Adenylosuccinate synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylosuccinate synthetase, putative

Species:

Leishmania major

UniProt:

PURA_LEIMA

TriTrypDb:

LmjF.13.1190 , LMJLV39_130016100 , LMJSD75_130016100

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QG35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG35

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006164	purine nucleotide biosynthetic process	6	12
GO:0006167	AMP biosynthetic process	8	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009123	nucleoside monophosphate metabolic process	5	12
GO:0009124	nucleoside monophosphate biosynthetic process	6	12
GO:0009126	purine nucleoside monophosphate metabolic process	6	12
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009152	purine ribonucleotide biosynthetic process	7	12
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	12
GO:0009161	ribonucleoside monophosphate metabolic process	6	12
GO:0009165	nucleotide biosynthetic process	6	12
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	12
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009260	ribonucleotide biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0044208	'de novo' AMP biosynthetic process	9	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0046033	AMP metabolic process	7	12
GO:0046040	IMP metabolic process	7	2
GO:0046390	ribose phosphate biosynthetic process	5	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:0072522	purine-containing compound biosynthetic process	5	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901293	nucleoside phosphate biosynthetic process	5	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0000287	magnesium ion binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004019	adenylosuccinate synthase activity	4	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.386
CLV_C14_Caspase3-7	356	360	PF00656	0.442
CLV_C14_Caspase3-7	58	62	PF00656	0.607
CLV_NRD_NRD_1	148	150	PF00675	0.500
CLV_NRD_NRD_1	218	220	PF00675	0.254
CLV_NRD_NRD_1	324	326	PF00675	0.351
CLV_NRD_NRD_1	4	6	PF00675	0.743
CLV_NRD_NRD_1	669	671	PF00675	0.258
CLV_PCSK_KEX2_1	148	150	PF00082	0.500
CLV_PCSK_KEX2_1	235	237	PF00082	0.264
CLV_PCSK_KEX2_1	309	311	PF00082	0.253
CLV_PCSK_KEX2_1	326	328	PF00082	0.213
CLV_PCSK_KEX2_1	4	6	PF00082	0.743
CLV_PCSK_KEX2_1	667	669	PF00082	0.242
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.253
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.253
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.213
CLV_PCSK_PC1ET2_1	667	669	PF00082	0.242
CLV_PCSK_SKI1_1	148	152	PF00082	0.508
CLV_PCSK_SKI1_1	220	224	PF00082	0.242
CLV_PCSK_SKI1_1	306	310	PF00082	0.289
CLV_PCSK_SKI1_1	414	418	PF00082	0.285
CLV_PCSK_SKI1_1	512	516	PF00082	0.306
CLV_Separin_Metazoa	85	89	PF03568	0.503
DEG_SPOP_SBC_1	291	295	PF00917	0.442
DOC_CDC14_PxL_1	138	146	PF14671	0.405
DOC_CKS1_1	276	281	PF01111	0.442
DOC_CYCLIN_RxL_1	279	289	PF00134	0.453
DOC_CYCLIN_RxL_1	506	517	PF00134	0.474
DOC_MAPK_gen_1	306	314	PF00069	0.442
DOC_MAPK_gen_1	456	464	PF00069	0.493
DOC_MAPK_MEF2A_6	456	464	PF00069	0.438
DOC_MAPK_MEF2A_6	71	79	PF00069	0.751
DOC_MAPK_RevD_3	223	236	PF00069	0.509
DOC_PP1_RVXF_1	375	381	PF00149	0.509
DOC_PP2B_LxvP_1	230	233	PF13499	0.489
DOC_USP7_MATH_1	103	107	PF00917	0.543
