Delta-6 fatty acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

delta-6 fatty acid desaturase

Species:

Leishmania major

UniProt:

Q4Q058_LEIMA

TriTrypDb:

LmjF.36.6950 , LMJLV39_360085000 , LMJSD75_360084800

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q058

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q058

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	9
GO:0008152	metabolic process	1	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016491	oxidoreductase activity	2	9
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	2
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.505
CLV_MEL_PAP_1	268	274	PF00089	0.239
CLV_NRD_NRD_1	104	106	PF00675	0.400
CLV_NRD_NRD_1	192	194	PF00675	0.268
CLV_NRD_NRD_1	220	222	PF00675	0.254
CLV_NRD_NRD_1	352	354	PF00675	0.309
CLV_NRD_NRD_1	355	357	PF00675	0.302
CLV_PCSK_KEX2_1	104	106	PF00082	0.389
CLV_PCSK_KEX2_1	220	222	PF00082	0.254
CLV_PCSK_KEX2_1	352	354	PF00082	0.334
CLV_PCSK_KEX2_1	68	70	PF00082	0.368
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.392
CLV_PCSK_SKI1_1	131	135	PF00082	0.528
CLV_PCSK_SKI1_1	244	248	PF00082	0.528
CLV_PCSK_SKI1_1	352	356	PF00082	0.318
CLV_PCSK_SKI1_1	49	53	PF00082	0.332
CLV_PCSK_SKI1_1	68	72	PF00082	0.275
DEG_APCC_DBOX_1	130	138	PF00400	0.294
DEG_APCC_DBOX_1	251	259	PF00400	0.378
DEG_APCC_DBOX_1	270	278	PF00400	0.158
DOC_CYCLIN_RxL_1	66	79	PF00134	0.595
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.641
DOC_MAPK_gen_1	104	110	PF00069	0.542
DOC_MAPK_gen_1	66	75	PF00069	0.572
DOC_MAPK_MEF2A_6	112	120	PF00069	0.371
DOC_MAPK_MEF2A_6	82	89	PF00069	0.536
DOC_PP2B_LxvP_1	208	211	PF13499	0.505
DOC_PP2B_LxvP_1	5	8	PF13499	0.634
DOC_USP7_MATH_1	211	215	PF00917	0.540
DOC_USP7_MATH_1	246	250	PF00917	0.340
DOC_USP7_MATH_1	390	394	PF00917	0.614
DOC_WW_Pin1_4	3	8	PF00397	0.694
DOC_WW_Pin1_4	385	390	PF00397	0.584
LIG_14-3-3_CanoR_1	221	227	PF00244	0.583
LIG_14-3-3_CanoR_1	239	244	PF00244	0.324
LIG_14-3-3_CanoR_1	271	275	PF00244	0.239
LIG_14-3-3_CanoR_1	33	37	PF00244	0.505
LIG_14-3-3_CanoR_1	356	365	PF00244	0.528
LIG_Actin_WH2_2	229	246	PF00022	0.419
LIG_Actin_WH2_2	60	78	PF00022	0.585
LIG_AP2alpha_2	321	323	PF02296	0.528
LIG_BRCT_BRCA1_1	129	133	PF00533	0.435
LIG_BRCT_BRCA1_1	241	245	PF00533	0.371
LIG_BRCT_BRCA1_1	319	323	PF00533	0.511
LIG_BRCT_BRCA1_1	85	89	PF00533	0.526
LIG_BRCT_BRCA1_2	85	91	PF00533	0.555
LIG_CSL_BTD_1	208	211	PF09270	0.505
LIG_deltaCOP1_diTrp_1	23	32	PF00928	0.481
LIG_deltaCOP1_diTrp_1	325	328	PF00928	0.505
LIG_deltaCOP1_diTrp_1	369	379	PF00928	0.621
LIG_deltaCOP1_diTrp_1	99	106	PF00928	0.551
LIG_DLG_GKlike_1	239	247	PF00625	0.419
LIG_eIF4E_1	262	268	PF01652	0.340
