Pescadillo homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Pescadillo homolog

Gene product:

Pescadillo N-terminus/BRCA1 C Terminus (BRCT) domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

PESC_LEIBR

TriTrypDb:

LbrM.04.0780 , LBRM2903_040014200

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	11
GO:0005730	nucleolus	5	12
GO:0030684	preribosome	3	11
GO:0030687	preribosome, large subunit precursor	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	11
GO:0070545	PeBoW complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H3Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Z2

Function

Biological processes
Term	Name	Level	Count
GO:0000460	maturation of 5.8S rRNA	9	11
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	11
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	11
GO:0000470	maturation of LSU-rRNA	9	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043021	ribonucleoprotein complex binding	3	11
GO:0044877	protein-containing complex binding	2	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	39	41	PF00675	0.254
CLV_NRD_NRD_1	448	450	PF00675	0.434
CLV_NRD_NRD_1	500	502	PF00675	0.550
CLV_NRD_NRD_1	545	547	PF00675	0.473
CLV_NRD_NRD_1	549	551	PF00675	0.454
CLV_NRD_NRD_1	567	569	PF00675	0.346
CLV_NRD_NRD_1	580	582	PF00675	0.459
CLV_NRD_NRD_1	588	590	PF00675	0.425
CLV_NRD_NRD_1	642	644	PF00675	0.520
CLV_PCSK_KEX2_1	10	12	PF00082	0.435
CLV_PCSK_KEX2_1	306	308	PF00082	0.512
CLV_PCSK_KEX2_1	39	41	PF00082	0.249
CLV_PCSK_KEX2_1	544	546	PF00082	0.466
CLV_PCSK_KEX2_1	574	576	PF00082	0.530
CLV_PCSK_KEX2_1	642	644	PF00082	0.479
CLV_PCSK_KEX2_1	95	97	PF00082	0.249
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.435
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.535
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.525
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.343
CLV_PCSK_PC7_1	638	644	PF00082	0.496
CLV_PCSK_SKI1_1	10	14	PF00082	0.441
CLV_PCSK_SKI1_1	20	24	PF00082	0.265
CLV_PCSK_SKI1_1	246	250	PF00082	0.323
CLV_PCSK_SKI1_1	318	322	PF00082	0.183
CLV_PCSK_SKI1_1	347	351	PF00082	0.224
CLV_PCSK_SKI1_1	364	368	PF00082	0.224
CLV_PCSK_SKI1_1	392	396	PF00082	0.213
CLV_PCSK_SKI1_1	50	54	PF00082	0.290
CLV_PCSK_SKI1_1	546	550	PF00082	0.556
CLV_PCSK_SKI1_1	609	613	PF00082	0.503
CLV_PCSK_SKI1_1	651	655	PF00082	0.588
CLV_PCSK_SKI1_1	70	74	PF00082	0.249
CLV_PCSK_SKI1_1	83	87	PF00082	0.359
CLV_PCSK_SKI1_1	92	96	PF00082	0.323
DOC_CYCLIN_RxL_1	315	325	PF00134	0.345
DOC_MAPK_gen_1	524	533	PF00069	0.492
DOC_MAPK_gen_1	581	587	PF00069	0.453
DOC_PP1_RVXF_1	210	216	PF00149	0.249
DOC_PP1_RVXF_1	244	251	PF00149	0.265
DOC_PP1_RVXF_1	320	327	PF00149	0.480
DOC_PP1_RVXF_1	68	75	PF00149	0.265
DOC_PP4_FxxP_1	150	153	PF00568	0.249
DOC_USP7_MATH_1	108	112	PF00917	0.426
DOC_USP7_MATH_1	116	120	PF00917	0.409
DOC_USP7_UBL2_3	10	14	PF12436	0.441
DOC_USP7_UBL2_3	652	656	PF12436	0.499
DOC_USP7_UBL2_3	663	667	PF12436	0.489
DOC_WW_Pin1_4	149	154	PF00397	0.265
DOC_WW_Pin1_4	408	413	PF00397	0.367
DOC_WW_Pin1_4	454	459	PF00397	0.348
DOC_WW_Pin1_4	558	563	PF00397	0.390
LIG_14-3-3_CanoR_1	117	121	PF00244	0.344
LIG_14-3-3_CanoR_1	322	327	PF00244	0.480
LIG_14-3-3_CanoR_1	517	525	PF00244	0.481
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_BRCT_BRCA1_1	34	38	PF00533	0.249
LIG_Clathr_ClatBox_1	249	253	PF01394	0.284
LIG_Clathr_ClatBox_1	30	34	PF01394	0.265
LIG_EH1_1	445	453	PF00400	0.376
LIG_FHA_1	158	164	PF00498	0.271
LIG_FHA_1	166	172	PF00498	0.225
LIG_FHA_1	26	32	PF00498	0.249
LIG_FHA_1	323	329	PF00498	0.459
LIG_FHA_1	348	354	PF00498	0.426
LIG_FHA_1	356	362	PF00498	0.397
LIG_FHA_1	510	516	PF00498	0.563
LIG_FHA_1	536	542	PF00498	0.516
LIG_FHA_2	121	127	PF00498	0.265
LIG_GLEBS_BUB3_1	471	479	PF00400	0.430
LIG_IBAR_NPY_1	660	662	PF08397	0.475
LIG_KLC1_Yacidic_2	239	243	PF13176	0.249
LIG_LIR_Apic_2	378	382	PF02991	0.414
LIG_LIR_Gen_1	193	204	PF02991	0.249
LIG_LIR_Gen_1	236	245	PF02991	0.253
LIG_LIR_Nem_3	126	131	PF02991	0.279
LIG_LIR_Nem_3	193	199	PF02991	0.353
LIG_LIR_Nem_3	236	240	PF02991	0.281
LIG_LIR_Nem_3	319	324	PF02991	0.466
LIG_LIR_Nem_3	35	41	PF02991	0.265
LIG_LIR_Nem_3	455	459	PF02991	0.521
LIG_LIR_Nem_3	659	665	PF02991	0.521
LIG_MYND_1	365	369	PF01753	0.424
LIG_PCNA_PIPBox_1	231	240	PF02747	0.309
LIG_PCNA_yPIPBox_3	224	238	PF02747	0.309
LIG_PTB_Apo_2	450	457	PF02174	0.439
LIG_PTB_Phospho_1	450	456	PF10480	0.435
LIG_RPA_C_Fungi	540	552	PF08784	0.505
LIG_SH2_CRK	148	152	PF00017	0.249
LIG_SH2_CRK	596	600	PF00017	0.432
LIG_SH2_CRK	662	666	PF00017	0.469
LIG_SH2_NCK_1	456	460	PF00017	0.476
LIG_SH2_PTP2	232	235	PF00017	0.249
LIG_SH2_PTP2	379	382	PF00017	0.249
LIG_SH2_SRC	440	443	PF00017	0.455
LIG_SH2_STAP1	204	208	PF00017	0.297
LIG_SH2_STAP1	221	225	PF00017	0.167
LIG_SH2_STAT5	130	133	PF00017	0.333
LIG_SH2_STAT5	185	188	PF00017	0.249
LIG_SH2_STAT5	21	24	PF00017	0.204
LIG_SH2_STAT5	232	235	PF00017	0.284
LIG_SH2_STAT5	241	244	PF00017	0.299
LIG_SH2_STAT5	327	330	PF00017	0.255
LIG_SH2_STAT5	352	355	PF00017	0.309
LIG_SH2_STAT5	379	382	PF00017	0.249
LIG_SH2_STAT5	384	387	PF00017	0.249
LIG_SH2_STAT5	440	443	PF00017	0.410
LIG_SH2_STAT5	67	70	PF00017	0.249
LIG_SH3_3	359	365	PF00018	0.251
LIG_SH3_3	455	461	PF00018	0.353
LIG_SH3_3	476	482	PF00018	0.656
LIG_SH3_3	512	518	PF00018	0.674
LIG_SH3_4	503	510	PF00018	0.631
LIG_TRAF2_1	473	476	PF00917	0.547
LIG_WRC_WIRS_1	234	239	PF05994	0.339
MOD_CDK_SPxxK_3	149	156	PF00069	0.343
MOD_CDK_SPxxK_3	558	565	PF00069	0.385
MOD_CK1_1	157	163	PF00069	0.260
MOD_CK1_1	166	172	PF00069	0.249
MOD_CK1_1	305	311	PF00069	0.524
MOD_CK1_1	355	361	PF00069	0.362
MOD_CK1_1	411	417	PF00069	0.355
MOD_CK2_1	120	126	PF00069	0.249
MOD_CK2_1	156	162	PF00069	0.249
MOD_CK2_1	233	239	PF00069	0.249
MOD_CK2_1	305	311	PF00069	0.434
MOD_CK2_1	470	476	PF00069	0.514
MOD_CK2_1	490	496	PF00069	0.598
MOD_CK2_1	57	63	PF00069	0.358
MOD_Cter_Amidation	649	652	PF01082	0.563
MOD_GlcNHglycan	168	171	PF01048	0.265
MOD_GlcNHglycan	281	284	PF01048	0.555
MOD_GlcNHglycan	419	422	PF01048	0.544
MOD_GlcNHglycan	492	495	PF01048	0.516
MOD_GlcNHglycan	520	523	PF01048	0.474
MOD_GlcNHglycan	59	62	PF01048	0.265
MOD_GlcNHglycan	599	602	PF01048	0.569
MOD_GSK3_1	116	123	PF00069	0.299
MOD_GSK3_1	165	172	PF00069	0.335
MOD_GSK3_1	322	329	PF00069	0.249
MOD_GSK3_1	411	418	PF00069	0.384
MOD_N-GLC_1	355	360	PF02516	0.265
MOD_N-GLC_2	342	344	PF02516	0.384
MOD_NEK2_1	109	114	PF00069	0.343
MOD_NEK2_1	120	125	PF00069	0.269
MOD_NEK2_1	25	30	PF00069	0.284
MOD_NEK2_1	413	418	PF00069	0.523
MOD_NEK2_1	52	57	PF00069	0.265
MOD_NEK2_2	195	200	PF00069	0.265
MOD_PKA_1	568	574	PF00069	0.521
MOD_PKA_2	116	122	PF00069	0.349
MOD_PKA_2	556	562	PF00069	0.523
MOD_Plk_1	157	163	PF00069	0.279
MOD_Plk_1	355	361	PF00069	0.265
MOD_Plk_1	488	494	PF00069	0.491
MOD_Plk_2-3	470	476	PF00069	0.529
MOD_Plk_2-3	509	515	PF00069	0.626
MOD_Plk_4	116	122	PF00069	0.265
MOD_Plk_4	140	146	PF00069	0.249
MOD_Plk_4	233	239	PF00069	0.284
MOD_Plk_4	322	328	PF00069	0.262
MOD_ProDKin_1	149	155	PF00069	0.265
MOD_ProDKin_1	408	414	PF00069	0.371
MOD_ProDKin_1	454	460	PF00069	0.347
MOD_ProDKin_1	558	564	PF00069	0.385
MOD_SUMO_for_1	12	15	PF00179	0.265
MOD_SUMO_for_1	155	158	PF00179	0.175
MOD_SUMO_for_1	208	211	PF00179	0.343
