REJ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF974), putative

Species:

Leishmania major

UniProt:

O97215_LEIMA

TriTrypDb:

LmjF.04.0730 , LMJLV39_040012700 , LMJSD75_040013100

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030008	TRAPP complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0099023	vesicle tethering complex	2	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1990072	TRAPPIII protein complex	4	2

Expansion

Sequence features

O97215

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97215

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.402
CLV_C14_Caspase3-7	393	397	PF00656	0.326
CLV_C14_Caspase3-7	428	432	PF00656	0.246
CLV_C14_Caspase3-7	689	693	PF00656	0.505
CLV_C14_Caspase3-7	729	733	PF00656	0.760
CLV_NRD_NRD_1	25	27	PF00675	0.497
CLV_NRD_NRD_1	264	266	PF00675	0.409
CLV_NRD_NRD_1	29	31	PF00675	0.477
CLV_NRD_NRD_1	307	309	PF00675	0.404
CLV_NRD_NRD_1	463	465	PF00675	0.402
CLV_NRD_NRD_1	519	521	PF00675	0.466
CLV_NRD_NRD_1	536	538	PF00675	0.212
CLV_NRD_NRD_1	55	57	PF00675	0.463
CLV_PCSK_FUR_1	53	57	PF00082	0.467
CLV_PCSK_KEX2_1	307	309	PF00082	0.404
CLV_PCSK_KEX2_1	519	521	PF00082	0.466
CLV_PCSK_KEX2_1	536	538	PF00082	0.212
CLV_PCSK_KEX2_1	55	57	PF00082	0.463
CLV_PCSK_SKI1_1	277	281	PF00082	0.350
CLV_PCSK_SKI1_1	307	311	PF00082	0.375
CLV_PCSK_SKI1_1	354	358	PF00082	0.358
CLV_PCSK_SKI1_1	433	437	PF00082	0.402
CLV_PCSK_SKI1_1	505	509	PF00082	0.408
CLV_PCSK_SKI1_1	553	557	PF00082	0.579
DEG_Nend_UBRbox_4	1	3	PF02207	0.412
DEG_ODPH_VHL_1	644	657	PF01847	0.482
DEG_SPOP_SBC_1	401	405	PF00917	0.246
DOC_CKS1_1	60	65	PF01111	0.456
DOC_CKS1_1	605	610	PF01111	0.635
DOC_CYCLIN_RxL_1	305	314	PF00134	0.434
DOC_CYCLIN_RxL_1	550	560	PF00134	0.508
DOC_CYCLIN_RxL_1	653	663	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.486
DOC_MAPK_HePTP_8	417	429	PF00069	0.447
DOC_MAPK_MEF2A_6	240	249	PF00069	0.721
DOC_MAPK_MEF2A_6	420	429	PF00069	0.388
DOC_MAPK_MEF2A_6	478	486	PF00069	0.402
DOC_MAPK_MEF2A_6	58	67	PF00069	0.455
DOC_MAPK_MEF2A_6	632	641	PF00069	0.427
DOC_PP1_RVXF_1	352	359	PF00149	0.335
DOC_PP2B_LxvP_1	166	169	PF13499	0.633
DOC_PP2B_LxvP_1	261	264	PF13499	0.335
DOC_PP2B_LxvP_1	434	437	PF13499	0.385
DOC_PP2B_LxvP_1	484	487	PF13499	0.447
DOC_PP2B_LxvP_1	66	69	PF13499	0.744
DOC_PP2B_LxvP_1	700	703	PF13499	0.585
DOC_USP7_MATH_1	106	110	PF00917	0.683
DOC_USP7_MATH_1	144	148	PF00917	0.696
DOC_USP7_MATH_1	18	22	PF00917	0.479
DOC_USP7_MATH_1	390	394	PF00917	0.399
DOC_USP7_MATH_1	401	405	PF00917	0.293
DOC_USP7_MATH_1	474	478	PF00917	0.459
DOC_USP7_MATH_1	574	578	PF00917	0.711
DOC_USP7_UBL2_3	27	31	PF12436	0.483
DOC_WW_Pin1_4	127	132	PF00397	0.602
DOC_WW_Pin1_4	225	230	PF00397	0.771
DOC_WW_Pin1_4	519	524	PF00397	0.386
DOC_WW_Pin1_4	59	64	PF00397	0.446
DOC_WW_Pin1_4	604	609	PF00397	0.709
DOC_WW_Pin1_4	67	72	PF00397	0.440
DOC_WW_Pin1_4	94	99	PF00397	0.591
LIG_14-3-3_CanoR_1	136	144	PF00244	0.756
LIG_14-3-3_CanoR_1	220	229	PF00244	0.790
LIG_14-3-3_CanoR_1	240	246	PF00244	0.537
LIG_14-3-3_CanoR_1	312	316	PF00244	0.411
LIG_14-3-3_CanoR_1	34	41	PF00244	0.579
LIG_14-3-3_CanoR_1	380	386	PF00244	0.439
LIG_14-3-3_CanoR_1	402	410	PF00244	0.421
LIG_14-3-3_CanoR_1	505	510	PF00244	0.450
LIG_14-3-3_CanoR_1	524	529	PF00244	0.435
LIG_Actin_WH2_2	292	309	PF00022	0.402
LIG_Actin_WH2_2	364	379	PF00022	0.480
LIG_Actin_WH2_2	490	507	PF00022	0.434
LIG_AP2alpha_2	206	208	PF02296	0.624
LIG_BRCT_BRCA1_1	272	276	PF00533	0.402
LIG_BRCT_BRCA1_1	665	669	PF00533	0.512
LIG_CSL_BTD_1	700	703	PF09270	0.585
LIG_CtBP_PxDLS_1	426	430	PF00389	0.246
LIG_EH1_1	494	502	PF00400	0.480
LIG_FHA_1	161	167	PF00498	0.605
LIG_FHA_1	242	248	PF00498	0.701
LIG_FHA_1	335	341	PF00498	0.346
LIG_FHA_1	380	386	PF00498	0.407
LIG_FHA_1	488	494	PF00498	0.445
LIG_FHA_1	516	522	PF00498	0.449
LIG_FHA_1	564	570	PF00498	0.572
LIG_FHA_1	60	66	PF00498	0.578
LIG_FHA_1	652	658	PF00498	0.540
LIG_FHA_1	666	672	PF00498	0.307
LIG_FHA_1	704	710	PF00498	0.601
LIG_FHA_2	470	476	PF00498	0.405
LIG_FHA_2	584	590	PF00498	0.740
LIG_FHA_2	759	765	PF00498	0.625
LIG_LIR_Apic_2	345	349	PF02991	0.411
LIG_LIR_Gen_1	206	216	PF02991	0.574
LIG_LIR_Gen_1	322	332	PF02991	0.480
LIG_LIR_Nem_3	198	204	PF02991	0.528
LIG_LIR_Nem_3	206	211	PF02991	0.484
LIG_LIR_Nem_3	273	279	PF02991	0.444
LIG_LIR_Nem_3	322	327	PF02991	0.480
LIG_LIR_Nem_3	407	413	PF02991	0.451
LIG_LIR_Nem_3	619	625	PF02991	0.425
LIG_NRBOX	656	662	PF00104	0.483
LIG_PDZ_Class_2	763	768	PF00595	0.616
LIG_Pex14_1	358	362	PF04695	0.447
LIG_RPA_C_Fungi	289	301	PF08784	0.285
LIG_SH2_CRK	324	328	PF00017	0.480
LIG_SH2_CRK	650	654	PF00017	0.431
LIG_SH2_NCK_1	324	328	PF00017	0.480
LIG_SH2_PTP2	378	381	PF00017	0.480
LIG_SH2_SRC	347	350	PF00017	0.393
LIG_SH2_STAP1	324	328	PF00017	0.451
LIG_SH2_STAP1	338	342	PF00017	0.276
LIG_SH2_STAP1	633	637	PF00017	0.508
LIG_SH2_STAT5	324	327	PF00017	0.422
LIG_SH2_STAT5	378	381	PF00017	0.447
LIG_SH2_STAT5	530	533	PF00017	0.356
LIG_SH2_STAT5	650	653	PF00017	0.453
LIG_SH3_2	131	136	PF14604	0.573
LIG_SH3_2	302	307	PF14604	0.434
LIG_SH3_3	128	134	PF00018	0.729
LIG_SH3_3	240	246	PF00018	0.771
LIG_SH3_3	296	302	PF00018	0.413
LIG_SH3_3	476	482	PF00018	0.428
LIG_SH3_3	57	63	PF00018	0.532
LIG_SH3_3	605	611	PF00018	0.684
LIG_SH3_3	68	74	PF00018	0.422
LIG_SH3_3	83	89	PF00018	0.449
LIG_SH3_3	92	98	PF00018	0.479
LIG_SUMO_SIM_anti_2	670	675	PF11976	0.429
LIG_SUMO_SIM_anti_2	686	692	PF11976	0.443
LIG_SUMO_SIM_par_1	423	432	PF11976	0.254
MOD_CDK_SPK_2	519	524	PF00069	0.480
MOD_CK1_1	109	115	PF00069	0.600
MOD_CK1_1	178	184	PF00069	0.661
MOD_CK1_1	219	225	PF00069	0.744
MOD_CK1_1	322	328	PF00069	0.447
MOD_CK1_1	333	339	PF00069	0.447
MOD_CK1_1	404	410	PF00069	0.383
MOD_CK1_1	468	474	PF00069	0.433
MOD_CK1_1	582	588	PF00069	0.785
MOD_CK1_1	663	669	PF00069	0.517
MOD_CK1_1	713	719	PF00069	0.658
MOD_CK1_1	73	79	PF00069	0.425
MOD_CK2_1	114	120	PF00069	0.556
MOD_CK2_1	182	188	PF00069	0.614
MOD_CK2_1	394	400	PF00069	0.327
MOD_CK2_1	469	475	PF00069	0.421
MOD_CK2_1	583	589	PF00069	0.739
MOD_GlcNHglycan	106	109	PF01048	0.525
MOD_GlcNHglycan	146	149	PF01048	0.775
MOD_GlcNHglycan	348	352	PF01048	0.461
MOD_GlcNHglycan	546	549	PF01048	0.344
MOD_GlcNHglycan	571	574	PF01048	0.683
MOD_GlcNHglycan	662	665	PF01048	0.576
MOD_GlcNHglycan	703	706	PF01048	0.683
MOD_GlcNHglycan	712	715	PF01048	0.633
MOD_GlcNHglycan	726	729	PF01048	0.647
MOD_GlcNHglycan	75	78	PF01048	0.561
MOD_GSK3_1	109	116	PF00069	0.450
MOD_GSK3_1	160	167	PF00069	0.560
MOD_GSK3_1	178	185	PF00069	0.655
MOD_GSK3_1	18	25	PF00069	0.768
MOD_GSK3_1	216	223	PF00069	0.699
MOD_GSK3_1	26	33	PF00069	0.697
MOD_GSK3_1	330	337	PF00069	0.434
MOD_GSK3_1	357	364	PF00069	0.369
MOD_GSK3_1	390	397	PF00069	0.407
MOD_GSK3_1	400	407	PF00069	0.409
MOD_GSK3_1	421	428	PF00069	0.246
MOD_GSK3_1	465	472	PF00069	0.433
MOD_GSK3_1	515	522	PF00069	0.424
MOD_GSK3_1	575	582	PF00069	0.763
MOD_GSK3_1	663	670	PF00069	0.435
MOD_GSK3_1	735	742	PF00069	0.754
MOD_GSK3_1	89	96	PF00069	0.570
MOD_N-GLC_1	286	291	PF02516	0.402
MOD_N-GLC_1	358	363	PF02516	0.407
MOD_N-GLC_1	394	399	PF02516	0.455
MOD_N-GLC_1	420	425	PF02516	0.373
MOD_N-GLC_1	625	630	PF02516	0.594
MOD_N-GLC_2	248	250	PF02516	0.622
MOD_NEK2_1	111	116	PF00069	0.546
MOD_NEK2_1	172	177	PF00069	0.577
MOD_NEK2_1	221	226	PF00069	0.795
MOD_NEK2_1	249	254	PF00069	0.664
MOD_NEK2_1	429	434	PF00069	0.367
MOD_NEK2_1	493	498	PF00069	0.407
MOD_NEK2_1	563	568	PF00069	0.494
MOD_NEK2_1	660	665	PF00069	0.496
MOD_NEK2_1	667	672	PF00069	0.421
MOD_NEK2_1	708	713	PF00069	0.736
MOD_NEK2_1	739	744	PF00069	0.721
MOD_NEK2_2	358	363	PF00069	0.447
MOD_PIKK_1	175	181	PF00454	0.663
MOD_PIKK_1	288	294	PF00454	0.470
MOD_PK_1	457	463	PF00069	0.246
MOD_PK_1	722	728	PF00069	0.634
MOD_PKA_1	26	32	PF00069	0.484
MOD_PKA_2	135	141	PF00069	0.699
MOD_PKA_2	219	225	PF00069	0.756
MOD_PKA_2	25	31	PF00069	0.557
MOD_PKA_2	311	317	PF00069	0.447
MOD_PKA_2	379	385	PF00069	0.423
MOD_PKA_2	401	407	PF00069	0.480
MOD_PKB_1	56	64	PF00069	0.448
MOD_Plk_1	286	292	PF00069	0.480
MOD_Plk_1	333	339	PF00069	0.406
MOD_Plk_1	358	364	PF00069	0.377
MOD_Plk_1	420	426	PF00069	0.373
MOD_Plk_1	474	480	PF00069	0.363
MOD_Plk_1	735	741	PF00069	0.763
MOD_Plk_2-3	394	400	PF00069	0.246
MOD_Plk_2-3	758	764	PF00069	0.666
MOD_Plk_4	114	120	PF00069	0.468
MOD_Plk_4	172	178	PF00069	0.521
MOD_Plk_4	322	328	PF00069	0.482
MOD_Plk_4	505	511	PF00069	0.485
MOD_Plk_4	669	675	PF00069	0.426
MOD_ProDKin_1	127	133	PF00069	0.602
MOD_ProDKin_1	225	231	PF00069	0.773
MOD_ProDKin_1	519	525	PF00069	0.386
MOD_ProDKin_1	59	65	PF00069	0.450
MOD_ProDKin_1	604	610	PF00069	0.700
MOD_ProDKin_1	67	73	PF00069	0.436
MOD_ProDKin_1	94	100	PF00069	0.592
MOD_SUMO_for_1	362	365	PF00179	0.447
MOD_SUMO_rev_2	428	435	PF00179	0.246
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.456
TRG_DiLeu_BaLyEn_6	608	613	PF01217	0.617
TRG_DiLeu_BaLyEn_6	653	658	PF01217	0.495
TRG_ENDOCYTIC_2	324	327	PF00928	0.480
TRG_ER_diArg_1	306	308	PF00400	0.415
TRG_ER_diArg_1	519	521	PF00400	0.460
TRG_ER_diArg_1	53	56	PF00400	0.471
TRG_ER_diArg_1	535	537	PF00400	0.229

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB8	Leptomonas seymouri	50%	100%
A0A1X0NLJ7	Trypanosomatidae	29%	100%
A0A3R7LPQ4	Trypanosoma rangeli	28%	100%
A0A3S5H5C3	Leishmania donovani	90%	100%
A4H407	Leishmania braziliensis	70%	100%
A4HS69	Leishmania infantum	90%	100%
C9ZY64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AK56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BIB6	Trypanosoma cruzi	28%	100%