Pteridine reductase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine reductase 1

Species:

Leishmania major

UniProt:

PTR1_LEIMA

TriTrypDb:

LmjF.23.0270 , LMJLV39_230008000 , LMJSD75_230008200

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q01782

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q01782

PDB structure(s): 1e7w_A , 1e7w_B , 1e92_A , 1e92_B , 1e92_C , 1e92_D , 1w0c_A , 1w0c_B , 1w0c_C , 1w0c_D , 1w0c_E , 1w0c_F , 1w0c_G , 1w0c_H , 2bf7_A , 2bf7_B , 2bf7_C , 2bf7_D , 2bfa_A , 2bfa_B , 2bfa_C , 2bfa_D , 2bfm_A , 2bfm_B , 2bfm_C , 2bfm_D , 2bfo_A , 2bfo_B , 2bfo_C , 2bfo_D , 2bfp_A , 2bfp_B , 2bfp_C , 2bfp_D , 2qhx_A , 2qhx_B , 2qhx_C , 2qhx_D , 3h4v_A , 3h4v_B , 3h4v_C , 3h4v_D , 3h4v_E , 3h4v_F , 3h4v_G , 3h4v_H , 5l42_A , 5l42_B , 5l42_C , 5l42_D , 5l4n_A , 5l4n_B , 5l4n_C , 5l4n_D , 6rxc_A , 6rxc_B , 6rxc_C , 6rxc_D , 7pxx_A , 7pxx_B , 7pxx_C , 7pxx_D

Function

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Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006729	tetrahydrobiopterin biosynthetic process	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	4
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0010033	response to organic substance	3	2
GO:0010243	response to organonitrogen compound	4	2
GO:0014070	response to organic cyclic compound	4	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004146	dihydrofolate reductase activity	5	2
GO:0004155	6,7-dihydropteridine reductase activity	5	2
GO:0004799	thymidylate synthase activity	6	2
GO:0008168	methyltransferase activity	4	2
GO:0016491	oxidoreductase activity	2	8
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	5
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	5
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	75	79	PF00656	0.287
CLV_NRD_NRD_1	54	56	PF00675	0.441
CLV_PCSK_KEX2_1	16	18	PF00082	0.441
CLV_PCSK_KEX2_1	54	56	PF00082	0.441
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.441
CLV_PCSK_SKI1_1	198	202	PF00082	0.387
CLV_PCSK_SKI1_1	270	274	PF00082	0.441
DOC_ANK_TNKS_1	19	26	PF00023	0.322
DOC_CKS1_1	114	119	PF01111	0.387
DOC_MAPK_gen_1	54	62	PF00069	0.441

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0B4FP77	Metarhizium brunneum (strain ARSEF 3297)	22%	100%
A0A0B4GT47	Metarhizium anisopliae (strain ARSEF 549)	23%	100%
A0A0B4GU97	Metarhizium guizhouense (strain ARSEF 977)	24%	100%
A0A0B4HVU2	Metarhizium majus (strain ARSEF 297)	23%	100%
A0A0N1HTL2	Leptomonas seymouri	27%	100%
A0A0N1I5Q6	Leptomonas seymouri	64%	100%
A0A0N1PCK0	Leptomonas seymouri	27%	100%
A0A0S4JMY5	Bodo saltans	26%	100%
A0A1A9TAK5	Narcissus pseudonarcissus	29%	100%
A0A1C9II22	Narcissus aff. pseudonarcissus MK-2014	29%	100%

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