TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania major

UniProt:

O97220_LEIMA

TriTrypDb:

LmjF.04.0420 , LMJLV39_040009000 , LMJSD75_040009300

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

O97220

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97220

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.670
CLV_PCSK_KEX2_1	8	10	PF00082	0.663
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.723
CLV_PCSK_SKI1_1	137	141	PF00082	0.494
CLV_PCSK_SKI1_1	271	275	PF00082	0.425
CLV_PCSK_SKI1_1	308	312	PF00082	0.531
CLV_PCSK_SKI1_1	39	43	PF00082	0.430
DEG_ODPH_VHL_1	53	65	PF01847	0.547
DOC_CDC14_PxL_1	51	59	PF14671	0.560
DOC_SPAK_OSR1_1	97	101	PF12202	0.524
DOC_USP7_MATH_1	125	129	PF00917	0.483
DOC_USP7_UBL2_3	15	19	PF12436	0.626
DOC_WW_Pin1_4	17	22	PF00397	0.495
LIG_14-3-3_CanoR_1	39	44	PF00244	0.508
LIG_14-3-3_CanoR_1	7	16	PF00244	0.569
LIG_Actin_WH2_2	140	155	PF00022	0.446
LIG_APCC_ABBA_1	53	58	PF00400	0.523
LIG_BIR_II_1	1	5	PF00653	0.760
LIG_BIR_III_3	1	5	PF00653	0.782
LIG_eIF4E_1	146	152	PF01652	0.444
LIG_FHA_1	247	253	PF00498	0.541
LIG_FHA_1	309	315	PF00498	0.506
LIG_FHA_1	334	340	PF00498	0.618
LIG_FHA_1	8	14	PF00498	0.683
LIG_FHA_2	168	174	PF00498	0.560
LIG_FHA_2	265	271	PF00498	0.492
LIG_LIR_Gen_1	138	148	PF02991	0.497
LIG_LIR_Nem_3	138	143	PF02991	0.503
LIG_NRBOX	146	152	PF00104	0.507
LIG_NRBOX	250	256	PF00104	0.453
LIG_PCNA_yPIPBox_3	244	255	PF02747	0.534
LIG_PCNA_yPIPBox_3	83	96	PF02747	0.447
LIG_Pex14_1	29	33	PF04695	0.405
LIG_SH2_CRK	144	148	PF00017	0.529
LIG_SH2_SRC	56	59	PF00017	0.482
LIG_SH2_STAP1	144	148	PF00017	0.502
LIG_SH2_STAP1	217	221	PF00017	0.470
LIG_SH2_STAT5	117	120	PF00017	0.527
LIG_SH2_STAT5	146	149	PF00017	0.446
LIG_SH2_STAT5	33	36	PF00017	0.421
LIG_SH2_STAT5	56	59	PF00017	0.514
LIG_SH3_3	49	55	PF00018	0.587
LIG_SUMO_SIM_anti_2	249	256	PF11976	0.546
LIG_SUMO_SIM_anti_2	298	306	PF11976	0.697
LIG_SUMO_SIM_par_1	249	256	PF11976	0.567
LIG_TRAF2_1	295	298	PF00917	0.517
LIG_TRFH_1	51	55	PF08558	0.549
LIG_WRC_WIRS_1	40	45	PF05994	0.528
MOD_CK2_1	102	108	PF00069	0.580
MOD_CK2_1	151	157	PF00069	0.601
MOD_CK2_1	167	173	PF00069	0.563
MOD_CK2_1	264	270	PF00069	0.517
MOD_CK2_1	303	309	PF00069	0.688
MOD_CK2_1	56	62	PF00069	0.555
MOD_GlcNHglycan	105	108	PF01048	0.541
MOD_GlcNHglycan	127	130	PF01048	0.570
MOD_GlcNHglycan	137	140	PF01048	0.538
MOD_GlcNHglycan	196	199	PF01048	0.458
MOD_GlcNHglycan	305	308	PF01048	0.671
MOD_GSK3_1	125	132	PF00069	0.696
MOD_GSK3_1	246	253	PF00069	0.446
MOD_GSK3_1	7	14	PF00069	0.697
MOD_GSK3_1	98	105	PF00069	0.529
MOD_N-GLC_1	125	130	PF02516	0.677
MOD_NEK2_1	264	269	PF00069	0.504
MOD_NEK2_1	310	315	PF00069	0.533
MOD_NEK2_1	355	360	PF00069	0.624
MOD_PKA_1	7	13	PF00069	0.658
MOD_PKB_1	7	15	PF00069	0.580
MOD_Plk_1	129	135	PF00069	0.617
MOD_Plk_1	61	67	PF00069	0.537
MOD_Plk_4	250	256	PF00069	0.518
MOD_Plk_4	310	316	PF00069	0.428
MOD_Plk_4	347	353	PF00069	0.560
MOD_ProDKin_1	17	23	PF00069	0.494
MOD_SUMO_for_1	43	46	PF00179	0.430
MOD_SUMO_rev_2	342	351	PF00179	0.595
TRG_DiLeu_BaEn_1	250	255	PF01217	0.452
TRG_DiLeu_BaEn_1	270	275	PF01217	0.425
TRG_DiLeu_BaEn_3	346	352	PF01217	0.467
TRG_ENDOCYTIC_2	144	147	PF00928	0.504
TRG_ENDOCYTIC_2	84	87	PF00928	0.431
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D5	Leptomonas seymouri	76%	98%
A0A0S4JCG4	Bodo saltans	43%	75%
A0A1X0NKZ6	Trypanosomatidae	42%	100%
A0A3R7R703	Trypanosoma rangeli	45%	100%
A0A3S5H5A3	Leishmania donovani	98%	100%
A4H3W2	Leishmania braziliensis	91%	100%
A4HS36	Leishmania infantum	98%	100%
C9ZY33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AK23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5D9X8	Trypanosoma cruzi	44%	100%