LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Adenylosuccinate synthetase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Adenylosuccinate synthetase
Gene product:
adenylosuccinate synthetase - putative
Species:
Leishmania infantum
UniProt:
PURA_LEIIN
TriTrypDb:
LINF_130016900
Length:
710

Annotations

Annotations by Jardim et al.

Purine metabolism, Adenylosuccinate synthetase LinJ13.1120

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A4HVP7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVP7

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006163 purine nucleotide metabolic process 5 12
GO:0006164 purine nucleotide biosynthetic process 6 12
GO:0006167 AMP biosynthetic process 8 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006753 nucleoside phosphate metabolic process 4 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009117 nucleotide metabolic process 5 12
GO:0009123 nucleoside monophosphate metabolic process 5 12
GO:0009124 nucleoside monophosphate biosynthetic process 6 12
GO:0009126 purine nucleoside monophosphate metabolic process 6 12
GO:0009127 purine nucleoside monophosphate biosynthetic process 7 12
GO:0009150 purine ribonucleotide metabolic process 6 12
GO:0009152 purine ribonucleotide biosynthetic process 7 12
GO:0009156 ribonucleoside monophosphate biosynthetic process 7 12
GO:0009161 ribonucleoside monophosphate metabolic process 6 12
GO:0009165 nucleotide biosynthetic process 6 12
GO:0009167 purine ribonucleoside monophosphate metabolic process 7 12
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 8 12
GO:0009259 ribonucleotide metabolic process 5 12
GO:0009260 ribonucleotide biosynthetic process 6 12
GO:0009987 cellular process 1 12
GO:0018130 heterocycle biosynthetic process 4 12
GO:0019438 aromatic compound biosynthetic process 4 12
GO:0019637 organophosphate metabolic process 3 12
GO:0019693 ribose phosphate metabolic process 4 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034654 nucleobase-containing compound biosynthetic process 4 12
GO:0044208 'de novo' AMP biosynthetic process 9 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0044281 small molecule metabolic process 2 12
GO:0046033 AMP metabolic process 7 12
GO:0046390 ribose phosphate biosynthetic process 5 12
GO:0046483 heterocycle metabolic process 3 12
GO:0055086 nucleobase-containing small molecule metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0072521 purine-containing compound metabolic process 4 12
GO:0072522 purine-containing compound biosynthetic process 5 12
GO:0090407 organophosphate biosynthetic process 4 12
GO:1901135 carbohydrate derivative metabolic process 3 12
GO:1901137 carbohydrate derivative biosynthetic process 4 12
GO:1901293 nucleoside phosphate biosynthetic process 5 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901362 organic cyclic compound biosynthetic process 4 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901566 organonitrogen compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
GO:0046040 IMP metabolic process 7 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0000287 magnesium ion binding 5 12
GO:0003824 catalytic activity 1 12
GO:0004019 adenylosuccinate synthase activity 4 12
GO:0005488 binding 1 12
GO:0005525 GTP binding 5 12
GO:0016874 ligase activity 2 12
GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 12
GO:0017076 purine nucleotide binding 4 12
GO:0019001 guanyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032561 guanyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 157 161 PF00656 0.514
CLV_C14_Caspase3-7 356 360 PF00656 0.503
CLV_C14_Caspase3-7 58 62 PF00656 0.724
CLV_NRD_NRD_1 148 150 PF00675 0.638
CLV_NRD_NRD_1 218 220 PF00675 0.315
CLV_NRD_NRD_1 324 326 PF00675 0.391
CLV_NRD_NRD_1 4 6 PF00675 0.792
CLV_NRD_NRD_1 669 671 PF00675 0.319
CLV_PCSK_FUR_1 109 113 PF00082 0.595
CLV_PCSK_KEX2_1 111 113 PF00082 0.590
CLV_PCSK_KEX2_1 148 150 PF00082 0.638
CLV_PCSK_KEX2_1 235 237 PF00082 0.313
CLV_PCSK_KEX2_1 309 311 PF00082 0.312
CLV_PCSK_KEX2_1 326 328 PF00082 0.268
CLV_PCSK_KEX2_1 4 6 PF00082 0.792
CLV_PCSK_KEX2_1 667 669 PF00082 0.303
CLV_PCSK_PC1ET2_1 111 113 PF00082 0.590
CLV_PCSK_PC1ET2_1 235 237 PF00082 0.314
CLV_PCSK_PC1ET2_1 309 311 PF00082 0.312
CLV_PCSK_PC1ET2_1 326 328 PF00082 0.268
CLV_PCSK_PC1ET2_1 667 669 PF00082 0.303
CLV_PCSK_SKI1_1 148 152 PF00082 0.547
CLV_PCSK_SKI1_1 220 224 PF00082 0.293
CLV_PCSK_SKI1_1 306 310 PF00082 0.409
CLV_PCSK_SKI1_1 414 418 PF00082 0.334
CLV_PCSK_SKI1_1 512 516 PF00082 0.362
DEG_SPOP_SBC_1 103 107 PF00917 0.558
DEG_SPOP_SBC_1 291 295 PF00917 0.503
DOC_CKS1_1 276 281 PF01111 0.503
DOC_CYCLIN_RxL_1 279 289 PF00134 0.514
DOC_CYCLIN_RxL_1 509 517 PF00134 0.598
DOC_MAPK_gen_1 306 314 PF00069 0.502
DOC_MAPK_gen_1 375 384 PF00069 0.578
DOC_MAPK_gen_1 456 464 PF00069 0.551
DOC_MAPK_MEF2A_6 456 464 PF00069 0.498
DOC_MAPK_MEF2A_6 543 550 PF00069 0.481
DOC_MAPK_MEF2A_6 71 79 PF00069 0.804
DOC_MAPK_RevD_3 223 236 PF00069 0.564
DOC_PP1_RVXF_1 375 381 PF00149 0.564
DOC_PP2B_LxvP_1 230 233 PF13499 0.608
DOC_PP4_FxxP_1 70 73 PF00568 0.720
DOC_USP7_MATH_1 101 105 PF00917 0.615
DOC_USP7_MATH_1 134 138 PF00917 0.625
DOC_USP7_MATH_1 15 19 PF00917 0.806
DOC_USP7_MATH_1 154 158 PF00917 0.476
DOC_USP7_MATH_1 290 294 PF00917 0.506
DOC_USP7_MATH_1 36 40 PF00917 0.783
DOC_USP7_MATH_1 468 472 PF00917 0.503
DOC_USP7_MATH_1 477 481 PF00917 0.503
DOC_USP7_MATH_1 551 555 PF00917 0.528
DOC_USP7_MATH_1 638 642 PF00917 0.530
DOC_USP7_MATH_1 87 91 PF00917 0.798
DOC_USP7_UBL2_3 216 220 PF12436 0.589
DOC_USP7_UBL2_3 326 330 PF12436 0.608
DOC_WW_Pin1_4 11 16 PF00397 0.817
DOC_WW_Pin1_4 19 24 PF00397 0.782
DOC_WW_Pin1_4 275 280 PF00397 0.503
DOC_WW_Pin1_4 29 34 PF00397 0.773
LIG_14-3-3_CanoR_1 112 122 PF00244 0.602
LIG_14-3-3_CanoR_1 127 132 PF00244 0.521
LIG_14-3-3_CanoR_1 9 15 PF00244 0.788
LIG_AP2alpha_1 515 519 PF02296 0.608
LIG_APCC_ABBA_1 382 387 PF00400 0.514
