13 Arabidopsis thaliana 31% 82%
Q95LM0 Macaca fascicularis 21% 82%
Q9DAN1 Mus musculus 21% 81%
Q9FF55 Arabidopsis thaliana 29% 80%
Q9SRG3 Arabidopsis thaliana 32% 94%
Q9XI01 Arabidopsis thaliana 32% 95%
V5BHP7 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS