Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q053_LEIMA

TriTrypDb:

LmjF.36.6990 , LMJLV39_360085600 , LMJSD75_360085400

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000123	histone acetyltransferase complex	4	6
GO:0031248	protein acetyltransferase complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0072487	MSL complex	6	6
GO:0140535	intracellular protein-containing complex	2	6
GO:1902493	acetyltransferase complex	4	6
GO:1902494	catalytic complex	2	6
GO:1902562	H4 histone acetyltransferase complex	5	6
GO:1990234	transferase complex	3	6

Expansion

Sequence features

Q4Q053

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q053

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	10
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	10
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	10
GO:0010556	regulation of macromolecule biosynthetic process	5	10
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	10
GO:0019222	regulation of metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	10
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0045892	negative regulation of DNA-templated transcription	7	2
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0045944	positive regulation of transcription by RNA polymerase II	8	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0051171	regulation of nitrogen compound metabolic process	4	10
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	10
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	10
GO:0065007	biological regulation	1	10
GO:0080090	regulation of primary metabolic process	4	10
GO:1902679	negative regulation of RNA biosynthetic process	7	2
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	10
GO:1903507	negative regulation of nucleic acid-templated transcription	8	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	10

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	2
GO:0003824	catalytic activity	1	10
GO:0004402	histone acetyltransferase activity	4	10
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008080	N-acetyltransferase activity	6	10
GO:0010485	histone H4 acetyltransferase activity	5	2
GO:0016407	acetyltransferase activity	5	10
GO:0016410	N-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0034212	peptide N-acetyltransferase activity	7	10
GO:0042393	histone binding	3	2
GO:0046972	histone H4K16 acetyltransferase activity	6	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0140110	transcription regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.362
CLV_NRD_NRD_1	259	261	PF00675	0.531
CLV_NRD_NRD_1	265	267	PF00675	0.485
CLV_NRD_NRD_1	73	75	PF00675	0.266
CLV_NRD_NRD_1	82	84	PF00675	0.265
CLV_NRD_NRD_1	92	94	PF00675	0.267
CLV_PCSK_KEX2_1	259	261	PF00082	0.492
CLV_PCSK_KEX2_1	264	266	PF00082	0.485
CLV_PCSK_KEX2_1	73	75	PF00082	0.292
CLV_PCSK_KEX2_1	92	94	PF00082	0.190
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.474
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.460
CLV_PCSK_PC7_1	260	266	PF00082	0.439
CLV_PCSK_PC7_1	69	75	PF00082	0.290
CLV_PCSK_SKI1_1	260	264	PF00082	0.509
CLV_PCSK_SKI1_1	99	103	PF00082	0.278
DEG_MDM2_SWIB_1	194	202	PF02201	0.464
DEG_Nend_UBRbox_3	1	3	PF02207	0.549
DOC_CKS1_1	179	184	PF01111	0.565
DOC_MAPK_gen_1	73	79	PF00069	0.464
DOC_MAPK_MEF2A_6	247	254	PF00069	0.541
DOC_PP1_RVXF_1	269	275	PF00149	0.541
DOC_PP4_FxxP_1	60	63	PF00568	0.430
DOC_USP7_MATH_1	11	15	PF00917	0.446
DOC_USP7_MATH_1	155	159	PF00917	0.484
DOC_WW_Pin1_4	178	183	PF00397	0.464
DOC_WW_Pin1_4	211	216	PF00397	0.510
DOC_WW_Pin1_4	7	12	PF00397	0.510
LIG_14-3-3_CanoR_1	12	16	PF00244	0.483
LIG_14-3-3_CanoR_1	167	171	PF00244	0.565
LIG_BRCT_BRCA1_1	23	27	PF00533	0.491
LIG_BRCT_BRCA1_1	56	60	PF00533	0.435
LIG_BRCT_BRCA1_1	97	101	PF00533	0.505
LIG_Clathr_ClatBox_1	100	104	PF01394	0.565
LIG_Clathr_ClatBox_1	119	123	PF01394	0.329
LIG_CSL_BTD_1	60	63	PF09270	0.430
LIG_deltaCOP1_diTrp_1	136	141	PF00928	0.398
LIG_FHA_1	30	36	PF00498	0.463
LIG_FHA_2	105	111	PF00498	0.468
LIG_FHA_2	215	221	PF00498	0.539
LIG_LIR_Apic_2	57	63	PF02991	0.456
LIG_LIR_Gen_1	115	122	PF02991	0.514
LIG_LIR_Gen_1	124	133	PF02991	0.445
LIG_LIR_Gen_1	138	147	PF02991	0.482
LIG_LIR_Gen_1	201	209	PF02991	0.482
LIG_LIR_Nem_3	110	116	PF02991	0.464
LIG_LIR_Nem_3	124	130	PF02991	0.464
LIG_LIR_Nem_3	14	18	PF02991	0.447
LIG_LIR_Nem_3	158	164	PF02991	0.505
LIG_LIR_Nem_3	201	207	PF02991	0.482
LIG_Pex14_2	116	120	PF04695	0.475
LIG_Pex14_2	129	133	PF04695	0.441
LIG_Pex14_2	194	198	PF04695	0.464
LIG_SH2_SRC	170	173	PF00017	0.482
LIG_SH2_STAT5	132	135	PF00017	0.464
LIG_SH2_STAT5	34	37	PF00017	0.400
LIG_SH2_STAT5	41	44	PF00017	0.356
LIG_SH3_3	149	155	PF00018	0.450
LIG_SH3_3	176	182	PF00018	0.469
LIG_SH3_3	5	11	PF00018	0.511
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.464
LIG_SUMO_SIM_anti_2	238	244	PF11976	0.458
LIG_SUMO_SIM_par_1	214	220	PF11976	0.482
LIG_SUMO_SIM_par_1	230	238	PF11976	0.482
LIG_UBA3_1	96	105	PF00899	0.576
LIG_WRC_WIRS_1	113	118	PF05994	0.565
LIG_WRC_WIRS_1	161	166	PF05994	0.510
LIG_WRC_WIRS_1	40	45	PF05994	0.439
MOD_CDK_SPK_2	7	12	PF00069	0.510
MOD_CDK_SPxK_1	178	184	PF00069	0.464
MOD_CK1_1	139	145	PF00069	0.565
MOD_CK1_1	214	220	PF00069	0.486
MOD_CK1_1	222	228	PF00069	0.444
MOD_CK2_1	214	220	PF00069	0.491
MOD_Cter_Amidation	81	84	PF01082	0.273
MOD_GlcNHglycan	188	191	PF01048	0.296
MOD_GlcNHglycan	275	278	PF01048	0.654
MOD_GSK3_1	131	138	PF00069	0.518
MOD_GSK3_1	139	146	PF00069	0.491
MOD_GSK3_1	219	226	PF00069	0.554
MOD_GSK3_1	272	279	PF00069	0.596
MOD_GSK3_1	35	42	PF00069	0.354
MOD_GSK3_1	7	14	PF00069	0.452
MOD_N-GLC_1	254	259	PF02516	0.571
MOD_NEK2_1	186	191	PF00069	0.528
MOD_NEK2_1	272	277	PF00069	0.520
MOD_NEK2_1	35	40	PF00069	0.448
MOD_OFUCOSY	143	149	PF10250	0.264
MOD_PKA_2	11	17	PF00069	0.523
MOD_PKA_2	166	172	PF00069	0.565
MOD_PKA_2	29	35	PF00069	0.223
MOD_PKA_2	54	60	PF00069	0.525
MOD_Plk_2-3	104	110	PF00069	0.464
MOD_Plk_4	160	166	PF00069	0.490
MOD_Plk_4	22	28	PF00069	0.567
MOD_Plk_4	223	229	PF00069	0.543
MOD_Plk_4	29	35	PF00069	0.465
MOD_ProDKin_1	178	184	PF00069	0.464
MOD_ProDKin_1	211	217	PF00069	0.510
MOD_ProDKin_1	7	13	PF00069	0.511
TRG_DiLeu_BaEn_1	258	263	PF01217	0.590
TRG_DiLeu_BaEn_2	124	130	PF01217	0.565
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.546
TRG_ENDOCYTIC_2	161	164	PF00928	0.464
TRG_ER_diArg_1	265	267	PF00400	0.570
TRG_ER_diArg_1	73	75	PF00400	0.503
TRG_ER_diArg_1	92	94	PF00400	0.427
TRG_NES_CRM1_1	220	231	PF08389	0.510
TRG_NLS_MonoExtN_4	261	268	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KI17	Bodo saltans	32%	100%
A0A1X0NLZ1	Trypanosomatidae	50%	99%
A0A3R7KL17	Trypanosoma rangeli	52%	99%
A4HQM2	Leishmania braziliensis	84%	95%
A4ICE0	Leishmania infantum	94%	100%
D0A3S6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	99%
E9AUD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P40963	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	83%
Q10325	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	69%
V5BHQ1	Trypanosoma cruzi	52%	100%
W0G5Y6	Leishmania donovani	94%	100%