LIG_deltaCOP1_diTrp_1 61 70 PF00928 0.517
LIG_EH1_1 648 656 PF00400 0.514
LIG_FHA_1 400 406 PF00498 0.604
LIG_FHA_2 128 134 PF00498 0.550
LIG_FHA_2 210 216 PF00498 0.503
LIG_FHA_2 42 48 PF00498 0.790
LIG_FHA_2 435 441 PF00498 0.496
LIG_FHA_2 493 499 PF00498 0.514
LIG_Integrin_RGD_1 597 599 PF01839 0.303
LIG_IRF3_LxIS_1 588 593 PF10401 0.503
LIG_LIR_Gen_1 130 140 PF02991 0.568
LIG_LIR_Gen_1 278 287 PF02991 0.503
LIG_LIR_Gen_1 599 609 PF02991 0.503
LIG_LIR_Nem_3 118 123 PF02991 0.604
LIG_LIR_Nem_3 130 135 PF02991 0.457
LIG_LIR_Nem_3 160 166 PF02991 0.430
LIG_LIR_Nem_3 278 283 PF02991 0.503
LIG_LIR_Nem_3 333 338 PF02991 0.504
LIG_LIR_Nem_3 599 604 PF02991 0.503
LIG_LIR_Nem_3 607 613 PF02991 0.503
LIG_MAD2 692 700 PF02301 0.564
LIG_NRBOX 282 288 PF00104 0.514
LIG_Pex14_2 515 519 PF04695 0.528
LIG_PTB_Apo_2 389 396 PF02174 0.589
LIG_SH2_CRK 280 284 PF00017 0.503
LIG_SH2_CRK 601 605 PF00017 0.528
LIG_SH2_GRB2like 123 126 PF00017 0.599
LIG_SH2_GRB2like 55 58 PF00017 0.636
LIG_SH2_GRB2like 612 615 PF00017 0.513
LIG_SH2_NCK_1 214 218 PF00017 0.564
LIG_SH2_NCK_1 601 605 PF00017 0.528
LIG_SH2_PTP2 238 241 PF00017 0.528
LIG_SH2_SRC 367 370 PF00017 0.608
LIG_SH2_STAP1 403 407 PF00017 0.615
LIG_SH2_STAP1 99 103 PF00017 0.616
LIG_SH2_STAT3 707 710 PF00017 0.448
LIG_SH2_STAT5 120 123 PF00017 0.472
LIG_SH2_STAT5 238 241 PF00017 0.514
LIG_SH2_STAT5 335 338 PF00017 0.520
LIG_SH2_STAT5 367 370 PF00017 0.521
LIG_SH2_STAT5 487 490 PF00017 0.516
LIG_SH2_STAT5 55 58 PF00017 0.694
LIG_SH2_STAT5 589 592 PF00017 0.503
LIG_SH2_STAT5 610 613 PF00017 0.503
LIG_SH2_STAT5 687 690 PF00017 0.589
LIG_SH2_STAT5 707 710 PF00017 0.265
LIG_SH2_STAT5 99 102 PF00017 0.597
LIG_SH3_1 390 396 PF00018 0.589
LIG_SH3_2 393 398 PF14604 0.589
LIG_SH3_3 241 247 PF00018 0.503
LIG_SH3_3 27 33 PF00018 0.816
LIG_SH3_3 359 365 PF00018 0.581
LIG_SH3_3 390 396 PF00018 0.589
LIG_SH3_3 637 643 PF00018 0.525
LIG_TRFH_1 223 227 PF08558 0.503
MOD_CDK_SPxxK_3 275 282 PF00069 0.503
MOD_CK1_1 104 110 PF00069 0.743
MOD_CK1_1 118 124 PF00069 0.489
MOD_CK1_1 22 28 PF00069 0.783
MOD_CK1_1 435 441 PF00069 0.503
MOD_CK1_1 538 544 PF00069 0.571
MOD_CK1_1 90 96 PF00069 0.829
MOD_CK2_1 127 133 PF00069 0.569
MOD_CK2_1 246 252 PF00069 0.496
MOD_CK2_1 680 686 PF00069 0.564
MOD_Cter_Amidation 217 220 PF01082 0.314
MOD_Cter_Amidation 233 236 PF01082 0.344
MOD_DYRK1A_RPxSP_1 29 33 PF00069 0.608
MOD_GlcNHglycan 106 109 PF01048 0.722
MOD_GlcNHglycan 117 120 PF01048 0.526
MOD_GlcNHglycan 204 207 PF01048 0.293
MOD_GlcNHglycan 227 230 PF01048 0.314
MOD_GlcNHglycan 288 291 PF01048 0.300
MOD_GlcNHglycan 437 440 PF01048 0.294
MOD_GlcNHglycan 488 491 PF01048 0.308
MOD_GlcNHglycan 553 556 PF01048 0.341
MOD_GlcNHglycan 592 595 PF01048 0.303
MOD_GSK3_1 11 18 PF00069 0.833
MOD_GSK3_1 154 161 PF00069 0.527
MOD_GSK3_1 19 26 PF00069 0.790
MOD_GSK3_1 286 293 PF00069 0.503
MOD_GSK3_1 36 43 PF00069 0.708
MOD_GSK3_1 419 426 PF00069 0.497
MOD_GSK3_1 434 441 PF00069 0.474
MOD_GSK3_1 97 104 PF00069 0.768
