6-phosphogluconate dehydrogenase, decarboxylating

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

6-phosphogluconate dehydrogenase, decarboxylating, putative

Species:

Leishmania donovani

UniProt:

Q18L02_LEIDO

TriTrypDb:

LdBPK_353390.1 , LdCL_350038900 , LDHU3_35.4460

Length:

479

Annotations

Annotations by Jardim et al.

Pentose Phosphate Pathway, 6-phosphogluconate dehydrogenase, decarboxylating gnd

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

Q18L02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006082	organic acid metabolic process	3	12
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006098	pentose-phosphate shunt	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006739	NADP metabolic process	7	12
GO:0006740	NADPH regeneration	4	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	12
GO:0036094	small molecule binding	2	12
GO:0050661	NADP binding	4	12
GO:0097159	organic cyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	465	469	PF00656	0.525
CLV_NRD_NRD_1	137	139	PF00675	0.262
CLV_NRD_NRD_1	71	73	PF00675	0.266
CLV_PCSK_KEX2_1	113	115	PF00082	0.262
CLV_PCSK_KEX2_1	71	73	PF00082	0.330
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.376
CLV_PCSK_SKI1_1	24	28	PF00082	0.321
CLV_PCSK_SKI1_1	290	294	PF00082	0.227
CLV_PCSK_SKI1_1	412	416	PF00082	0.303
CLV_PCSK_SKI1_1	454	458	PF00082	0.227

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4G8	Leptomonas seymouri	83%	100%
A0A0S4JHR8	Bodo saltans	68%	100%
A0A1X0P6E0	Trypanosomatidae	76%	100%
A0A3R7REV2	Trypanosoma rangeli	72%	100%
A4HN01	Leishmania braziliensis	86%	100%
C8VP36	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	97%
C9ZZ10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9B6L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O13287	Candida albicans	38%	93%
O60037	Cunninghamella elegans	39%	99%

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