Protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

O97216_LEIMA

TriTrypDb:

LmjF.04.0720 , LMJLV39_040012500 , LMJSD75_040012900

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

O97216

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97216

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.766
CLV_NRD_NRD_1	110	112	PF00675	0.763
CLV_NRD_NRD_1	187	189	PF00675	0.622
CLV_NRD_NRD_1	207	209	PF00675	0.769
CLV_NRD_NRD_1	330	332	PF00675	0.763
CLV_NRD_NRD_1	414	416	PF00675	0.601
CLV_NRD_NRD_1	53	55	PF00675	0.616
CLV_NRD_NRD_1	619	621	PF00675	0.826
CLV_PCSK_FUR_1	617	621	PF00082	0.827
CLV_PCSK_KEX2_1	109	111	PF00082	0.774
CLV_PCSK_KEX2_1	187	189	PF00082	0.622
CLV_PCSK_KEX2_1	330	332	PF00082	0.763
CLV_PCSK_KEX2_1	414	416	PF00082	0.601
CLV_PCSK_KEX2_1	53	55	PF00082	0.616
CLV_PCSK_KEX2_1	619	621	PF00082	0.826
CLV_PCSK_PC7_1	183	189	PF00082	0.631
CLV_PCSK_PC7_1	49	55	PF00082	0.616
CLV_PCSK_SKI1_1	209	213	PF00082	0.854
CLV_PCSK_SKI1_1	486	490	PF00082	0.727
DEG_APCC_DBOX_1	116	124	PF00400	0.708
DEG_COP1_1	169	177	PF00400	0.634
DEG_Nend_UBRbox_2	1	3	PF02207	0.686
DEG_SPOP_SBC_1	371	375	PF00917	0.749
DOC_CKS1_1	174	179	PF01111	0.770
DOC_MAPK_gen_1	53	60	PF00069	0.673
DOC_PP2B_LxvP_1	529	532	PF13499	0.697
DOC_SPAK_OSR1_1	495	499	PF12202	0.796
DOC_USP7_MATH_1	175	179	PF00917	0.812
DOC_USP7_MATH_1	191	195	PF00917	0.589
DOC_USP7_MATH_1	216	220	PF00917	0.748
DOC_USP7_MATH_1	29	33	PF00917	0.652
DOC_USP7_MATH_1	371	375	PF00917	0.811
DOC_USP7_MATH_1	376	380	PF00917	0.827
DOC_USP7_MATH_1	442	446	PF00917	0.606
DOC_USP7_MATH_1	467	471	PF00917	0.713
DOC_USP7_MATH_1	532	536	PF00917	0.651
DOC_USP7_MATH_1	575	579	PF00917	0.580
DOC_USP7_MATH_1	582	586	PF00917	0.539
DOC_USP7_MATH_1	647	651	PF00917	0.581
DOC_USP7_MATH_1	70	74	PF00917	0.735
DOC_USP7_MATH_1	710	714	PF00917	0.797
DOC_USP7_MATH_1	90	94	PF00917	0.619
DOC_WW_Pin1_4	168	173	PF00397	0.859
DOC_WW_Pin1_4	186	191	PF00397	0.546
DOC_WW_Pin1_4	247	252	PF00397	0.746
DOC_WW_Pin1_4	25	30	PF00397	0.651
DOC_WW_Pin1_4	380	385	PF00397	0.665
DOC_WW_Pin1_4	473	478	PF00397	0.777
DOC_WW_Pin1_4	519	524	PF00397	0.590
DOC_WW_Pin1_4	580	585	PF00397	0.680
DOC_WW_Pin1_4	690	695	PF00397	0.768
DOC_WW_Pin1_4	97	102	PF00397	0.755
LIG_14-3-3_CanoR_1	110	120	PF00244	0.651
LIG_14-3-3_CanoR_1	208	214	PF00244	0.846
LIG_14-3-3_CanoR_1	23	31	PF00244	0.613
LIG_14-3-3_CanoR_1	281	289	PF00244	0.779
LIG_14-3-3_CanoR_1	320	328	PF00244	0.680
