Purine metabolism, Nucleoside hydrolase-like nh2
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | yes | yes: 6 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 20 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005737 | cytoplasm | 2 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 1 |
Related structures:
AlphaFold database: Q18L05
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 1 |
| GO:0006166 | purine ribonucleoside salvage | 5 | 1 |
| GO:0006179 | guanosine salvage | 6 | 1 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 1 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 1 |
| GO:0008152 | metabolic process | 1 | 3 |
| GO:0008617 | guanosine metabolic process | 8 | 1 |
| GO:0009058 | biosynthetic process | 2 | 1 |
| GO:0009116 | nucleoside metabolic process | 4 | 1 |
| GO:0009119 | ribonucleoside metabolic process | 5 | 1 |
| GO:0009163 | nucleoside biosynthetic process | 5 | 1 |
| GO:0009987 | cellular process | 1 | 1 |
| GO:0018130 | heterocycle biosynthetic process | 4 | 1 |
| GO:0019438 | aromatic compound biosynthetic process | 4 | 1 |
| GO:0034404 | nucleobase-containing small molecule biosynthetic process | 4 | 1 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 1 |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 4 | 1 |
| GO:0042278 | purine nucleoside metabolic process | 5 | 1 |
| GO:0042451 | purine nucleoside biosynthetic process | 6 | 1 |
| GO:0042455 | ribonucleoside biosynthetic process | 6 | 1 |
| GO:0043094 | cellular metabolic compound salvage | 3 | 1 |
| GO:0043101 | purine-containing compound salvage | 4 | 1 |
| GO:0043174 | nucleoside salvage | 4 | 1 |
| GO:0044237 | cellular metabolic process | 2 | 1 |
| GO:0044238 | primary metabolic process | 2 | 1 |
| GO:0044249 | cellular biosynthetic process | 3 | 1 |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 4 | 1 |
| GO:0044281 | small molecule metabolic process | 2 | 1 |
| GO:0044283 | small molecule biosynthetic process | 3 | 1 |
| GO:0046114 | guanosine biosynthetic process | 9 | 1 |
| GO:0046128 | purine ribonucleoside metabolic process | 6 | 1 |
| GO:0046129 | purine ribonucleoside biosynthetic process | 7 | 1 |
| GO:0046483 | heterocycle metabolic process | 3 | 1 |
| GO:0055086 | nucleobase-containing small molecule metabolic process | 3 | 1 |
| GO:0071704 | organic substance metabolic process | 2 | 1 |
| GO:0072521 | purine-containing compound metabolic process | 4 | 1 |
| GO:0072522 | purine-containing compound biosynthetic process | 5 | 1 |
| GO:1901068 | guanosine-containing compound metabolic process | 7 | 1 |
| GO:1901070 | guanosine-containing compound biosynthetic process | 8 | 1 |
| GO:1901135 | carbohydrate derivative metabolic process | 3 | 1 |
| GO:1901137 | carbohydrate derivative biosynthetic process | 4 | 1 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 1 |
| GO:1901362 | organic cyclic compound biosynthetic process | 4 | 1 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 1 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 1 |
| GO:1901576 | organic substance biosynthetic process | 3 | 1 |
| GO:1901657 | glycosyl compound metabolic process | 4 | 1 |
| GO:1901659 | glycosyl compound biosynthetic process | 5 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0016787 | hydrolase activity | 2 | 12 |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | 3 | 12 |
| GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds | 4 | 12 |
| GO:0008477 | purine nucleosidase activity | 5 | 3 |
| GO:0047724 | inosine nucleosidase activity | 6 | 1 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 333 | 337 | PF00656 | 0.501 |
| CLV_NRD_NRD_1 | 3 | 5 | PF00675 | 0.370 |
| CLV_PCSK_KEX2_1 | 322 | 324 | PF00082 | 0.305 |
| CLV_PCSK_PC1ET2_1 | 322 | 324 | PF00082 | 0.305 |
| CLV_PCSK_SKI1_1 | 116 | 120 | PF00082 | 0.314 |
| CLV_PCSK_SKI1_1 | 291 | 295 | PF00082 | 0.319 |
| CLV_Separin_Metazoa | 113 | 117 | PF03568 | 0.526 |
| DOC_ANK_TNKS_1 | 249 | 256 | PF00023 | 0.526 |
| DOC_PP1_RVXF_1 | 198 | 205 | PF00149 | 0.563 |
| DOC_PP1_SILK_1 | 345 | 350 | PF00149 | 0.313 |
| DOC_PP2B_PxIxI_1 | 156 | 162 | PF00149 | 0.526 |
| DOC_PP4_FxxP_1 | 248 | 251 | PF00568 | 0.470 |
| DOC_SPAK_OSR1_1 | 233 | 237 | PF12202 | 0.474 |
| DOC_USP7_MATH_1 | 70 | 74 | PF00917 | 0.521 |
| LIG_14-3-3_CanoR_1 | 200 | 205 | PF00244 | 0.544 |
| LIG_14-3-3_CanoR_1 | 291 | 296 | PF00244 | 0.519 |
| LIG_14-3-3_CanoR_1 | 306 | 314 | PF00244 | 0.405 |
| LIG_APCC_ABBA_1 | 178 | 183 | PF00400 | 0.563 |
| LIG_APCC_ABBA_1 | 234 | 239 | PF00400 | 0.563 |
| LIG_APCC_ABBAyCdc20_2 | 233 | 239 | PF00400 | 0.563 |
| LIG_BIR_III_4 | 16 | 20 | PF00653 | 0.470 |
| LIG_FHA_1 | 110 | 116 | PF00498 | 0.505 |
| LIG_FHA_1 | 247 | 253 | PF00498 | 0.575 |
| LIG_FHA_1 | 268 | 274 | PF00498 | 0.470 |
| LIG_FHA_1 | 27 | 33 | PF00498 | 0.563 |
| LIG_FHA_1 | 295 | 301 | PF00498 | 0.507 |
| LIG_FHA_1 | 343 | 349 | PF00498 | 0.283 |
| LIG_FHA_2 | 213 | 219 | PF00498 | 0.505 |
| LIG_FHA_2 | 307 | 313 | PF00498 | 0.458 |
| LIG_FHA_2 | 331 | 337 | PF00498 | 0.501 |
| LIG_LIR_Apic_2 | 246 | 251 | PF02991 | 0.470 |
| LIG_LIR_Gen_1 | 123 | 134 | PF02991 | 0.486 |
| LIG_LIR_Gen_1 | 146 | 154 | PF02991 | 0.489 |
| LIG_LIR_Gen_1 | 185 | 196 | PF02991 | 0.483 |
| LIG_LIR_Gen_1 | 211 | 221 | PF02991 | 0.502 |
| LIG_LIR_Gen_1 | 239 | 248 | PF02991 | 0.459 |
| LIG_LIR_Gen_1 | 294 | 300 | PF02991 | 0.485 |
| LIG_LIR_Nem_3 | 123 | 129 | PF02991 | 0.486 |
| LIG_LIR_Nem_3 | 146 | 151 | PF02991 | 0.482 |
| LIG_LIR_Nem_3 | 185 | 191 | PF02991 | 0.483 |
| LIG_LIR_Nem_3 | 211 | 217 | PF02991 | 0.502 |
| LIG_LIR_Nem_3 | 239 | 245 | PF02991 | 0.468 |
| LIG_LIR_Nem_3 | 290 | 295 | PF02991 | 0.482 |
| LIG_LIR_Nem_3 | 35 | 41 | PF02991 | 0.501 |
| LIG_LIR_Nem_3 | 77 | 83 | PF02991 | 0.459 |
| LIG_PDZ_Class_2 | 347 | 352 | PF00595 | 0.380 |
| LIG_Pex14_2 | 216 | 220 | PF04695 | 0.470 |
| LIG_PTB_Apo_2 | 334 | 341 | PF02174 | 0.501 |
| LIG_SH2_CRK | 126 | 130 | PF00017 | 0.459 |
| LIG_SH2_STAT5 | 188 | 191 | PF00017 | 0.505 |
