Putative eukaryotic translation initiation factor 3 subunit 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit c

Species:

Leishmania major

UniProt:

Q4Q055_LEIMA

TriTrypDb:

LmjF.36.6980 , LMJLV39_360085300 , LMJSD75_360085100

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005852	eukaryotic translation initiation factor 3 complex	2	10
GO:0032991	protein-containing complex	1	10
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q055

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q055

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003743	translation initiation factor activity	4	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0031369	translation initiation factor binding	3	10
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.505
CLV_C14_Caspase3-7	7	11	PF00656	0.595
CLV_NRD_NRD_1	208	210	PF00675	0.519
CLV_NRD_NRD_1	229	231	PF00675	0.582
CLV_NRD_NRD_1	232	234	PF00675	0.611
CLV_NRD_NRD_1	330	332	PF00675	0.305
CLV_NRD_NRD_1	351	353	PF00675	0.315
CLV_NRD_NRD_1	598	600	PF00675	0.474
CLV_NRD_NRD_1	642	644	PF00675	0.549
CLV_NRD_NRD_1	93	95	PF00675	0.514
CLV_PCSK_KEX2_1	229	231	PF00082	0.570
CLV_PCSK_KEX2_1	332	334	PF00082	0.300
CLV_PCSK_KEX2_1	351	353	PF00082	0.401
CLV_PCSK_KEX2_1	600	602	PF00082	0.448
CLV_PCSK_KEX2_1	642	644	PF00082	0.549
CLV_PCSK_KEX2_1	83	85	PF00082	0.449
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.302
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.415
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.449
CLV_PCSK_SKI1_1	132	136	PF00082	0.446
CLV_PCSK_SKI1_1	17	21	PF00082	0.682
CLV_PCSK_SKI1_1	233	237	PF00082	0.589
CLV_PCSK_SKI1_1	244	248	PF00082	0.499
CLV_PCSK_SKI1_1	309	313	PF00082	0.318
CLV_PCSK_SKI1_1	374	378	PF00082	0.241
CLV_PCSK_SKI1_1	485	489	PF00082	0.375
CLV_PCSK_SKI1_1	498	502	PF00082	0.272
CLV_PCSK_SKI1_1	76	80	PF00082	0.463
DEG_Nend_UBRbox_3	1	3	PF02207	0.658
DEG_SPOP_SBC_1	5	9	PF00917	0.650
DOC_CYCLIN_yClb1_LxF_4	126	131	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	501	504	PF00134	0.502
DOC_MAPK_gen_1	132	140	PF00069	0.536
DOC_MAPK_gen_1	209	217	PF00069	0.488
DOC_MAPK_gen_1	229	237	PF00069	0.351
DOC_MAPK_gen_1	605	614	PF00069	0.387
DOC_MAPK_MEF2A_6	338	345	PF00069	0.569
DOC_MAPK_MEF2A_6	381	390	PF00069	0.602
DOC_MAPK_MEF2A_6	605	613	PF00069	0.387
DOC_MAPK_RevD_3	339	352	PF00069	0.529
DOC_PP1_RVXF_1	126	132	PF00149	0.534
