Putative aspartate aminotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aspartate aminotransferase, putative

Species:

Leishmania major

UniProt:

Q4FX34_LEIMA

TriTrypDb:

LmjF.35.0820 , LMJLV39_350013800 , LMJSD75_350013300

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4FX34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4FX34

PDB structure(s): 4h51_A , 4h51_B

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009987	cellular process	1	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044281	small molecule metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	5	13
GO:0005488	binding	1	13
GO:0008483	transaminase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016769	transferase activity, transferring nitrogenous groups	3	13
GO:0019842	vitamin binding	3	13
GO:0030170	pyridoxal phosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0070279	vitamin B6 binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.466
CLV_C14_Caspase3-7	401	405	PF00656	0.596
CLV_NRD_NRD_1	244	246	PF00675	0.524
CLV_NRD_NRD_1	314	316	PF00675	0.463
CLV_NRD_NRD_1	333	335	PF00675	0.297
CLV_NRD_NRD_1	59	61	PF00675	0.442
CLV_PCSK_KEX2_1	244	246	PF00082	0.522
CLV_PCSK_KEX2_1	278	280	PF00082	0.466
CLV_PCSK_KEX2_1	29	31	PF00082	0.626
CLV_PCSK_KEX2_1	333	335	PF00082	0.496
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.466
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.626
CLV_PCSK_PC7_1	240	246	PF00082	0.522
CLV_PCSK_SKI1_1	119	123	PF00082	0.530
CLV_PCSK_SKI1_1	174	178	PF00082	0.521
CLV_Separin_Metazoa	339	343	PF03568	0.544
DOC_CKS1_1	343	348	PF01111	0.442
DOC_MAPK_gen_1	244	251	PF00069	0.522
DOC_MAPK_gen_1	35	43	PF00069	0.544
DOC_MAPK_gen_1	57	67	PF00069	0.471
DOC_MAPK_MEF2A_6	244	251	PF00069	0.490
DOC_MAPK_MEF2A_6	265	273	PF00069	0.544
DOC_MAPK_MEF2A_6	60	69	PF00069	0.544
DOC_PP2B_LxvP_1	177	180	PF13499	0.466
DOC_USP7_MATH_1	180	184	PF00917	0.419
DOC_USP7_MATH_1	228	232	PF00917	0.385
DOC_USP7_UBL2_3	274	278	PF12436	0.544
DOC_WW_Pin1_4	127	132	PF00397	0.414
DOC_WW_Pin1_4	342	347	PF00397	0.395
LIG_14-3-3_CanoR_1	328	333	PF00244	0.490
LIG_APCC_ABBA_1	259	264	PF00400	0.395
LIG_APCC_ABBAyCdc20_2	333	339	PF00400	0.522
LIG_BIR_II_1	1	5	PF00653	0.689
LIG_BRCT_BRCA1_1	165	169	PF00533	0.482
LIG_FHA_1	109	115	PF00498	0.310
LIG_FHA_1	127	133	PF00498	0.301
LIG_FHA_1	162	168	PF00498	0.420
LIG_FHA_1	266	272	PF00498	0.525
LIG_FHA_1	94	100	PF00498	0.541
LIG_FHA_2	193	199	PF00498	0.395
LIG_FHA_2	333	339	PF00498	0.511
LIG_FHA_2	399	405	PF00498	0.600
LIG_FHA_2	6	12	PF00498	0.680
LIG_LIR_Apic_2	156	162	PF02991	0.517
LIG_LIR_Apic_2	292	297	PF02991	0.489
LIG_LIR_Gen_1	11	21	PF02991	0.571
LIG_LIR_Gen_1	202	212	PF02991	0.424
LIG_LIR_Gen_1	335	343	PF02991	0.468
LIG_LIR_Gen_1	348	356	PF02991	0.376
LIG_LIR_Gen_1	72	81	PF02991	0.517
LIG_LIR_Nem_3	11	16	PF02991	0.552
LIG_LIR_Nem_3	156	160	PF02991	0.429
LIG_LIR_Nem_3	202	207	PF02991	0.397
LIG_LIR_Nem_3	221	227	PF02991	0.384
LIG_LIR_Nem_3	335	340	PF02991	0.442
LIG_LIR_Nem_3	348	352	PF02991	0.362
LIG_LIR_Nem_3	360	364	PF02991	0.365
LIG_LIR_Nem_3	72	78	PF02991	0.517
LIG_LIR_Nem_3	79	84	PF02991	0.485
LIG_NRBOX	268	274	PF00104	0.544
LIG_PCNA_PIPBox_1	355	364	PF02747	0.408
LIG_PCNA_yPIPBox_3	355	366	PF02747	0.392
LIG_Pex14_1	139	143	PF04695	0.420
LIG_SH2_CRK	143	147	PF00017	0.466
LIG_SH2_CRK	294	298	PF00017	0.408
LIG_SH2_NCK_1	294	298	PF00017	0.408
LIG_SH2_SRC	75	78	PF00017	0.490
LIG_SH2_STAP1	237	241	PF00017	0.442
LIG_SH2_STAP1	262	266	PF00017	0.414
LIG_SH2_STAP1	337	341	PF00017	0.544
LIG_SH2_STAT5	133	136	PF00017	0.396
LIG_SH2_STAT5	294	297	PF00017	0.545
LIG_SH2_STAT5	371	374	PF00017	0.452
LIG_SH2_STAT5	75	78	PF00017	0.408
LIG_SH2_STAT6	80	84	PF00017	0.522
LIG_SH3_3	134	140	PF00018	0.411
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.544
LIG_SUMO_SIM_par_1	101	107	PF11976	0.503
LIG_SUMO_SIM_par_1	95	100	PF11976	0.537
LIG_TRAF2_1	199	202	PF00917	0.524
LIG_TYR_ITIM	71	76	PF00017	0.457
LIG_UBA3_1	24	29	PF00899	0.571
LIG_UBA3_1	358	366	PF00899	0.463
LIG_WRC_WIRS_1	358	363	PF05994	0.522
MOD_CK1_1	135	141	PF00069	0.422
MOD_CK1_1	231	237	PF00069	0.466
MOD_CK2_1	307	313	PF00069	0.424
MOD_CK2_1	5	11	PF00069	0.645
MOD_GlcNHglycan	108	111	PF01048	0.407
MOD_GlcNHglycan	221	224	PF01048	0.424
MOD_GlcNHglycan	228	231	PF01048	0.424
MOD_GlcNHglycan	321	325	PF01048	0.466
MOD_GlcNHglycan	381	384	PF01048	0.444
MOD_GlcNHglycan	78	81	PF01048	0.483
MOD_GSK3_1	104	111	PF00069	0.401
MOD_GSK3_1	281	288	PF00069	0.467
MOD_GSK3_1	328	335	PF00069	0.511
MOD_N-GLC_2	153	155	PF02516	0.427
MOD_NEK2_1	108	113	PF00069	0.390
MOD_NEK2_1	219	224	PF00069	0.437
MOD_NEK2_1	251	256	PF00069	0.422
MOD_NEK2_1	307	312	PF00069	0.445
MOD_NEK2_1	332	337	PF00069	0.511
MOD_NEK2_1	362	367	PF00069	0.370
MOD_NEK2_1	398	403	PF00069	0.558
MOD_NEK2_2	180	185	PF00069	0.522
MOD_PIKK_1	197	203	PF00454	0.544
MOD_PKA_2	332	338	PF00069	0.511
MOD_Plk_1	320	326	PF00069	0.535
MOD_Plk_2-3	281	287	PF00069	0.544
MOD_Plk_4	180	186	PF00069	0.424
MOD_Plk_4	206	212	PF00069	0.466
MOD_Plk_4	267	273	PF00069	0.442
MOD_Plk_4	281	287	PF00069	0.442
MOD_ProDKin_1	127	133	PF00069	0.414
MOD_ProDKin_1	342	348	PF00069	0.395
MOD_SUMO_rev_2	275	285	PF00179	0.453
TRG_DiLeu_BaEn_1	206	211	PF01217	0.496
TRG_DiLeu_BaEn_1	98	103	PF01217	0.540
TRG_ENDOCYTIC_2	143	146	PF00928	0.411
TRG_ENDOCYTIC_2	337	340	PF00928	0.442
TRG_ENDOCYTIC_2	73	76	PF00928	0.476
TRG_ENDOCYTIC_2	81	84	PF00928	0.414
TRG_ER_diArg_1	332	334	PF00400	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0F7CUE9	Hapsidospora irregularis	34%	100%
A0A0N0P7Z5	Leptomonas seymouri	35%	94%
A0A0N1PAS7	Leptomonas seymouri	67%	100%
A0A0S4IPP7	Bodo saltans	39%	100%
A0A0S4JFW4	Bodo saltans	49%	100%
A0A1X0NIT8	Trypanosomatidae	54%	100%
A0A1X0NJG0	Trypanosomatidae	36%	99%
A0A1X0NJN9	Trypanosomatidae	55%	100%
A0A1X0NKG0	Trypanosomatidae	36%	99%
A0A3Q8IG20	Leishmania donovani	97%	100%
A0A3R7MWM6	Trypanosoma rangeli	38%	99%
A0A3S7WY33	Leishmania donovani	35%	96%
A0A422NI78	Trypanosoma rangeli	55%	99%
A4HD93	Leishmania braziliensis	35%	100%
A4HMB3	Leishmania braziliensis	85%	100%
A5A6K8	Pan troglodytes	43%	100%
D0A277	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A706	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
E9AH48	Leishmania infantum	35%	96%
E9AWM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	96%
E9B5W2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O42652	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
O85746	Klebsiella pneumoniae	33%	100%
O94320	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	94%
P00503	Sus scrofa	44%	100%
P00504	Gallus gallus	44%	100%
P00505	Homo sapiens	43%	96%
P00506	Sus scrofa	42%	96%
P00507	Rattus norvegicus	42%	96%
P00508	Gallus gallus	42%	97%
P00509	Escherichia coli (strain K12)	38%	100%
P04693	Escherichia coli (strain K12)	33%	100%
P05201	Mus musculus	46%	100%
P05202	Mus musculus	43%	96%
P08906	Equus caballus	43%	100%
P08907	Equus caballus	42%	100%
P12344	Bos taurus	42%	96%
P12345	Oryctolagus cuniculus	43%	96%
P13221	Rattus norvegicus	46%	100%
P17174	Homo sapiens	44%	100%
P23542	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	99%
P26563	Lupinus angustifolius	42%	91%
P28011	Medicago sativa	46%	99%
P28734	Daucus carota	47%	100%
P33097	Bos taurus	44%	100%
P37833	Oryza sativa subsp. japonica	46%	100%
P43336	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	35%	100%
P44425	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	37%	100%
P46248	Arabidopsis thaliana	42%	91%
P46643	Arabidopsis thaliana	42%	96%
P46644	Arabidopsis thaliana	46%	92%
P46645	Arabidopsis thaliana	45%	100%
P46646	Arabidopsis thaliana	43%	100%
P58661	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	39%	100%
P72173	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	37%	100%
P74861	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	34%	100%
P95468	Paracoccus denitrificans	36%	100%
Q01802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	91%
Q02636	Rhizobium meliloti (strain 1021)	37%	100%
Q22067	Caenorhabditis elegans	42%	100%
Q28F67	Xenopus tropicalis	42%	96%
Q2PD92	Leishmania infantum	97%	100%
Q2T9S8	Bos taurus	31%	100%
Q4QAU4	Leishmania major	35%	96%
Q4R559	Macaca fascicularis	42%	96%
Q4R5L1	Macaca fascicularis	43%	100%
Q54SF7	Dictyostelium discoideum	45%	94%
Q55F21	Dictyostelium discoideum	40%	97%
Q56114	Salmonella typhi	39%	100%
Q5R691	Pongo abelii	44%	100%
Q5REB0	Pongo abelii	42%	96%
Q7SYK7	Danio rerio	43%	96%
Q7TSV6	Mus musculus	28%	100%
Q8NHS2	Homo sapiens	29%	98%
V5BSS0	Trypanosoma cruzi	56%	100%
V5BVY2	Trypanosoma cruzi	38%	99%