| LIG_SH2_STAT5 | 295 | 298 | PF00017 | 0.492 |
| LIG_SH3_3 | 69 | 75 | PF00018 | 0.505 |
| LIG_SUMO_SIM_par_1 | 52 | 58 | PF11976 | 0.505 |
| LIG_TYR_ITIM | 293 | 298 | PF00017 | 0.467 |
| LIG_TYR_ITSM | 122 | 129 | PF00017 | 0.550 |
| LIG_ULM_U2AF65_1 | 322 | 327 | PF00076 | 0.470 |
| LIG_WRC_WIRS_1 | 245 | 250 | PF05994 | 0.495 |
| MOD_CK1_1 | 172 | 178 | PF00069 | 0.527 |
| MOD_CK2_1 | 150 | 156 | PF00069 | 0.510 |
| MOD_CK2_1 | 70 | 76 | PF00069 | 0.563 |
| MOD_Cter_Amidation | 226 | 229 | PF01082 | 0.363 |
| MOD_GlcNHglycan | 95 | 98 | PF01048 | 0.350 |
| MOD_GSK3_1 | 169 | 176 | PF00069 | 0.516 |
| MOD_GSK3_1 | 200 | 207 | PF00069 | 0.500 |
| MOD_GSK3_1 | 208 | 215 | PF00069 | 0.487 |
| MOD_GSK3_1 | 253 | 260 | PF00069 | 0.452 |
| MOD_GSK3_1 | 263 | 270 | PF00069 | 0.471 |
| MOD_GSK3_1 | 302 | 309 | PF00069 | 0.515 |
| MOD_GSK3_1 | 70 | 77 | PF00069 | 0.572 |
| MOD_N-GLC_1 | 172 | 177 | PF02516 | 0.313 |
| MOD_N-GLC_2 | 269 | 271 | PF02516 | 0.305 |
| MOD_NEK2_1 | 100 | 105 | PF00069 | 0.463 |
| MOD_NEK2_1 | 212 | 217 | PF00069 | 0.563 |
| MOD_PIKK_1 | 263 | 269 | PF00454 | 0.459 |
| MOD_PKA_2 | 302 | 308 | PF00069 | 0.505 |
| MOD_Plk_1 | 121 | 127 | PF00069 | 0.553 |
| MOD_Plk_1 | 204 | 210 | PF00069 | 0.459 |
| MOD_Plk_1 | 267 | 273 | PF00069 | 0.480 |
| MOD_Plk_4 | 121 | 127 | PF00069 | 0.550 |
| MOD_Plk_4 | 284 | 290 | PF00069 | 0.482 |
| TRG_ENDOCYTIC_2 | 126 | 129 | PF00928 | 0.459 |
| TRG_ENDOCYTIC_2 | 188 | 191 | PF00928 | 0.505 |
| TRG_ENDOCYTIC_2 | 295 | 298 | PF00928 | 0.496 |
| TRG_ER_diArg_1 | 323 | 326 | PF00400 | 0.563 |
| TRG_NES_CRM1_1 | 45 | 60 | PF08389 | 0.470 |
| TRG_Pf-PMV_PEXEL_1 | 250 | 254 | PF00026 | 0.305 |
| TRG_Pf-PMV_PEXEL_1 | 98 | 102 | PF00026 | 0.400 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IKH5 | Leptomonas seymouri | 81% | 100% |
| A0A0S4ITJ9 | Bodo saltans | 61% | 98% |
| A0A1X0NNR9 | Trypanosomatidae | 66% | 98% |
| A0A3R7KUP9 | Trypanosoma rangeli | 66% | 99% |
| A1A8R9 | Escherichia coli O1:K1 / APEC | 27% | 100% |
| A4H7H4 | Leishmania braziliensis | 88% | 100% |
| A4H9Q9 | Leishmania braziliensis | 28% | 91% |
| A4W829 | Enterobacter sp. (strain 638) | 28% | 100% |
| A6T9S2 | Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) | 28% | 100% |
| A7ZJ42 | Escherichia coli O139:H28 (strain E24377A / ETEC) | 27% | 100% |
| A7ZXS0 | Escherichia coli O9:H4 (strain HS) | 28% | 100% |
| A8AJF8 | Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) | 27% | 100% |
| A9MKC6 | Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) | 29% | 100% |
| A9MUJ0 | Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) | 28% | 100% |
| B1IYF7 | Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) | 27% | 100% |
| B1KHA5 | Shewanella woodyi (strain ATCC 51908 / MS32) | 28% | 100% |
| B1LLA1 | Escherichia coli (strain SMS-3-5 / SECEC) | 27% | 100% |
| B2TU69 | Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) | 27% | 100% |
| B4SYM0 | Salmonella newport (strain SL254) | 28% | 100% |
