Putative actin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein, putative

Species:

Leishmania major

UniProt:

Q4FXC8_LEIMA

TriTrypDb:

LmjF.29.2740 , LMJLV39_290035700 , LMJSD75_290036000

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005869	dynactin complex	3	2
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4FXC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4FXC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.457
CLV_NRD_NRD_1	23	25	PF00675	0.652
CLV_NRD_NRD_1	34	36	PF00675	0.573
CLV_PCSK_KEX2_1	34	36	PF00082	0.569
CLV_PCSK_SKI1_1	277	281	PF00082	0.332
CLV_PCSK_SKI1_1	81	85	PF00082	0.229
DEG_COP1_1	180	188	PF00400	0.551
DEG_Nend_UBRbox_2	1	3	PF02207	0.406
DEG_SPOP_SBC_1	237	241	PF00917	0.530
DOC_CYCLIN_RxL_1	268	280	PF00134	0.525
DOC_MAPK_DCC_7	181	190	PF00069	0.553
DOC_MAPK_gen_1	21	31	PF00069	0.580
DOC_MAPK_HePTP_8	178	190	PF00069	0.553
DOC_MAPK_MEF2A_6	181	190	PF00069	0.553
DOC_MAPK_MEF2A_6	24	31	PF00069	0.590
DOC_MAPK_MEF2A_6	61	70	PF00069	0.538
DOC_PP2B_LxvP_1	188	191	PF13499	0.496
DOC_USP7_MATH_1	191	195	PF00917	0.515
DOC_USP7_UBL2_3	21	25	PF12436	0.647
LIG_14-3-3_CanoR_1	142	147	PF00244	0.509
LIG_14-3-3_CanoR_1	208	215	PF00244	0.554
LIG_14-3-3_CanoR_1	24	28	PF00244	0.645
LIG_APCC_ABBA_1	195	200	PF00400	0.553
LIG_BRCT_BRCA1_1	232	236	PF00533	0.553
LIG_FHA_1	111	117	PF00498	0.447
LIG_FHA_1	146	152	PF00498	0.466
LIG_FHA_1	165	171	PF00498	0.556
LIG_FHA_1	2	8	PF00498	0.362
LIG_FHA_1	208	214	PF00498	0.495
LIG_FHA_1	216	222	PF00498	0.474
LIG_FHA_1	238	244	PF00498	0.531
LIG_FHA_1	24	30	PF00498	0.564
LIG_FHA_1	65	71	PF00498	0.468
LIG_FHA_2	187	193	PF00498	0.468
LIG_FHA_2	200	206	PF00498	0.468
LIG_Integrin_RGD_1	160	162	PF01839	0.298
LIG_LIR_Gen_1	239	250	PF02991	0.474
LIG_LIR_Gen_1	87	97	PF02991	0.515
LIG_LIR_Nem_3	13	19	PF02991	0.407
LIG_LIR_Nem_3	239	245	PF02991	0.463
LIG_LIR_Nem_3	304	309	PF02991	0.538
LIG_LIR_Nem_3	87	92	PF02991	0.504
LIG_NRBOX	154	160	PF00104	0.496
LIG_NRBOX	67	73	PF00104	0.524
LIG_SH2_CRK	16	20	PF00017	0.454
LIG_SH2_STAP1	101	105	PF00017	0.530
LIG_SH2_STAT5	101	104	PF00017	0.505
LIG_SH2_STAT5	5	8	PF00017	0.454
LIG_SUMO_SIM_anti_2	26	31	PF11976	0.586
LIG_SUMO_SIM_anti_2	63	70	PF11976	0.490
LIG_SUMO_SIM_par_1	67	74	PF11976	0.497
LIG_TRAF2_1	62	65	PF00917	0.530
LIG_TYR_ITIM	14	19	PF00017	0.439
LIG_UBA3_1	289	297	PF00899	0.481
LIG_WRC_WIRS_1	72	77	PF05994	0.498
MOD_CK1_1	145	151	PF00069	0.529
MOD_CK1_1	216	222	PF00069	0.524
MOD_CK1_1	249	255	PF00069	0.541
MOD_CK1_1	77	83	PF00069	0.510
MOD_CK2_1	174	180	PF00069	0.506
MOD_CK2_1	199	205	PF00069	0.530
MOD_CK2_1	301	307	PF00069	0.505
MOD_CK2_1	84	90	PF00069	0.530
MOD_GlcNHglycan	103	106	PF01048	0.272
MOD_GlcNHglycan	112	116	PF01048	0.254
MOD_GlcNHglycan	210	213	PF01048	0.277
MOD_GlcNHglycan	251	254	PF01048	0.278
MOD_GlcNHglycan	284	287	PF01048	0.263
MOD_GlcNHglycan	56	59	PF01048	0.296
MOD_GSK3_1	134	141	PF00069	0.537
MOD_GSK3_1	170	177	PF00069	0.525
MOD_GSK3_1	213	220	PF00069	0.499
MOD_LATS_1	275	281	PF00433	0.538
MOD_N-GLC_2	36	38	PF02516	0.590
MOD_NEK2_1	1	6	PF00069	0.383
MOD_NEK2_1	170	175	PF00069	0.448
MOD_NEK2_1	213	218	PF00069	0.513
MOD_NEK2_1	71	76	PF00069	0.491
MOD_NEK2_1	84	89	PF00069	0.468
MOD_NEK2_1	99	104	PF00069	0.440
MOD_NEK2_2	10	15	PF00069	0.370
MOD_NEK2_2	191	196	PF00069	0.538
MOD_PIKK_1	288	294	PF00454	0.457
MOD_PIKK_1	74	80	PF00454	0.559
MOD_PK_1	142	148	PF00069	0.538
MOD_PKA_2	141	147	PF00069	0.531
MOD_PKA_2	207	213	PF00069	0.526
MOD_PKA_2	23	29	PF00069	0.596
MOD_Plk_1	1	7	PF00069	0.378
MOD_Plk_1	164	170	PF00069	0.541
MOD_Plk_1	186	192	PF00069	0.524
MOD_Plk_1	237	243	PF00069	0.518
MOD_Plk_1	64	70	PF00069	0.491
MOD_Plk_4	1	7	PF00069	0.444
MOD_Plk_4	174	180	PF00069	0.535
MOD_Plk_4	191	197	PF00069	0.538
MOD_Plk_4	238	244	PF00069	0.489
MOD_Plk_4	246	252	PF00069	0.489
MOD_Plk_4	64	70	PF00069	0.464
TRG_DiLeu_BaEn_1	154	159	PF01217	0.538
TRG_DiLeu_BaEn_1	180	185	PF01217	0.558
TRG_DiLeu_BaEn_1	64	69	PF01217	0.538
TRG_DiLeu_BaEn_2	36	42	PF01217	0.214
TRG_DiLeu_BaEn_3	64	70	PF01217	0.530
TRG_DiLeu_LyEn_5	154	159	PF01217	0.553
TRG_ENDOCYTIC_2	16	19	PF00928	0.417
TRG_ENDOCYTIC_2	86	89	PF00928	0.538
TRG_NES_CRM1_1	292	305	PF08389	0.468
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.226

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y8	Leptomonas seymouri	78%	100%
A0A0S4KG45	Bodo saltans	27%	89%
A0A0S4KJ86	Bodo saltans	28%	100%
A0A1X0NIU0	Trypanosomatidae	22%	82%
A0A1X0NRG7	Trypanosomatidae	26%	83%
A0A1X0P9A3	Trypanosomatidae	37%	99%
A0A3S5IR27	Trypanosoma rangeli	37%	95%
A0A3S7X2U7	Leishmania donovani	95%	100%
A4HHT1	Leishmania braziliensis	85%	100%
A4I4Z1	Leishmania infantum	96%	100%
C9ZKK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	99%
E9ALF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P02581	Glycine max	26%	86%
P30161	Costaria costata	26%	98%
Q4QR76	Rattus norvegicus	24%	77%
V5BDL0	Trypanosoma cruzi	23%	86%
V5C0Q2	Trypanosoma cruzi	23%	83%
V5DTX0	Trypanosoma cruzi	35%	99%