WASH_WAHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

O97214_LEIMA

TriTrypDb:

LmjF.04.0740 , LMJLV39_040012800 , LMJSD75_040013200

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

O97214

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97214

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.773
CLV_C14_Caspase3-7	35	39	PF00656	0.613
CLV_C14_Caspase3-7	769	773	PF00656	0.850
CLV_NRD_NRD_1	106	108	PF00675	0.369
CLV_NRD_NRD_1	128	130	PF00675	0.370
CLV_NRD_NRD_1	196	198	PF00675	0.717
CLV_NRD_NRD_1	371	373	PF00675	0.603
CLV_NRD_NRD_1	478	480	PF00675	0.713
CLV_NRD_NRD_1	513	515	PF00675	0.858
CLV_NRD_NRD_1	517	519	PF00675	0.789
CLV_NRD_NRD_1	539	541	PF00675	0.809
CLV_NRD_NRD_1	567	569	PF00675	0.731
CLV_NRD_NRD_1	738	740	PF00675	0.749
CLV_NRD_NRD_1	764	766	PF00675	0.726
CLV_PCSK_FUR_1	126	130	PF00082	0.512
CLV_PCSK_FUR_1	194	198	PF00082	0.717
CLV_PCSK_KEX2_1	106	108	PF00082	0.369
CLV_PCSK_KEX2_1	113	115	PF00082	0.332
CLV_PCSK_KEX2_1	128	130	PF00082	0.338
CLV_PCSK_KEX2_1	196	198	PF00082	0.717
CLV_PCSK_KEX2_1	371	373	PF00082	0.603
CLV_PCSK_KEX2_1	478	480	PF00082	0.713
CLV_PCSK_KEX2_1	513	515	PF00082	0.856
CLV_PCSK_KEX2_1	517	519	PF00082	0.787
CLV_PCSK_KEX2_1	538	540	PF00082	0.695
CLV_PCSK_KEX2_1	566	568	PF00082	0.739
CLV_PCSK_KEX2_1	737	739	PF00082	0.747
CLV_PCSK_KEX2_1	764	766	PF00082	0.765
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.286
CLV_PCSK_PC7_1	513	519	PF00082	0.856
CLV_PCSK_PC7_1	535	541	PF00082	0.819
CLV_PCSK_PC7_1	562	568	PF00082	0.729
CLV_PCSK_SKI1_1	158	162	PF00082	0.815
CLV_PCSK_SKI1_1	459	463	PF00082	0.785
CLV_PCSK_SKI1_1	738	742	PF00082	0.747
DEG_APCC_DBOX_1	458	466	PF00400	0.780
DEG_SCF_TRCP1_1	22	27	PF00400	0.619
DEG_SPOP_SBC_1	330	334	PF00917	0.777
DEG_SPOP_SBC_1	380	384	PF00917	0.677
DEG_SPOP_SBC_1	687	691	PF00917	0.630
DOC_CDC14_PxL_1	54	62	PF14671	0.730
DOC_CKS1_1	436	441	PF01111	0.773
DOC_MAPK_DCC_7	137	146	PF00069	0.368
DOC_MAPK_DCC_7	631	639	PF00069	0.610
DOC_MAPK_gen_1	137	146	PF00069	0.471
DOC_MAPK_MEF2A_6	631	639	PF00069	0.610
DOC_PP2B_LxvP_1	592	595	PF13499	0.788
DOC_PP2B_LxvP_1	60	63	PF13499	0.622
DOC_PP2B_LxvP_1	602	605	PF13499	0.696
DOC_PP2B_LxvP_1	649	652	PF13499	0.658
DOC_PP2B_LxvP_1	680	683	PF13499	0.587
DOC_PP2B_LxvP_1	798	801	PF13499	0.714
DOC_PP4_FxxP_1	192	195	PF00568	0.818
DOC_PP4_FxxP_1	436	439	PF00568	0.675
DOC_USP7_MATH_1	100	104	PF00917	0.512
DOC_USP7_MATH_1	159	163	PF00917	0.622
DOC_USP7_MATH_1	195	199	PF00917	0.712
DOC_USP7_MATH_1	238	242	PF00917	0.744
DOC_USP7_MATH_1	26	30	PF00917	0.689
DOC_USP7_MATH_1	330	334	PF00917	0.757
DOC_USP7_MATH_1	364	368	PF00917	0.779
DOC_USP7_MATH_1	380	384	PF00917	0.567
DOC_USP7_MATH_1	392	396	PF00917	0.718
DOC_USP7_MATH_1	454	458	PF00917	0.664
DOC_USP7_MATH_1	63	67	PF00917	0.676
DOC_USP7_MATH_1	638	642	PF00917	0.803
DOC_USP7_MATH_1	673	677	PF00917	0.763
DOC_USP7_MATH_1	688	692	PF00917	0.731
DOC_USP7_MATH_1	722	726	PF00917	0.773
DOC_USP7_MATH_1	729	733	PF00917	0.780
DOC_USP7_MATH_1	75	79	PF00917	0.333
DOC_USP7_MATH_1	768	772	PF00917	0.740
DOC_USP7_MATH_1	805	809	PF00917	0.853
DOC_WW_Pin1_4	196	201	PF00397	0.773
DOC_WW_Pin1_4	266	271	PF00397	0.710
DOC_WW_Pin1_4	416	421	PF00397	0.735
DOC_WW_Pin1_4	435	440	PF00397	0.648
DOC_WW_Pin1_4	775	780	PF00397	0.719
LIG_14-3-3_CanoR_1	126	134	PF00244	0.419
LIG_14-3-3_CanoR_1	194	200	PF00244	0.710
LIG_14-3-3_CanoR_1	248	257	PF00244	0.789
LIG_14-3-3_CanoR_1	33	38	PF00244	0.653
LIG_14-3-3_CanoR_1	612	617	PF00244	0.738
LIG_BIR_III_4	388	392	PF00653	0.572
LIG_BRCT_BRCA1_1	188	192	PF00533	0.810
LIG_CtBP_PxDLS_1	599	603	PF00389	0.750
LIG_DCNL_PONY_1	1	4	PF03556	0.545
LIG_EVH1_1	649	653	PF00568	0.654
LIG_EVH1_1	680	684	PF00568	0.587
LIG_EVH1_1	798	802	PF00568	0.713
LIG_FHA_1	128	134	PF00498	0.512
LIG_FHA_1	288	294	PF00498	0.808
LIG_FHA_1	419	425	PF00498	0.730
LIG_FHA_1	427	433	PF00498	0.662
LIG_FHA_1	435	441	PF00498	0.615
LIG_FHA_1	49	55	PF00498	0.620
LIG_FHA_1	5	11	PF00498	0.612
LIG_FHA_1	587	593	PF00498	0.663
LIG_FHA_1	729	735	PF00498	0.831
LIG_FHA_2	130	136	PF00498	0.403
LIG_FHA_2	493	499	PF00498	0.776
LIG_FHA_2	546	552	PF00498	0.737
LIG_FHA_2	9	15	PF00498	0.613
LIG_Integrin_isoDGR_2	317	319	PF01839	0.628
LIG_LIR_Apic_2	189	195	PF02991	0.713
LIG_LIR_Apic_2	229	233	PF02991	0.836
LIG_MYND_1	600	604	PF01753	0.748
LIG_MYND_1	620	624	PF01753	0.485
LIG_MYND_1	647	651	PF01753	0.622
LIG_MYND_1	678	682	PF01753	0.815
LIG_MYND_1	796	800	PF01753	0.640
LIG_PROFILIN_1	617	623	PF00235	0.711
LIG_PROFILIN_1	650	656	PF00235	0.669
LIG_PROFILIN_1	681	687	PF00235	0.775
LIG_PROFILIN_1	713	719	PF00235	0.795
LIG_RPA_C_Fungi	36	48	PF08784	0.710
LIG_RPA_C_Fungi	562	574	PF08784	0.729
LIG_SH2_CRK	230	234	PF00017	0.833
LIG_SH2_CRK	445	449	PF00017	0.697
LIG_SH2_NCK_1	49	53	PF00017	0.621
LIG_SH2_SRC	230	233	PF00017	0.750
LIG_SH2_STAP1	49	53	PF00017	0.722
LIG_SH3_1	197	203	PF00018	0.802
LIG_SH3_1	648	654	PF00018	0.707
LIG_SH3_1	711	717	PF00018	0.728
LIG_SH3_2	719	724	PF14604	0.597
LIG_SH3_3	135	141	PF00018	0.411
LIG_SH3_3	142	148	PF00018	0.702
LIG_SH3_3	197	203	PF00018	0.789
LIG_SH3_3	222	228	PF00018	0.737
LIG_SH3_3	264	270	PF00018	0.703
LIG_SH3_3	363	369	PF00018	0.753
LIG_SH3_3	593	599	PF00018	0.800
LIG_SH3_3	601	607	PF00018	0.825
LIG_SH3_3	614	620	PF00018	0.745
LIG_SH3_3	629	635	PF00018	0.734
LIG_SH3_3	644	650	PF00018	0.761
LIG_SH3_3	651	657	PF00018	0.775
LIG_SH3_3	675	681	PF00018	0.833
LIG_SH3_3	682	688	PF00018	0.690
LIG_SH3_3	701	707	PF00018	0.808
LIG_SH3_3	709	715	PF00018	0.683
LIG_SH3_3	716	722	PF00018	0.629
LIG_SH3_3	793	799	PF00018	0.692
LIG_SUMO_SIM_par_1	289	294	PF11976	0.764
LIG_TRAF2_1	528	531	PF00917	0.714
LIG_TRAF2_1	549	552	PF00917	0.679
LIG_UBA3_1	666	671	PF00899	0.712
LIG_WW_2	620	623	PF00397	0.709
LIG_WW_2	678	681	PF00397	0.600
LIG_WW_3	645	649	PF00397	0.712
MOD_CK1_1	18	24	PF00069	0.703
MOD_CK1_1	182	188	PF00069	0.700
MOD_CK1_1	207	213	PF00069	0.735
MOD_CK1_1	265	271	PF00069	0.693
MOD_CK1_1	27	33	PF00069	0.722
MOD_CK1_1	299	305	PF00069	0.728
MOD_CK1_1	331	337	PF00069	0.671
MOD_CK1_1	36	42	PF00069	0.464
MOD_CK1_1	360	366	PF00069	0.571
MOD_CK1_1	384	390	PF00069	0.580
MOD_CK1_1	418	424	PF00069	0.655
MOD_CK1_1	426	432	PF00069	0.631
MOD_CK1_1	492	498	PF00069	0.826
MOD_CK1_1	547	553	PF00069	0.818
MOD_CK1_1	641	647	PF00069	0.616
MOD_CK1_1	66	72	PF00069	0.708
MOD_CK1_1	725	731	PF00069	0.800
MOD_CK1_1	746	752	PF00069	0.736
MOD_CK1_1	770	776	PF00069	0.854
MOD_CK1_1	808	814	PF00069	0.830
MOD_CK2_1	129	135	PF00069	0.411
MOD_CK2_1	545	551	PF00069	0.761
MOD_CK2_1	8	14	PF00069	0.614
MOD_Cter_Amidation	126	129	PF01082	0.512
MOD_GlcNHglycan	177	180	PF01048	0.703
MOD_GlcNHglycan	181	184	PF01048	0.660
MOD_GlcNHglycan	209	212	PF01048	0.742
MOD_GlcNHglycan	22	25	PF01048	0.727
MOD_GlcNHglycan	240	243	PF01048	0.793
MOD_GlcNHglycan	26	29	PF01048	0.689
MOD_GlcNHglycan	296	301	PF01048	0.692
MOD_GlcNHglycan	333	336	PF01048	0.773
MOD_GlcNHglycan	362	365	PF01048	0.698
MOD_GlcNHglycan	38	41	PF01048	0.611
MOD_GlcNHglycan	394	397	PF01048	0.738
MOD_GlcNHglycan	491	494	PF01048	0.622
MOD_GlcNHglycan	592	595	PF01048	0.825
MOD_GlcNHglycan	640	643	PF01048	0.808
MOD_GlcNHglycan	65	68	PF01048	0.679
MOD_GlcNHglycan	671	674	PF01048	0.832
MOD_GlcNHglycan	724	727	PF01048	0.828
MOD_GlcNHglycan	750	753	PF01048	0.840
MOD_GlcNHglycan	77	80	PF01048	0.333
MOD_GlcNHglycan	792	795	PF01048	0.723
MOD_GSK3_1	129	136	PF00069	0.452
MOD_GSK3_1	16	23	PF00069	0.711
MOD_GSK3_1	175	182	PF00069	0.751
MOD_GSK3_1	205	212	PF00069	0.735
MOD_GSK3_1	262	269	PF00069	0.714
MOD_GSK3_1	27	34	PF00069	0.802
MOD_GSK3_1	295	302	PF00069	0.633
MOD_GSK3_1	324	331	PF00069	0.730
MOD_GSK3_1	353	360	PF00069	0.711
MOD_GSK3_1	380	387	PF00069	0.573
MOD_GSK3_1	4	11	PF00069	0.633
MOD_GSK3_1	412	419	PF00069	0.731
MOD_GSK3_1	488	495	PF00069	0.760
MOD_GSK3_1	550	557	PF00069	0.727
MOD_GSK3_1	581	588	PF00069	0.831
MOD_GSK3_1	608	615	PF00069	0.742
MOD_GSK3_1	62	69	PF00069	0.718
MOD_GSK3_1	661	668	PF00069	0.696
MOD_GSK3_1	669	676	PF00069	0.730
MOD_GSK3_1	725	732	PF00069	0.745
MOD_GSK3_1	743	750	PF00069	0.675
MOD_GSK3_1	75	82	PF00069	0.298
MOD_GSK3_1	767	774	PF00069	0.825
MOD_GSK3_1	805	812	PF00069	0.752
MOD_LATS_1	565	571	PF00433	0.623
MOD_N-GLC_1	353	358	PF02516	0.724
MOD_N-GLC_1	384	389	PF02516	0.647
MOD_N-GLC_1	434	439	PF02516	0.552
MOD_NEK2_1	133	138	PF00069	0.411
MOD_NEK2_1	16	21	PF00069	0.741
MOD_NEK2_1	282	287	PF00069	0.671
MOD_NEK2_1	4	9	PF00069	0.621
MOD_NEK2_1	412	417	PF00069	0.717
MOD_NEK2_1	424	429	PF00069	0.609
MOD_NEK2_1	790	795	PF00069	0.778
MOD_PIKK_1	100	106	PF00454	0.512
MOD_PIKK_1	159	165	PF00454	0.689
MOD_PIKK_1	582	588	PF00454	0.849
MOD_PK_1	33	39	PF00069	0.719
MOD_PKA_1	128	134	PF00069	0.368
MOD_PKA_1	513	519	PF00069	0.856
MOD_PKA_1	567	573	PF00069	0.737
MOD_PKA_2	127	133	PF00069	0.412
MOD_PKA_2	195	201	PF00069	0.707
MOD_PKA_2	318	324	PF00069	0.726
MOD_PKA_2	32	38	PF00069	0.667
MOD_PKA_2	513	519	PF00069	0.852
MOD_PKA_2	567	573	PF00069	0.773
MOD_PKA_2	580	586	PF00069	0.542
MOD_PKA_2	611	617	PF00069	0.739
MOD_PKB_1	126	134	PF00069	0.430
MOD_PKB_1	566	574	PF00069	0.682
MOD_Plk_1	16	22	PF00069	0.718
MOD_Plk_1	296	302	PF00069	0.694
MOD_Plk_4	129	135	PF00069	0.411
MOD_Plk_4	287	293	PF00069	0.703
MOD_Plk_4	318	324	PF00069	0.726
MOD_Plk_4	419	425	PF00069	0.673
MOD_Plk_4	729	735	PF00069	0.831
MOD_Plk_4	89	95	PF00069	0.430
MOD_ProDKin_1	196	202	PF00069	0.769
MOD_ProDKin_1	266	272	PF00069	0.708
MOD_ProDKin_1	416	422	PF00069	0.736
MOD_ProDKin_1	435	441	PF00069	0.646
MOD_ProDKin_1	775	781	PF00069	0.720
MOD_SUMO_rev_2	131	138	PF00179	0.388
MOD_SUMO_rev_2	382	392	PF00179	0.561
MOD_SUMO_rev_2	664	673	PF00179	0.713
TRG_ENDOCYTIC_2	375	378	PF00928	0.700
TRG_ENDOCYTIC_2	445	448	PF00928	0.697
TRG_ER_diArg_1	106	108	PF00400	0.375
TRG_ER_diArg_1	125	128	PF00400	0.249
TRG_ER_diArg_1	148	151	PF00400	0.724
TRG_ER_diArg_1	193	196	PF00400	0.719
TRG_ER_diArg_1	371	373	PF00400	0.603
TRG_ER_diArg_1	477	479	PF00400	0.704
TRG_ER_diArg_1	533	536	PF00400	0.738
TRG_ER_diArg_1	538	540	PF00400	0.786
TRG_ER_diArg_1	566	568	PF00400	0.766
TRG_ER_diArg_1	572	575	PF00400	0.802
TRG_ER_diArg_1	737	739	PF00400	0.845
TRG_ER_diArg_1	787	790	PF00400	0.854
TRG_Pf-PMV_PEXEL_1	459	464	PF00026	0.787
TRG_Pf-PMV_PEXEL_1	467	472	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.712
TRG_Pf-PMV_PEXEL_1	739	744	PF00026	0.848

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV3	Leptomonas seymouri	41%	94%
A0A3S7WNR6	Leishmania donovani	88%	100%
A4H408	Leishmania braziliensis	67%	98%
A4HS70	Leishmania infantum	87%	100%
E9AK57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%