LIG_14-3-3_CanoR_1	330	338	PF00244	0.583
LIG_14-3-3_CanoR_1	393	398	PF00244	0.787
LIG_14-3-3_CanoR_1	406	413	PF00244	0.574
LIG_14-3-3_CanoR_1	414	424	PF00244	0.595
LIG_14-3-3_CanoR_1	486	496	PF00244	0.736
LIG_14-3-3_CanoR_1	514	523	PF00244	0.604
LIG_14-3-3_CanoR_1	53	59	PF00244	0.756
LIG_14-3-3_CanoR_1	533	540	PF00244	0.639
LIG_14-3-3_CanoR_1	663	668	PF00244	0.825
LIG_Actin_WH2_2	398	416	PF00022	0.647
LIG_BIR_III_4	38	42	PF00653	0.740
LIG_BRCT_BRCA1_1	382	386	PF00533	0.690
LIG_BRCT_BRCA1_1	492	496	PF00533	0.746
LIG_BRCT_BRCA1_1	630	634	PF00533	0.612
LIG_deltaCOP1_diTrp_1	588	592	PF00928	0.732
LIG_FHA_1	174	180	PF00498	0.866
LIG_FHA_1	187	193	PF00498	0.710
LIG_FHA_1	241	247	PF00498	0.571
LIG_FHA_1	284	290	PF00498	0.810
LIG_FHA_1	373	379	PF00498	0.766
LIG_FHA_1	421	427	PF00498	0.609
LIG_FHA_1	551	557	PF00498	0.747
LIG_FHA_1	559	565	PF00498	0.641
LIG_FHA_1	6	12	PF00498	0.575
LIG_FHA_1	673	679	PF00498	0.798
LIG_FHA_2	14	20	PF00498	0.821
LIG_FHA_2	332	338	PF00498	0.688
LIG_FHA_2	414	420	PF00498	0.597
LIG_FHA_2	635	641	PF00498	0.734
LIG_Integrin_RGD_1	348	350	PF01839	0.695
LIG_LIR_Apic_2	194	198	PF02991	0.839
LIG_LIR_Gen_1	383	394	PF02991	0.562
LIG_LIR_Gen_1	563	574	PF02991	0.575
LIG_LIR_Nem_3	223	229	PF02991	0.693
LIG_LIR_Nem_3	383	389	PF02991	0.601
LIG_LIR_Nem_3	563	569	PF02991	0.584
LIG_LIR_Nem_3	586	592	PF02991	0.794
LIG_MYND_1	478	482	PF01753	0.687
LIG_MYND_2	477	481	PF01753	0.581
LIG_Rb_LxCxE_1	100	116	PF01857	0.631
LIG_SH2_CRK	332	336	PF00017	0.734
LIG_SH2_CRK	369	373	PF00017	0.740
LIG_SH2_CRK	566	570	PF00017	0.573
LIG_SH2_GRB2like	566	569	PF00017	0.576
LIG_SH2_NCK_1	332	336	PF00017	0.578
LIG_SH2_STAP1	133	137	PF00017	0.621
LIG_SH2_STAP1	302	306	PF00017	0.603
LIG_SH2_STAP1	332	336	PF00017	0.562
LIG_SH2_STAP1	687	691	PF00017	0.621
LIG_SH2_STAT5	705	708	PF00017	0.807
LIG_SH3_3	169	175	PF00018	0.764
LIG_SH3_3	245	251	PF00018	0.819
LIG_SH3_3	286	292	PF00018	0.621
LIG_SH3_3	308	314	PF00018	0.613
LIG_SH3_3	433	439	PF00018	0.709
LIG_SH3_3	472	478	PF00018	0.690
LIG_SH3_3	517	523	PF00018	0.638
LIG_SH3_3	630	636	PF00018	0.711
LIG_SH3_3	688	694	PF00018	0.766
LIG_SUMO_SIM_anti_2	650	656	PF11976	0.568
LIG_SUMO_SIM_par_1	422	427	PF11976	0.611
LIG_SUMO_SIM_par_1	650	656	PF11976	0.671
LIG_SxIP_EBH_1	474	486	PF03271	0.582
LIG_TYR_ITIM	564	569	PF00017	0.582
MOD_CK1_1	100	106	PF00069	0.833
MOD_CK1_1	112	118	PF00069	0.671
MOD_CK1_1	173	179	PF00069	0.704
MOD_CK1_1	204	210	PF00069	0.760