LIG_FHA_1	134	140	PF00498	0.315
LIG_FHA_1	223	229	PF00498	0.579
LIG_FHA_1	312	318	PF00498	0.505
LIG_FHA_1	386	392	PF00498	0.597
LIG_LIR_Apic_2	128	132	PF02991	0.326
LIG_LIR_Gen_1	301	308	PF02991	0.482
LIG_LIR_Gen_1	321	331	PF02991	0.342
LIG_LIR_Gen_1	86	96	PF02991	0.524
LIG_LIR_Nem_3	125	129	PF02991	0.458
LIG_LIR_Nem_3	301	307	PF02991	0.466
LIG_LIR_Nem_3	321	327	PF02991	0.342
LIG_LIR_Nem_3	52	58	PF02991	0.481
LIG_LIR_Nem_3	86	92	PF02991	0.528
LIG_LYPXL_yS_3	348	351	PF13949	0.540
LIG_PCNA_PIPBox_1	332	341	PF02747	0.481
LIG_Pex14_1	106	110	PF04695	0.481
LIG_Pex14_2	102	106	PF04695	0.551
LIG_Pex14_2	175	179	PF04695	0.495
LIG_Pex14_2	323	327	PF04695	0.481
LIG_SH2_CRK	129	133	PF00017	0.338
LIG_SH2_CRK	231	235	PF00017	0.343
LIG_SH2_CRK	304	308	PF00017	0.481
LIG_SH2_NCK_1	129	133	PF00017	0.435
LIG_SH2_STAP1	224	228	PF00017	0.366
LIG_SH2_STAP1	231	235	PF00017	0.310
LIG_SH2_STAT5	126	129	PF00017	0.467
LIG_SH2_STAT5	224	227	PF00017	0.408
LIG_SH2_STAT5	235	238	PF00017	0.305
LIG_SH2_STAT5	262	265	PF00017	0.301
LIG_SH2_STAT5	306	309	PF00017	0.495
LIG_SH3_3	338	344	PF00018	0.481
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.305
LIG_TRFH_1	3	7	PF08558	0.649
LIG_TYR_ITIM	260	265	PF00017	0.305
MOD_CDK_SPxxK_3	3	10	PF00069	0.638
MOD_CK1_1	214	220	PF00069	0.528
MOD_CK1_1	273	279	PF00069	0.454
MOD_CK1_1	384	390	PF00069	0.466
MOD_CK1_1	57	63	PF00069	0.505
MOD_GlcNHglycan	248	251	PF01048	0.540
MOD_GlcNHglycan	392	395	PF01048	0.519
MOD_GlcNHglycan	397	400	PF01048	0.542
MOD_GSK3_1	28	35	PF00069	0.505
MOD_GSK3_1	381	388	PF00069	0.480
MOD_LATS_1	47	53	PF00433	0.540
MOD_N-GLC_2	166	168	PF02516	0.211
MOD_NEK2_1	127	132	PF00069	0.341
MOD_NEK2_1	133	138	PF00069	0.337
MOD_NEK2_1	234	239	PF00069	0.352
MOD_NEK2_1	253	258	PF00069	0.340
MOD_NEK2_2	222	227	PF00069	0.578
MOD_NEK2_2	54	59	PF00069	0.540
MOD_PKA_1	356	362	PF00069	0.490
MOD_PKA_2	270	276	PF00069	0.239
MOD_PKA_2	311	317	PF00069	0.479
MOD_PKA_2	32	38	PF00069	0.481
MOD_Plk_1	253	259	PF00069	0.340
MOD_Plk_1	27	33	PF00069	0.487
MOD_Plk_4	122	128	PF00069	0.343
MOD_Plk_4	133	139	PF00069	0.337
MOD_Plk_4	222	228	PF00069	0.507
MOD_Plk_4	253	259	PF00069	0.374
MOD_Plk_4	273	279	PF00069	0.142
MOD_ProDKin_1	3	9	PF00069	0.692
MOD_ProDKin_1	385	391	PF00069	0.588
MOD_SUMO_rev_2	393	398	PF00179	0.588
TRG_DiLeu_BaEn_1	350	355	PF01217	0.411
TRG_DiLeu_BaEn_2	202	208	PF01217	0.540
TRG_DiLeu_LyEn_5	350	355	PF01217	0.411
TRG_ENDOCYTIC_2	231	234	PF00928	0.379
TRG_ENDOCYTIC_2	262	265	PF00928	0.281
TRG_ENDOCYTIC_2	304	307	PF00928	0.481
TRG_ENDOCYTIC_2	348	351	PF00928	0.540
TRG_ER_diArg_1	104	106	PF00400	0.625
TRG_ER_diArg_1	220	222	PF00400	0.456
TRG_ER_diArg_1	351	353	PF00400	0.537
TRG_NES_CRM1_1	65	79	PF08389	0.626
TRG_NLS_MonoExtN_4	66	72	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PRW9	Tachysurus fulvidraco	26%	90%
A0A0N1HZP4	Leptomonas seymouri	24%	97%
A0A0N1IMB2	Leptomonas seymouri	81%	100%
A0A0N1PAQ6	Leptomonas seymouri	26%	96%
A0A0S4IVF3	Bodo saltans	24%	93%
A0A0S4KLP1	Bodo saltans	55%	100%
A0A1X0NMZ1	Trypanosomatidae	67%	100%
A0A1X0NPK3	Trypanosomatidae	22%	95%
A0A3Q8I9Z6	Leishmania donovani	24%	97%
A0A3Q8IK71	Leishmania donovani	97%	100%
A0A3S5H618	Leishmania donovani	24%	96%
A0A422NCE1	Trypanosoma rangeli	23%	94%
A0PJ29	Rebecca salina	22%	89%
A4FV48	Bos taurus	24%	90%
A4H558	Leishmania braziliensis	23%	96%
A4H7V4	Leishmania braziliensis	22%	97%
A4HQL7	Leishmania braziliensis	90%	100%
A4HTD5	Leishmania infantum	24%	96%
A4HW80	Leishmania infantum	24%	97%
A4IFP3	Bos taurus	26%	90%
A4KDP0	Rebecca salina	27%	94%
A4KDP1	Rebecca salina	26%	94%
A4UVI1	Papio anubis	26%	90%
B2KKL4	Siganus canaliculatus	25%	90%
B8R1K0	Papio anubis	22%	90%
C4QVU3	Komagataella phaffii (strain GS115 / ATCC 20864)	23%	74%
D8X2C5	Siganus canaliculatus	26%	90%
E9AI08	Leishmania infantum	97%	100%
E9ALC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	96%
E9APY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	97%
E9AUD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
G5EG11	Caenorhabditis elegans	29%	89%
I2CYZ4	Chlamydomonas reinhardtii	24%	78%
O04353	Borago officinalis	25%	89%
O60427	Homo sapiens	26%	90%
O74212	Mortierella alpina	21%	90%
O95864	Homo sapiens	22%	90%
P19967	Drosophila melanogaster	26%	92%
Q08871	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
Q0VAX3	Mus musculus	25%	82%
Q23221	Caenorhabditis elegans	27%	90%
Q3EBF7	Arabidopsis thaliana	25%	89%
Q43469	Helianthus annuus	27%	87%
Q4QFK0	Leishmania major	23%	93%
Q4QIH7	Leishmania major	25%	96%
Q4R749	Macaca fascicularis	22%	90%
Q5REA7	Pongo abelii	22%	90%
Q6CMK7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	21%	70%
Q6DDK2	Xenopus laevis	25%	90%
Q8K1P9	Rattus norvegicus	26%	89%
Q8NKG8	Kluyveromyces lactis	21%	70%
Q8NKG9	Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651)	23%	70%
Q8S3C1	Thraustochytrium sp.	21%	91%
Q920L1	Mus musculus	26%	89%
Q920R3	Rattus norvegicus	26%	89%
Q9DEX7	Danio rerio	23%	90%
Q9FR82	Borago officinalis	27%	90%
Q9JJE7	Mus musculus	27%	89%
Q9LEM9	Ceratodon purpureus	29%	77%
Q9LEN0	Ceratodon purpureus	27%	83%
Q9SWQ9	Euglena gracilis	30%	95%
Q9Y1W0	Dictyostelium discoideum	20%	86%
Q9Y5Q0	Homo sapiens	27%	90%
Q9Z0R9	Mus musculus	24%	90%
Q9Z122	Rattus norvegicus	23%	90%
Q9ZNW2	Physcomitrium patens	27%	76%
Q9ZRP7	Arabidopsis thaliana	24%	89%