Putative aspartate aminotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aspartate aminotransferase, putative

Species:

Leishmania major

UniProt:

Q4FX34_LEIMA

TriTrypDb:

LmjF.35.0820 , LMJLV39_350013800 , LMJSD75_350013300

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4FX34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4FX34

PDB structure(s): 4h51_A , 4h51_B

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009987	cellular process	1	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	5	13
GO:0005488	binding	1	13
GO:0008483	transaminase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016769	transferase activity, transferring nitrogenous groups	3	13
GO:0019842	vitamin binding	3	13
GO:0030170	pyridoxal phosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.466
CLV_C14_Caspase3-7	401	405	PF00656	0.596
CLV_NRD_NRD_1	244	246	PF00675	0.524
CLV_NRD_NRD_1	314	316	PF00675	0.463
CLV_NRD_NRD_1	333	335	PF00675	0.297
CLV_NRD_NRD_1	59	61	PF00675	0.442
CLV_PCSK_KEX2_1	244	246	PF00082	0.522
CLV_PCSK_KEX2_1	278	280	PF00082	0.466
CLV_PCSK_KEX2_1	29	31	PF00082	0.626
CLV_PCSK_KEX2_1	333	335	PF00082	0.496

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0F7CUE9	Hapsidospora irregularis	34%	100%
A0A0N0P7Z5	Leptomonas seymouri	35%	94%
A0A0N1PAS7	Leptomonas seymouri	67%	100%
A0A0S4IPP7	Bodo saltans	39%	100%
A0A0S4JFW4	Bodo saltans	49%	100%
A0A1X0NIT8	Trypanosomatidae	54%	100%
A0A1X0NJG0	Trypanosomatidae	36%	99%
A0A1X0NJN9	Trypanosomatidae	55%	100%
A0A1X0NKG0	Trypanosomatidae	36%	99%
A0A3Q8IG20	Leishmania donovani	97%	100%

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