DOC_USP7_MATH_1	134	138	PF00917	0.604
DOC_USP7_MATH_1	15	19	PF00917	0.793
DOC_USP7_MATH_1	154	158	PF00917	0.237
DOC_USP7_MATH_1	290	294	PF00917	0.445
DOC_USP7_MATH_1	36	40	PF00917	0.752
DOC_USP7_MATH_1	468	472	PF00917	0.442
DOC_USP7_MATH_1	477	481	PF00917	0.442
DOC_USP7_MATH_1	551	555	PF00917	0.467
DOC_USP7_MATH_1	638	642	PF00917	0.469
DOC_USP7_MATH_1	87	91	PF00917	0.735
DOC_USP7_UBL2_3	216	220	PF12436	0.546
DOC_USP7_UBL2_3	326	330	PF12436	0.489
DOC_WW_Pin1_4	11	16	PF00397	0.768
DOC_WW_Pin1_4	275	280	PF00397	0.442
DOC_WW_Pin1_4	29	34	PF00397	0.661
DOC_WW_Pin1_4	611	616	PF00397	0.477
LIG_14-3-3_CanoR_1	119	123	PF00244	0.529
LIG_14-3-3_CanoR_1	9	15	PF00244	0.732
LIG_AP2alpha_1	515	519	PF02296	0.489
LIG_APCC_ABBA_1	382	387	PF00400	0.453
LIG_EH1_1	648	656	PF00400	0.453
LIG_FHA_1	400	406	PF00498	0.493
LIG_FHA_1	541	547	PF00498	0.477
LIG_FHA_2	210	216	PF00498	0.442
LIG_FHA_2	42	48	PF00498	0.661
LIG_FHA_2	435	441	PF00498	0.442
LIG_FHA_2	493	499	PF00498	0.453
LIG_Integrin_RGD_1	597	599	PF01839	0.242
LIG_IRF3_LxIS_1	588	593	PF10401	0.442
LIG_LIR_Gen_1	130	140	PF02991	0.504
LIG_LIR_Gen_1	278	287	PF02991	0.470
LIG_LIR_Gen_1	599	609	PF02991	0.442
LIG_LIR_Nem_3	118	123	PF02991	0.591
LIG_LIR_Nem_3	130	135	PF02991	0.368
LIG_LIR_Nem_3	160	166	PF02991	0.354
LIG_LIR_Nem_3	278	283	PF02991	0.468
LIG_LIR_Nem_3	333	339	PF02991	0.453
LIG_LIR_Nem_3	599	604	PF02991	0.442
LIG_LIR_Nem_3	607	613	PF02991	0.442
LIG_MAD2	692	700	PF02301	0.509
LIG_NRBOX	282	288	PF00104	0.453
LIG_Pex14_2	515	519	PF04695	0.467
LIG_PTB_Apo_2	389	396	PF02174	0.546
LIG_SH2_CRK	280	284	PF00017	0.468
LIG_SH2_CRK	601	605	PF00017	0.467
LIG_SH2_GRB2like	123	126	PF00017	0.456
LIG_SH2_NCK_1	123	127	PF00017	0.311
LIG_SH2_NCK_1	214	218	PF00017	0.509
LIG_SH2_NCK_1	601	605	PF00017	0.467
LIG_SH2_PTP2	238	241	PF00017	0.467
LIG_SH2_SRC	367	370	PF00017	0.489
LIG_SH2_STAP1	123	127	PF00017	0.311
LIG_SH2_STAP1	403	407	PF00017	0.489
LIG_SH2_STAT3	707	710	PF00017	0.366
LIG_SH2_STAT5	120	123	PF00017	0.424
LIG_SH2_STAT5	238	241	PF00017	0.500
LIG_SH2_STAT5	335	338	PF00017	0.459
LIG_SH2_STAT5	367	370	PF00017	0.460
LIG_SH2_STAT5	487	490	PF00017	0.454
LIG_SH2_STAT5	55	58	PF00017	0.595
LIG_SH2_STAT5	589	592	PF00017	0.442
LIG_SH2_STAT5	610	613	PF00017	0.442
LIG_SH2_STAT5	687	690	PF00017	0.546
LIG_SH2_STAT5	707	710	PF00017	0.245
LIG_SH3_1	390	396	PF00018	0.546
LIG_SH3_2	393	398	PF14604	0.546
LIG_SH3_3	241	247	PF00018	0.442
LIG_SH3_3	27	33	PF00018	0.603
LIG_SH3_3	359	365	PF00018	0.533
LIG_SH3_3	390	396	PF00018	0.546
LIG_SH3_3	637	643	PF00018	0.442
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.697
LIG_TRFH_1	223	227	PF08558	0.442
LIG_WW_3	85	89	PF00397	0.503
MOD_CDK_SPxxK_3	275	282	PF00069	0.442
MOD_CDK_SPxxK_3	611	618	PF00069	0.477
MOD_CK1_1	107	113	PF00069	0.691
MOD_CK1_1	118	124	PF00069	0.552
MOD_CK1_1	34	40	PF00069	0.568
MOD_CK1_1	435	441	PF00069	0.442
MOD_CK1_1	538	544	PF00069	0.519
MOD_CK2_1	127	133	PF00069	0.504
MOD_CK2_1	246	252	PF00069	0.458
MOD_CK2_1	680	686	PF00069	0.509
MOD_Cter_Amidation	217	220	PF01082	0.251
MOD_Cter_Amidation	233	236	PF01082	0.216
MOD_GlcNHglycan	106	109	PF01048	0.629
MOD_GlcNHglycan	204	207	PF01048	0.242
MOD_GlcNHglycan	227	230	PF01048	0.277
MOD_GlcNHglycan	288	291	PF01048	0.256
MOD_GlcNHglycan	437	440	PF01048	0.242