MOD_CK1_1	231	237	PF00069	0.775
MOD_CK1_1	25	31	PF00069	0.729
MOD_CK1_1	250	256	PF00069	0.797
MOD_CK1_1	3	9	PF00069	0.777
MOD_CK1_1	358	364	PF00069	0.768
MOD_CK1_1	374	380	PF00069	0.567
MOD_CK1_1	408	414	PF00069	0.707
MOD_CK1_1	469	475	PF00069	0.745
MOD_CK1_1	476	482	PF00069	0.634
MOD_CK1_1	536	542	PF00069	0.789
MOD_CK1_1	557	563	PF00069	0.706
MOD_CK1_1	56	62	PF00069	0.830
MOD_CK1_1	591	597	PF00069	0.815
MOD_CK1_1	627	633	PF00069	0.827
MOD_CK1_1	690	696	PF00069	0.811
MOD_CK1_1	708	714	PF00069	0.502
MOD_CK2_1	100	106	PF00069	0.742
MOD_CK2_1	119	125	PF00069	0.661
MOD_CK2_1	393	399	PF00069	0.687
MOD_CK2_1	424	430	PF00069	0.613
MOD_CK2_1	634	640	PF00069	0.740
MOD_CK2_1	663	669	PF00069	0.824
MOD_DYRK1A_RPxSP_1	97	101	PF00069	0.727
MOD_GlcNHglycan	203	206	PF01048	0.749
MOD_GlcNHglycan	265	268	PF01048	0.834
MOD_GlcNHglycan	274	277	PF01048	0.677
MOD_GlcNHglycan	323	326	PF01048	0.649
MOD_GlcNHglycan	357	360	PF01048	0.659
MOD_GlcNHglycan	444	447	PF01048	0.754
MOD_GlcNHglycan	452	455	PF01048	0.707
MOD_GlcNHglycan	469	472	PF01048	0.841
MOD_GlcNHglycan	490	493	PF01048	0.810
MOD_GlcNHglycan	498	501	PF01048	0.685
MOD_GlcNHglycan	540	543	PF01048	0.814
MOD_GlcNHglycan	545	548	PF01048	0.733
MOD_GlcNHglycan	585	588	PF01048	0.720
MOD_GlcNHglycan	660	663	PF01048	0.806
MOD_GlcNHglycan	707	710	PF01048	0.719
MOD_GlcNHglycan	72	75	PF01048	0.694
MOD_GlcNHglycan	82	85	PF01048	0.679
MOD_GSK3_1	109	116	PF00069	0.667
MOD_GSK3_1	166	173	PF00069	0.732
MOD_GSK3_1	21	28	PF00069	0.747
MOD_GSK3_1	227	234	PF00069	0.668
MOD_GSK3_1	280	287	PF00069	0.665
MOD_GSK3_1	370	377	PF00069	0.812
MOD_GSK3_1	389	396	PF00069	0.537
MOD_GSK3_1	413	420	PF00069	0.695
MOD_GSK3_1	461	468	PF00069	0.732
MOD_GSK3_1	469	476	PF00069	0.743
MOD_GSK3_1	486	493	PF00069	0.633
MOD_GSK3_1	532	539	PF00069	0.689
MOD_GSK3_1	543	550	PF00069	0.767
MOD_GSK3_1	554	561	PF00069	0.688
MOD_GSK3_1	569	576	PF00069	0.550
MOD_GSK3_1	591	598	PF00069	0.772
MOD_GSK3_1	620	627	PF00069	0.804
MOD_GSK3_1	65	72	PF00069	0.689
MOD_GSK3_1	658	665	PF00069	0.781
MOD_GSK3_1	672	679	PF00069	0.567
MOD_GSK3_1	683	690	PF00069	0.667
MOD_GSK3_1	693	700	PF00069	0.645
MOD_GSK3_1	708	715	PF00069	0.558
MOD_GSK3_1	76	83	PF00069	0.671
MOD_LATS_1	107	113	PF00433	0.739
MOD_N-GLC_1	272	277	PF02516	0.630
MOD_N-GLC_1	551	556	PF02516	0.830
MOD_N-GLC_1	557	562	PF02516	0.727
MOD_N-GLC_1	627	632	PF02516	0.753
MOD_N-GLC_1	658	663	PF02516	0.587
MOD_N-GLC_2	704	706	PF02516	0.810
MOD_NEK2_1	323	328	PF00069	0.598
MOD_NEK2_1	372	377	PF00069	0.776
MOD_NEK2_1	389	394	PF00069	0.543
MOD_NEK2_1	413	418	PF00069	0.618
MOD_NEK2_1	424	429	PF00069	0.555
MOD_NEK2_1	496	501	PF00069	0.678
MOD_NEK2_1	538	543	PF00069	0.673
MOD_NEK2_1	595	600	PF00069	0.809
MOD_NEK2_1	699	704	PF00069	0.741
MOD_NEK2_2	285	290	PF00069	0.734
MOD_PIKK_1	160	166	PF00454	0.652
MOD_PIKK_1	393	399	PF00454	0.800
MOD_PIKK_1	48	54	PF00454	0.741
MOD_PIKK_1	91	97	PF00454	0.758
MOD_PKA_1	109	115	PF00069	0.631
MOD_PKA_1	330	336	PF00069	0.659
MOD_PKA_1	53	59	PF00069	0.617
MOD_PKA_2	109	115	PF00069	0.631
MOD_PKA_2	22	28	PF00069	0.759
MOD_PKA_2	280	286	PF00069	0.861
MOD_PKA_2	330	336	PF00069	0.705
MOD_PKA_2	405	411	PF00069	0.715
MOD_PKA_2	413	419	PF00069	0.632
MOD_PKA_2	442	448	PF00069	0.610
MOD_PKA_2	48	54	PF00069	0.735
MOD_PKA_2	494	500	PF00069	0.753
MOD_PKA_2	532	538	PF00069	0.821
MOD_PKA_2	662	668	PF00069	0.822
MOD_PKB_1	109	117	PF00069	0.628
MOD_PKB_1	279	287	PF00069	0.778
MOD_PKB_1	415	423	PF00069	0.598
MOD_Plk_1	408	414	PF00069	0.604
MOD_Plk_1	461	467	PF00069	0.751
MOD_Plk_1	562	568	PF00069	0.687
MOD_Plk_4	119	125	PF00069	0.681
MOD_Plk_4	358	364	PF00069	0.665
MOD_Plk_4	408	414	PF00069	0.604
MOD_Plk_4	469	475	PF00069	0.832
MOD_Plk_4	476	482	PF00069	0.692
MOD_Plk_4	575	581	PF00069	0.581
MOD_Plk_4	6	12	PF00069	0.575
MOD_Plk_4	629	635	PF00069	0.718
MOD_Plk_4	647	653	PF00069	0.528
MOD_Plk_4	676	682	PF00069	0.712
MOD_ProDKin_1	168	174	PF00069	0.859
MOD_ProDKin_1	186	192	PF00069	0.546
MOD_ProDKin_1	247	253	PF00069	0.749
MOD_ProDKin_1	25	31	PF00069	0.650
MOD_ProDKin_1	380	386	PF00069	0.665
MOD_ProDKin_1	473	479	PF00069	0.777
MOD_ProDKin_1	519	525	PF00069	0.589
MOD_ProDKin_1	580	586	PF00069	0.680
MOD_ProDKin_1	690	696	PF00069	0.769
MOD_ProDKin_1	97	103	PF00069	0.757
TRG_ENDOCYTIC_2	332	335	PF00928	0.731
TRG_ENDOCYTIC_2	369	372	PF00928	0.738
TRG_ENDOCYTIC_2	566	569	PF00928	0.576
TRG_ENDOCYTIC_2	667	670	PF00928	0.740
TRG_ER_diArg_1	109	111	PF00400	0.720
TRG_ER_diArg_1	279	282	PF00400	0.855
TRG_ER_diArg_1	330	332	PF00400	0.680
TRG_ER_diArg_1	413	415	PF00400	0.599
TRG_ER_diArg_1	513	516	PF00400	0.699
TRG_ER_diArg_1	53	55	PF00400	0.616
TRG_ER_diArg_1	618	620	PF00400	0.829
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5C2	Leishmania donovani	80%	100%
A4H406	Leishmania braziliensis	48%	100%
A4HS68	Leishmania infantum	79%	100%
E9AK55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%