Cytochrome c oxidase subunit I

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome oxidase subunit IX, putative

Species:

Leishmania major

UniProt:

Q4Q052_LEIMA

TriTrypDb:

LmjF.36.6995 , LMJLV39_360085700 , LMJSD75_360085500

Length:

125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q052

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q052

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	92	94	PF00675	0.616
CLV_PCSK_KEX2_1	11	13	PF00082	0.439
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.477
CLV_PCSK_SKI1_1	4	8	PF00082	0.429
DOC_MAPK_gen_1	11	18	PF00069	0.706
DOC_USP7_MATH_1	17	21	PF00917	0.709
LIG_14-3-3_CanoR_1	4	10	PF00244	0.635
LIG_FHA_1	11	17	PF00498	0.705
LIG_FHA_1	35	41	PF00498	0.593
LIG_LIR_Apic_2	38	44	PF02991	0.607
LIG_LIR_Gen_1	55	66	PF02991	0.354
LIG_LIR_Gen_1	67	76	PF02991	0.475
LIG_LIR_Nem_3	55	61	PF02991	0.350
LIG_LIR_Nem_3	67	73	PF02991	0.470
LIG_Pex14_1	96	100	PF04695	0.414
LIG_SH2_CRK	41	45	PF00017	0.605
LIG_SH3_3	109	115	PF00018	0.455
MOD_CK1_1	10	16	PF00069	0.631
MOD_GlcNHglycan	116	119	PF01048	0.700
MOD_GlcNHglycan	74	79	PF01048	0.683
MOD_GlcNHglycan	81	84	PF01048	0.714
MOD_NEK2_1	7	12	PF00069	0.618
MOD_Plk_1	96	102	PF00069	0.471
TRG_ENDOCYTIC_2	48	51	PF00928	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P812	Leptomonas seymouri	92%	100%
A0A0S4KK00	Bodo saltans	65%	93%
A0A1X0NL41	Trypanosomatidae	80%	100%
A0A3Q8IM95	Leishmania donovani	99%	100%
A0A422NW07	Trypanosoma rangeli	79%	100%
A4HQM3	Leishmania braziliensis	91%	100%
A4ICE1	Leishmania infantum	99%	100%
D0A3S7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AUD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%