MOD_N-GLC_1 10 15 PF02516 0.786
MOD_N-GLC_1 101 106 PF02516 0.788
MOD_N-GLC_1 291 296 PF02516 0.303
MOD_N-GLC_1 342 347 PF02516 0.389
MOD_N-GLC_2 273 275 PF02516 0.389
MOD_NEK2_1 158 163 PF00069 0.509
MOD_NEK2_1 286 291 PF00069 0.510
MOD_NEK2_1 41 46 PF00069 0.689
MOD_NEK2_1 432 437 PF00069 0.503
MOD_NEK2_1 447 452 PF00069 0.503
MOD_NEK2_1 590 595 PF00069 0.508
MOD_NEK2_2 134 139 PF00069 0.625
MOD_NEK2_2 154 159 PF00069 0.481
MOD_NEK2_2 209 214 PF00069 0.499
MOD_PIKK_1 447 453 PF00454 0.588
MOD_PIKK_1 87 93 PF00454 0.759
MOD_PK_1 456 462 PF00069 0.551
MOD_PK_1 692 698 PF00069 0.503
MOD_PK_1 71 77 PF00069 0.803
MOD_PK_1 92 98 PF00069 0.837
MOD_Plk_1 154 160 PF00069 0.485
MOD_Plk_1 291 297 PF00069 0.503
MOD_Plk_1 320 326 PF00069 0.559
MOD_Plk_1 399 405 PF00069 0.553
MOD_Plk_2-3 246 252 PF00069 0.503
MOD_Plk_4 118 124 PF00069 0.614
MOD_Plk_4 127 133 PF00069 0.451
MOD_Plk_4 158 164 PF00069 0.487
MOD_Plk_4 209 215 PF00069 0.499
MOD_Plk_4 246 252 PF00069 0.615
MOD_Plk_4 331 337 PF00069 0.515
MOD_Plk_4 419 425 PF00069 0.503
MOD_Plk_4 456 462 PF00069 0.558
MOD_Plk_4 478 484 PF00069 0.528
MOD_ProDKin_1 11 17 PF00069 0.820
MOD_ProDKin_1 19 25 PF00069 0.781
MOD_ProDKin_1 275 281 PF00069 0.503
MOD_ProDKin_1 29 35 PF00069 0.772
TRG_DiLeu_BaEn_1 254 259 PF01217 0.514
TRG_ENDOCYTIC_2 132 135 PF00928 0.444
TRG_ENDOCYTIC_2 163 166 PF00928 0.398
TRG_ENDOCYTIC_2 280 283 PF00928 0.503
TRG_ENDOCYTIC_2 335 338 PF00928 0.503
TRG_ENDOCYTIC_2 589 592 PF00928 0.503
TRG_ENDOCYTIC_2 601 604 PF00928 0.503
TRG_ER_diArg_1 147 149 PF00400 0.637
TRG_ER_diArg_1 3 5 PF00400 0.788
TRG_ER_diArg_1 324 327 PF00400 0.514
TRG_ER_diArg_1 668 670 PF00400 0.589
TRG_NLS_MonoCore_2 565 570 PF00514 0.514
TRG_NLS_MonoCore_2 666 671 PF00514 0.608
TRG_Pf-PMV_PEXEL_1 139 143 PF00026 0.611
TRG_Pf-PMV_PEXEL_1 414 418 PF00026 0.328
TRG_Pf-PMV_PEXEL_1 497 502 PF00026 0.365
TRG_Pf-PMV_PEXEL_1 512 517 PF00026 0.410

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAY9 Leptomonas seymouri 75% 100%
A0A0S4JP31 Bodo saltans 66% 100%
A0A1X0NMZ2 Trypanosomatidae 70% 100%
A0A3S5H6P5 Leishmania donovani 99% 100%
A0A422NLD0 Trypanosoma rangeli 67% 100%
A2XD35 Oryza sativa subsp. indica 24% 100%
A4H7A3 Leishmania braziliensis 87% 100%
A4HVP7 Leishmania infantum 100% 100%
A7LBL2 Leishmania donovani 99% 100%
A9TIK2 Physcomitrium patens 24% 100%
C5WVW2 Sorghum bicolor 24% 100%
D0A6J7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 100%
E9APE3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O24578 Zea mays 24% 100%
Q017T9 Ostreococcus tauri 23% 100%
Q10R17 Oryza sativa subsp. japonica 24% 100%
Q386E7 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 68% 100%
Q4CWX1 Trypanosoma cruzi (strain CL Brener) 71% 100%
Q4DLT6 Trypanosoma cruzi (strain CL Brener) 71% 100%
Q4QG35 Leishmania major 95% 100%
Q851S8 Oryza sativa subsp. japonica 23% 100%
Q96529 Arabidopsis thaliana 24% 100%
V5BBP4 Trypanosoma cruzi 71% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS