Nascent polypeptide associated complex subunit-like protein, copy 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nascent polypeptide associated complex subunit- like protein, copy 2

Species:

Leishmania major

UniProt:

O97212_LEIMA

TriTrypDb:

LmjF.04.0760 , LMJLV39_040013100 , LMJSD75_040013400

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005854	nascent polypeptide-associated complex	2	15
GO:0032991	protein-containing complex	1	15
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

O97212

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O97212

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	3
GO:0006612	protein targeting to membrane	5	3
GO:0006810	transport	3	3
GO:0006886	intracellular protein transport	4	3
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0051668	localization within membrane	3	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0072657	protein localization to membrane	4	3
GO:0090150	establishment of protein localization to membrane	4	3

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0051082	unfolded protein binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.295
CLV_NRD_NRD_1	40	42	PF00675	0.383
CLV_NRD_NRD_1	8	10	PF00675	0.395
CLV_PCSK_KEX2_1	105	107	PF00082	0.288
CLV_PCSK_KEX2_1	40	42	PF00082	0.383
CLV_PCSK_KEX2_1	8	10	PF00082	0.395
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.288
CLV_PCSK_PC7_1	36	42	PF00082	0.382
CLV_PCSK_SKI1_1	106	110	PF00082	0.281
CLV_PCSK_SKI1_1	223	227	PF00082	0.341
CLV_PCSK_SKI1_1	55	59	PF00082	0.432
CLV_PCSK_SKI1_1	8	12	PF00082	0.389
DEG_Nend_Nbox_1	1	3	PF02207	0.400
DOC_CYCLIN_RxL_1	5	14	PF00134	0.387
DOC_CYCLIN_yCln2_LP_2	13	19	PF00134	0.399
DOC_MAPK_gen_1	105	116	PF00069	0.481
DOC_MAPK_gen_1	128	135	PF00069	0.495
DOC_MAPK_gen_1	8	15	PF00069	0.392
DOC_MAPK_MEF2A_6	8	15	PF00069	0.392
DOC_MAPK_NFAT4_5	8	16	PF00069	0.391
DOC_MAPK_RevD_3	114	129	PF00069	0.495
DOC_PP1_RVXF_1	46	52	PF00149	0.380
DOC_USP7_MATH_1	101	105	PF00917	0.572
DOC_USP7_MATH_1	173	177	PF00917	0.656
DOC_USP7_MATH_1	179	183	PF00917	0.718
DOC_USP7_MATH_1	185	189	PF00917	0.715
DOC_USP7_MATH_1	217	221	PF00917	0.569
DOC_USP7_UBL2_3	105	109	PF12436	0.481
DOC_USP7_UBL2_3	113	117	PF12436	0.481
DOC_WW_Pin1_4	18	23	PF00397	0.473
DOC_WW_Pin1_4	57	62	PF00397	0.459
LIG_14-3-3_CanoR_1	48	52	PF00244	0.391
LIG_14-3-3_CanoR_1	55	64	PF00244	0.424
LIG_APCC_ABBA_1	151	156	PF00400	0.481
LIG_BRCT_BRCA1_1	131	135	PF00533	0.513
LIG_eIF4E_1	7	13	PF01652	0.389
LIG_FHA_1	148	154	PF00498	0.471
LIG_FHA_1	160	166	PF00498	0.475
LIG_FHA_1	70	76	PF00498	0.592
LIG_FHA_2	236	242	PF00498	0.569
LIG_LIR_Apic_2	141	146	PF02991	0.481
LIG_LIR_Gen_1	132	143	PF02991	0.544
LIG_LIR_Gen_1	148	159	PF02991	0.409
LIG_LIR_Nem_3	132	138	PF02991	0.544
LIG_LIR_Nem_3	148	154	PF02991	0.409
LIG_PROFILIN_1	61	67	PF00235	0.402
LIG_RPA_C_Fungi	216	228	PF08784	0.450
LIG_SH2_CRK	143	147	PF00017	0.326
LIG_SH2_CRK	7	11	PF00017	0.413
LIG_SH2_STAP1	107	111	PF00017	0.326
LIG_SH3_3	13	19	PF00018	0.415
LIG_SH3_3	58	64	PF00018	0.451
LIG_SUMO_SIM_par_1	9	14	PF11976	0.388
LIG_TRAF2_1	191	194	PF00917	0.714
LIG_TRAF2_1	74	77	PF00917	0.724
LIG_TRAF2_1	85	88	PF00917	0.720
LIG_TRFH_1	15	19	PF08558	0.403
LIG_TYR_ITIM	5	10	PF00017	0.384
MOD_CK1_1	180	186	PF00069	0.731
MOD_CK1_1	21	27	PF00069	0.418
MOD_CK2_1	235	241	PF00069	0.450
MOD_CK2_1	71	77	PF00069	0.515
MOD_GlcNHglycan	160	165	PF01048	0.559
MOD_GlcNHglycan	175	178	PF01048	0.477
MOD_GlcNHglycan	179	182	PF01048	0.607
MOD_GSK3_1	173	180	PF00069	0.655
MOD_GSK3_1	53	60	PF00069	0.488
MOD_GSK3_1	67	74	PF00069	0.486
MOD_N-GLC_1	120	125	PF02516	0.340
MOD_N-GLC_1	217	222	PF02516	0.450
MOD_NEK2_1	11	16	PF00069	0.397
MOD_NEK2_1	159	164	PF00069	0.485
MOD_NEK2_1	34	39	PF00069	0.387
MOD_NEK2_1	53	58	PF00069	0.501
MOD_PIKK_1	212	218	PF00454	0.373
MOD_PKA_2	47	53	PF00069	0.389
MOD_Plk_1	160	166	PF00069	0.529
MOD_Plk_2-3	88	94	PF00069	0.593
MOD_Plk_4	147	153	PF00069	0.414
MOD_Plk_4	235	241	PF00069	0.450
MOD_ProDKin_1	18	24	PF00069	0.471
MOD_ProDKin_1	57	63	PF00069	0.456
MOD_SUMO_for_1	116	119	PF00179	0.329
MOD_SUMO_rev_2	204	210	PF00179	0.379
TRG_DiLeu_BaEn_4	87	93	PF01217	0.706
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.387
TRG_ENDOCYTIC_2	7	10	PF00928	0.412
TRG_ER_diArg_1	40	42	PF00400	0.383
TRG_ER_diArg_1	7	9	PF00400	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRE4	Leptomonas seymouri	88%	100%
A0A1X0NL03	Trypanosomatidae	63%	100%
A0A3S5H5C5	Leishmania donovani	98%	100%
A0A3S5H5C6	Leishmania donovani	98%	100%
A1CMF8	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	41%	100%
A1DLM0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	41%	100%
A2R4V1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	39%	100%
A3GHD3	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	34%	100%
A4H3Y9	Leishmania braziliensis	90%	100%
A4HS72	Leishmania infantum	75%	92%
A4HS73	Leishmania infantum	98%	100%
A5DGN9	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	35%	100%
A5DXK7	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	32%	100%
A6R641	Ajellomyces capsulatus (strain NAm1 / WU24)	37%	100%
A6SB28	Botryotinia fuckeliana (strain B05.10)	35%	100%
A6ZT99	Saccharomyces cerevisiae (strain YJM789)	34%	100%
A7EIZ1	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	37%	100%
C9ZY67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
C9ZY68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AK59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	87%
E9AK60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P0C2C7	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	39%	100%
P0CP06	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	29%	100%
P0CP07	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	29%	100%
P38879	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q0UKB5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	37%	100%
Q1DHR3	Coccidioides immitis (strain RS)	38%	100%
Q2U955	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	42%	100%
Q45FF9	Babesia divergens	33%	100%
Q4WD81	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	100%
Q5ANP2	Candida albicans (strain SC5314 / ATCC MYA-2876)	35%	100%
Q5AYK0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	100%
Q61UX1	Caenorhabditis briggsae	37%	100%
Q6BSN9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	36%	100%
Q6CDH0	Yarrowia lipolytica (strain CLIB 122 / E 150)	31%	100%
Q6CWG6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	100%
Q6FJD5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	38%	100%
Q756T5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	38%	100%
Q9BZK3	Homo sapiens	41%	100%
Q9H009	Homo sapiens	42%	100%
Q9U111	Leishmania major	99%	100%
V5BDN6	Trypanosoma cruzi	62%	100%