Adenylosuccinate synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylosuccinate synthetase, putative

Species:

Leishmania braziliensis

UniProt:

PURA_LEIBR

TriTrypDb:

LbrM.13.0970 , LBRM2903_130016000

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H7A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7A3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006164	purine nucleotide biosynthetic process	6	12
GO:0006167	AMP biosynthetic process	8	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009123	nucleoside monophosphate metabolic process	5	12
GO:0009124	nucleoside monophosphate biosynthetic process	6	12
GO:0009126	purine nucleoside monophosphate metabolic process	6	12
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009152	purine ribonucleotide biosynthetic process	7	12
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	12
GO:0009161	ribonucleoside monophosphate metabolic process	6	12
GO:0009165	nucleotide biosynthetic process	6	12
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	12
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009260	ribonucleotide biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0044208	'de novo' AMP biosynthetic process	9	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0046033	AMP metabolic process	7	12
GO:0046390	ribose phosphate biosynthetic process	5	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:0072522	purine-containing compound biosynthetic process	5	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901293	nucleoside phosphate biosynthetic process	5	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0046040	IMP metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0000287	magnesium ion binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004019	adenylosuccinate synthase activity	4	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.503
CLV_NRD_NRD_1	148	150	PF00675	0.653
CLV_NRD_NRD_1	218	220	PF00675	0.315
CLV_NRD_NRD_1	324	326	PF00675	0.390
CLV_NRD_NRD_1	4	6	PF00675	0.801
CLV_NRD_NRD_1	669	671	PF00675	0.319
CLV_PCSK_KEX2_1	148	150	PF00082	0.653
CLV_PCSK_KEX2_1	235	237	PF00082	0.313
CLV_PCSK_KEX2_1	309	311	PF00082	0.312
CLV_PCSK_KEX2_1	326	328	PF00082	0.267
CLV_PCSK_KEX2_1	4	6	PF00082	0.801
CLV_PCSK_KEX2_1	667	669	PF00082	0.303
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.314
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.312
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.267
CLV_PCSK_PC1ET2_1	667	669	PF00082	0.303
CLV_PCSK_SKI1_1	148	152	PF00082	0.559
CLV_PCSK_SKI1_1	220	224	PF00082	0.293
CLV_PCSK_SKI1_1	306	310	PF00082	0.409
CLV_PCSK_SKI1_1	414	418	PF00082	0.334
CLV_PCSK_SKI1_1	512	516	PF00082	0.361
DEG_SPOP_SBC_1	20	24	PF00917	0.811
DEG_SPOP_SBC_1	291	295	PF00917	0.503
DOC_CDC14_PxL_1	138	146	PF14671	0.493
DOC_CKS1_1	276	281	PF01111	0.503
DOC_CYCLIN_RxL_1	279	289	PF00134	0.514
DOC_CYCLIN_RxL_1	509	517	PF00134	0.597
DOC_MAPK_gen_1	148	158	PF00069	0.364
DOC_MAPK_gen_1	306	314	PF00069	0.502
DOC_MAPK_gen_1	375	384	PF00069	0.578
DOC_MAPK_gen_1	69	77	PF00069	0.553
DOC_MAPK_MEF2A_6	69	77	PF00069	0.792
DOC_MAPK_RevD_3	223	236	PF00069	0.564
DOC_PP1_RVXF_1	375	381	PF00149	0.564
DOC_PP2B_LxvP_1	230	233	PF13499	0.608
DOC_PP2B_LxvP_1	362	365	PF13499	0.427
DOC_PP4_FxxP_1	70	73	PF00568	0.705
DOC_USP7_MATH_1	134	138	PF00917	0.636
DOC_USP7_MATH_1	20	24	PF00917	0.775
DOC_USP7_MATH_1	290	294	PF00917	0.506
DOC_USP7_MATH_1	31	35	PF00917	0.650
DOC_USP7_MATH_1	468	472	PF00917	0.503
DOC_USP7_MATH_1	477	481	PF00917	0.503
DOC_USP7_MATH_1	551	555	PF00917	0.528
DOC_USP7_MATH_1	638	642	PF00917	0.530
DOC_USP7_UBL2_3	216	220	PF12436	0.589
DOC_USP7_UBL2_3	326	330	PF12436	0.608
DOC_USP7_UBL2_3	375	379	PF12436	0.530
DOC_WW_Pin1_4	275	280	PF00397	0.503
DOC_WW_Pin1_4	29	34	PF00397	0.772
DOC_WW_Pin1_4	37	42	PF00397	0.723
DOC_WW_Pin1_4	669	674	PF00397	0.473
LIG_14-3-3_CanoR_1	116	123	PF00244	0.593
LIG_14-3-3_CanoR_1	9	17	PF00244	0.796
LIG_Actin_WH2_2	14	32	PF00022	0.567
LIG_AP2alpha_1	515	519	PF02296	0.608
LIG_APCC_ABBA_1	382	387	PF00400	0.514
LIG_EH1_1	648	656	PF00400	0.514
LIG_FHA_1	24	30	PF00498	0.568
LIG_FHA_2	122	128	PF00498	0.586
LIG_FHA_2	210	216	PF00498	0.503
LIG_FHA_2	42	48	PF00498	0.789
LIG_FHA_2	435	441	PF00498	0.496
LIG_FHA_2	493	499	PF00498	0.514
LIG_Integrin_RGD_1	597	599	PF01839	0.303
LIG_IRF3_LxIS_1	588	593	PF10401	0.503
LIG_LIR_Gen_1	152	158	PF02991	0.347
LIG_LIR_Gen_1	278	287	PF02991	0.503
LIG_LIR_Gen_1	599	609	PF02991	0.503
LIG_LIR_Nem_3	117	123	PF02991	0.648
LIG_LIR_Nem_3	152	156	PF02991	0.478
LIG_LIR_Nem_3	160	166	PF02991	0.429
LIG_LIR_Nem_3	278	283	PF02991	0.503
LIG_LIR_Nem_3	333	338	PF02991	0.504
LIG_LIR_Nem_3	599	604	PF02991	0.503
LIG_LIR_Nem_3	607	613	PF02991	0.503
LIG_MAD2	692	700	PF02301	0.564
LIG_NRBOX	282	288	PF00104	0.514
LIG_NRBOX	677	683	PF00104	0.427
LIG_Pex14_2	515	519	PF04695	0.528
LIG_PTB_Apo_2	389	396	PF02174	0.589
LIG_SH2_CRK	280	284	PF00017	0.503
LIG_SH2_CRK	601	605	PF00017	0.528
LIG_SH2_GRB2like	123	126	PF00017	0.613
LIG_SH2_GRB2like	521	524	PF00017	0.427
LIG_SH2_GRB2like	612	615	PF00017	0.513
LIG_SH2_NCK_1	153	157	PF00017	0.371
LIG_SH2_NCK_1	214	218	PF00017	0.564
LIG_SH2_NCK_1	601	605	PF00017	0.528
LIG_SH2_PTP2	238	241	PF00017	0.528
LIG_SH2_SRC	367	370	PF00017	0.608
LIG_SH2_STAP1	403	407	PF00017	0.614
LIG_SH2_STAT3	707	710	PF00017	0.445
LIG_SH2_STAT5	120	123	PF00017	0.482
LIG_SH2_STAT5	238	241	PF00017	0.514
LIG_SH2_STAT5	335	338	PF00017	0.520
LIG_SH2_STAT5	367	370	PF00017	0.521
LIG_SH2_STAT5	589	592	PF00017	0.503
LIG_SH2_STAT5	610	613	PF00017	0.503
LIG_SH2_STAT5	687	690	PF00017	0.589
LIG_SH2_STAT5	707	710	PF00017	0.261
LIG_SH3_1	390	396	PF00018	0.589
LIG_SH3_2	393	398	PF14604	0.589
LIG_SH3_3	241	247	PF00018	0.503
LIG_SH3_3	390	396	PF00018	0.589
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.760
LIG_TRFH_1	223	227	PF08558	0.503
MOD_CDK_SPxxK_3	275	282	PF00069	0.503
MOD_CDK_SPxxK_3	29	36	PF00069	0.569
MOD_CDK_SPxxK_3	669	676	PF00069	0.427
MOD_CK1_1	118	124	PF00069	0.511
MOD_CK1_1	15	21	PF00069	0.782
MOD_CK1_1	154	160	PF00069	0.494
MOD_CK1_1	22	28	PF00069	0.779
MOD_CK1_1	32	38	PF00069	0.804
MOD_CK1_1	435	441	PF00069	0.503
MOD_CK1_1	538	544	PF00069	0.571
MOD_CK2_1	154	160	PF00069	0.411
MOD_CK2_1	246	252	PF00069	0.496
MOD_CK2_1	31	37	PF00069	0.566
MOD_CK2_1	680	686	PF00069	0.564
MOD_Cter_Amidation	217	220	PF01082	0.314
MOD_Cter_Amidation	233	236	PF01082	0.344
MOD_GlcNHglycan	106	109	PF01048	0.732
MOD_GlcNHglycan	14	17	PF01048	0.730
MOD_GlcNHglycan	204	207	PF01048	0.293
MOD_GlcNHglycan	227	230	PF01048	0.314
MOD_GlcNHglycan	259	262	PF01048	0.227