| B4TB65 | Salmonella heidelberg (strain SL476) | 28% | 100% |
| B4TPY1 | Salmonella schwarzengrund (strain CVM19633) | 27% | 100% |
| B5BCD9 | Salmonella paratyphi A (strain AKU_12601) | 27% | 100% |
| B5EZA2 | Salmonella agona (strain SL483) | 27% | 100% |
| B5FNA2 | Salmonella dublin (strain CT_02021853) | 27% | 100% |
| B5QVR2 | Salmonella enteritidis PT4 (strain P125109) | 27% | 100% |
| B5R809 | Salmonella gallinarum (strain 287/91 / NCTC 13346) | 27% | 100% |
| B5XWV7 | Klebsiella pneumoniae (strain 342) | 28% | 100% |
| B5YQK2 | Escherichia coli O157:H7 (strain EC4115 / EHEC) | 27% | 100% |
| B6I163 | Escherichia coli (strain SE11) | 27% | 100% |
| B7L9J7 | Escherichia coli (strain 55989 / EAEC) | 27% | 100% |
| B7LKV4 | Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) | 27% | 100% |
| B7LVN6 | Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) | 35% | 100% |
| B7M5H8 | Escherichia coli O8 (strain IAI1) | 27% | 100% |
| B7MFR7 | Escherichia coli O45:K1 (strain S88 / ExPEC) | 27% | 100% |
| B7MRT1 | Escherichia coli O81 (strain ED1a) | 27% | 100% |
| B7N9Q7 | Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) | 27% | 100% |
| B7NM03 | Escherichia coli O7:K1 (strain IAI39 / ExPEC) | 27% | 100% |
| B7UKT4 | Escherichia coli O127:H6 (strain E2348/69 / EPEC) | 27% | 100% |
| C0PW90 | Salmonella paratyphi C (strain RKS4594) | 27% | 100% |
| C4ZWD8 | Escherichia coli (strain K12 / MC4100 / BW2952) | 27% | 100% |
| C9ZT72 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 64% | 99% |
| E9APK7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 97% | 100% |
| P41409 | Escherichia coli (strain K12) | 27% | 100% |
| Q04179 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 26% | 100% |
| Q0T6R1 | Shigella flexneri serotype 5b (strain 8401) | 27% | 100% |
| Q0TK29 | Escherichia coli O6:K15:H31 (strain 536 / UPEC) | 27% | 100% |
| Q10314 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 23% | 100% |
| Q18L65 | Leishmania donovani | 100% | 100% |
| Q27546 | Crithidia fasciculata | 27% | 100% |
| Q2PDC5 | Leishmania infantum | 27% | 92% |
| Q324P5 | Shigella boydii serotype 4 (strain Sb227) | 27% | 100% |
| Q326J3 | Shigella boydii serotype 4 (strain Sb227) | 34% | 100% |
| Q3Z4E1 | Shigella sonnei (strain Ss046) | 27% | 100% |
| Q4QFX2 | Leishmania major | 97% | 100% |
| Q57RR6 | Salmonella choleraesuis (strain SC-B67) | 27% | 100% |
| Q5PM78 | Salmonella paratyphi A (strain ATCC 9150 / SARB42) | 27% | 100% |
| Q652Q8 | Oryza sativa subsp. japonica | 32% | 100% |
| Q6ZJ05 | Oryza sativa subsp. japonica | 31% | 100% |
| Q7KWM9 | Dictyostelium discoideum | 24% | 100% |
| Q83LY1 | Shigella flexneri | 27% | 100% |
| Q8FJY8 | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) | 27% | 100% |
| Q8WQX2 | Leishmania donovani | 28% | 100% |
| Q8XBL8 | Escherichia coli O157:H7 | 27% | 100% |
| Q8Z8H0 | Salmonella typhi | 28% | 100% |
| Q8ZQY4 | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) | 28% | 100% |
| V5DDY4 | Trypanosoma cruzi | 68% | 99% |