MOD_SUMO_for_1	250	253	PF00179	0.284
MOD_SUMO_rev_2	104	109	PF00179	0.262
MOD_SUMO_rev_2	152	157	PF00179	0.393
MOD_SUMO_rev_2	302	308	PF00179	0.581
MOD_SUMO_rev_2	457	466	PF00179	0.475
MOD_SUMO_rev_2	629	634	PF00179	0.532
TRG_DiLeu_BaEn_1	447	452	PF01217	0.382
TRG_DiLeu_BaEn_1	71	76	PF01217	0.265
TRG_DiLeu_BaEn_2	242	248	PF01217	0.249
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.265
TRG_ENDOCYTIC_2	128	131	PF00928	0.277
TRG_ENDOCYTIC_2	148	151	PF00928	0.122
TRG_ENDOCYTIC_2	204	207	PF00928	0.309
TRG_ENDOCYTIC_2	232	235	PF00928	0.284
TRG_ENDOCYTIC_2	241	244	PF00928	0.299
TRG_ENDOCYTIC_2	456	459	PF00928	0.431
TRG_ENDOCYTIC_2	596	599	PF00928	0.440
TRG_ENDOCYTIC_2	662	665	PF00928	0.476
TRG_ER_diArg_1	212	215	PF00400	0.249
TRG_ER_diArg_1	38	40	PF00400	0.249
TRG_ER_diArg_1	544	546	PF00400	0.465
TRG_ER_diArg_1	642	645	PF00400	0.517
TRG_NES_CRM1_1	243	255	PF08389	0.339
TRG_NLS_Bipartite_1	4	22	PF00514	0.265
TRG_NLS_Bipartite_1	574	593	PF00514	0.476
TRG_NLS_MonoExtC_3	9	14	PF00514	0.438
TRG_NLS_MonoExtN_4	16	22	PF00514	0.265
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	651	655	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Q9	Leptomonas seymouri	84%	100%
A0A0S4JN88	Bodo saltans	61%	100%
A0A1X0NKV4	Trypanosomatidae	69%	100%
A0A3R7LRI0	Trypanosoma rangeli	69%	100%
A0A3S5H5C9	Leishmania donovani	92%	100%
A1CHD1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	30%	99%
A1CXF4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	30%	99%
A4H3Z2	Leishmania braziliensis	100%	100%
A4HS78	Leishmania infantum	92%	100%
A4RLI4	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	30%	99%
A5DGY0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	31%	100%
A5DYS6	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	30%	100%
A6SK81	Botryotinia fuckeliana (strain B05.10)	29%	99%
A7EGB5	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	31%	99%
A7TSA8	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	33%	100%
A8N1X3	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	30%	100%
A9URZ4	Monosiga brevicollis	30%	100%
B0CQL7	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	31%	100%
B0Y612	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	30%	99%
B2WBA7	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	29%	99%
C9ZY72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AK64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O60164	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O97209	Leishmania major	92%	100%
P0CP58	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	29%	100%
P0CP59	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	29%	100%
Q0CLP9	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	31%	99%
Q0V577	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	29%	99%
Q1DLJ4	Coccidioides immitis (strain RS)	30%	97%
Q2HCV1	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	29%	100%
Q2UGQ8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	31%	98%
Q4WP65	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	30%	99%
Q59X38	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	100%
Q5B6K3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	99%
Q6CDK0	Yarrowia lipolytica (strain CLIB 122 / E 150)	31%	100%
Q6CQQ1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	100%
Q6FSU1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	100%
Q75EI5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	31%	100%
Q7R7N4	Plasmodium yoelii yoelii	23%	100%
Q851S7	Oryza sativa subsp. japonica	32%	100%
Q9LYK7	Arabidopsis thaliana	33%	100%
V5AY93	Trypanosoma cruzi	69%	100%