Mannose-6-phosphate isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphomannose isomerase

Species:

Leishmania braziliensis

UniProt:

Q2V6T4_LEIBR

TriTrypDb:

LbrM.32.1750 , LBRM2903_320023800

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q2V6T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q2V6T4

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009225	nucleotide-sugar metabolic process	4	11
GO:0009226	nucleotide-sugar biosynthetic process	5	11
GO:0009298	GDP-mannose biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019673	GDP-mannose metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0005996	monosaccharide metabolic process	3	1
GO:0006013	mannose metabolic process	5	1
GO:0016051	carbohydrate biosynthetic process	4	1
GO:0019307	mannose biosynthetic process	6	1
GO:0019318	hexose metabolic process	4	1
GO:0019319	hexose biosynthetic process	5	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046364	monosaccharide biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004476	mannose-6-phosphate isomerase activity	5	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0016853	isomerase activity	2	11
GO:0016860	intramolecular oxidoreductase activity	3	11
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	405	407	PF00675	0.315
CLV_PCSK_KEX2_1	158	160	PF00082	0.365
CLV_PCSK_KEX2_1	74	76	PF00082	0.252
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.365
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.252
CLV_PCSK_SKI1_1	100	104	PF00082	0.297
CLV_PCSK_SKI1_1	148	152	PF00082	0.197
CLV_PCSK_SKI1_1	29	33	PF00082	0.374
CLV_PCSK_SKI1_1	406	410	PF00082	0.344
DEG_APCC_DBOX_1	192	200	PF00400	0.452
DEG_APCC_DBOX_1	215	223	PF00400	0.538
DEG_APCC_DBOX_1	405	413	PF00400	0.260
DOC_CDC14_PxL_1	157	165	PF14671	0.393
DOC_MAPK_gen_1	406	412	PF00069	0.253
DOC_PP1_RVXF_1	405	412	PF00149	0.412
DOC_PP4_FxxP_1	392	395	PF00568	0.284
DOC_USP7_MATH_1	186	190	PF00917	0.349
DOC_USP7_MATH_1	20	24	PF00917	0.443
DOC_USP7_MATH_1	56	60	PF00917	0.535
DOC_USP7_MATH_1	80	84	PF00917	0.488
DOC_WW_Pin1_4	136	141	PF00397	0.452
DOC_WW_Pin1_4	293	298	PF00397	0.334
LIG_14-3-3_CanoR_1	193	197	PF00244	0.482
LIG_Actin_WH2_2	137	153	PF00022	0.403
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_BRCT_BRCA1_1	317	321	PF00533	0.289
LIG_BRCT_BRCA1_1	82	86	PF00533	0.520
LIG_BRCT_BRCA1_2	317	323	PF00533	0.293
LIG_Clathr_ClatBox_1	4	8	PF01394	0.472
LIG_EVH1_2	339	343	PF00568	0.333
LIG_FHA_1	210	216	PF00498	0.497
LIG_FHA_1	231	237	PF00498	0.469
LIG_FHA_1	311	317	PF00498	0.330
LIG_FHA_1	359	365	PF00498	0.423
LIG_FHA_1	366	372	PF00498	0.322
LIG_FHA_1	413	419	PF00498	0.415
LIG_FHA_2	137	143	PF00498	0.443
LIG_LIR_Apic_2	123	128	PF02991	0.455
LIG_LIR_Apic_2	201	207	PF02991	0.452
LIG_LIR_Apic_2	390	395	PF02991	0.290
LIG_LIR_Gen_1	139	149	PF02991	0.482
LIG_LIR_Gen_1	232	243	PF02991	0.455
LIG_LIR_Nem_3	139	144	PF02991	0.468
LIG_LIR_Nem_3	232	238	PF02991	0.465
LIG_LIR_Nem_3	296	302	PF02991	0.350
LIG_LIR_Nem_3	345	349	PF02991	0.301
LIG_LIR_Nem_3	8	14	PF02991	0.436
LIG_Pex14_1	249	253	PF04695	0.443
LIG_SH2_CRK	337	341	PF00017	0.328
LIG_SH2_CRK	396	400	PF00017	0.405
LIG_SH2_NCK_1	204	208	PF00017	0.405
LIG_SH2_SRC	337	340	PF00017	0.364
LIG_SH2_STAP1	40	44	PF00017	0.395
LIG_SH2_STAT3	349	352	PF00017	0.390
LIG_SH2_STAT5	156	159	PF00017	0.360
LIG_SH2_STAT5	252	255	PF00017	0.443
LIG_SH2_STAT5	256	259	PF00017	0.303
LIG_SH2_STAT5	275	278	PF00017	0.309
LIG_SH2_STAT5	76	79	PF00017	0.552
LIG_SH2_STAT5	92	95	PF00017	0.526
LIG_SH3_2	49	54	PF14604	0.490
LIG_SH3_3	361	367	PF00018	0.481
LIG_SH3_3	46	52	PF00018	0.448
LIG_SUMO_SIM_anti_2	279	285	PF11976	0.301
LIG_SUMO_SIM_par_1	95	101	PF11976	0.484
LIG_TRAF2_2	340	345	PF00917	0.467
LIG_TYR_ITIM	394	399	PF00017	0.358