MOD_GlcNHglycan	488	491	PF01048	0.247
MOD_GlcNHglycan	500	503	PF01048	0.242
MOD_GlcNHglycan	553	556	PF01048	0.281
MOD_GlcNHglycan	592	595	PF01048	0.242
MOD_GlcNHglycan	682	685	PF01048	0.195
MOD_GSK3_1	103	110	PF00069	0.713
MOD_GSK3_1	11	18	PF00069	0.791
MOD_GSK3_1	154	161	PF00069	0.452
MOD_GSK3_1	286	293	PF00069	0.462
MOD_GSK3_1	36	43	PF00069	0.723
MOD_GSK3_1	419	426	PF00069	0.442
MOD_GSK3_1	434	441	PF00069	0.442
MOD_N-GLC_1	10	15	PF02516	0.729
MOD_N-GLC_1	103	108	PF02516	0.707
MOD_N-GLC_1	291	296	PF02516	0.242
MOD_N-GLC_1	342	347	PF02516	0.355
MOD_N-GLC_2	273	275	PF02516	0.346
MOD_NEK2_1	158	163	PF00069	0.438
MOD_NEK2_1	286	291	PF00069	0.453
MOD_NEK2_1	432	437	PF00069	0.442
MOD_NEK2_1	447	452	PF00069	0.442
MOD_NEK2_1	590	595	PF00069	0.447
MOD_NEK2_2	127	132	PF00069	0.526
MOD_NEK2_2	134	139	PF00069	0.595
MOD_NEK2_2	154	159	PF00069	0.243
MOD_NEK2_2	209	214	PF00069	0.442
MOD_PIKK_1	447	453	PF00454	0.546
MOD_PIKK_1	87	93	PF00454	0.663
MOD_PK_1	456	462	PF00069	0.493
MOD_PK_1	692	698	PF00069	0.442
MOD_PK_1	71	77	PF00069	0.749
MOD_PK_1	92	98	PF00069	0.815
MOD_PKA_2	118	124	PF00069	0.592
MOD_PKA_2	87	93	PF00069	0.734
MOD_Plk_1	154	160	PF00069	0.402
MOD_Plk_1	291	297	PF00069	0.474
MOD_Plk_1	320	326	PF00069	0.558
MOD_Plk_1	399	405	PF00069	0.457
MOD_Plk_2-3	246	252	PF00069	0.442
MOD_Plk_4	118	124	PF00069	0.486
MOD_Plk_4	127	133	PF00069	0.347
MOD_Plk_4	158	164	PF00069	0.429
MOD_Plk_4	209	215	PF00069	0.442
MOD_Plk_4	246	252	PF00069	0.489
MOD_Plk_4	331	337	PF00069	0.453
MOD_Plk_4	419	425	PF00069	0.442
MOD_Plk_4	456	462	PF00069	0.502
MOD_Plk_4	478	484	PF00069	0.467
MOD_ProDKin_1	11	17	PF00069	0.770
MOD_ProDKin_1	275	281	PF00069	0.442
MOD_ProDKin_1	29	35	PF00069	0.660
MOD_ProDKin_1	611	617	PF00069	0.477
MOD_SUMO_for_1	56	59	PF00179	0.568
MOD_SUMO_rev_2	614	620	PF00179	0.455
TRG_DiLeu_BaEn_1	254	259	PF01217	0.453
TRG_ENDOCYTIC_2	132	135	PF00928	0.361
TRG_ENDOCYTIC_2	163	166	PF00928	0.338
TRG_ENDOCYTIC_2	280	283	PF00928	0.468
TRG_ENDOCYTIC_2	335	338	PF00928	0.442
TRG_ENDOCYTIC_2	589	592	PF00928	0.442
TRG_ENDOCYTIC_2	601	604	PF00928	0.442
TRG_ER_diArg_1	147	149	PF00400	0.487
TRG_ER_diArg_1	3	5	PF00400	0.739
TRG_ER_diArg_1	324	327	PF00400	0.453
TRG_ER_diArg_1	668	670	PF00400	0.546
TRG_NLS_MonoCore_2	565	570	PF00514	0.453
TRG_NLS_MonoCore_2	666	671	PF00514	0.489
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAY9	Leptomonas seymouri	74%	100%
A0A0S4JP31	Bodo saltans	67%	100%
A0A1X0NMZ2	Trypanosomatidae	69%	100%
A0A3S5H6P5	Leishmania donovani	95%	100%
A0A422NLD0	Trypanosoma rangeli	69%	100%
A4H7A3	Leishmania braziliensis	86%	100%
A4HVP7	Leishmania infantum	95%	100%
A7LBL2	Leishmania donovani	95%	100%
A9TIK2	Physcomitrium patens	23%	100%
C5WVW2	Sorghum bicolor	24%	100%
D0A6J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9APE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O24578	Zea mays	23%	100%
Q017T9	Ostreococcus tauri	23%	100%
Q10R17	Oryza sativa subsp. japonica	24%	100%
Q386E7	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	68%	100%
Q4CWX1	Trypanosoma cruzi (strain CL Brener)	71%	100%
Q4DLT6	Trypanosoma cruzi (strain CL Brener)	71%	100%
Q4QG35	Leishmania major	100%	100%
Q851S8	Oryza sativa subsp. japonica	22%	100%
Q96529	Arabidopsis thaliana	24%	100%
V5BBP4	Trypanosoma cruzi	71%	100%