MOD_GlcNHglycan	288	291	PF01048	0.300
MOD_GlcNHglycan	437	440	PF01048	0.294
MOD_GlcNHglycan	488	491	PF01048	0.308
MOD_GlcNHglycan	553	556	PF01048	0.341
MOD_GlcNHglycan	592	595	PF01048	0.303
MOD_GlcNHglycan	642	645	PF01048	0.352
MOD_GSK3_1	11	18	PF00069	0.836
MOD_GSK3_1	111	118	PF00069	0.653
MOD_GSK3_1	154	161	PF00069	0.528
MOD_GSK3_1	19	26	PF00069	0.786
MOD_GSK3_1	286	293	PF00069	0.503
MOD_GSK3_1	32	39	PF00069	0.723
MOD_GSK3_1	419	426	PF00069	0.497
MOD_GSK3_1	434	441	PF00069	0.474
MOD_N-GLC_1	10	15	PF02516	0.795
MOD_N-GLC_1	104	109	PF02516	0.781
MOD_N-GLC_1	112	117	PF02516	0.652
MOD_N-GLC_1	291	296	PF02516	0.303
MOD_N-GLC_1	342	347	PF02516	0.389
MOD_N-GLC_1	37	42	PF02516	0.733
MOD_N-GLC_2	273	275	PF02516	0.389
MOD_NEK2_1	21	26	PF00069	0.776
MOD_NEK2_1	286	291	PF00069	0.510
MOD_NEK2_1	432	437	PF00069	0.503
MOD_NEK2_1	447	452	PF00069	0.503
MOD_NEK2_1	50	55	PF00069	0.649
MOD_NEK2_1	590	595	PF00069	0.508
MOD_NEK2_2	134	139	PF00069	0.636
MOD_NEK2_2	209	214	PF00069	0.499
MOD_PIKK_1	447	453	PF00454	0.587
MOD_PK_1	692	698	PF00069	0.503
MOD_PK_1	71	77	PF00069	0.790
MOD_PKA_2	115	121	PF00069	0.658
MOD_PKB_1	69	77	PF00069	0.553
MOD_Plk_1	118	124	PF00069	0.404
MOD_Plk_1	154	160	PF00069	0.486
MOD_Plk_1	291	297	PF00069	0.503
MOD_Plk_1	320	326	PF00069	0.559
MOD_Plk_2-3	246	252	PF00069	0.503
MOD_Plk_4	118	124	PF00069	0.636
MOD_Plk_4	158	164	PF00069	0.486
MOD_Plk_4	209	215	PF00069	0.499
MOD_Plk_4	246	252	PF00069	0.614
MOD_Plk_4	331	337	PF00069	0.514
MOD_Plk_4	419	425	PF00069	0.503
MOD_Plk_4	456	462	PF00069	0.558
MOD_Plk_4	478	484	PF00069	0.528
MOD_ProDKin_1	275	281	PF00069	0.503
MOD_ProDKin_1	29	35	PF00069	0.773
MOD_ProDKin_1	37	43	PF00069	0.721
MOD_ProDKin_1	669	675	PF00069	0.473
MOD_SUMO_for_1	56	59	PF00179	0.642
MOD_SUMO_rev_2	126	131	PF00179	0.581
TRG_DiLeu_BaEn_1	254	259	PF01217	0.514
TRG_DiLeu_BaEn_2	375	381	PF01217	0.427
TRG_ENDOCYTIC_2	132	135	PF00928	0.454
TRG_ENDOCYTIC_2	153	156	PF00928	0.460
TRG_ENDOCYTIC_2	163	166	PF00928	0.397
TRG_ENDOCYTIC_2	280	283	PF00928	0.503
TRG_ENDOCYTIC_2	335	338	PF00928	0.503
TRG_ENDOCYTIC_2	589	592	PF00928	0.503
TRG_ENDOCYTIC_2	601	604	PF00928	0.503
TRG_ER_diArg_1	147	149	PF00400	0.642
TRG_ER_diArg_1	3	5	PF00400	0.799
TRG_ER_diArg_1	324	327	PF00400	0.514
TRG_ER_diArg_1	668	670	PF00400	0.589
TRG_NLS_MonoCore_2	565	570	PF00514	0.514
TRG_NLS_MonoCore_2	666	671	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	676	680	PF00026	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAY9	Leptomonas seymouri	72%	100%
A0A0S4JP31	Bodo saltans	64%	100%
A0A1X0NMZ2	Trypanosomatidae	69%	100%
A0A3S5H6P5	Leishmania donovani	87%	100%
A0A422NLD0	Trypanosoma rangeli	67%	100%
A4H7A3	Leishmania braziliensis	100%	100%
A4HVP7	Leishmania infantum	87%	100%
A7LBL2	Leishmania donovani	87%	100%
C5WVW2	Sorghum bicolor	24%	100%
D0A6J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9APE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O24578	Zea mays	24%	100%
Q017T9	Ostreococcus tauri	23%	100%
Q386E7	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	66%	100%
Q4CWX1	Trypanosoma cruzi (strain CL Brener)	70%	100%
Q4DLT6	Trypanosoma cruzi (strain CL Brener)	66%	100%
Q4QG35	Leishmania major	86%	100%
Q96529	Arabidopsis thaliana	25%	100%
V5BBP4	Trypanosoma cruzi	67%	100%