LIG_UBA3_1	153	158	PF00899	0.358
LIG_UBA3_1	234	240	PF00899	0.203
MOD_CDK_SPK_2	293	298	PF00069	0.334
MOD_CDK_SPxxK_3	293	300	PF00069	0.340
MOD_CK1_1	195	201	PF00069	0.299
MOD_CK1_1	359	365	PF00069	0.398
MOD_CK1_1	50	56	PF00069	0.460
MOD_CK1_1	98	104	PF00069	0.332
MOD_CK2_1	136	142	PF00069	0.273
MOD_CK2_1	186	192	PF00069	0.384
MOD_CK2_1	265	271	PF00069	0.356
MOD_CK2_1	422	428	PF00069	0.462
MOD_GlcNHglycan	1	4	PF01048	0.334
MOD_GlcNHglycan	181	184	PF01048	0.446
MOD_GlcNHglycan	276	279	PF01048	0.445
MOD_GlcNHglycan	317	320	PF01048	0.498
MOD_GlcNHglycan	33	38	PF01048	0.404
MOD_GlcNHglycan	356	359	PF01048	0.490
MOD_GlcNHglycan	376	380	PF01048	0.220
MOD_GlcNHglycan	417	421	PF01048	0.402
MOD_GlcNHglycan	58	61	PF01048	0.213
MOD_GlcNHglycan	77	80	PF01048	0.175
MOD_GSK3_1	168	175	PF00069	0.296
MOD_GSK3_1	29	36	PF00069	0.383
MOD_GSK3_1	311	318	PF00069	0.472
MOD_GSK3_1	354	361	PF00069	0.408
MOD_GSK3_1	412	419	PF00069	0.406
MOD_GSK3_1	82	89	PF00069	0.421
MOD_N-GLC_1	323	328	PF02516	0.297
MOD_N-GLC_1	381	386	PF02516	0.388
MOD_N-GLC_1	56	61	PF02516	0.402
MOD_NEK2_1	309	314	PF00069	0.334
MOD_NEK2_1	375	380	PF00069	0.367
MOD_NEK2_1	411	416	PF00069	0.303
MOD_NEK2_1	418	423	PF00069	0.465
MOD_NEK2_1	7	12	PF00069	0.203
MOD_NEK2_1	86	91	PF00069	0.321
MOD_NEK2_2	230	235	PF00069	0.203
MOD_PK_1	95	101	PF00069	0.273
MOD_PKA_2	192	198	PF00069	0.203
MOD_PKA_2	86	92	PF00069	0.317
MOD_Plk_1	207	213	PF00069	0.419
MOD_Plk_1	230	236	PF00069	0.285
MOD_Plk_1	7	13	PF00069	0.203
MOD_Plk_4	168	174	PF00069	0.291
MOD_Plk_4	195	201	PF00069	0.272
MOD_Plk_4	20	26	PF00069	0.273
MOD_Plk_4	230	236	PF00069	0.285
MOD_Plk_4	301	307	PF00069	0.330
MOD_Plk_4	381	387	PF00069	0.251
MOD_ProDKin_1	136	142	PF00069	0.285
MOD_ProDKin_1	293	299	PF00069	0.338
MOD_SUMO_rev_2	404	409	PF00179	0.287
TRG_DiLeu_BaEn_1	405	410	PF01217	0.274
TRG_DiLeu_BaEn_2	230	236	PF01217	0.252
TRG_ENDOCYTIC_2	256	259	PF00928	0.303
TRG_ENDOCYTIC_2	396	399	PF00928	0.348
TRG_ENDOCYTIC_2	40	43	PF00928	0.207
TRG_NLS_MonoExtN_4	70	77	PF00514	0.274
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.207
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.240
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I488	Leptomonas seymouri	75%	100%
A0A1X0NUN2	Trypanosomatidae	57%	100%
A0A3R7KE75	Trypanosoma rangeli	55%	100%
A2CIG5	Leishmania infantum	85%	100%
A2CIH3	Leishmania donovani	85%	100%
A5A6K3	Pan troglodytes	37%	100%
D0AA38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B2T4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O43014	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P00946	Escherichia coli (strain K12)	32%	100%
P25081	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	36%	100%
P29951	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	93%
P29952	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P34650	Caenorhabditis elegans	33%	100%
P34948	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	97%
P34949	Homo sapiens	37%	100%
Q3SZI0	Bos taurus	38%	100%
Q4Q5C3	Leishmania major	84%	100%
Q54PA0	Dictyostelium discoideum	42%	95%
Q66WM4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	43%	94%
Q68FX1	Rattus norvegicus	38%	100%
Q75AB5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	34%	100%
Q76IQ2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q83KZ1	Shigella flexneri	32%	100%
Q870Y1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	35%	93%
Q8HXX2	Macaca fascicularis	37%	100%
Q8J093	Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1)	39%	100%
Q924M7	Mus musculus	39%	100%
Q9FZH5	Arabidopsis thaliana	39%	97%
Q9GP38	Echinococcus multilocularis	36%	99%
Q9HFU4	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	37%	99%
Q9M884	Arabidopsis thaliana	36%	99%
V5DFU6	Trypanosoma cruzi	54%	100%