DOC_PP1_RVXF_1	307	314	PF00149	0.569
DOC_PP2B_LxvP_1	500	503	PF13499	0.485
DOC_USP7_MATH_1	5	9	PF00917	0.650
DOC_USP7_MATH_1	55	59	PF00917	0.469
DOC_USP7_UBL2_3	146	150	PF12436	0.537
DOC_USP7_UBL2_3	247	251	PF12436	0.509
DOC_USP7_UBL2_3	596	600	PF12436	0.458
DOC_WW_Pin1_4	478	483	PF00397	0.602
DOC_WW_Pin1_4	547	552	PF00397	0.527
LIG_14-3-3_CanoR_1	619	628	PF00244	0.490
LIG_Actin_WH2_2	295	311	PF00022	0.569
LIG_Actin_WH2_2	376	393	PF00022	0.505
LIG_Actin_WH2_2	451	468	PF00022	0.569
LIG_Actin_WH2_2	557	574	PF00022	0.401
LIG_BRCT_BRCA1_1	341	345	PF00533	0.605
LIG_deltaCOP1_diTrp_1	240	248	PF00928	0.502
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.427
LIG_EH_1	29	33	PF12763	0.609
LIG_eIF4E_1	288	294	PF01652	0.529
LIG_FHA_1	142	148	PF00498	0.569
LIG_FHA_1	289	295	PF00498	0.535
LIG_FHA_1	364	370	PF00498	0.503
LIG_FHA_1	422	428	PF00498	0.489
LIG_FHA_1	548	554	PF00498	0.543
LIG_FHA_1	589	595	PF00498	0.390
LIG_FHA_1	622	628	PF00498	0.424
LIG_FHA_2	175	181	PF00498	0.517
LIG_FHA_2	211	217	PF00498	0.530
LIG_FHA_2	35	41	PF00498	0.569
LIG_FHA_2	585	591	PF00498	0.551
LIG_GBD_Chelix_1	515	523	PF00786	0.347
LIG_IBAR_NPY_1	532	534	PF08397	0.574
LIG_LIR_Gen_1	178	188	PF02991	0.571
LIG_LIR_Gen_1	297	307	PF02991	0.509
LIG_LIR_Gen_1	375	383	PF02991	0.521
LIG_LIR_Gen_1	587	594	PF02991	0.467
LIG_LIR_Gen_1	620	630	PF02991	0.471
LIG_LIR_Gen_1	662	673	PF02991	0.441
LIG_LIR_Nem_3	130	134	PF02991	0.424
LIG_LIR_Nem_3	178	184	PF02991	0.581
LIG_LIR_Nem_3	297	302	PF02991	0.506
LIG_LIR_Nem_3	304	310	PF02991	0.479
LIG_LIR_Nem_3	342	348	PF02991	0.624
LIG_LIR_Nem_3	375	380	PF02991	0.521
LIG_LIR_Nem_3	494	500	PF02991	0.485
LIG_LIR_Nem_3	587	592	PF02991	0.553
LIG_LIR_Nem_3	662	668	PF02991	0.419
LIG_NRBOX	518	524	PF00104	0.557
LIG_NRP_CendR_1	728	731	PF00754	0.744
LIG_PCNA_PIPBox_1	110	119	PF02747	0.637
LIG_PCNA_PIPBox_1	407	416	PF02747	0.569
LIG_PCNA_yPIPBox_3	407	418	PF02747	0.569
LIG_PCNA_yPIPBox_3	443	454	PF02747	0.569
LIG_PCNA_yPIPBox_3	652	661	PF02747	0.473
LIG_Pex14_1	242	246	PF04695	0.374
LIG_Pex14_1	248	252	PF04695	0.380
LIG_Pex14_2	32	36	PF04695	0.626
LIG_Rb_pABgroove_1	339	347	PF01858	0.529
LIG_REV1ctd_RIR_1	250	259	PF16727	0.464
LIG_SH2_CRK	181	185	PF00017	0.551
LIG_SH2_CRK	360	364	PF00017	0.569
LIG_SH2_CRK	497	501	PF00017	0.563
LIG_SH2_CRK	544	548	PF00017	0.441
LIG_SH2_GRB2like	212	215	PF00017	0.532
LIG_SH2_GRB2like	616	619	PF00017	0.494
LIG_SH2_NCK_1	544	548	PF00017	0.549
LIG_SH2_SRC	406	409	PF00017	0.567
LIG_SH2_STAP1	181	185	PF00017	0.555
LIG_SH2_STAT5	212	215	PF00017	0.474
LIG_SH2_STAT5	288	291	PF00017	0.570
LIG_SH2_STAT5	307	310	PF00017	0.408
LIG_SH2_STAT5	420	423	PF00017	0.563
LIG_SH2_STAT5	542	545	PF00017	0.432
LIG_SH2_STAT5	576	579	PF00017	0.427
LIG_SH2_STAT5	602	605	PF00017	0.488
LIG_SH2_STAT5	616	619	PF00017	0.381
LIG_SH2_STAT5	665	668	PF00017	0.416
LIG_SUMO_SIM_anti_2	136	145	PF11976	0.487
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.569
LIG_SUMO_SIM_anti_2	364	373	PF11976	0.564
LIG_SUMO_SIM_anti_2	608	613	PF11976	0.463
LIG_SUMO_SIM_par_1	136	145	PF11976	0.546
LIG_TRAF2_1	303	306	PF00917	0.529
LIG_TRAF2_1	37	40	PF00917	0.652
LIG_TYR_ITIM	358	363	PF00017	0.569
LIG_TYR_ITIM	566	571	PF00017	0.500
LIG_WRC_WIRS_1	310	315	PF05994	0.505
LIG_WRC_WIRS_1	586	591	PF05994	0.526
LIG_WRC_WIRS_1	89	94	PF05994	0.374
MOD_CDK_SPxxK_3	478	485	PF00069	0.529
MOD_CK1_1	15	21	PF00069	0.612
MOD_CK1_1	238	244	PF00069	0.485
MOD_CK1_1	362	368	PF00069	0.569
MOD_CK1_1	517	523	PF00069	0.529
MOD_CK1_1	623	629	PF00069	0.517
MOD_CK1_1	650	656	PF00069	0.499
MOD_CK1_1	8	14	PF00069	0.596
MOD_CK2_1	130	136	PF00069	0.457
MOD_CK2_1	174	180	PF00069	0.631
MOD_CK2_1	210	216	PF00069	0.617
MOD_CK2_1	294	300	PF00069	0.569
MOD_CK2_1	34	40	PF00069	0.550
MOD_CK2_1	556	562	PF00069	0.502
MOD_CK2_1	71	77	PF00069	0.454
MOD_CK2_1	8	14	PF00069	0.590
MOD_CMANNOS	33	36	PF00535	0.627
MOD_GlcNHglycan	186	191	PF01048	0.572
MOD_GlcNHglycan	216	220	PF01048	0.495
MOD_GlcNHglycan	224	227	PF01048	0.504
MOD_GlcNHglycan	396	399	PF01048	0.335
MOD_GlcNHglycan	519	522	PF01048	0.386
MOD_GlcNHglycan	655	658	PF01048	0.546
MOD_GSK3_1	284	291	PF00069	0.635
MOD_GSK3_1	359	366	PF00069	0.570
MOD_GSK3_1	372	379	PF00069	0.513
MOD_GSK3_1	390	397	PF00069	0.521
MOD_GSK3_1	4	11	PF00069	0.700
MOD_GSK3_1	426	433	PF00069	0.525
MOD_GSK3_1	543	550	PF00069	0.512
MOD_GSK3_1	584	591	PF00069	0.492
MOD_GSK3_1	617	624	PF00069	0.545
MOD_GSK3_1	647	654	PF00069	0.465
MOD_GSK3_1	681	688	PF00069	0.511
MOD_N-GLC_1	294	299	PF02516	0.369
MOD_N-GLC_1	617	622	PF02516	0.542
MOD_N-GLC_1	651	656	PF02516	0.495
MOD_N-GLC_1	671	676	PF02516	0.534
MOD_N-GLC_1	71	76	PF02516	0.569
MOD_NEK2_1	215	220	PF00069	0.379
MOD_NEK2_1	359	364	PF00069	0.569
MOD_NEK2_1	396	401	PF00069	0.574
MOD_NEK2_1	4	9	PF00069	0.696
MOD_NEK2_1	421	426	PF00069	0.565
MOD_NEK2_1	464	469	PF00069	0.628
MOD_NEK2_1	614	619	PF00069	0.465
MOD_PIKK_1	301	307	PF00454	0.539
MOD_PKA_1	229	235	PF00069	0.601
MOD_PKA_2	229	235	PF00069	0.562
MOD_PKA_2	390	396	PF00069	0.540
MOD_Plk_1	15	21	PF00069	0.637
MOD_Plk_1	215	221	PF00069	0.458
MOD_Plk_1	266	272	PF00069	0.529
MOD_Plk_1	620	626	PF00069	0.527
MOD_Plk_1	650	656	PF00069	0.501
MOD_Plk_1	671	677	PF00069	0.530
MOD_Plk_1	71	77	PF00069	0.560
MOD_Plk_2-3	10	16	PF00069	0.660
MOD_Plk_2-3	130	136	PF00069	0.491
MOD_Plk_4	15	21	PF00069	0.678
MOD_Plk_4	284	290	PF00069	0.646
MOD_Plk_4	367	373	PF00069	0.535
MOD_Plk_4	483	489	PF00069	0.529
MOD_Plk_4	514	520	PF00069	0.502
MOD_Plk_4	623	629	PF00069	0.410
MOD_Plk_4	88	94	PF00069	0.585
MOD_ProDKin_1	478	484	PF00069	0.602
MOD_ProDKin_1	547	553	PF00069	0.535
MOD_SUMO_for_1	50	53	PF00179	0.555
MOD_SUMO_for_1	526	529	PF00179	0.512
MOD_SUMO_rev_2	124	134	PF00179	0.579
TRG_DiLeu_BaEn_1	136	141	PF01217	0.440
TRG_DiLeu_BaEn_1	496	501	PF01217	0.564
TRG_DiLeu_BaEn_1	608	613	PF01217	0.477
TRG_DiLeu_BaEn_2	87	93	PF01217	0.532
TRG_DiLeu_BaEn_4	142	148	PF01217	0.469
TRG_ENDOCYTIC_2	181	184	PF00928	0.559
TRG_ENDOCYTIC_2	212	215	PF00928	0.505
TRG_ENDOCYTIC_2	307	310	PF00928	0.485
TRG_ENDOCYTIC_2	360	363	PF00928	0.485
TRG_ENDOCYTIC_2	497	500	PF00928	0.502
TRG_ENDOCYTIC_2	544	547	PF00928	0.436
TRG_ENDOCYTIC_2	568	571	PF00928	0.486
TRG_ENDOCYTIC_2	665	668	PF00928	0.425
TRG_ER_diArg_1	228	230	PF00400	0.498
TRG_ER_diArg_1	331	334	PF00400	0.579
TRG_ER_diArg_1	599	602	PF00400	0.450
TRG_ER_diArg_1	641	643	PF00400	0.539
TRG_NES_CRM1_1	584	597	PF08389	0.374
TRG_NLS_Bipartite_1	83	98	PF00514	0.461
TRG_NLS_MonoExtN_4	596	603	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	411	416	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I262	Leptomonas seymouri	76%	99%
A0A1X0NL84	Trypanosomatidae	39%	100%
A0A3Q8IWP7	Leishmania donovani	98%	100%
A0A422NVW4	Trypanosoma rangeli	39%	100%
A4HQM0	Leishmania braziliensis	93%	100%
A4ICD8	Leishmania infantum	98%	100%
A7E471	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	21%	84%
E9AUD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QR58	Xenopus laevis	23%	79%
Q54X97	Dictyostelium discoideum	23%	78%
Q6BJF7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	86%
Q6P1V4	Xenopus tropicalis	22%	79%
Q6PFQ2	Danio rerio	22%	79%
Q8R1B4	Mus musculus	22%	80%
V5DDW8	Trypanosoma cruzi	39%	100%