9,11-endoperoxide prostaglandin H2 reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prostaglandin f2-alpha synthase

Species:

Leishmania major

UniProt:

PGFS_LEIMA

TriTrypDb:

LmjF.31.2150 , LMJLV39_310030400 , LMJSD75_310030400

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

P22045

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: P22045

PDB structure(s): 4f40_A , 4f40_B , 4g5d_A , 4g5d_B

Function

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Biological processes
Term	Name	Level	Count
GO:0001516	prostaglandin biosynthetic process	8	5
GO:0006082	organic acid metabolic process	3	5
GO:0006629	lipid metabolic process	3	5
GO:0006631	fatty acid metabolic process	4	5
GO:0006633	fatty acid biosynthetic process	5	5
GO:0006636	unsaturated fatty acid biosynthetic process	6	5
GO:0006690	icosanoid metabolic process	6	5
GO:0006692	prostanoid metabolic process	6	5
GO:0006693	prostaglandin metabolic process	7	5
GO:0008152	metabolic process	1	5

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	9
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	6
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	6
GO:0036094	small molecule binding	2	2
GO:0036130	prostaglandin H2 endoperoxidase reductase activity	5	2
GO:0036131	prostaglandin D2 11-ketoreductase activity	5	4
GO:0047017	prostaglandin-F synthase activity	5	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	117	121	PF00082	0.365
CLV_PCSK_SKI1_1	190	194	PF00082	0.372
CLV_PCSK_SKI1_1	38	42	PF00082	0.409
DOC_MAPK_gen_1	139	148	PF00069	0.517
DOC_MAPK_gen_1	217	227	PF00069	0.512
DOC_USP7_UBL2_3	122	126	PF12436	0.593
DOC_WW_Pin1_4	163	168	PF00397	0.556
DOC_WW_Pin1_4	195	200	PF00397	0.494
DOC_WW_Pin1_4	24	29	PF00397	0.592
LIG_BIR_II_1	1	5	PF00653	0.483

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R8	Leptomonas seymouri	28%	75%
A0A0N0P8F4	Leptomonas seymouri	34%	78%
A0A0N1I3R2	Leptomonas seymouri	28%	99%
A0A0N1I9Z1	Leptomonas seymouri	58%	100%
A0A0N1PCR7	Leptomonas seymouri	47%	100%
A0A0S4J2H7	Bodo saltans	34%	100%
A0A0S4J7K9	Bodo saltans	32%	80%
A0A1D5XGW0	Triticum aestivum	35%	90%
A0A1X0NFW0	Trypanosomatidae	34%	84%
A0A1X0NIH1	Trypanosomatidae	34%	90%

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