Pex2 / Pex12 amino terminal region family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosome import protein

Species:

Leishmania donovani

UniProt:

P90634_LEIDO

TriTrypDb:

LdBPK_252330.1 , LdCL_250029100 , LDHU3_25.2810

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0016020	membrane	2	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

P90634

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0006082	organic acid metabolic process	3	1
GO:0006090	pyruvate metabolic process	7	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006096	glycolytic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006757	obsolete ATP generation from ADP	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009132	nucleoside diphosphate metabolic process	5	1
GO:0009135	purine nucleoside diphosphate metabolic process	6	1
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009144	purine nucleoside triphosphate metabolic process	6	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	1
GO:0009185	ribonucleoside diphosphate metabolic process	6	1
GO:0009199	ribonucleoside triphosphate metabolic process	6	1
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016052	carbohydrate catabolic process	4	1
GO:0016310	phosphorylation	5	1
GO:0017038	protein import	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0033036	macromolecule localization	2	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046031	ADP metabolic process	7	1
GO:0046034	ATP metabolic process	7	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046939	obsolete nucleotide phosphorylation	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	6	10	PF00656	0.488
CLV_NRD_NRD_1	135	137	PF00675	0.291
CLV_NRD_NRD_1	152	154	PF00675	0.148
CLV_NRD_NRD_1	156	158	PF00675	0.222
CLV_NRD_NRD_1	255	257	PF00675	0.514
CLV_PCSK_KEX2_1	135	137	PF00082	0.314
CLV_PCSK_KEX2_1	255	257	PF00082	0.514
CLV_PCSK_SKI1_1	125	129	PF00082	0.265
CLV_PCSK_SKI1_1	135	139	PF00082	0.196
CLV_PCSK_SKI1_1	157	161	PF00082	0.324
CLV_PCSK_SKI1_1	175	179	PF00082	0.244
CLV_PCSK_SKI1_1	256	260	PF00082	0.521
CLV_PCSK_SKI1_1	316	320	PF00082	0.509
DEG_APCC_DBOX_1	114	122	PF00400	0.514
DEG_SPOP_SBC_1	264	268	PF00917	0.349
DOC_CYCLIN_RxL_1	111	124	PF00134	0.514
DOC_PP2B_LxvP_1	146	149	PF13499	0.514
DOC_PP2B_LxvP_1	65	68	PF13499	0.413
DOC_USP7_MATH_1	265	269	PF00917	0.274
DOC_USP7_MATH_1	323	327	PF00917	0.348
DOC_USP7_UBL2_3	154	158	PF12436	0.462
LIG_14-3-3_CanoR_1	210	215	PF00244	0.209
LIG_14-3-3_CanoR_1	246	251	PF00244	0.231
LIG_14-3-3_CanoR_1	256	262	PF00244	0.198
LIG_14-3-3_CanoR_1	91	95	PF00244	0.478
LIG_BIR_II_1	1	5	PF00653	0.428
LIG_BRCT_BRCA1_1	26	30	PF00533	0.445
LIG_EH1_1	140	148	PF00400	0.478
LIG_FAT_LD_1	85	93	PF03623	0.463
LIG_FHA_1	122	128	PF00498	0.466
LIG_FHA_1	150	156	PF00498	0.477
LIG_FHA_1	184	190	PF00498	0.399
LIG_FHA_1	225	231	PF00498	0.264
LIG_FHA_2	204	210	PF00498	0.222
LIG_GBD_Chelix_1	53	61	PF00786	0.222
LIG_GBD_Chelix_1	81	89	PF00786	0.278
LIG_LIR_Gen_1	186	193	PF02991	0.343
LIG_LIR_Gen_1	195	204	PF02991	0.363
LIG_LIR_Gen_1	240	248	PF02991	0.273
LIG_LIR_Gen_1	27	38	PF02991	0.433
LIG_LIR_Gen_1	59	70	PF02991	0.483
LIG_LIR_Nem_3	186	190	PF02991	0.343
LIG_LIR_Nem_3	195	199	PF02991	0.251
LIG_LIR_Nem_3	201	207	PF02991	0.224
