Uncharacterized protein pkac1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cAMP-dependent protein kinase catalytic subunit 3

Species:

Leishmania major

UniProt:

Q27687_LEIMA

TriTrypDb:

LmjF.18.1080 , LMJLV39_180016300 , LMJSD75_180016500

Length:

332

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005952	cAMP-dependent protein kinase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1902554	serine/threonine protein kinase complex	6	2

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Expansion

Sequence features

Q27687

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q27687

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	16
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016310	phosphorylation	5	16
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0004672	protein kinase activity	3	16
GO:0004674	protein serine/threonine kinase activity	4	16
GO:0004679	AMP-activated protein kinase activity	5	1
GO:0004690	cyclic nucleotide-dependent protein kinase activity	5	3
GO:0004691	cAMP-dependent protein kinase activity	6	3
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016301	kinase activity	4	16

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.321
CLV_PCSK_KEX2_1	161	163	PF00082	0.312
CLV_PCSK_KEX2_1	251	253	PF00082	0.274
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.324
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.277
CLV_PCSK_SKI1_1	137	141	PF00082	0.280
CLV_PCSK_SKI1_1	161	165	PF00082	0.297
CLV_PCSK_SKI1_1	166	170	PF00082	0.282
CLV_PCSK_SKI1_1	226	230	PF00082	0.376
CLV_PCSK_SKI1_1	242	246	PF00082	0.166

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N5	Leptomonas seymouri	29%	77%
A0A0N0P4J7	Leptomonas seymouri	29%	75%
A0A0N0P787	Leptomonas seymouri	31%	86%
A0A0N0P8H5	Leptomonas seymouri	86%	100%
A0A0N1HWQ2	Leptomonas seymouri	33%	100%
A0A0N1I6T8	Leptomonas seymouri	32%	100%
A0A0N1IIF9	Leptomonas seymouri	35%	100%
A0A0N1IM47	Leptomonas seymouri	29%	90%
A0A0N1PC31	Leptomonas seymouri	32%	85%
A0A0N1PD05	Leptomonas seymouri	28%	74%

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