Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ARP2/3 complex subunit, putative

Species:

Leishmania major

UniProt:

Q19R45_LEIMA

TriTrypDb:

LmjF.02.0600 , LMJLV39_020011200 , LMJSD75_020011300

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005885	Arp2/3 protein complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q19R45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q19R45

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	11
GO:0008064	regulation of actin polymerization or depolymerization	6	11
GO:0008154	actin polymerization or depolymerization	6	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0030041	actin filament polymerization	7	11
GO:0030832	regulation of actin filament length	5	11
GO:0030833	regulation of actin filament polymerization	7	11
GO:0032271	regulation of protein polymerization	6	11
GO:0032535	regulation of cellular component size	4	11
GO:0032956	regulation of actin cytoskeleton organization	5	11
GO:0032970	regulation of actin filament-based process	4	11
GO:0033043	regulation of organelle organization	5	11
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	11
GO:0043254	regulation of protein-containing complex assembly	5	11
GO:0043933	protein-containing complex organization	4	11
GO:0044087	regulation of cellular component biogenesis	4	11
GO:0045010	actin nucleation	6	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051128	regulation of cellular component organization	4	11
GO:0051258	protein polymerization	6	11
GO:0051493	regulation of cytoskeleton organization	6	11
GO:0065003	protein-containing complex assembly	5	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090066	regulation of anatomical structure size	3	11
GO:0097435	supramolecular fiber organization	4	11
GO:0110053	regulation of actin filament organization	6	11
GO:1902903	regulation of supramolecular fiber organization	5	11

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	6
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0008092	cytoskeletal protein binding	3	6
GO:0044877	protein-containing complex binding	2	2
GO:0051015	actin filament binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.460
CLV_NRD_NRD_1	164	166	PF00675	0.260
CLV_NRD_NRD_1	226	228	PF00675	0.226
CLV_NRD_NRD_1	23	25	PF00675	0.656
CLV_NRD_NRD_1	27	29	PF00675	0.486
CLV_PCSK_FUR_1	11	15	PF00082	0.458
CLV_PCSK_KEX2_1	13	15	PF00082	0.460
CLV_PCSK_KEX2_1	164	166	PF00082	0.288
CLV_PCSK_KEX2_1	225	227	PF00082	0.233
CLV_PCSK_KEX2_1	23	25	PF00082	0.608
CLV_PCSK_KEX2_1	27	29	PF00082	0.432
CLV_PCSK_PC7_1	23	29	PF00082	0.376
CLV_PCSK_PC7_1	9	15	PF00082	0.455
CLV_PCSK_SKI1_1	14	18	PF00082	0.731
CLV_PCSK_SKI1_1	202	206	PF00082	0.337
CLV_PCSK_SKI1_1	27	31	PF00082	0.342
CLV_PCSK_SKI1_1	42	46	PF00082	0.346
DEG_APCC_DBOX_1	41	49	PF00400	0.538
DEG_Nend_UBRbox_1	1	4	PF02207	0.486
DOC_CYCLIN_yCln2_LP_2	68	71	PF00134	0.463
DOC_MAPK_gen_1	23	31	PF00069	0.403
DOC_MAPK_MEF2A_6	42	50	PF00069	0.544
DOC_PP1_RVXF_1	116	122	PF00149	0.457
DOC_PP1_RVXF_1	97	103	PF00149	0.515
DOC_PP2B_LxvP_1	48	51	PF13499	0.388
DOC_PP2B_LxvP_1	68	71	PF13499	0.351
DOC_PP4_FxxP_1	234	237	PF00568	0.539
DOC_USP7_MATH_1	214	218	PF00917	0.401
LIG_14-3-3_CanoR_1	118	122	PF00244	0.415
LIG_14-3-3_CanoR_1	164	171	PF00244	0.488
LIG_14-3-3_CanoR_1	27	32	PF00244	0.285
LIG_14-3-3_CanoR_1	99	109	PF00244	0.457
LIG_Actin_WH2_2	204	221	PF00022	0.463
LIG_BIR_III_4	174	178	PF00653	0.413
LIG_BRCT_BRCA1_1	119	123	PF00533	0.433
LIG_BRCT_BRCA1_1	51	55	PF00533	0.388
LIG_eIF4E_1	181	187	PF01652	0.440
LIG_EVH1_2	78	82	PF00568	0.488
LIG_FHA_1	150	156	PF00498	0.567
LIG_FHA_1	41	47	PF00498	0.500
LIG_FHA_2	177	183	PF00498	0.464
LIG_FHA_2	60	66	PF00498	0.496
LIG_LIR_Gen_1	12	19	PF02991	0.453
LIG_LIR_Gen_1	140	145	PF02991	0.548
LIG_LIR_Gen_1	182	192	PF02991	0.538
LIG_LIR_Nem_3	12	18	PF02991	0.693
LIG_LIR_Nem_3	140	144	PF02991	0.548
LIG_LIR_Nem_3	182	188	PF02991	0.538
LIG_PDZ_Class_2	233	238	PF00595	0.582
LIG_SH2_CRK	15	19	PF00017	0.449
LIG_SH2_NCK_1	37	41	PF00017	0.538
LIG_SH2_STAP1	181	185	PF00017	0.440
LIG_SH2_STAT3	195	198	PF00017	0.488
LIG_SUMO_SIM_anti_2	65	70	PF11976	0.509
LIG_WRC_WIRS_1	50	55	PF05994	0.538
MOD_CK1_1	113	119	PF00069	0.472
MOD_CK1_1	149	155	PF00069	0.388
MOD_CK2_1	101	107	PF00069	0.459
MOD_CK2_1	59	65	PF00069	0.549
MOD_GlcNHglycan	103	106	PF01048	0.345
MOD_GlcNHglycan	133	136	PF01048	0.328
MOD_GlcNHglycan	148	151	PF01048	0.259
MOD_GlcNHglycan	166	169	PF01048	0.204
MOD_GlcNHglycan	5	8	PF01048	0.452
MOD_GSK3_1	110	117	PF00069	0.461
MOD_GSK3_1	214	221	PF00069	0.483
MOD_GSK3_1	55	62	PF00069	0.468
MOD_NEK2_1	100	105	PF00069	0.488
MOD_NEK2_1	144	149	PF00069	0.540
MOD_NEK2_1	200	205	PF00069	0.460
MOD_NEK2_1	218	223	PF00069	0.383
MOD_NEK2_1	55	60	PF00069	0.521
MOD_NEK2_2	214	219	PF00069	0.401
MOD_OFUCOSY	108	114	PF10250	0.288
MOD_PIKK_1	55	61	PF00454	0.388
MOD_PKA_1	164	170	PF00069	0.488
MOD_PKA_1	27	33	PF00069	0.143
MOD_PKA_2	117	123	PF00069	0.440
MOD_PKA_2	163	169	PF00069	0.488
MOD_PKA_2	27	33	PF00069	0.271
MOD_Plk_1	114	120	PF00069	0.455
MOD_Plk_1	181	187	PF00069	0.440
MOD_Plk_1	40	46	PF00069	0.528
MOD_Plk_4	117	123	PF00069	0.476
MOD_Plk_4	181	187	PF00069	0.538
MOD_Plk_4	78	84	PF00069	0.488
TRG_DiLeu_BaEn_1	41	46	PF01217	0.463
TRG_ENDOCYTIC_2	141	144	PF00928	0.454
TRG_ENDOCYTIC_2	15	18	PF00928	0.451
TRG_ENDOCYTIC_2	37	40	PF00928	0.454
TRG_ER_diArg_1	11	14	PF00400	0.458
TRG_ER_diArg_1	163	165	PF00400	0.488
TRG_ER_diArg_1	225	227	PF00400	0.424
TRG_ER_diArg_1	26	28	PF00400	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAU0	Leptomonas seymouri	46%	100%
A0A0S4KGM1	Bodo saltans	27%	100%
A0A1X0NJU3	Trypanosomatidae	30%	100%
A0A3R7MB12	Trypanosoma rangeli	27%	100%
A0A451EJJ5	Leishmania donovani	88%	100%
A4H3F1	Leishmania braziliensis	67%	100%
A4HRQ5	Leishmania infantum	87%	100%
C9ZJ46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AJM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
F4JUL9	Arabidopsis thaliana	27%	100%
P33204	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P59998	Homo sapiens	25%	100%
P59999	Mus musculus	25%	100%
Q148J6	Bos taurus	25%	100%
Q641G7	Xenopus laevis	25%	100%
Q92352	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%