LIG_LIR_Nem_3	240	244	PF02991	0.273
LIG_LIR_Nem_3	27	33	PF02991	0.439
LIG_LIR_Nem_3	312	318	PF02991	0.238
LIG_LIR_Nem_3	59	65	PF02991	0.459
LIG_MYND_1	129	133	PF01753	0.436
LIG_NRBOX	84	90	PF00104	0.463
LIG_Pex14_1	241	245	PF04695	0.263
LIG_PTB_Apo_2	225	232	PF02174	0.211
LIG_PTB_Phospho_1	225	231	PF10480	0.211
LIG_SH2_CRK	182	186	PF00017	0.319
LIG_SH2_CRK	204	208	PF00017	0.211
LIG_SH2_GRB2like	231	234	PF00017	0.211
LIG_SH2_STAT3	218	221	PF00017	0.218
LIG_SH2_STAT3	231	234	PF00017	0.197
LIG_SH2_STAT5	12	15	PF00017	0.537
LIG_SH2_STAT5	150	153	PF00017	0.442
LIG_SH2_STAT5	253	256	PF00017	0.236
LIG_SH2_STAT5	297	300	PF00017	0.242
LIG_SUMO_SIM_anti_2	52	60	PF11976	0.416
LIG_SUMO_SIM_anti_2	79	86	PF11976	0.514
LIG_SUMO_SIM_par_1	79	86	PF11976	0.514
LIG_TRAF2_1	76	79	PF00917	0.478
LIG_TYR_ITIM	180	185	PF00017	0.429
LIG_UBA3_1	118	125	PF00899	0.509
MOD_CK1_1	188	194	PF00069	0.375
MOD_CK1_1	260	266	PF00069	0.238
MOD_CK1_1	309	315	PF00069	0.289
MOD_CK2_1	203	209	PF00069	0.222
MOD_CK2_1	269	275	PF00069	0.326
MOD_CMANNOS	238	241	PF00535	0.422
MOD_GlcNHglycan	267	270	PF01048	0.447
MOD_GlcNHglycan	278	281	PF01048	0.425
MOD_GSK3_1	123	130	PF00069	0.419
MOD_GSK3_1	188	195	PF00069	0.310
MOD_GSK3_1	24	31	PF00069	0.438
MOD_GSK3_1	259	266	PF00069	0.270
MOD_N-GLC_2	276	278	PF02516	0.445
MOD_NEK2_1	121	126	PF00069	0.488
MOD_NEK2_1	192	197	PF00069	0.342
MOD_NEK2_1	198	203	PF00069	0.259
MOD_NEK2_1	224	229	PF00069	0.272
MOD_NEK2_1	257	262	PF00069	0.254
MOD_NEK2_1	306	311	PF00069	0.266
MOD_NEK2_1	57	62	PF00069	0.438
MOD_NEK2_1	97	102	PF00069	0.487
MOD_OFUCOSY	320	327	PF10250	0.518
MOD_PIKK_1	217	223	PF00454	0.222
MOD_PIKK_1	306	312	PF00454	0.306
MOD_PKA_2	224	230	PF00069	0.222
MOD_PKA_2	90	96	PF00069	0.486
MOD_Plk_4	123	129	PF00069	0.412
MOD_Plk_4	142	148	PF00069	0.365
MOD_Plk_4	237	243	PF00069	0.247
MOD_Plk_4	57	63	PF00069	0.428
MOD_Plk_4	90	96	PF00069	0.488
TRG_DiLeu_BaEn_1	114	119	PF01217	0.514
TRG_DiLeu_BaEn_1	79	84	PF01217	0.437
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.425
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.225
TRG_DiLeu_LyEn_5	114	119	PF01217	0.514
TRG_ENDOCYTIC_2	182	185	PF00928	0.405
TRG_ENDOCYTIC_2	204	207	PF00928	0.222
TRG_ENDOCYTIC_2	299	302	PF00928	0.256
TRG_ER_diArg_1	115	118	PF00400	0.514
TRG_ER_diArg_1	135	137	PF00400	0.321
TRG_ER_diArg_1	173	176	PF00400	0.432
TRG_ER_diArg_1	254	256	PF00400	0.314
TRG_NES_CRM1_1	55	71	PF08389	0.422
TRG_NES_CRM1_1	99	114	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.219
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N2	Leptomonas seymouri	82%	100%
A0A0S4J1C5	Bodo saltans	38%	99%
A0A1X0NYP2	Trypanosomatidae	53%	100%
A0A422P4J9	Trypanosoma rangeli	53%	100%
A4HEC7	Leishmania braziliensis	92%	100%
A4I1S2	Leishmania infantum	100%	100%
C9ZKD0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	99%
E9AXV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P24392	Rattus norvegicus	26%	100%
P28328	Homo sapiens	24%	100%
P55098	Mus musculus	26%	100%
Q01964	Komagataella pastoris	24%	72%
Q06438	Cricetulus griseus	26%	100%
Q4Q9L4	Leishmania major	95%	100%
Q75JQ3	Dictyostelium discoideum	25%	78%
Q99155	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	87%
Q9CA86	Arabidopsis thaliana	27%	99%
V5ASI5	Trypanosoma cruzi	53%	100%