LeishMANIAdb
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TPR repeat family protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR repeat family protein
Gene product:
stress-induced protein sti1
Species:
Leishmania donovani
UniProt:
Q4JHN0_LEIDO
TriTrypDb:
LdBPK_081020.1 , LdCL_080015800 , LDHU3_08.1470
Length:
546

Annotations

Annotations by Jardim et al.

Metal Binding, Stress-induced sti1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 2
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

Q4JHN0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 12
GO:0009987 cellular process 1 12
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0030544 Hsp70 protein binding 4 12
GO:0031072 heat shock protein binding 3 12
GO:0051879 Hsp90 protein binding 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 461 465 PF00656 0.493
CLV_NRD_NRD_1 135 137 PF00675 0.302
CLV_NRD_NRD_1 311 313 PF00675 0.416
CLV_NRD_NRD_1 430 432 PF00675 0.263
CLV_NRD_NRD_1 489 491 PF00675 0.268
CLV_NRD_NRD_1 76 78 PF00675 0.324
CLV_NRD_NRD_1 85 87 PF00675 0.272
CLV_PCSK_KEX2_1 322 324 PF00082 0.335
CLV_PCSK_KEX2_1 386 388 PF00082 0.456
CLV_PCSK_KEX2_1 489 491 PF00082 0.226
CLV_PCSK_KEX2_1 76 78 PF00082 0.362
CLV_PCSK_KEX2_1 85 87 PF00082 0.281
CLV_PCSK_PC1ET2_1 322 324 PF00082 0.346
CLV_PCSK_PC1ET2_1 386 388 PF00082 0.456
CLV_PCSK_SKI1_1 128 132 PF00082 0.496
CLV_PCSK_SKI1_1 175 179 PF00082 0.308
CLV_PCSK_SKI1_1 214 218 PF00082 0.544
CLV_PCSK_SKI1_1 221 225 PF00082 0.434
CLV_PCSK_SKI1_1 299 303 PF00082 0.265
CLV_PCSK_SKI1_1 322 326 PF00082 0.260
CLV_PCSK_SKI1_1 335 339 PF00082 0.415
CLV_PCSK_SKI1_1 54 58 PF00082 0.472
CLV_PCSK_SKI1_1 96 100 PF00082 0.332
DEG_APCC_DBOX_1 174 182 PF00400 0.472
DEG_Nend_UBRbox_2 1 3 PF02207 0.467
DOC_CKS1_1 129 134 PF01111 0.547
DOC_MAPK_gen_1 252 260 PF00069 0.522
DOC_MAPK_gen_1 310 320 PF00069 0.260
DOC_MAPK_gen_1 463 473 PF00069 0.414
DOC_MAPK_MEF2A_6 137 146 PF00069 0.450
DOC_USP7_MATH_1 102 106 PF00917 0.406
DOC_USP7_MATH_2 389 395 PF00917 0.561
DOC_USP7_UBL2_3 342 346 PF12436 0.386
DOC_USP7_UBL2_3 413 417 PF12436 0.406
DOC_WW_Pin1_4 128 133 PF00397 0.496
LIG_14-3-3_CanoR_1 175 181 PF00244 0.426
LIG_BRCT_BRCA1_1 235 239 PF00533 0.500
LIG_BRCT_BRCA1_1 43 47 PF00533 0.469
LIG_FHA_1 255 261 PF00498 0.351
LIG_FHA_1 380 386 PF00498 0.430
LIG_FHA_2 215 221 PF00498 0.509
LIG_FHA_2 336 342 PF00498 0.473
LIG_LIR_Apic_2 327 331 PF02991 0.482
LIG_LIR_Apic_2 349 355 PF02991 0.417
LIG_LIR_Gen_1 152 161 PF02991 0.432
LIG_LIR_Gen_1 293 301 PF02991 0.260
LIG_LIR_Gen_1 44 53 PF02991 0.384
LIG_LIR_Gen_1 503 513 PF02991 0.426
LIG_LIR_Nem_3 133 138 PF02991 0.499
LIG_LIR_Nem_3 293 297 PF02991 0.260
LIG_LIR_Nem_3 464 470 PF02991 0.419
LIG_LIR_Nem_3 503 508 PF02991 0.437
LIG_Pex14_1 438 442 PF04695 0.260
LIG_Pex14_1 70 74 PF04695 0.276
LIG_SH2_CRK 294 298 PF00017 0.260
LIG_SH2_CRK 467 471 PF00017 0.419
LIG_SH2_CRK 505 509 PF00017 0.437
LIG_SH2_GRB2like 395 398 PF00017 0.260
LIG_SH2_GRB2like 40 43 PF00017 0.368
LIG_SH2_NCK_1 294 298 PF00017 0.320
LIG_SH2_PTP2 352 355 PF00017 0.435
LIG_SH2_PTP2 402 405 PF00017 0.325
LIG_SH2_SRC 19 22 PF00017 0.463
LIG_SH2_SRC 246 249 PF00017 0.438
LIG_SH2_SRC 352 355 PF00017 0.420
LIG_SH2_SRC 449 452 PF00017 0.294
LIG_SH2_SRC 87 90 PF00017 0.294
LIG_SH2_STAP1 273 277 PF00017 0.276
LIG_SH2_STAP1 294 298 PF00017 0.276
LIG_SH2_STAP1 314 318 PF00017 0.139
LIG_SH2_STAP1 381 385 PF00017 0.450
LIG_SH2_STAP1 395 399 PF00017 0.293
LIG_SH2_STAP1 87 91 PF00017 0.294
LIG_SH2_STAT3 267 270 PF00017 0.406
LIG_SH2_STAT5 153 156 PF00017 0.469
LIG_SH2_STAT5 182 185 PF00017 0.554
LIG_SH2_STAT5 19 22 PF00017 0.386
LIG_SH2_STAT5 234 237 PF00017 0.508
LIG_SH2_STAT5 25 28 PF00017 0.370
LIG_SH2_STAT5 259 262 PF00017 0.276
LIG_SH2_STAT5 267 270 PF00017 0.276
LIG_SH2_STAT5 294 297 PF00017 0.260
LIG_SH2_STAT5 352 355 PF00017 0.420
LIG_SH2_STAT5 368 371 PF00017 0.412
LIG_SH2_STAT5 381 384 PF00017 0.350
LIG_SH2_STAT5 402 405 PF00017 0.260
LIG_SH2_STAT5 436 439 PF00017 0.354
LIG_SH2_STAT5 74 77 PF00017 0.276
LIG_SH3_3 126 132 PF00018 0.458
LIG_SH3_3 248 254 PF00018 0.383
LIG_TRAF2_1 210 213 PF00917 0.620
LIG_TRAF2_1 347 350 PF00917 0.522
LIG_UBA3_1 180 187 PF00899 0.550
MOD_CK1_1 103 109 PF00069 0.522
MOD_CK1_1 41 47 PF00069 0.342
MOD_CK1_1 478 484 PF00069 0.514
MOD_CK1_1 527 533 PF00069 0.441
MOD_CK2_1 214 220 PF00069 0.594
MOD_CK2_1 335 341 PF00069 0.473
MOD_DYRK1A_RPxSP_1 128 132 PF00069 0.547
MOD_GlcNHglycan 12 17 PF01048 0.393
MOD_GlcNHglycan 183 186 PF01048 0.380
MOD_GlcNHglycan 200 203 PF01048 0.573
MOD_GlcNHglycan 263 266 PF01048 0.325
MOD_GlcNHglycan 43 46 PF01048 0.340
MOD_GlcNHglycan 477 480 PF01048 0.451
MOD_GlcNHglycan 526 529 PF01048 0.251
MOD_GlcNHglycan 537 540 PF01048 0.310
MOD_GSK3_1 34 41 PF00069 0.516
MOD_N-GLC_1 103 108 PF02516 0.353
MOD_N-GLC_1 261 266 PF02516 0.256
MOD_N-GLC_1 41 46 PF02516 0.343
MOD_N-GLC_2 290 292 PF02516 0.294
MOD_NEK2_1 156 161 PF00069 0.485
MOD_NEK2_1 176 181 PF00069 0.362
MOD_NEK2_1 233 238 PF00069 0.497
MOD_NEK2_1 261 266 PF00069 0.260
MOD_NEK2_1 501 506 PF00069 0.426
MOD_NEK2_1 524 529 PF00069 0.441
MOD_NEK2_2 254 259 PF00069 0.410
MOD_PIKK_1 162 168 PF00454 0.530
MOD_PK_1 62 68 PF00069 0.401
MOD_PKA_1 335 341 PF00069 0.559
MOD_PKA_2 198 204 PF00069 0.627
MOD_Plk_1 261 267 PF00069 0.266
MOD_Plk_1 292 298 PF00069 0.260
MOD_Plk_1 390 396 PF00069 0.411
MOD_Plk_4 142 148 PF00069 0.436
MOD_Plk_4 156 162 PF00069 0.368
MOD_Plk_4 176 182 PF00069 0.367
MOD_Plk_4 254 260 PF00069 0.350
MOD_Plk_4 292 298 PF00069 0.274
MOD_Plk_4 34 40 PF00069 0.443
MOD_Plk_4 501 507 PF00069 0.428
MOD_ProDKin_1 128 134 PF00069 0.495
MOD_SUMO_for_1 210 213 PF00179 0.610
MOD_SUMO_for_1 226 229 PF00179 0.408
MOD_SUMO_rev_2 206 216 PF00179 0.601
MOD_SUMO_rev_2 248 257 PF00179 0.508
MOD_SUMO_rev_2 414 423 PF00179 0.354
TRG_DiLeu_BaEn_4 228 234 PF01217 0.355
TRG_ENDOCYTIC_2 153 156 PF00928 0.426
TRG_ENDOCYTIC_2 294 297 PF00928 0.260
TRG_ENDOCYTIC_2 402 405 PF00928 0.260
TRG_ENDOCYTIC_2 467 470 PF00928 0.524
TRG_ENDOCYTIC_2 505 508 PF00928 0.426
TRG_ER_diArg_1 75 77 PF00400 0.352
TRG_ER_diArg_1 84 86 PF00400 0.227
TRG_Pf-PMV_PEXEL_1 136 140 PF00026 0.349
TRG_Pf-PMV_PEXEL_1 323 327 PF00026 0.308
TRG_Pf-PMV_PEXEL_1 335 339 PF00026 0.463

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK79 Leptomonas seymouri 85% 100%
A0A0S4IP08 Bodo saltans 55% 94%
A0A0S4JM87 Bodo saltans 21% 78%
A0A1X0NFP0 Trypanosomatidae 67% 100%
A0A1X0P1G8 Trypanosomatidae 23% 77%
A0A422NFX1 Trypanosoma rangeli 63% 98%
A4H5F0 Leishmania braziliensis 94% 100%
A4HTP4 Leishmania infantum 100% 100%
C9ZPE6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 99%
E9AMI1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
F8RP11 Triticum aestivum 41% 94%
O35814 Rattus norvegicus 40% 100%
O54981 Cricetulus griseus 40% 100%
O94826 Homo sapiens 23% 90%
P15705 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 93%
P31948 Homo sapiens 40% 100%
Q3ZBZ8 Bos taurus 40% 100%
Q43468 Glycine max 41% 95%
Q4QI58 Leishmania major 98% 100%
Q4R8N7 Macaca fascicularis 40% 100%
Q54DA8 Dictyostelium discoideum 37% 97%
Q54IP0 Dictyostelium discoideum 24% 100%
Q5R8D8 Pongo abelii 23% 100%
Q5XEP2 Arabidopsis thaliana 41% 96%
Q60864 Mus musculus 40% 100%
Q75Q39 Rattus norvegicus 23% 90%
Q7ZWU1 Xenopus laevis 39% 100%
Q8ILC1 Plasmodium falciparum (isolate 3D7) 37% 97%
Q99615 Homo sapiens 24% 100%
Q9CZW5 Mus musculus 23% 89%
Q9LNB6 Arabidopsis thaliana 39% 95%
Q9QYI3 Mus musculus 23% 100%
Q9STH1 Arabidopsis thaliana 40% 98%
Q9USI5 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 92%
V5AUF3 Trypanosoma cruzi 64% 98%
V5BSG3 Trypanosoma cruzi 22% 78%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS