Glucose-6-phosphate isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucose-6-phosphate isomerase

Species:

Leishmania donovani

UniProt:

Q3C164_LEIDO

TriTrypDb:

LdBPK_120490.1 , LdCL_120010600 , LDHU3_12.0750

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

Q3C164

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0005996	monosaccharide metabolic process	3	11
GO:0006006	glucose metabolic process	5	11
GO:0006082	organic acid metabolic process	3	11
GO:0006090	pyruvate metabolic process	7	11
GO:0006091	generation of precursor metabolites and energy	3	11
GO:0006094	gluconeogenesis	6	11
GO:0006096	glycolytic process	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004347	glucose-6-phosphate isomerase activity	5	11
GO:0005488	binding	1	11
GO:0016853	isomerase activity	2	11
GO:0016860	intramolecular oxidoreductase activity	3	11
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	4	11
GO:0030246	carbohydrate binding	2	1
GO:0036094	small molecule binding	2	1
GO:0048029	monosaccharide binding	3	1
GO:0097367	carbohydrate derivative binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.566
CLV_C14_Caspase3-7	232	236	PF00656	0.535
CLV_NRD_NRD_1	38	40	PF00675	0.492
CLV_PCSK_KEX2_1	223	225	PF00082	0.376
CLV_PCSK_KEX2_1	38	40	PF00082	0.513
CLV_PCSK_KEX2_1	57	59	PF00082	0.524
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.413
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.574
CLV_PCSK_SKI1_1	112	116	PF00082	0.347
CLV_PCSK_SKI1_1	129	133	PF00082	0.354

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X8	Leptomonas seymouri	83%	100%
A0A1X0NNY8	Trypanosomatidae	73%	100%
A0A3S5IQU0	Trypanosoma rangeli	72%	100%
A0KEM2	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	58%	100%
A0L003	Shewanella sp. (strain ANA-3)	51%	100%
A0L900	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	58%	100%
A0LPA9	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	58%	100%
A0M665	Gramella forsetii (strain KT0803)	50%	100%
A0PVN7	Mycobacterium ulcerans (strain Agy99)	49%	100%
A0Q5P0	Francisella tularensis subsp. novicida (strain U112)	47%	100%

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