MutS-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

MutS-like protein

Gene product:

MutS-like protein

Species:

Leishmania major

UniProt:

Q4FXN1_LEIMA

TriTrypDb:

LmjF.29.1710 , LMJLV39_290024500 , LMJSD75_290025000

Length:

1096

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4FXN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4FXN1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006298	mismatch repair	6	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0032042	mitochondrial DNA metabolic process	5	2
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043504	mitochondrial DNA repair	6	2
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003690	double-stranded DNA binding	5	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008094	ATP-dependent activity, acting on DNA	2	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0030983	mismatched DNA binding	6	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140299	small molecule sensor activity	1	8
GO:0140612	DNA damage sensor activity	2	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0140657	ATP-dependent activity	1	8
GO:0140664	ATP-dependent DNA damage sensor activity	3	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	556	560	PF00656	0.431
CLV_C14_Caspase3-7	948	952	PF00656	0.553
CLV_NRD_NRD_1	1052	1054	PF00675	0.596
CLV_NRD_NRD_1	630	632	PF00675	0.253
CLV_NRD_NRD_1	640	642	PF00675	0.274
CLV_NRD_NRD_1	90	92	PF00675	0.609
CLV_PCSK_KEX2_1	1052	1054	PF00082	0.596
CLV_PCSK_KEX2_1	630	632	PF00082	0.255
CLV_PCSK_KEX2_1	640	642	PF00082	0.228
CLV_PCSK_KEX2_1	90	92	PF00082	0.615
CLV_PCSK_SKI1_1	243	247	PF00082	0.469
CLV_PCSK_SKI1_1	284	288	PF00082	0.279
CLV_PCSK_SKI1_1	296	300	PF00082	0.302
CLV_PCSK_SKI1_1	336	340	PF00082	0.277
CLV_PCSK_SKI1_1	751	755	PF00082	0.236
CLV_PCSK_SKI1_1	838	842	PF00082	0.485
CLV_PCSK_SKI1_1	95	99	PF00082	0.509
CLV_Separin_Metazoa	399	403	PF03568	0.449
CLV_Separin_Metazoa	87	91	PF03568	0.555
DEG_APCC_DBOX_1	242	250	PF00400	0.437
DEG_APCC_DBOX_1	335	343	PF00400	0.436
DEG_APCC_DBOX_1	500	508	PF00400	0.474
DEG_Nend_UBRbox_3	1	3	PF02207	0.563
DEG_SPOP_SBC_1	342	346	PF00917	0.474
DEG_SPOP_SBC_1	786	790	PF00917	0.452
DEG_SPOP_SBC_1	793	797	PF00917	0.573
DOC_ANK_TNKS_1	879	886	PF00023	0.389
DOC_CKS1_1	96	101	PF01111	0.567
DOC_CYCLIN_RxL_1	850	861	PF00134	0.396
DOC_MAPK_gen_1	473	481	PF00069	0.474
DOC_MAPK_MEF2A_6	475	483	PF00069	0.474
DOC_MAPK_MEF2A_6	739	746	PF00069	0.295
DOC_MAPK_NFAT4_5	739	747	PF00069	0.295
DOC_MIT_MIM_1	470	480	PF04212	0.474
DOC_PP1_RVXF_1	471	477	PF00149	0.428
DOC_PP1_RVXF_1	824	831	PF00149	0.388
DOC_PP2B_LxvP_1	516	519	PF13499	0.474
DOC_PP2B_LxvP_1	572	575	PF13499	0.428
DOC_PP2B_LxvP_1	912	915	PF13499	0.517
DOC_PP4_FxxP_1	188	191	PF00568	0.387
DOC_PP4_FxxP_1	323	326	PF00568	0.598
DOC_PP4_FxxP_1	77	80	PF00568	0.547
DOC_USP7_MATH_1	102	106	PF00917	0.565
DOC_USP7_MATH_1	1025	1029	PF00917	0.577
DOC_USP7_MATH_1	121	125	PF00917	0.539
DOC_USP7_MATH_1	232	236	PF00917	0.465
DOC_USP7_MATH_1	289	293	PF00917	0.458
DOC_USP7_MATH_1	565	569	PF00917	0.444
DOC_USP7_MATH_1	671	675	PF00917	0.360
DOC_USP7_MATH_1	787	791	PF00917	0.543
DOC_USP7_MATH_1	794	798	PF00917	0.718
DOC_USP7_MATH_1	799	803	PF00917	0.580
DOC_USP7_MATH_1	840	844	PF00917	0.433
DOC_WW_Pin1_4	1018	1023	PF00397	0.564
DOC_WW_Pin1_4	1034	1039	PF00397	0.570
DOC_WW_Pin1_4	1043	1048	PF00397	0.604
DOC_WW_Pin1_4	172	177	PF00397	0.432
DOC_WW_Pin1_4	578	583	PF00397	0.454
DOC_WW_Pin1_4	864	869	PF00397	0.453
DOC_WW_Pin1_4	893	898	PF00397	0.516
DOC_WW_Pin1_4	95	100	PF00397	0.601
DOC_WW_Pin1_4	978	983	PF00397	0.574
LIG_14-3-3_CanoR_1	181	188	PF00244	0.465
LIG_14-3-3_CanoR_1	284	294	PF00244	0.488
LIG_14-3-3_CanoR_1	316	320	PF00244	0.474
LIG_14-3-3_CanoR_1	480	484	PF00244	0.474
LIG_14-3-3_CanoR_1	499	505	PF00244	0.474
LIG_14-3-3_CanoR_1	576	582	PF00244	0.440
LIG_14-3-3_CanoR_1	589	594	PF00244	0.395
LIG_14-3-3_CanoR_1	66	76	PF00244	0.419
LIG_14-3-3_CanoR_1	672	679	PF00244	0.381
LIG_14-3-3_CanoR_1	734	743	PF00244	0.389
LIG_14-3-3_CanoR_1	777	781	PF00244	0.474
LIG_14-3-3_CanoR_1	801	809	PF00244	0.566
LIG_Actin_WH2_2	465	482	PF00022	0.474
LIG_Actin_WH2_2	491	507	PF00022	0.474
LIG_Actin_WH2_2	720	736	PF00022	0.415
LIG_BRCT_BRCA1_1	788	792	PF00533	0.436
LIG_Clathr_ClatBox_1	856	860	PF01394	0.333
LIG_eIF4E_1	150	156	PF01652	0.382
LIG_eIF4E_1	649	655	PF01652	0.474
LIG_FHA_1	1007	1013	PF00498	0.575
LIG_FHA_1	1086	1092	PF00498	0.413
LIG_FHA_1	343	349	PF00498	0.474
LIG_FHA_1	442	448	PF00498	0.436
LIG_FHA_1	585	591	PF00498	0.418
LIG_FHA_1	643	649	PF00498	0.474
LIG_FHA_1	656	662	PF00498	0.474
LIG_FHA_1	735	741	PF00498	0.452
LIG_FHA_1	773	779	PF00498	0.481
LIG_FHA_1	904	910	PF00498	0.373
LIG_FHA_2	1005	1011	PF00498	0.599
LIG_FHA_2	157	163	PF00498	0.468
LIG_FHA_2	173	179	PF00498	0.454
LIG_FHA_2	260	266	PF00498	0.474
LIG_FHA_2	465	471	PF00498	0.517
LIG_FHA_2	696	702	PF00498	0.606
LIG_FHA_2	733	739	PF00498	0.419
LIG_FHA_2	864	870	PF00498	0.468
LIG_FHA_2	943	949	PF00498	0.545
LIG_GBD_Chelix_1	331	339	PF00786	0.274
LIG_Integrin_RGD_1	125	127	PF01839	0.565
LIG_LIR_Apic_2	186	191	PF02991	0.398
LIG_LIR_Apic_2	677	682	PF02991	0.334
LIG_LIR_Apic_2	75	80	PF02991	0.537
LIG_LIR_Gen_1	346	357	PF02991	0.437
LIG_LIR_Gen_1	364	374	PF02991	0.426
LIG_LIR_Gen_1	387	398	PF02991	0.437
LIG_LIR_Gen_1	488	498	PF02991	0.438
LIG_LIR_Gen_1	646	657	PF02991	0.474
LIG_LIR_Gen_1	669	675	PF02991	0.502
LIG_LIR_Gen_1	986	993	PF02991	0.502
LIG_LIR_Nem_3	1037	1043	PF02991	0.611
LIG_LIR_Nem_3	387	393	PF02991	0.437
LIG_LIR_Nem_3	488	494	PF02991	0.474
LIG_LIR_Nem_3	646	652	PF02991	0.474
LIG_LIR_Nem_3	669	673	PF02991	0.474
LIG_LIR_Nem_3	710	716	PF02991	0.342
LIG_LIR_Nem_3	986	990	PF02991	0.508
LIG_LYPXL_yS_3	439	442	PF13949	0.438
LIG_MAD2	129	137	PF02301	0.513
LIG_NRBOX	282	288	PF00104	0.474
LIG_NRBOX	388	394	PF00104	0.474
LIG_NRBOX	663	669	PF00104	0.474
LIG_PCNA_yPIPBox_3	234	243	PF02747	0.457
LIG_Pex14_1	142	146	PF04695	0.357
LIG_Pex14_1	987	991	PF04695	0.507
LIG_PTB_Apo_2	779	786	PF02174	0.474
LIG_SH2_CRK	1040	1044	PF00017	0.620
LIG_SH2_CRK	508	512	PF00017	0.474
LIG_SH2_CRK	649	653	PF00017	0.474
LIG_SH2_PTP2	362	365	PF00017	0.474
LIG_SH2_PTP2	390	393	PF00017	0.474
LIG_SH2_SRC	1040	1043	PF00017	0.595
LIG_SH2_STAT3	150	153	PF00017	0.397
LIG_SH2_STAT3	201	204	PF00017	0.459
LIG_SH2_STAT5	146	149	PF00017	0.406
LIG_SH2_STAT5	250	253	PF00017	0.348
LIG_SH2_STAT5	362	365	PF00017	0.469
LIG_SH2_STAT5	390	393	PF00017	0.474
LIG_SH2_STAT5	508	511	PF00017	0.496
LIG_SH2_STAT5	514	517	PF00017	0.454
LIG_SH2_STAT5	881	884	PF00017	0.430
LIG_SH3_1	918	924	PF00018	0.503
LIG_SH3_1	93	99	PF00018	0.537
LIG_SH3_3	1016	1022	PF00018	0.625
LIG_SH3_3	146	152	PF00018	0.380
LIG_SH3_3	42	48	PF00018	0.560
LIG_SH3_3	434	440	PF00018	0.465
LIG_SH3_3	452	458	PF00018	0.515
LIG_SH3_3	788	794	PF00018	0.499
LIG_SH3_3	894	900	PF00018	0.599
LIG_SH3_3	918	924	PF00018	0.635
LIG_SH3_3	93	99	PF00018	0.566
LIG_SH3_CIN85_PxpxPR_1	1047	1052	PF14604	0.593
LIG_SH3_CIN85_PxpxPR_1	191	196	PF14604	0.386
LIG_SUMO_SIM_anti_2	166	173	PF11976	0.446
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.445
LIG_SUMO_SIM_par_1	1032	1037	PF11976	0.557
LIG_SUMO_SIM_par_1	371	377	PF11976	0.459
LIG_SUMO_SIM_par_1	703	711	PF11976	0.386
LIG_SUMO_SIM_par_1	855	861	PF11976	0.338
LIG_TRAF2_1	202	205	PF00917	0.469
LIG_TRAF2_1	374	377	PF00917	0.438
LIG_TRAF2_1	431	434	PF00917	0.397
LIG_TRAF2_1	617	620	PF00917	0.459
LIG_TRAF2_1	674	677	PF00917	0.361
LIG_TYR_ITIM	144	149	PF00017	0.489
LIG_TYR_ITIM	647	652	PF00017	0.316
LIG_WRC_WIRS_1	448	453	PF05994	0.265
LIG_WRC_WIRS_1	667	672	PF05994	0.316
LIG_WW_3	573	577	PF00397	0.265
MOD_CDK_SPxxK_3	582	589	PF00069	0.287
MOD_CK1_1	114	120	PF00069	0.688
MOD_CK1_1	183	189	PF00069	0.560
MOD_CK1_1	25	31	PF00069	0.634
MOD_CK1_1	407	413	PF00069	0.369
MOD_CK1_1	552	558	PF00069	0.265
MOD_CK1_1	749	755	PF00069	0.262
MOD_CK1_1	797	803	PF00069	0.517
MOD_CK1_1	960	966	PF00069	0.625
MOD_CK2_1	1004	1010	PF00069	0.611
MOD_CK2_1	1080	1086	PF00069	0.398
MOD_CK2_1	156	162	PF00069	0.445
MOD_CK2_1	172	178	PF00069	0.499
MOD_CK2_1	25	31	PF00069	0.587
MOD_CK2_1	259	265	PF00069	0.379
MOD_CK2_1	582	588	PF00069	0.294
MOD_CK2_1	671	677	PF00069	0.329
MOD_CK2_1	863	869	PF00069	0.468
MOD_CK2_1	942	948	PF00069	0.551
MOD_CK2_1	961	967	PF00069	0.599
MOD_DYRK1A_RPxSP_1	95	99	PF00069	0.509
MOD_GlcNHglycan	1027	1030	PF01048	0.577
MOD_GlcNHglycan	119	122	PF01048	0.706
MOD_GlcNHglycan	182	185	PF01048	0.548
MOD_GlcNHglycan	269	272	PF01048	0.371
MOD_GlcNHglycan	287	290	PF01048	0.368
MOD_GlcNHglycan	353	356	PF01048	0.316
MOD_GlcNHglycan	409	412	PF01048	0.312
MOD_GlcNHglycan	614	617	PF01048	0.297
MOD_GlcNHglycan	673	676	PF01048	0.348
MOD_GlcNHglycan	748	751	PF01048	0.262
MOD_GlcNHglycan	796	799	PF01048	0.563
MOD_GlcNHglycan	801	804	PF01048	0.555
MOD_GlcNHglycan	940	943	PF01048	0.699
MOD_GlcNHglycan	962	966	PF01048	0.631
MOD_GSK3_1	113	120	PF00069	0.531
MOD_GSK3_1	285	292	PF00069	0.374
MOD_GSK3_1	343	350	PF00069	0.316
MOD_GSK3_1	361	368	PF00069	0.262
MOD_GSK3_1	578	585	PF00069	0.493
MOD_GSK3_1	772	779	PF00069	0.405
MOD_GSK3_1	793	800	PF00069	0.499
MOD_GSK3_1	938	945	PF00069	0.626
MOD_GSK3_1	957	964	PF00069	0.594
MOD_LATS_1	732	738	PF00433	0.399
MOD_N-GLC_1	559	564	PF02516	0.466
MOD_N-GLC_1	746	751	PF02516	0.262
MOD_NEK2_1	219	224	PF00069	0.488
MOD_NEK2_1	259	264	PF00069	0.379
MOD_NEK2_1	351	356	PF00069	0.425
MOD_NEK2_1	365	370	PF00069	0.205
MOD_NEK2_1	378	383	PF00069	0.262
MOD_NEK2_1	392	397	PF00069	0.232
MOD_NEK2_1	479	484	PF00069	0.316
MOD_NEK2_1	594	599	PF00069	0.316
MOD_NEK2_1	643	648	PF00069	0.316
MOD_NEK2_1	780	785	PF00069	0.316
MOD_NEK2_1	846	851	PF00069	0.484
MOD_NEK2_1	875	880	PF00069	0.351
MOD_NEK2_1	903	908	PF00069	0.350
MOD_NEK2_2	1085	1090	PF00069	0.405
MOD_NEK2_2	500	505	PF00069	0.265
MOD_NEK2_2	787	792	PF00069	0.423
MOD_PIKK_1	114	120	PF00454	0.535
MOD_PK_1	589	595	PF00069	0.265
MOD_PKA_2	111	117	PF00069	0.719
MOD_PKA_2	180	186	PF00069	0.473
MOD_PKA_2	315	321	PF00069	0.316
MOD_PKA_2	479	485	PF00069	0.316
MOD_PKA_2	500	506	PF00069	0.312
MOD_PKA_2	655	661	PF00069	0.316
MOD_PKA_2	671	677	PF00069	0.371
MOD_PKA_2	733	739	PF00069	0.419
MOD_PKA_2	776	782	PF00069	0.316
MOD_PKA_2	863	869	PF00069	0.468
MOD_PKA_2	888	894	PF00069	0.509
MOD_Plk_1	1085	1091	PF00069	0.408
MOD_Plk_1	214	220	PF00069	0.433
MOD_Plk_1	384	390	PF00069	0.286
MOD_Plk_1	41	47	PF00069	0.798
MOD_Plk_1	50	56	PF00069	0.501
MOD_Plk_1	643	649	PF00069	0.316
MOD_Plk_2-3	1080	1086	PF00069	0.384
MOD_Plk_4	1080	1086	PF00069	0.384
MOD_Plk_4	136	142	PF00069	0.405
MOD_Plk_4	315	321	PF00069	0.268
MOD_Plk_4	361	367	PF00069	0.340
MOD_Plk_4	464	470	PF00069	0.376
MOD_Plk_4	620	626	PF00069	0.295
MOD_Plk_4	643	649	PF00069	0.316
MOD_Plk_4	749	755	PF00069	0.262
MOD_Plk_4	776	782	PF00069	0.270
MOD_Plk_4	787	793	PF00069	0.432
MOD_Plk_4	813	819	PF00069	0.466
MOD_ProDKin_1	1018	1024	PF00069	0.563
MOD_ProDKin_1	1034	1040	PF00069	0.567
MOD_ProDKin_1	1043	1049	PF00069	0.601
MOD_ProDKin_1	172	178	PF00069	0.433
MOD_ProDKin_1	578	584	PF00069	0.287
MOD_ProDKin_1	864	870	PF00069	0.447
MOD_ProDKin_1	893	899	PF00069	0.500
MOD_ProDKin_1	95	101	PF00069	0.602
MOD_ProDKin_1	978	984	PF00069	0.569
MOD_SUMO_for_1	485	488	PF00179	0.280
MOD_SUMO_rev_2	1010	1020	PF00179	0.525
TRG_DiLeu_BaEn_1	522	527	PF01217	0.295
TRG_DiLeu_BaEn_1	663	668	PF01217	0.262
TRG_DiLeu_BaLyEn_6	712	717	PF01217	0.387
TRG_ENDOCYTIC_2	1040	1043	PF00928	0.616
TRG_ENDOCYTIC_2	146	149	PF00928	0.495
TRG_ENDOCYTIC_2	362	365	PF00928	0.262
TRG_ENDOCYTIC_2	366	369	PF00928	0.262
TRG_ENDOCYTIC_2	390	393	PF00928	0.316
TRG_ENDOCYTIC_2	439	442	PF00928	0.396
TRG_ENDOCYTIC_2	649	652	PF00928	0.316
TRG_ER_diArg_1	1051	1053	PF00400	0.608
TRG_ER_diArg_1	459	462	PF00400	0.375
TRG_ER_diArg_1	472	475	PF00400	0.282
TRG_ER_diArg_1	498	501	PF00400	0.316
TRG_ER_diArg_1	630	632	PF00400	0.291
TRG_ER_diArg_1	639	641	PF00400	0.333
TRG_ER_diArg_1	89	91	PF00400	0.591
TRG_ER_diArg_1	93	96	PF00400	0.572
TRG_NES_CRM1_1	470	484	PF08389	0.305
TRG_Pf-PMV_PEXEL_1	659	663	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I950	Leptomonas seymouri	55%	97%
A0A3Q8IED3	Leishmania donovani	92%	100%
A4HHI3	Leishmania braziliensis	78%	100%
A4I4N1	Leishmania infantum	93%	100%
E9ALQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5D9V0	Trypanosoma cruzi	29%	100%